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Updated November 2019
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Protein Info
Short Name:
ECM29
Full Name:
Proteasome-associated protein ECM29 homolog
Alias:
KIAA0368
Type:
Vesicle protein
Mass (Da):
204291
Number AA:
1845
UniProt ID:
Q5VYK3
International Prot ID:
IPI00157790
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030134
GO:0005793
GO:0005813
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0030433
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
P
P
V
L
L
K
L
S
S
T
Q
E
G
V
R
Site 2
S49
P
V
L
L
K
L
S
S
T
Q
E
G
V
R
K
Site 3
T50
V
L
L
K
L
S
S
T
Q
E
G
V
R
K
K
Site 4
S71
H
L
N
K
R
I
K
S
R
P
K
I
Q
L
P
Site 5
Y86
V
E
T
L
L
V
Q
Y
Q
D
P
A
A
V
S
Site 6
Y102
V
T
N
F
T
I
I
Y
V
K
M
G
Y
P
R
Site 7
Y107
I
I
Y
V
K
M
G
Y
P
R
L
P
V
E
K
Site 8
S136
K
P
Q
P
Q
Q
D
S
L
M
H
L
L
I
P
Site 9
Y150
P
T
L
F
H
M
K
Y
P
V
E
S
S
K
S
Site 10
S154
H
M
K
Y
P
V
E
S
S
K
S
A
S
P
F
Site 11
S155
M
K
Y
P
V
E
S
S
K
S
A
S
P
F
N
Site 12
S157
Y
P
V
E
S
S
K
S
A
S
P
F
N
L
A
Site 13
S159
V
E
S
S
K
S
A
S
P
F
N
L
A
E
K
Site 14
T169
N
L
A
E
K
P
K
T
V
Q
L
L
L
D
F
Site 15
S192
Y
G
Y
V
L
N
E
S
Q
S
R
Q
N
S
S
Site 16
S194
Y
V
L
N
E
S
Q
S
R
Q
N
S
S
S
A
Site 17
S198
E
S
Q
S
R
Q
N
S
S
S
A
Q
G
S
S
Site 18
S199
S
Q
S
R
Q
N
S
S
S
A
Q
G
S
S
S
Site 19
S200
Q
S
R
Q
N
S
S
S
A
Q
G
S
S
S
N
Site 20
S204
N
S
S
S
A
Q
G
S
S
S
N
S
G
G
G
Site 21
S205
S
S
S
A
Q
G
S
S
S
N
S
G
G
G
S
Site 22
S206
S
S
A
Q
G
S
S
S
N
S
G
G
G
S
G
Site 23
S208
A
Q
G
S
S
S
N
S
G
G
G
S
G
I
P
Site 24
S212
S
S
N
S
G
G
G
S
G
I
P
Q
P
P
P
Site 25
S222
P
Q
P
P
P
G
M
S
F
Y
A
A
K
R
V
Site 26
Y224
P
P
P
G
M
S
F
Y
A
A
K
R
V
I
G
Site 27
T236
V
I
G
D
N
P
W
T
P
E
Q
L
E
Q
C
Site 28
S275
A
S
S
D
T
R
H
S
V
A
T
A
A
D
L
Site 29
S286
A
A
D
L
E
L
K
S
K
Q
S
L
I
D
W
Site 30
S289
L
E
L
K
S
K
Q
S
L
I
D
W
N
N
P
Site 31
Y306
I
N
K
M
Y
K
V
Y
L
G
D
I
P
L
K
Site 32
T314
L
G
D
I
P
L
K
T
K
E
G
A
V
L
K
Site 33
S330
E
L
K
R
D
P
V
S
T
R
V
K
L
K
I
Site 34
T331
L
K
R
D
P
V
S
T
R
V
K
L
K
I
V
Site 35
T350
R
S
R
Q
A
A
E
T
F
P
A
N
I
Q
V
Site 36
T365
V
Y
D
G
L
F
G
T
N
T
N
S
K
L
R
Site 37
T367
D
G
L
F
G
T
N
T
N
S
K
L
R
T
L
Site 38
S369
L
F
G
T
N
T
N
S
K
L
R
T
L
S
L
Site 39
T373
N
T
N
S
K
L
R
T
L
S
L
Q
F
V
H
Site 40
S375
N
S
K
L
R
T
L
S
L
Q
F
V
H
H
I
Site 41
S417
K
E
D
P
K
L
L
S
M
A
Y
S
A
V
G
Site 42
S427
Y
S
A
V
G
K
L
S
S
R
M
P
H
L
F
Site 43
S428
S
A
V
G
K
L
S
S
R
M
P
H
L
F
T
Site 44
T455
L
C
K
E
E
P
E
T
R
L
A
I
Q
E
A
Site 45
Y470
L
S
M
M
V
G
A
Y
S
T
L
E
G
A
Q
Site 46
S510
F
A
S
T
V
F
P
S
D
H
I
P
S
R
Y
Site 47
S549
P
G
R
N
R
K
E
S
T
S
E
Q
M
P
S
Site 48
S551
R
N
R
K
E
S
T
S
E
Q
M
P
S
F
P
Site 49
S556
S
T
S
E
Q
M
P
S
F
P
E
M
V
Y
Y
Site 50
Y562
P
S
F
P
E
M
V
Y
Y
I
Q
E
K
A
S
Site 51
Y563
S
F
P
E
M
V
Y
Y
I
Q
E
K
A
S
H
Site 52
T574
K
A
S
H
R
M
K
T
P
V
K
Y
M
T
G
Site 53
Y578
R
M
K
T
P
V
K
Y
M
T
G
T
T
V
L
Site 54
S613
S
A
G
V
V
P
T
S
Q
S
L
A
D
M
Q
Site 55
S615
G
V
V
P
T
S
Q
S
L
A
D
M
Q
D
H
Site 56
Y629
H
A
P
A
I
G
R
Y
I
R
T
L
M
S
S
Site 57
T632
A
I
G
R
Y
I
R
T
L
M
S
S
G
Q
M
Site 58
S635
R
Y
I
R
T
L
M
S
S
G
Q
M
A
P
S
Site 59
S636
Y
I
R
T
L
M
S
S
G
Q
M
A
P
S
S
Site 60
S642
S
S
G
Q
M
A
P
S
S
S
N
K
S
G
E
Site 61
S643
S
G
Q
M
A
P
S
S
S
N
K
S
G
E
T
Site 62
S644
G
Q
M
A
P
S
S
S
N
K
S
G
E
T
N
Site 63
S647
A
P
S
S
S
N
K
S
G
E
T
N
P
V
Q
Site 64
Y683
L
L
E
A
V
S
V
Y
P
E
K
L
A
T
K
Site 65
T689
V
Y
P
E
K
L
A
T
K
F
V
D
K
T
E
Site 66
T695
A
T
K
F
V
D
K
T
E
W
I
K
S
L
M
Site 67
S700
D
K
T
E
W
I
K
S
L
M
N
N
S
K
E
Site 68
S731
V
S
G
N
E
L
K
S
M
I
E
Q
L
I
K
Site 69
S745
K
T
T
K
D
N
H
S
P
E
I
Q
H
G
S
Site 70
Y763
L
G
F
T
V
G
R
Y
L
A
K
K
K
M
R
Site 71
S772
A
K
K
K
M
R
M
S
E
Q
Q
D
L
E
R
Site 72
T783
D
L
E
R
N
A
D
T
L
P
D
Q
E
E
L
Site 73
S793
D
Q
E
E
L
I
Q
S
A
T
E
T
I
G
S
Site 74
S800
S
A
T
E
T
I
G
S
F
L
D
S
T
S
P
Site 75
S830
N
G
P
L
P
I
P
S
E
G
S
G
F
T
K
Site 76
S833
L
P
I
P
S
E
G
S
G
F
T
K
L
H
L
Site 77
T836
P
S
E
G
S
G
F
T
K
L
H
L
V
E
S
Site 78
S846
H
L
V
E
S
L
L
S
R
I
P
S
S
K
E
Site 79
S850
S
L
L
S
R
I
P
S
S
K
E
T
N
K
M
Site 80
S851
L
L
S
R
I
P
S
S
K
E
T
N
K
M
K
Site 81
T854
R
I
P
S
S
K
E
T
N
K
M
K
E
R
A
Site 82
T864
M
K
E
R
A
I
Q
T
L
G
Y
F
P
V
G
Site 83
Y867
R
A
I
Q
T
L
G
Y
F
P
V
G
D
G
D
Site 84
S888
L
L
Q
G
L
M
D
S
V
E
A
K
Q
I
E
Site 85
Y927
W
Q
M
T
E
E
E
Y
T
P
P
A
G
A
K
Site 86
T928
Q
M
T
E
E
E
Y
T
P
P
A
G
A
K
V
Site 87
S953
I
L
N
K
H
I
I
S
P
N
P
H
V
R
Q
Site 88
S974
L
S
L
V
R
K
L
S
T
H
K
E
V
K
S
Site 89
S981
S
T
H
K
E
V
K
S
H
L
K
E
I
Q
S
Site 90
S992
E
I
Q
S
A
F
V
S
V
L
S
E
N
D
E
Site 91
S995
S
A
F
V
S
V
L
S
E
N
D
E
L
S
Q
Site 92
S1001
L
S
E
N
D
E
L
S
Q
D
V
A
S
K
G
Site 93
Y1013
S
K
G
L
G
L
V
Y
E
L
G
N
E
Q
D
Site 94
T1027
D
Q
Q
E
L
V
S
T
L
V
E
T
L
M
T
Site 95
T1034
T
L
V
E
T
L
M
T
G
K
R
V
K
H
E
Site 96
T1046
K
H
E
V
S
G
E
T
V
V
F
Q
G
G
A
Site 97
T1057
Q
G
G
A
L
G
K
T
P
D
G
Q
G
L
S
Site 98
S1064
T
P
D
G
Q
G
L
S
T
Y
K
E
L
C
S
Site 99
Y1066
D
G
Q
G
L
S
T
Y
K
E
L
C
S
L
A
Site 100
S1071
S
T
Y
K
E
L
C
S
L
A
S
D
L
S
Q
Site 101
S1074
K
E
L
C
S
L
A
S
D
L
S
Q
P
D
L
Site 102
S1077
C
S
L
A
S
D
L
S
Q
P
D
L
V
Y
K
Site 103
Y1083
L
S
Q
P
D
L
V
Y
K
F
M
N
L
A
N
Site 104
Y1128
P
Q
L
V
P
R
L
Y
R
Y
Q
F
D
P
N
Site 105
T1143
L
G
I
R
Q
A
M
T
S
I
W
N
A
L
V
Site 106
S1144
G
I
R
Q
A
M
T
S
I
W
N
A
L
V
T
Site 107
T1151
S
I
W
N
A
L
V
T
D
K
S
M
V
D
K
Site 108
S1154
N
A
L
V
T
D
K
S
M
V
D
K
Y
L
K
Site 109
Y1159
D
K
S
M
V
D
K
Y
L
K
E
I
L
Q
D
Site 110
T1172
Q
D
L
V
K
N
L
T
S
N
M
W
R
V
R
Site 111
S1182
M
W
R
V
R
E
S
S
C
L
A
L
N
D
L
Site 112
T1208
K
L
P
E
I
W
E
T
L
F
R
V
Q
D
D
Site 113
S1219
V
Q
D
D
I
K
E
S
V
R
K
A
A
E
L
Site 114
T1277
V
R
A
L
S
I
N
T
L
V
K
I
S
K
S
Site 115
Y1314
L
E
P
Q
V
L
N
Y
L
S
L
R
A
T
E
Site 116
S1316
P
Q
V
L
N
Y
L
S
L
R
A
T
E
Q
E
Site 117
T1320
N
Y
L
S
L
R
A
T
E
Q
E
K
A
A
M
Site 118
S1329
Q
E
K
A
A
M
D
S
A
R
L
S
A
A
K
Site 119
S1333
A
M
D
S
A
R
L
S
A
A
K
S
S
P
M
Site 120
S1337
A
R
L
S
A
A
K
S
S
P
M
M
E
T
I
Site 121
S1338
R
L
S
A
A
K
S
S
P
M
M
E
T
I
N
Site 122
T1395
T
Q
C
P
Q
D
L
T
P
Y
S
G
K
L
M
Site 123
S1398
P
Q
D
L
T
P
Y
S
G
K
L
M
S
A
L
Site 124
S1407
K
L
M
S
A
L
L
S
G
L
T
D
R
N
S
Site 125
S1414
S
G
L
T
D
R
N
S
V
I
Q
K
S
C
A
Site 126
T1430
A
M
G
H
L
V
R
T
S
R
D
S
S
T
E
Site 127
S1431
M
G
H
L
V
R
T
S
R
D
S
S
T
E
K
Site 128
S1434
L
V
R
T
S
R
D
S
S
T
E
K
L
L
Q
Site 129
S1435
V
R
T
S
R
D
S
S
T
E
K
L
L
Q
K
Site 130
Y1455
M
E
K
E
E
P
I
Y
K
T
S
C
A
L
T
Site 131
T1457
K
E
E
P
I
Y
K
T
S
C
A
L
T
I
H
Site 132
S1470
I
H
A
I
G
R
Y
S
P
D
V
L
K
N
H
Site 133
S1498
E
I
A
D
E
E
K
S
E
K
E
E
C
N
L
Site 134
S1517
W
Q
E
N
V
P
G
S
F
G
G
I
R
L
Y
Site 135
S1538
I
T
Q
K
A
L
Q
S
Q
S
W
K
M
K
A
Site 136
S1560
S
I
A
K
Q
T
S
S
L
V
P
P
Y
L
G
Site 137
S1606
C
S
A
E
L
E
K
S
V
P
N
Q
P
S
T
Site 138
T1613
S
V
P
N
Q
P
S
T
N
E
I
L
Q
A
V
Site 139
S1655
E
D
R
F
Q
E
F
S
N
I
V
I
P
L
I
Site 140
S1666
I
P
L
I
K
K
N
S
L
E
S
S
G
V
R
Site 141
S1670
K
K
N
S
L
E
S
S
G
V
R
T
T
K
N
Site 142
T1675
E
S
S
G
V
R
T
T
K
N
E
E
E
N
E
Site 143
S1698
Y
L
L
G
A
F
E
S
L
G
K
A
W
P
R
Site 144
Y1713
N
A
E
T
Q
R
C
Y
R
Q
E
L
C
K
L
Site 145
T1729
C
E
R
L
K
L
S
T
W
K
V
Q
L
G
V
Site 146
S1774
T
C
K
S
I
T
Y
S
L
E
N
K
T
Y
S
Site 147
Y1780
Y
S
L
E
N
K
T
Y
S
S
V
R
T
E
A
Site 148
S1781
S
L
E
N
K
T
Y
S
S
V
R
T
E
A
L
Site 149
S1782
L
E
N
K
T
Y
S
S
V
R
T
E
A
L
S
Site 150
T1785
K
T
Y
S
S
V
R
T
E
A
L
S
V
I
E
Site 151
T1821
L
L
I
E
S
L
A
T
M
E
P
D
S
R
P
Site 152
S1826
L
A
T
M
E
P
D
S
R
P
E
L
Q
E
K
Site 153
T1840
K
A
A
L
L
K
K
T
L
E
N
L
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation