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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZCCHC6
Full Name:
Terminal uridylyltransferase 7
Alias:
FLJ13409; KIAA1711; PAP associated domain containing 6; PAPD6; ZCHC6; Zinc finger CCHC domain-containing 6; Zinc finger, CCHC domain containing 6
Type:
Transferase
Mass (Da):
171229
Number AA:
1495
UniProt ID:
Q5VYS8
International Prot ID:
IPI00604491
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0050265
GO:0003676
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0031123
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
G
D
T
A
K
P
Y
F
V
K
R
T
K
D
Site 2
T18
K
R
T
K
D
R
G
T
M
D
D
D
D
F
R
Site 3
Y33
R
G
H
P
Q
Q
D
Y
L
I
I
D
D
H
A
Site 4
T57
G
L
Q
K
K
K
I
T
P
G
N
Y
G
N
T
Site 5
Y61
K
K
I
T
P
G
N
Y
G
N
T
P
R
K
G
Site 6
T64
T
P
G
N
Y
G
N
T
P
R
K
G
P
C
A
Site 7
Y77
C
A
V
S
S
N
P
Y
A
F
K
N
P
I
Y
Site 8
Y84
Y
A
F
K
N
P
I
Y
S
Q
P
A
W
M
N
Site 9
S85
A
F
K
N
P
I
Y
S
Q
P
A
W
M
N
D
Site 10
S98
N
D
S
H
K
D
Q
S
K
R
W
L
S
D
E
Site 11
S103
D
Q
S
K
R
W
L
S
D
E
H
T
G
N
S
Site 12
T107
R
W
L
S
D
E
H
T
G
N
S
D
N
W
R
Site 13
S110
S
D
E
H
T
G
N
S
D
N
W
R
E
F
K
Site 14
S132
I
N
R
Q
R
K
D
S
F
Q
E
N
E
D
G
Site 15
Y140
F
Q
E
N
E
D
G
Y
R
W
Q
D
T
R
G
Site 16
T150
Q
D
T
R
G
C
R
T
V
R
R
L
F
H
K
Site 17
T160
R
L
F
H
K
D
L
T
S
L
E
T
T
S
E
Site 18
S161
L
F
H
K
D
L
T
S
L
E
T
T
S
E
M
Site 19
S172
T
S
E
M
E
A
G
S
P
E
N
K
K
Q
R
Site 20
S180
P
E
N
K
K
Q
R
S
R
P
R
K
P
R
K
Site 21
T188
R
P
R
K
P
R
K
T
R
N
E
E
N
E
Q
Site 22
S207
E
G
P
V
I
D
E
S
V
L
S
T
K
E
L
Site 23
Y239
L
K
R
R
P
R
N
Y
P
T
A
K
Y
T
C
Site 24
Y244
R
N
Y
P
T
A
K
Y
T
C
R
L
C
D
V
Site 25
T282
K
Q
E
E
E
L
L
T
T
L
P
P
P
T
P
Site 26
T283
Q
E
E
E
L
L
T
T
L
P
P
P
T
P
S
Site 27
T288
L
T
T
L
P
P
P
T
P
S
Q
I
N
A
V
Site 28
S335
Q
H
K
L
P
D
C
S
L
R
L
Y
G
S
S
Site 29
Y339
P
D
C
S
L
R
L
Y
G
S
S
C
S
R
L
Site 30
S342
S
L
R
L
Y
G
S
S
C
S
R
L
G
F
K
Site 31
S344
R
L
Y
G
S
S
C
S
R
L
G
F
K
N
S
Site 32
S351
S
R
L
G
F
K
N
S
D
V
N
I
D
I
Q
Site 33
S379
V
Q
E
C
L
K
N
S
D
S
F
I
D
V
D
Site 34
S381
E
C
L
K
N
S
D
S
F
I
D
V
D
A
D
Site 35
S448
R
Y
W
A
K
L
C
S
I
D
R
P
E
E
G
Site 36
S490
G
S
W
I
E
G
F
S
L
S
K
L
G
N
F
Site 37
S514
V
I
W
E
H
T
D
S
A
A
G
D
T
G
I
Site 38
T530
K
E
E
A
P
R
E
T
P
I
K
R
G
Q
V
Site 39
S538
P
I
K
R
G
Q
V
S
L
I
L
D
V
K
H
Site 40
S548
L
D
V
K
H
Q
P
S
V
P
V
G
Q
L
W
Site 41
Y599
R
I
A
I
E
D
P
Y
S
V
K
R
N
V
A
Site 42
S600
I
A
I
E
D
P
Y
S
V
K
R
N
V
A
R
Site 43
T608
V
K
R
N
V
A
R
T
L
N
S
Q
P
V
F
Site 44
S611
N
V
A
R
T
L
N
S
Q
P
V
F
E
Y
I
Site 45
Y626
L
H
C
L
R
T
T
Y
K
Y
F
A
L
P
H
Site 46
Y628
C
L
R
T
T
Y
K
Y
F
A
L
P
H
K
I
Site 47
S638
L
P
H
K
I
T
K
S
S
L
L
K
P
L
N
Site 48
S674
K
D
D
K
L
K
N
S
V
L
A
Q
G
P
G
Site 49
S685
Q
G
P
G
A
T
S
S
A
A
N
T
C
K
V
Site 50
T689
A
T
S
S
A
A
N
T
C
K
V
Q
P
L
T
Site 51
T696
T
C
K
V
Q
P
L
T
L
K
E
T
A
E
S
Site 52
T700
Q
P
L
T
L
K
E
T
A
E
S
F
G
S
P
Site 53
S703
T
L
K
E
T
A
E
S
F
G
S
P
P
K
E
Site 54
S706
E
T
A
E
S
F
G
S
P
P
K
E
E
M
G
Site 55
S718
E
M
G
N
E
H
I
S
V
H
P
E
N
S
D
Site 56
S724
I
S
V
H
P
E
N
S
D
C
I
Q
A
D
V
Site 57
S733
C
I
Q
A
D
V
N
S
D
D
Y
K
G
D
K
Site 58
Y736
A
D
V
N
S
D
D
Y
K
G
D
K
V
Y
H
Site 59
Y742
D
Y
K
G
D
K
V
Y
H
P
E
T
G
R
K
Site 60
T746
D
K
V
Y
H
P
E
T
G
R
K
N
E
K
E
Site 61
T764
R
K
G
K
H
L
L
T
V
D
Q
K
R
G
E
Site 62
S777
G
E
H
V
V
C
G
S
T
R
N
N
E
S
E
Site 63
S783
G
S
T
R
N
N
E
S
E
S
T
L
D
L
E
Site 64
T786
R
N
N
E
S
E
S
T
L
D
L
E
G
F
Q
Site 65
T805
K
E
C
E
G
L
A
T
L
D
N
K
A
D
L
Site 66
S816
K
A
D
L
D
G
E
S
T
E
G
T
E
E
L
Site 67
T820
D
G
E
S
T
E
G
T
E
E
L
E
D
S
L
Site 68
S826
G
T
E
E
L
E
D
S
L
N
H
F
T
H
S
Site 69
S833
S
L
N
H
F
T
H
S
V
Q
G
Q
T
S
E
Site 70
S844
Q
T
S
E
M
I
P
S
D
E
E
E
E
D
D
Site 71
T863
E
E
E
E
P
R
L
T
I
N
Q
R
E
D
E
Site 72
T882
N
E
D
E
L
D
N
T
Y
T
G
S
G
D
E
Site 73
Y883
E
D
E
L
D
N
T
Y
T
G
S
G
D
E
D
Site 74
S886
L
D
N
T
Y
T
G
S
G
D
E
D
A
L
S
Site 75
S893
S
G
D
E
D
A
L
S
E
E
D
D
E
L
G
Site 76
Y905
E
L
G
E
A
A
K
Y
E
D
V
K
E
C
G
Site 77
S939
N
V
C
E
E
K
N
S
P
V
D
Q
S
D
F
Site 78
S944
K
N
S
P
V
D
Q
S
D
F
F
Y
E
F
S
Site 79
S951
S
D
F
F
Y
E
F
S
K
L
I
F
T
K
G
Site 80
T956
E
F
S
K
L
I
F
T
K
G
K
S
P
T
V
Site 81
S966
K
S
P
T
V
V
C
S
L
C
K
R
E
G
H
Site 82
T994
L
E
P
L
P
P
L
T
P
K
F
L
N
I
L
Site 83
Y1009
D
Q
V
C
I
Q
C
Y
K
D
F
S
P
T
I
Site 84
S1031
H
I
R
Q
N
L
E
S
F
I
R
Q
D
F
P
Site 85
S1043
D
F
P
G
T
K
L
S
L
F
G
S
S
K
N
Site 86
S1047
T
K
L
S
L
F
G
S
S
K
N
G
F
G
F
Site 87
S1048
K
L
S
L
F
G
S
S
K
N
G
F
G
F
K
Site 88
S1091
A
R
V
L
R
K
H
S
G
L
R
N
I
L
P
Site 89
T1125
V
D
I
S
L
Y
N
T
L
A
L
H
N
T
R
Site 90
T1131
N
T
L
A
L
H
N
T
R
L
L
S
A
Y
S
Site 91
S1135
L
H
N
T
R
L
L
S
A
Y
S
A
I
D
P
Site 92
Y1137
N
T
R
L
L
S
A
Y
S
A
I
D
P
R
V
Site 93
S1138
T
R
L
L
S
A
Y
S
A
I
D
P
R
V
K
Site 94
Y1149
P
R
V
K
Y
L
C
Y
T
M
K
V
F
T
K
Site 95
S1164
M
C
D
I
G
D
A
S
R
G
S
L
S
S
Y
Site 96
S1167
I
G
D
A
S
R
G
S
L
S
S
Y
A
Y
T
Site 97
S1169
D
A
S
R
G
S
L
S
S
Y
A
Y
T
L
M
Site 98
Y1212
F
V
D
G
W
N
I
Y
F
F
D
Q
I
D
E
Site 99
Y1223
Q
I
D
E
L
P
T
Y
W
S
E
C
G
K
N
Site 100
S1233
E
C
G
K
N
T
E
S
V
G
Q
L
W
L
G
Site 101
Y1245
W
L
G
L
L
R
F
Y
T
E
E
F
D
F
K
Site 102
T1246
L
G
L
L
R
F
Y
T
E
E
F
D
F
K
E
Site 103
S1257
D
F
K
E
H
V
I
S
I
R
R
K
S
L
L
Site 104
S1262
V
I
S
I
R
R
K
S
L
L
T
T
F
K
K
Site 105
T1265
I
R
R
K
S
L
L
T
T
F
K
K
Q
W
T
Site 106
T1266
R
R
K
S
L
L
T
T
F
K
K
Q
W
T
S
Site 107
Y1275
K
K
Q
W
T
S
K
Y
I
V
I
E
D
P
F
Site 108
S1293
H
N
L
G
A
G
L
S
R
K
M
T
N
F
I
Site 109
T1297
A
G
L
S
R
K
M
T
N
F
I
M
K
A
F
Site 110
Y1322
V
K
G
F
P
K
D
Y
P
S
K
M
E
Y
F
Site 111
Y1328
D
Y
P
S
K
M
E
Y
F
F
D
P
D
V
L
Site 112
T1336
F
F
D
P
D
V
L
T
E
G
E
L
A
P
N
Site 113
Y1380
E
D
A
L
N
Q
R
Y
P
E
N
K
E
K
R
Site 114
S1388
P
E
N
K
E
K
R
S
K
E
D
K
E
I
H
Site 115
Y1398
D
K
E
I
H
N
K
Y
T
E
R
E
V
S
T
Site 116
T1399
K
E
I
H
N
K
Y
T
E
R
E
V
S
T
K
Site 117
S1404
K
Y
T
E
R
E
V
S
T
K
E
D
K
P
I
Site 118
T1414
E
D
K
P
I
Q
C
T
P
Q
K
A
K
P
M
Site 119
S1472
E
C
P
Q
F
K
G
S
S
G
S
L
S
S
K
Site 120
S1473
C
P
Q
F
K
G
S
S
G
S
L
S
S
K
Y
Site 121
S1475
Q
F
K
G
S
S
G
S
L
S
S
K
Y
M
T
Site 122
S1477
K
G
S
S
G
S
L
S
S
K
Y
M
T
Q
G
Site 123
S1478
G
S
S
G
S
L
S
S
K
Y
M
T
Q
G
K
Site 124
Y1480
S
G
S
L
S
S
K
Y
M
T
Q
G
K
A
S
Site 125
T1482
S
L
S
S
K
Y
M
T
Q
G
K
A
S
A
K
Site 126
T1491
G
K
A
S
A
K
R
T
Q
Q
E
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation