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Updated November 2019
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Protein Info
Short Name:
FAM46C
Full Name:
Protein FAM46C
Alias:
Type:
Mass (Da):
44944
Number AA:
391
UniProt ID:
Q5VWP2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
H
G
R
G
N
F
P
T
L
E
I
T
L
K
D
Site 2
T54
T
L
K
D
I
V
Q
T
V
R
S
R
L
E
E
Site 3
S130
G
V
N
K
L
K
I
S
P
V
T
L
K
E
A
Site 4
T147
Q
K
L
V
K
V
C
T
D
T
D
R
W
S
L
Site 5
S153
C
T
D
T
D
R
W
S
L
I
S
L
S
N
K
Site 6
S156
T
D
R
W
S
L
I
S
L
S
N
K
N
G
K
Site 7
S158
R
W
S
L
I
S
L
S
N
K
N
G
K
N
V
Site 8
S172
V
E
L
K
F
V
D
S
I
R
R
Q
F
E
F
Site 9
S180
I
R
R
Q
F
E
F
S
V
D
S
F
Q
I
I
Site 10
T209
I
S
E
H
F
H
P
T
V
I
G
E
S
M
Y
Site 11
Y216
T
V
I
G
E
S
M
Y
G
D
F
E
E
A
F
Site 12
Y247
R
G
G
G
L
L
K
Y
S
N
L
L
V
R
D
Site 13
T258
L
V
R
D
F
R
P
T
D
Q
E
E
I
K
T
Site 14
T265
T
D
Q
E
E
I
K
T
L
E
R
Y
M
C
S
Site 15
Y269
E
I
K
T
L
E
R
Y
M
C
S
R
F
F
I
Site 16
Y291
Q
Q
R
K
L
E
T
Y
L
Q
N
H
F
A
E
Site 17
Y304
A
E
E
E
R
S
K
Y
D
Y
L
M
I
L
R
Site 18
Y306
E
E
R
S
K
Y
D
Y
L
M
I
L
R
R
V
Site 19
T318
R
R
V
V
N
E
S
T
V
C
L
M
G
H
E
Site 20
T329
M
G
H
E
R
R
Q
T
L
N
L
I
S
L
L
Site 21
Y356
S
A
T
N
V
T
C
Y
Y
Q
P
A
P
Y
V
Site 22
Y362
C
Y
Y
Q
P
A
P
Y
V
S
D
G
N
F
S
Site 23
S364
Y
Q
P
A
P
Y
V
S
D
G
N
F
S
N
Y
Site 24
Y371
S
D
G
N
F
S
N
Y
Y
V
A
H
P
P
V
Site 25
Y372
D
G
N
F
S
N
Y
Y
V
A
H
P
P
V
T
Site 26
Y380
V
A
H
P
P
V
T
Y
S
Q
P
Y
P
T
W
Site 27
S381
A
H
P
P
V
T
Y
S
Q
P
Y
P
T
W
L
Site 28
Y384
P
V
T
Y
S
Q
P
Y
P
T
W
L
P
C
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation