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Updated November 2019
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Protein Info
Short Name:
FAM75A3
Full Name:
Protein FAM75A3
Alias:
Type:
Mass (Da):
148706
Number AA:
1347
UniProt ID:
Q5VYP0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
L
K
L
L
S
A
S
S
L
N
A
P
S
S
Site 2
S20
A
S
S
L
N
A
P
S
S
T
P
W
V
L
D
Site 3
S21
S
S
L
N
A
P
S
S
T
P
W
V
L
D
I
Site 4
Y48
L
L
L
P
Y
L
S
Y
F
R
C
D
D
P
P
Site 5
S56
F
R
C
D
D
P
P
S
P
S
P
G
K
R
K
Site 6
S58
C
D
D
P
P
S
P
S
P
G
K
R
K
C
P
Site 7
S80
R
G
R
M
K
N
H
S
L
R
A
G
R
E
C
Site 8
T94
C
R
R
G
L
E
E
T
S
D
L
L
S
Q
L
Site 9
S95
R
R
G
L
E
E
T
S
D
L
L
S
Q
L
Q
Site 10
S99
E
E
T
S
D
L
L
S
Q
L
Q
S
L
L
G
Site 11
S103
D
L
L
S
Q
L
Q
S
L
L
G
P
H
L
D
Site 12
S118
K
G
D
F
G
Q
L
S
G
P
D
P
P
G
E
Site 13
S135
E
R
A
P
D
G
A
S
Q
S
S
H
E
P
M
Site 14
S137
A
P
D
G
A
S
Q
S
S
H
E
P
M
E
D
Site 15
S154
P
I
L
S
L
L
A
S
P
D
P
Q
A
K
H
Site 16
S167
K
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
Site 17
T168
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
T
Site 18
S170
Q
D
L
A
S
T
P
S
P
G
P
M
T
T
S
Site 19
T175
T
P
S
P
G
P
M
T
T
S
V
S
S
L
S
Site 20
T176
P
S
P
G
P
M
T
T
S
V
S
S
L
S
A
Site 21
S177
S
P
G
P
M
T
T
S
V
S
S
L
S
A
S
Site 22
S179
G
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
Site 23
S180
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
P
Site 24
S182
T
T
S
V
S
S
L
S
A
S
Q
P
P
E
P
Site 25
S184
S
V
S
S
L
S
A
S
Q
P
P
E
P
S
L
Site 26
S190
A
S
Q
P
P
E
P
S
L
P
L
E
H
P
S
Site 27
S197
S
L
P
L
E
H
P
S
P
E
P
P
A
L
F
Site 28
T210
L
F
P
H
P
P
H
T
P
D
P
L
A
C
S
Site 29
S217
T
P
D
P
L
A
C
S
L
P
P
P
K
G
F
Site 30
S232
T
A
P
P
L
R
D
S
T
L
I
T
P
S
H
Site 31
T233
A
P
P
L
R
D
S
T
L
I
T
P
S
H
C
Site 32
T236
L
R
D
S
T
L
I
T
P
S
H
C
D
S
V
Site 33
S253
P
L
G
T
V
P
Q
S
L
S
P
H
E
D
L
Site 34
S255
G
T
V
P
Q
S
L
S
P
H
E
D
L
V
A
Site 35
S273
A
I
S
G
L
G
G
S
N
S
H
V
S
A
S
Site 36
S275
S
G
L
G
G
S
N
S
H
V
S
A
S
S
R
Site 37
S278
G
G
S
N
S
H
V
S
A
S
S
R
W
Q
E
Site 38
S280
S
N
S
H
V
S
A
S
S
R
W
Q
E
T
A
Site 39
T286
A
S
S
R
W
Q
E
T
A
R
T
S
C
A
F
Site 40
T289
R
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
Site 41
S290
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
V
Site 42
S295
R
T
S
C
A
F
N
S
S
V
Q
Q
D
H
L
Site 43
S296
T
S
C
A
F
N
S
S
V
Q
Q
D
H
L
S
Site 44
S303
S
V
Q
Q
D
H
L
S
R
H
P
P
E
T
C
Site 45
T309
L
S
R
H
P
P
E
T
C
Q
M
E
A
G
S
Site 46
S349
E
E
K
E
N
V
G
S
F
T
N
R
M
T
P
Site 47
T355
G
S
F
T
N
R
M
T
P
E
K
H
L
N
S
Site 48
S362
T
P
E
K
H
L
N
S
L
R
N
L
A
K
S
Site 49
S369
S
L
R
N
L
A
K
S
L
D
A
E
Q
D
T
Site 50
T376
S
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
Site 51
T377
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
N
Site 52
S399
L
P
G
P
Q
K
L
S
D
P
R
L
W
Q
E
Site 53
T434
L
V
A
N
A
W
V
T
D
R
S
Y
T
L
Q
Site 54
S437
N
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
Site 55
Y438
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
Site 56
T439
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
L
Site 57
S442
D
R
S
Y
T
L
Q
S
P
P
F
L
F
N
E
Site 58
T461
C
P
I
Q
R
E
T
T
M
S
P
L
L
F
Q
Site 59
S463
I
Q
R
E
T
T
M
S
P
L
L
F
Q
A
Q
Site 60
S473
L
F
Q
A
Q
P
L
S
H
L
G
P
E
C
Q
Site 61
S485
E
C
Q
P
F
I
S
S
T
P
Q
F
R
P
T
Site 62
T486
C
Q
P
F
I
S
S
T
P
Q
F
R
P
T
P
Site 63
T492
S
T
P
Q
F
R
P
T
P
M
A
Q
A
E
A
Site 64
S505
E
A
Q
A
H
L
Q
S
S
F
P
V
L
S
P
Site 65
S536
Q
N
K
V
Q
A
L
S
L
P
E
T
Q
H
P
Site 66
T540
Q
A
L
S
L
P
E
T
Q
H
P
E
W
P
L
Site 67
S560
E
G
R
L
A
L
P
S
R
V
Q
K
S
Q
D
Site 68
S565
L
P
S
R
V
Q
K
S
Q
D
V
F
S
V
S
Site 69
S570
Q
K
S
Q
D
V
F
S
V
S
T
P
N
L
P
Site 70
S572
S
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
Site 71
T573
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
S
Site 72
S580
T
P
N
L
P
Q
E
S
L
T
S
I
L
P
E
Site 73
S583
L
P
Q
E
S
L
T
S
I
L
P
E
N
F
P
Site 74
S592
L
P
E
N
F
P
V
S
P
E
L
R
R
Q
L
Site 75
S630
L
M
Q
L
Q
D
E
S
P
G
T
S
Q
A
K
Site 76
T633
L
Q
D
E
S
P
G
T
S
Q
A
K
G
K
P
Site 77
S634
Q
D
E
S
P
G
T
S
Q
A
K
G
K
P
S
Site 78
S641
S
Q
A
K
G
K
P
S
P
W
Q
S
S
M
S
Site 79
S645
G
K
P
S
P
W
Q
S
S
M
S
T
G
E
S
Site 80
S646
K
P
S
P
W
Q
S
S
M
S
T
G
E
S
S
Site 81
S648
S
P
W
Q
S
S
M
S
T
G
E
S
S
K
E
Site 82
T649
P
W
Q
S
S
M
S
T
G
E
S
S
K
E
A
Site 83
S652
S
S
M
S
T
G
E
S
S
K
E
A
Q
K
V
Site 84
S653
S
M
S
T
G
E
S
S
K
E
A
Q
K
V
K
Site 85
T678
L
G
Q
I
L
G
E
T
P
Q
N
L
S
R
D
Site 86
S683
G
E
T
P
Q
N
L
S
R
D
M
K
S
F
P
Site 87
S688
N
L
S
R
D
M
K
S
F
P
R
K
V
L
G
Site 88
S698
R
K
V
L
G
V
T
S
E
E
L
E
R
N
L
Site 89
S711
N
L
R
K
P
L
R
S
D
S
G
S
D
L
L
Site 90
S713
R
K
P
L
R
S
D
S
G
S
D
L
L
R
C
Site 91
S715
P
L
R
S
D
S
G
S
D
L
L
R
C
T
E
Site 92
T721
G
S
D
L
L
R
C
T
E
R
T
H
I
E
N
Site 93
T724
L
L
R
C
T
E
R
T
H
I
E
N
I
L
K
Site 94
T741
M
G
R
N
L
G
Q
T
N
E
G
L
I
P
V
Site 95
S753
I
P
V
R
V
R
R
S
W
L
A
V
N
Q
A
Site 96
S764
V
N
Q
A
L
P
V
S
N
T
H
V
K
T
S
Site 97
T766
Q
A
L
P
V
S
N
T
H
V
K
T
S
N
L
Site 98
S778
S
N
L
A
A
P
K
S
G
K
A
C
V
N
T
Site 99
T796
L
S
F
L
E
P
C
T
Q
Q
G
L
G
A
H
Site 100
T837
K
V
S
S
L
S
L
T
Q
L
A
G
P
S
S
Site 101
S844
T
Q
L
A
G
P
S
S
A
T
C
E
S
G
A
Site 102
S849
P
S
S
A
T
C
E
S
G
A
G
S
E
V
E
Site 103
S853
T
C
E
S
G
A
G
S
E
V
E
V
D
M
F
Site 104
S868
L
R
K
P
P
M
A
S
L
R
K
Q
V
L
T
Site 105
T875
S
L
R
K
Q
V
L
T
K
A
S
D
H
M
P
Site 106
S884
A
S
D
H
M
P
E
S
L
L
A
S
S
P
A
Site 107
S888
M
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Site 108
S889
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Q
Site 109
S924
G
Q
E
G
R
W
P
S
K
P
L
T
Y
S
L
Site 110
T928
R
W
P
S
K
P
L
T
Y
S
L
T
G
S
T
Site 111
S930
P
S
K
P
L
T
Y
S
L
T
G
S
T
Q
Q
Site 112
T932
K
P
L
T
Y
S
L
T
G
S
T
Q
Q
S
R
Site 113
S934
L
T
Y
S
L
T
G
S
T
Q
Q
S
R
S
L
Site 114
S938
L
T
G
S
T
Q
Q
S
R
S
L
G
A
Q
S
Site 115
S940
G
S
T
Q
Q
S
R
S
L
G
A
Q
S
S
K
Site 116
S946
R
S
L
G
A
Q
S
S
K
A
G
E
T
R
E
Site 117
T985
H
G
F
E
A
P
G
T
S
K
S
S
L
H
P
Site 118
S986
G
F
E
A
P
G
T
S
K
S
S
L
H
P
R
Site 119
S988
E
A
P
G
T
S
K
S
S
L
H
P
R
V
S
Site 120
S989
A
P
G
T
S
K
S
S
L
H
P
R
V
S
V
Site 121
S995
S
S
L
H
P
R
V
S
V
S
Q
D
P
R
K
Site 122
S997
L
H
P
R
V
S
V
S
Q
D
P
R
K
L
C
Site 123
S1021
E
P
G
M
A
T
K
S
E
T
Q
P
Q
V
C
Site 124
S1040
L
L
P
D
G
Q
A
S
V
V
P
H
A
S
E
Site 125
S1051
H
A
S
E
N
L
V
S
Q
V
P
Q
G
H
L
Site 126
S1060
V
P
Q
G
H
L
Q
S
M
P
T
G
N
M
R
Site 127
S1069
P
T
G
N
M
R
A
S
Q
E
L
H
D
L
M
Site 128
S1081
D
L
M
A
A
R
R
S
K
L
V
H
E
E
P
Site 129
T1130
E
R
L
E
G
L
R
T
P
Q
L
T
P
V
R
Site 130
T1134
G
L
R
T
P
Q
L
T
P
V
R
K
T
E
D
Site 131
T1139
Q
L
T
P
V
R
K
T
E
D
T
H
Q
D
E
Site 132
T1142
P
V
R
K
T
E
D
T
H
Q
D
E
G
V
Q
Site 133
S1153
E
G
V
Q
L
L
P
S
K
K
Q
P
P
S
V
Site 134
S1159
P
S
K
K
Q
P
P
S
V
S
P
F
G
E
N
Site 135
S1161
K
K
Q
P
P
S
V
S
P
F
G
E
N
I
K
Site 136
S1180
W
I
F
S
K
K
K
S
K
P
A
P
V
T
A
Site 137
S1189
P
A
P
V
T
A
E
S
Q
K
T
V
K
N
R
Site 138
T1192
V
T
A
E
S
Q
K
T
V
K
N
R
S
C
V
Site 139
S1197
Q
K
T
V
K
N
R
S
C
V
Y
S
S
S
A
Site 140
S1201
K
N
R
S
C
V
Y
S
S
S
A
E
A
Q
G
Site 141
S1203
R
S
C
V
Y
S
S
S
A
E
A
Q
G
L
M
Site 142
S1256
N
H
R
H
L
F
Y
S
E
H
G
R
I
L
S
Site 143
S1263
S
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
Site 144
Y1264
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
A
Site 145
S1267
R
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
Site 146
S1268
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
S
Site 147
T1272
A
A
S
S
Q
Q
A
T
L
K
S
Q
G
C
P
Site 148
S1275
S
Q
Q
A
T
L
K
S
Q
G
C
P
N
R
D
Site 149
S1293
R
N
Q
Q
P
L
K
S
V
R
C
N
N
E
Q
Site 150
S1316
L
H
P
K
K
A
V
S
P
V
S
P
P
Q
H
Site 151
S1319
K
K
A
V
S
P
V
S
P
P
Q
H
W
P
K
Site 152
T1327
P
P
Q
H
W
P
K
T
S
G
A
S
S
H
H
Site 153
S1328
P
Q
H
W
P
K
T
S
G
A
S
S
H
H
H
Site 154
S1332
P
K
T
S
G
A
S
S
H
H
H
H
C
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation