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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PEAR1
Full Name:
Platelet endothelial aggregation receptor 1
Alias:
FLJ00193; Jedi; MEGF12; platelet endothelial aggregation receptor 1
Type:
Receptor, misc.
Mass (Da):
110666
Number AA:
1037
UniProt ID:
Q5VY43
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
V
G
L
R
L
A
G
T
L
N
P
S
D
P
N
Site 2
S24
L
A
G
T
L
N
P
S
D
P
N
T
C
S
F
Site 3
T28
L
N
P
S
D
P
N
T
C
S
F
W
E
S
F
Site 4
S30
P
S
D
P
N
T
C
S
F
W
E
S
F
T
T
Site 5
T37
S
F
W
E
S
F
T
T
T
T
K
E
S
H
S
Site 6
T38
F
W
E
S
F
T
T
T
T
K
E
S
H
S
R
Site 7
S44
T
T
T
K
E
S
H
S
R
P
F
S
L
L
P
Site 8
S48
E
S
H
S
R
P
F
S
L
L
P
S
E
P
C
Site 9
S52
R
P
F
S
L
L
P
S
E
P
C
E
R
P
W
Site 10
T64
R
P
W
E
G
P
H
T
C
P
Q
P
T
V
V
Site 11
T69
P
H
T
C
P
Q
P
T
V
V
Y
R
T
V
Y
Site 12
Y76
T
V
V
Y
R
T
V
Y
R
Q
V
V
K
T
D
Site 13
T82
V
Y
R
Q
V
V
K
T
D
H
R
Q
R
L
Q
Site 14
S154
P
C
S
C
G
N
N
S
S
C
D
P
K
S
G
Site 15
S155
C
S
C
G
N
N
S
S
C
D
P
K
S
G
V
Site 16
S160
N
S
S
C
D
P
K
S
G
V
C
S
C
P
S
Site 17
S164
D
P
K
S
G
V
C
S
C
P
S
G
L
Q
P
Site 18
S167
S
G
V
C
S
C
P
S
G
L
Q
P
P
N
C
Site 19
T179
P
N
C
L
Q
P
C
T
P
G
Y
Y
G
P
A
Site 20
Y182
L
Q
P
C
T
P
G
Y
Y
G
P
A
C
Q
F
Site 21
S215
P
A
E
R
T
G
P
S
C
D
V
S
C
S
Q
Site 22
S219
T
G
P
S
C
D
V
S
C
S
Q
G
T
S
G
Site 23
S221
P
S
C
D
V
S
C
S
Q
G
T
S
G
F
F
Site 24
T243
Q
N
G
G
V
F
Q
T
P
Q
G
S
C
S
C
Site 25
Y297
Q
C
R
C
A
P
G
Y
T
G
D
R
C
R
E
Site 26
T346
G
F
T
G
D
R
C
T
D
R
L
C
P
D
G
Site 27
Y355
R
L
C
P
D
G
F
Y
G
L
S
C
Q
A
P
Site 28
T364
L
S
C
Q
A
P
C
T
C
D
R
E
H
S
L
Site 29
T399
N
E
S
C
P
Q
D
T
H
G
P
G
C
Q
E
Site 30
Y443
S
L
C
P
P
D
T
Y
G
V
N
C
S
A
R
Site 31
S605
A
P
G
F
R
G
P
S
C
Q
R
S
C
Q
P
Site 32
S609
R
G
P
S
C
Q
R
S
C
Q
P
G
R
Y
G
Site 33
S795
H
H
L
A
V
A
Y
S
S
G
R
L
D
G
S
Site 34
S796
H
L
A
V
A
Y
S
S
G
R
L
D
G
S
E
Site 35
S802
S
S
G
R
L
D
G
S
E
Y
V
M
P
D
V
Site 36
Y804
G
R
L
D
G
S
E
Y
V
M
P
D
V
P
P
Site 37
S812
V
M
P
D
V
P
P
S
Y
S
H
Y
Y
S
N
Site 38
Y813
M
P
D
V
P
P
S
Y
S
H
Y
Y
S
N
P
Site 39
S814
P
D
V
P
P
S
Y
S
H
Y
Y
S
N
P
S
Site 40
Y816
V
P
P
S
Y
S
H
Y
Y
S
N
P
S
Y
H
Site 41
Y817
P
P
S
Y
S
H
Y
Y
S
N
P
S
Y
H
T
Site 42
S818
P
S
Y
S
H
Y
Y
S
N
P
S
Y
H
T
L
Site 43
Y822
H
Y
Y
S
N
P
S
Y
H
T
L
S
Q
C
S
Site 44
T824
Y
S
N
P
S
Y
H
T
L
S
Q
C
S
P
N
Site 45
S826
N
P
S
Y
H
T
L
S
Q
C
S
P
N
P
P
Site 46
S829
Y
H
T
L
S
Q
C
S
P
N
P
P
P
P
N
Site 47
S845
V
P
G
P
L
F
A
S
L
Q
N
P
E
R
P
Site 48
T862
A
Q
G
H
D
N
H
T
T
L
P
A
D
W
K
Site 49
S883
P
G
P
L
D
R
G
S
S
R
L
D
R
S
Y
Site 50
S884
G
P
L
D
R
G
S
S
R
L
D
R
S
Y
S
Site 51
S889
G
S
S
R
L
D
R
S
Y
S
Y
S
Y
S
N
Site 52
Y890
S
S
R
L
D
R
S
Y
S
Y
S
Y
S
N
G
Site 53
S891
S
R
L
D
R
S
Y
S
Y
S
Y
S
N
G
P
Site 54
S893
L
D
R
S
Y
S
Y
S
Y
S
N
G
P
G
P
Site 55
S895
R
S
Y
S
Y
S
Y
S
N
G
P
G
P
F
Y
Site 56
Y902
S
N
G
P
G
P
F
Y
N
K
G
L
I
S
E
Site 57
S908
F
Y
N
K
G
L
I
S
E
E
E
L
G
A
S
Site 58
S915
S
E
E
E
L
G
A
S
V
A
S
L
S
S
E
Site 59
S918
E
L
G
A
S
V
A
S
L
S
S
E
N
P
Y
Site 60
S920
G
A
S
V
A
S
L
S
S
E
N
P
Y
A
T
Site 61
Y925
S
L
S
S
E
N
P
Y
A
T
I
R
D
L
P
Site 62
T927
S
S
E
N
P
Y
A
T
I
R
D
L
P
S
L
Site 63
S933
A
T
I
R
D
L
P
S
L
P
G
G
P
R
E
Site 64
S941
L
P
G
G
P
R
E
S
S
Y
M
E
M
K
G
Site 65
S942
P
G
G
P
R
E
S
S
Y
M
E
M
K
G
P
Site 66
Y943
G
G
P
R
E
S
S
Y
M
E
M
K
G
P
P
Site 67
S951
M
E
M
K
G
P
P
S
G
S
P
P
R
Q
P
Site 68
S953
M
K
G
P
P
S
G
S
P
P
R
Q
P
P
Q
Site 69
S964
Q
P
P
Q
F
W
D
S
Q
R
R
R
Q
P
Q
Site 70
S976
Q
P
Q
P
Q
R
D
S
G
T
Y
E
Q
P
S
Site 71
T978
Q
P
Q
R
D
S
G
T
Y
E
Q
P
S
P
L
Site 72
Y979
P
Q
R
D
S
G
T
Y
E
Q
P
S
P
L
I
Site 73
S983
S
G
T
Y
E
Q
P
S
P
L
I
H
D
R
D
Site 74
S991
P
L
I
H
D
R
D
S
V
G
S
Q
P
P
L
Site 75
S994
H
D
R
D
S
V
G
S
Q
P
P
L
P
P
G
Site 76
Y1007
P
G
L
P
P
G
H
Y
D
S
P
K
N
S
H
Site 77
S1009
L
P
P
G
H
Y
D
S
P
K
N
S
H
I
P
Site 78
Y1019
N
S
H
I
P
G
H
Y
D
L
P
P
V
R
H
Site 79
S1029
P
P
V
R
H
P
P
S
P
P
L
R
R
Q
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation