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Updated November 2019
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Protein Info
Short Name:
VAD1.3
Full Name:
Protein FAM75A6
Alias:
Type:
Uncharacterized protein
Mass (Da):
147818
Number AA:
1343
UniProt ID:
Q5VVP1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
L
K
L
L
S
A
S
S
L
N
A
P
S
S
Site 2
S20
A
S
S
L
N
A
P
S
S
T
P
W
V
L
D
Site 3
S21
S
S
L
N
A
P
S
S
T
P
W
V
L
D
I
Site 4
S56
F
H
C
D
D
P
P
S
P
S
P
G
K
R
K
Site 5
S58
C
D
D
P
P
S
P
S
P
G
K
R
K
C
P
Site 6
S80
R
G
R
M
K
N
H
S
L
R
A
G
R
E
C
Site 7
T94
C
P
R
G
L
E
E
T
S
D
L
L
S
Q
L
Site 8
S99
E
E
T
S
D
L
L
S
Q
L
Q
S
L
L
G
Site 9
S103
D
L
L
S
Q
L
Q
S
L
L
G
P
H
L
D
Site 10
S118
K
G
D
F
G
Q
L
S
G
P
D
P
P
G
E
Site 11
S135
E
R
A
P
D
G
A
S
Q
S
S
H
E
P
M
Site 12
S137
A
P
D
G
A
S
Q
S
S
H
E
P
M
E
D
Site 13
S150
E
D
A
A
P
I
L
S
P
L
A
S
P
D
P
Site 14
S154
P
I
L
S
P
L
A
S
P
D
P
Q
A
K
H
Site 15
S167
K
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
Site 16
T168
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
T
Site 17
S170
Q
D
L
A
S
T
P
S
P
G
P
M
T
T
S
Site 18
T175
T
P
S
P
G
P
M
T
T
S
V
S
S
L
S
Site 19
T176
P
S
P
G
P
M
T
T
S
V
S
S
L
S
A
Site 20
S177
S
P
G
P
M
T
T
S
V
S
S
L
S
A
S
Site 21
S179
G
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
Site 22
S180
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
P
Site 23
S182
T
T
S
V
S
S
L
S
A
S
Q
P
P
E
P
Site 24
S184
S
V
S
S
L
S
A
S
Q
P
P
E
P
S
L
Site 25
S190
A
S
Q
P
P
E
P
S
L
P
L
E
H
P
S
Site 26
S197
S
L
P
L
E
H
P
S
P
E
P
P
A
L
F
Site 27
T210
L
F
P
H
P
P
H
T
P
D
P
L
A
C
S
Site 28
S217
T
P
D
P
L
A
C
S
P
P
P
P
K
G
F
Site 29
T225
P
P
P
P
K
G
F
T
A
P
P
L
R
D
S
Site 30
S232
T
A
P
P
L
R
D
S
T
L
I
T
P
S
H
Site 31
T233
A
P
P
L
R
D
S
T
L
I
T
P
S
H
C
Site 32
T236
L
R
D
S
T
L
I
T
P
S
H
C
D
S
V
Site 33
S253
P
L
G
T
V
P
Q
S
L
S
P
H
E
D
L
Site 34
S255
G
T
V
P
Q
S
L
S
P
H
E
D
L
V
A
Site 35
S273
A
I
S
G
L
G
G
S
N
S
H
V
S
A
S
Site 36
S275
S
G
L
G
G
S
N
S
H
V
S
A
S
S
R
Site 37
S278
G
G
S
N
S
H
V
S
A
S
S
R
W
Q
E
Site 38
S280
S
N
S
H
V
S
A
S
S
R
W
Q
E
T
A
Site 39
T286
A
S
S
R
W
Q
E
T
A
R
T
S
C
A
F
Site 40
T289
R
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
Site 41
S290
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
V
Site 42
S296
T
S
C
A
F
N
S
S
V
Q
Q
D
P
L
S
Site 43
S303
S
V
Q
Q
D
P
L
S
R
H
P
P
E
T
C
Site 44
T309
L
S
R
H
P
P
E
T
C
Q
M
E
A
G
S
Site 45
S349
E
E
K
E
N
V
G
S
F
T
N
Q
M
T
P
Site 46
T355
G
S
F
T
N
Q
M
T
P
E
K
H
L
N
S
Site 47
S369
S
L
G
N
L
A
K
S
L
D
A
E
Q
D
T
Site 48
T376
S
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
Site 49
T377
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
N
Site 50
S407
D
P
R
L
L
Q
E
S
F
W
K
N
Y
S
Q
Site 51
T434
L
V
A
N
A
W
V
T
D
R
S
Y
T
L
Q
Site 52
S437
N
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
Site 53
Y438
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
Site 54
T439
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
L
Site 55
S442
D
R
S
Y
T
L
Q
S
P
P
F
L
F
N
E
Site 56
T461
C
P
I
Q
R
E
T
T
M
S
P
L
L
F
Q
Site 57
S463
I
Q
R
E
T
T
M
S
P
L
L
F
Q
A
Q
Site 58
S473
L
F
Q
A
Q
P
L
S
H
R
Q
P
F
I
S
Site 59
S480
S
H
R
Q
P
F
I
S
S
T
P
Q
F
L
P
Site 60
T482
R
Q
P
F
I
S
S
T
P
Q
F
L
P
T
P
Site 61
T488
S
T
P
Q
F
L
P
T
P
M
A
Q
A
E
A
Site 62
S501
E
A
Q
A
H
L
Q
S
S
F
P
V
L
S
P
Site 63
S532
Q
N
K
V
Q
A
L
S
L
P
E
T
Q
H
P
Site 64
T536
Q
A
L
S
L
P
E
T
Q
H
P
E
W
P
L
Site 65
S556
E
G
R
L
A
L
P
S
R
V
Q
K
S
Q
D
Site 66
S561
L
P
S
R
V
Q
K
S
Q
D
V
F
S
V
S
Site 67
S566
Q
K
S
Q
D
V
F
S
V
S
T
P
N
L
P
Site 68
S568
S
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
Site 69
T569
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
S
Site 70
S576
T
P
N
L
P
Q
E
S
L
T
S
I
L
P
E
Site 71
S579
L
P
Q
E
S
L
T
S
I
L
P
E
N
F
P
Site 72
S588
L
P
E
N
F
P
V
S
P
E
L
R
R
Q
L
Site 73
S626
L
M
Q
L
R
D
E
S
P
G
T
S
Q
A
K
Site 74
T629
L
R
D
E
S
P
G
T
S
Q
A
K
G
K
P
Site 75
S630
R
D
E
S
P
G
T
S
Q
A
K
G
K
P
S
Site 76
S637
S
Q
A
K
G
K
P
S
P
W
Q
S
S
T
S
Site 77
S641
G
K
P
S
P
W
Q
S
S
T
S
T
G
E
S
Site 78
S642
K
P
S
P
W
Q
S
S
T
S
T
G
E
S
S
Site 79
T643
P
S
P
W
Q
S
S
T
S
T
G
E
S
S
K
Site 80
S644
S
P
W
Q
S
S
T
S
T
G
E
S
S
K
E
Site 81
T645
P
W
Q
S
S
T
S
T
G
E
S
S
K
E
A
Site 82
S648
S
S
T
S
T
G
E
S
S
K
E
A
Q
K
V
Site 83
S649
S
T
S
T
G
E
S
S
K
E
A
Q
K
V
K
Site 84
T674
L
G
Q
I
L
G
E
T
P
Q
N
L
S
R
D
Site 85
S679
G
E
T
P
Q
N
L
S
R
D
M
K
S
F
P
Site 86
S684
N
L
S
R
D
M
K
S
F
P
R
K
V
L
G
Site 87
S694
R
K
V
L
G
V
T
S
E
E
S
E
R
N
L
Site 88
S697
L
G
V
T
S
E
E
S
E
R
N
L
R
K
P
Site 89
S707
N
L
R
K
P
L
R
S
D
S
G
S
D
L
L
Site 90
S709
R
K
P
L
R
S
D
S
G
S
D
L
L
R
C
Site 91
S711
P
L
R
S
D
S
G
S
D
L
L
R
C
T
E
Site 92
T717
G
S
D
L
L
R
C
T
E
R
T
H
I
E
N
Site 93
T720
L
L
R
C
T
E
R
T
H
I
E
N
I
L
K
Site 94
T737
M
G
R
N
L
G
Q
T
N
E
G
L
I
P
V
Site 95
S749
I
P
V
R
V
R
R
S
W
L
A
V
N
Q
A
Site 96
S760
V
N
Q
A
L
P
V
S
N
T
H
V
K
T
S
Site 97
T762
Q
A
L
P
V
S
N
T
H
V
K
T
S
N
L
Site 98
S774
S
N
L
A
A
P
K
S
G
K
A
C
V
N
T
Site 99
T792
L
S
F
L
E
P
C
T
Q
Q
G
L
G
A
H
Site 100
T833
K
V
S
S
L
S
L
T
Q
L
A
G
P
S
S
Site 101
S840
T
Q
L
A
G
P
S
S
A
T
C
E
S
G
A
Site 102
S845
P
S
S
A
T
C
E
S
G
A
G
S
E
V
E
Site 103
S849
T
C
E
S
G
A
G
S
E
V
E
V
D
M
F
Site 104
S864
L
R
K
P
P
M
A
S
L
R
K
Q
V
L
T
Site 105
T871
S
L
R
K
Q
V
L
T
K
A
S
D
H
M
P
Site 106
S880
A
S
D
H
M
P
E
S
L
L
A
S
S
P
A
Site 107
S884
M
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Site 108
S885
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Q
Site 109
S900
R
A
P
R
G
I
P
S
W
N
D
H
G
P
L
Site 110
S920
G
Q
E
G
R
W
P
S
K
P
L
T
Y
S
L
Site 111
T924
R
W
P
S
K
P
L
T
Y
S
L
T
G
S
T
Site 112
S926
P
S
K
P
L
T
Y
S
L
T
G
S
T
Q
Q
Site 113
T928
K
P
L
T
Y
S
L
T
G
S
T
Q
Q
S
R
Site 114
S930
L
T
Y
S
L
T
G
S
T
Q
Q
S
R
S
L
Site 115
S934
L
T
G
S
T
Q
Q
S
R
S
L
G
A
Q
S
Site 116
S936
G
S
T
Q
Q
S
R
S
L
G
A
Q
S
S
K
Site 117
S942
R
S
L
G
A
Q
S
S
K
A
G
E
T
R
E
Site 118
T981
H
G
F
E
A
P
G
T
S
K
S
S
L
H
P
Site 119
S982
G
F
E
A
P
G
T
S
K
S
S
L
H
P
R
Site 120
S984
E
A
P
G
T
S
K
S
S
L
H
P
R
V
S
Site 121
S985
A
P
G
T
S
K
S
S
L
H
P
R
V
S
V
Site 122
S991
S
S
L
H
P
R
V
S
V
S
Q
D
P
R
K
Site 123
S993
L
H
P
R
V
S
V
S
Q
D
P
R
K
L
C
Site 124
S1007
C
L
M
E
E
V
V
S
E
F
E
P
G
M
A
Site 125
S1017
E
P
G
M
A
T
K
S
E
T
Q
P
Q
V
C
Site 126
S1036
L
L
P
D
G
Q
A
S
V
V
P
H
A
S
E
Site 127
S1047
H
A
S
E
N
L
V
S
Q
V
P
Q
G
H
L
Site 128
S1056
V
P
Q
G
H
L
Q
S
M
P
T
G
N
M
R
Site 129
S1065
P
T
G
N
M
R
A
S
Q
E
L
H
D
L
M
Site 130
S1077
D
L
M
A
A
R
R
S
K
L
V
Q
E
E
P
Site 131
S1106
M
F
P
P
I
H
K
S
E
K
S
R
K
P
N
Site 132
S1109
P
I
H
K
S
E
K
S
R
K
P
N
L
E
K
Site 133
T1126
E
R
L
E
G
L
R
T
P
Q
L
T
P
V
R
Site 134
T1130
G
L
R
T
P
Q
L
T
P
V
R
K
T
E
D
Site 135
T1135
Q
L
T
P
V
R
K
T
E
D
T
H
Q
D
E
Site 136
T1138
P
V
R
K
T
E
D
T
H
Q
D
E
G
V
Q
Site 137
S1149
E
G
V
Q
L
L
P
S
K
K
Q
P
P
S
V
Site 138
S1155
P
S
K
K
Q
P
P
S
V
S
H
F
G
E
N
Site 139
S1157
K
K
Q
P
P
S
V
S
H
F
G
E
N
I
K
Site 140
S1176
W
I
F
S
K
K
K
S
K
P
A
P
V
T
A
Site 141
S1185
P
A
P
V
T
A
E
S
Q
K
T
V
K
N
R
Site 142
T1188
V
T
A
E
S
Q
K
T
V
K
N
R
S
C
V
Site 143
S1193
Q
K
T
V
K
N
R
S
C
V
Y
S
S
S
A
Site 144
S1197
K
N
R
S
C
V
Y
S
S
S
A
E
A
Q
G
Site 145
S1199
R
S
C
V
Y
S
S
S
A
E
A
Q
G
L
M
Site 146
S1218
Q
M
L
D
K
K
M
S
L
C
H
A
H
H
A
Site 147
S1252
N
H
R
H
L
F
Y
S
E
H
G
R
I
L
S
Site 148
S1259
S
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
Site 149
Y1260
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
A
Site 150
S1263
R
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
Site 151
S1264
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
S
Site 152
T1268
A
A
S
S
Q
Q
A
T
L
K
S
Q
G
C
P
Site 153
S1271
S
Q
Q
A
T
L
K
S
Q
G
C
P
N
R
D
Site 154
S1289
R
N
Q
Q
P
L
K
S
V
R
C
N
N
E
Q
Site 155
S1312
L
H
P
K
K
A
V
S
P
V
S
P
P
Q
H
Site 156
S1315
K
K
A
V
S
P
V
S
P
P
Q
H
W
P
K
Site 157
T1323
P
P
Q
H
W
P
K
T
S
G
A
S
S
H
H
Site 158
S1324
P
Q
H
W
P
K
T
S
G
A
S
S
H
H
H
Site 159
S1328
P
K
T
S
G
A
S
S
H
H
H
H
C
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation