PhosphoNET

           
Protein Info 
   
Short Name:  SHE
Full Name:  SH2 domain-containing adapter protein E
Alias:  Src homology 2 domain containing E
Type:  Adaptor/scaffold
Mass (Da):  53950
Number AA:  495
UniProt ID:  Q5VZ18
International Prot ID:  IPI00402077
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0005515     PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S10WSPTPGASACLGWAS
Site 2T51EFPLNLKTVSERAKP
Site 3S53PLNLKTVSERAKPGG
Site 4S69GGKLRKNSEAGGAGP
Site 5S85PGKGRKNSAAELGSG
Site 6S91NSAAELGSGRAGVGP
Site 7S101AGVGPKDSRLSRDSL
Site 8S104GPKDSRLSRDSLQGL
Site 9S107DSRLSRDSLQGLIQA
Site 10S123AGKGRKNSRATEEEP
Site 11T126GRKNSRATEEEPHRG
Site 12T135EEPHRGATKSSGCST
Site 13S137PHRGATKSSGCSTYI
Site 14S138HRGATKSSGCSTYIN
Site 15S141ATKSSGCSTYINRLI
Site 16T142TKSSGCSTYINRLIK
Site 17Y143KSSGCSTYINRLIKV
Site 18T152NRLIKVDTQEKNGKS
Site 19S159TQEKNGKSNYPSSSS
Site 20Y161EKNGKSNYPSSSSSS
Site 21S163NGKSNYPSSSSSSSS
Site 22S164GKSNYPSSSSSSSSS
Site 23S165KSNYPSSSSSSSSSS
Site 24S166SNYPSSSSSSSSSSS
Site 25S167NYPSSSSSSSSSSSS
Site 26S168YPSSSSSSSSSSSSA
Site 27S169PSSSSSSSSSSSSAS
Site 28S170SSSSSSSSSSSSASS
Site 29S171SSSSSSSSSSSASSS
Site 30S172SSSSSSSSSSASSSP
Site 31S173SSSSSSSSSASSSPS
Site 32S174SSSSSSSSASSSPSS
Site 33S176SSSSSSASSSPSSLG
Site 34S177SSSSSASSSPSSLGP
Site 35S178SSSSASSSPSSLGPE
Site 36S180SSASSSPSSLGPELD
Site 37S181SASSSPSSLGPELDK
Site 38Y204TVIILEDYADPYDAK
Site 39Y208LEDYADPYDAKRTKG
Site 40Y228RVGENDGYMEPYDAQ
Site 41Y232NDGYMEPYDAQQMIT
Site 42S246TEIRRRGSKDPLVKA
Site 43S259KALQLLDSPCEPADG
Site 44S270PADGGLKSETLAKRR
Site 45T272DGGLKSETLAKRRSS
Site 46S278ETLAKRRSSKDLLGK
Site 47S279TLAKRRSSKDLLGKP
Site 48Y290LGKPPQLYDTPYEPA
Site 49T292KPPQLYDTPYEPAEG
Site 50Y294PQLYDTPYEPAEGGP
Site 51S312GKARPPDSRLPENDE
Site 52Y325DERPAAEYEQPWEWK
Site 53S341EQIVRALSVQFEGAE
Site 54S351FEGAERPSFREETVR
Site 55T356RPSFREETVRQHHRQ
Site 56S365RQHHRQKSWTQKILK
Site 57T367HHRQKSWTQKILKPA
Site 58S376KILKPALSDHSEGEK
Site 59Y396PLEKQPWYHGAISRA
Site 60S401PWYHGAISRAEAESR
Site 61S407ISRAEAESRLQPCKE
Site 62Y417QPCKEAGYLVRNSES
Site 63S422AGYLVRNSESGNSRY
Site 64S424YLVRNSESGNSRYSI
Site 65S427RNSESGNSRYSIALK
Site 66S430ESGNSRYSIALKTSQ
Site 67Y452AQTKDNKYTLNQTSA
Site 68S463QTSAVFDSIPEVVHY
Site 69Y470SIPEVVHYYSNEKLP
Site 70Y471IPEVVHYYSNEKLPF
Site 71S472PEVVHYYSNEKLPFK
Site 72Y488AEHMTLLYPVHSKLH
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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