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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DCAF12L2
Full Name:
DDB1- and CUL4-associated factor 12-like protein 2
Alias:
WD repeat-containing protein 40C
Type:
Mass (Da):
50803
Number AA:
463
UniProt ID:
Q5VW00
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
V
E
A
G
A
G
S
S
S
S
Q
G
L
A
A
Site 2
S25
A
G
A
G
S
S
S
S
Q
G
L
A
A
A
D
Site 3
T47
K
K
Q
K
R
P
A
T
R
R
R
L
V
H
Y
Site 4
Y54
T
R
R
R
L
V
H
Y
L
K
G
R
E
V
G
Site 5
Y78
F
E
G
E
L
R
G
Y
A
V
Q
R
L
P
E
Site 6
T88
Q
R
L
P
E
L
L
T
E
R
Q
L
D
L
G
Site 7
T96
E
R
Q
L
D
L
G
T
L
N
K
V
F
A
S
Site 8
T131
D
V
Q
S
G
H
I
T
R
I
P
L
M
R
D
Site 9
S160
H
A
I
E
L
N
P
S
K
T
L
L
A
T
G
Site 10
T162
I
E
L
N
P
S
K
T
L
L
A
T
G
G
E
Site 11
S173
T
G
G
E
N
P
N
S
L
A
I
Y
Q
L
P
Site 12
Y177
N
P
N
S
L
A
I
Y
Q
L
P
T
L
D
P
Site 13
S210
L
S
D
T
V
A
V
S
G
S
R
D
G
T
V
Site 14
T216
V
S
G
S
R
D
G
T
V
A
L
W
R
M
D
Site 15
S235
N
G
S
I
A
W
H
S
E
V
G
L
P
V
Y
Site 16
Y242
S
E
V
G
L
P
V
Y
A
H
I
R
P
R
D
Site 17
S257
V
E
A
I
P
R
A
S
T
N
P
S
N
R
K
Site 18
T258
E
A
I
P
R
A
S
T
N
P
S
N
R
K
V
Site 19
S261
P
R
A
S
T
N
P
S
N
R
K
V
R
A
L
Site 20
S271
K
V
R
A
L
A
F
S
G
K
N
Q
E
L
G
Site 21
S281
N
Q
E
L
G
A
V
S
L
D
G
Y
F
H
L
Site 22
Y285
G
A
V
S
L
D
G
Y
F
H
L
W
K
A
R
Site 23
S293
F
H
L
W
K
A
R
S
T
L
S
R
L
L
S
Site 24
T294
H
L
W
K
A
R
S
T
L
S
R
L
L
S
I
Site 25
S296
W
K
A
R
S
T
L
S
R
L
L
S
I
R
L
Site 26
S300
S
T
L
S
R
L
L
S
I
R
L
P
Y
C
R
Site 27
Y314
R
E
N
V
C
L
T
Y
C
D
E
L
S
L
Y
Site 28
Y321
Y
C
D
E
L
S
L
Y
A
V
G
S
Q
S
H
Site 29
S330
V
G
S
Q
S
H
V
S
F
L
D
P
R
Q
R
Site 30
S346
Q
N
I
R
P
L
C
S
R
E
G
G
T
G
V
Site 31
T351
L
C
S
R
E
G
G
T
G
V
R
S
L
S
F
Site 32
S355
E
G
G
T
G
V
R
S
L
S
F
Y
Q
H
I
Site 33
T364
S
F
Y
Q
H
I
I
T
V
G
T
G
H
G
S
Site 34
Y375
G
H
G
S
L
L
F
Y
D
I
R
A
Q
K
F
Site 35
S388
K
F
L
E
E
R
A
S
S
S
L
D
S
M
P
Site 36
S389
F
L
E
E
R
A
S
S
S
L
D
S
M
P
G
Site 37
S390
L
E
E
R
A
S
S
S
L
D
S
M
P
G
P
Site 38
S393
R
A
S
S
S
L
D
S
M
P
G
P
A
G
R
Site 39
Y420
Q
D
D
V
W
V
N
Y
F
G
G
M
G
E
F
Site 40
Y458
P
S
G
L
H
G
N
Y
A
G
L
W
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation