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Updated November 2019
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Protein Info
Short Name:
DENND4C
Full Name:
DENN domain-containing protein 4C
Alias:
BA513M16.3; C9orf55; C9orf55B; DEN4C; DENN/MADD domain containing 4C; FLJ20686; FLJ22052
Type:
Membrane protein, integral
Mass (Da):
186857
Number AA:
1673
UniProt ID:
Q5VZ89
International Prot ID:
IPI00746398
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
C
W
D
P
E
T
K
Y
P
L
P
V
F
S
T
Site 2
Y40
Y
G
A
A
I
Q
F
Y
E
P
Y
S
R
E
L
Site 3
Y43
A
I
Q
F
Y
E
P
Y
S
R
E
L
L
S
E
Site 4
S44
I
Q
F
Y
E
P
Y
S
R
E
L
L
S
E
K
Site 5
S49
P
Y
S
R
E
L
L
S
E
K
Q
L
M
H
L
Site 6
S68
P
V
E
R
K
M
V
S
K
S
I
N
T
N
K
Site 7
S124
M
Q
N
I
P
F
P
S
P
Q
R
P
R
I
L
Site 8
S236
P
F
I
V
G
V
D
S
R
Y
F
D
L
H
D
Site 9
Y238
I
V
G
V
D
S
R
Y
F
D
L
H
D
P
P
Site 10
Y259
D
L
D
T
N
M
L
Y
V
S
D
E
K
K
N
Site 11
S282
K
P
C
K
N
L
L
S
T
L
K
K
L
Y
P
Site 12
Y288
L
S
T
L
K
K
L
Y
P
Q
L
S
S
V
H
Site 13
S292
K
K
L
Y
P
Q
L
S
S
V
H
Q
K
T
Q
Site 14
T298
L
S
S
V
H
Q
K
T
Q
E
G
S
A
I
D
Site 15
T307
E
G
S
A
I
D
M
T
P
I
E
A
D
F
S
Site 16
T343
S
I
L
K
G
Y
R
T
Y
L
R
P
I
T
E
Site 17
Y344
I
L
K
G
Y
R
T
Y
L
R
P
I
T
E
A
Site 18
T349
R
T
Y
L
R
P
I
T
E
A
P
S
N
K
A
Site 19
T357
E
A
P
S
N
K
A
T
A
A
D
S
L
F
D
Site 20
S361
N
K
A
T
A
A
D
S
L
F
D
R
Q
G
F
Site 21
S371
D
R
Q
G
F
L
K
S
R
D
R
A
Y
A
K
Site 22
Y376
L
K
S
R
D
R
A
Y
A
K
F
Y
T
L
L
Site 23
S397
I
R
F
I
E
E
C
S
F
V
S
D
K
D
T
Site 24
T404
S
F
V
S
D
K
D
T
G
L
A
F
F
D
D
Site 25
S432
T
D
K
V
D
F
D
S
A
E
D
T
R
L
I
Site 26
T436
D
F
D
S
A
E
D
T
R
L
I
E
L
D
D
Site 27
S444
R
L
I
E
L
D
D
S
Q
K
S
E
H
T
V
Site 28
S447
E
L
D
D
S
Q
K
S
E
H
T
V
F
I
M
Site 29
T450
D
S
Q
K
S
E
H
T
V
F
I
M
P
P
E
Site 30
S467
P
D
D
G
K
D
L
S
P
K
Y
S
Y
K
Y
Site 31
Y470
G
K
D
L
S
P
K
Y
S
Y
K
Y
F
P
R
Site 32
S471
K
D
L
S
P
K
Y
S
Y
K
Y
F
P
R
L
Site 33
Y474
S
P
K
Y
S
Y
K
Y
F
P
R
L
D
L
K
Site 34
S494
Q
E
L
K
L
C
F
S
R
H
P
T
G
N
S
Site 35
T498
L
C
F
S
R
H
P
T
G
N
S
I
T
K
S
Site 36
S501
S
R
H
P
T
G
N
S
I
T
K
S
P
P
L
Site 37
S505
T
G
N
S
I
T
K
S
P
P
L
M
A
K
R
Site 38
T519
R
T
K
Q
E
I
K
T
A
H
K
L
A
K
R
Site 39
Y528
H
K
L
A
K
R
C
Y
T
N
P
P
Q
W
A
Site 40
T529
K
L
A
K
R
C
Y
T
N
P
P
Q
W
A
K
Site 41
T577
V
L
I
K
M
R
K
T
D
V
D
P
L
D
E
Site 42
T612
R
V
L
F
E
M
K
T
A
R
I
K
P
N
A
Site 43
S632
Y
N
K
V
V
L
E
S
P
W
P
S
S
T
R
Site 44
S636
V
L
E
S
P
W
P
S
S
T
R
S
G
I
F
Site 45
S637
L
E
S
P
W
P
S
S
T
R
S
G
I
F
L
Site 46
T638
E
S
P
W
P
S
S
T
R
S
G
I
F
L
W
Site 47
S640
P
W
P
S
S
T
R
S
G
I
F
L
W
T
K
Site 48
T646
R
S
G
I
F
L
W
T
K
V
R
N
V
V
R
Site 49
T665
F
R
Q
P
L
K
K
T
V
Q
R
S
Q
V
S
Site 50
S669
L
K
K
T
V
Q
R
S
Q
V
S
S
I
S
G
Site 51
S673
V
Q
R
S
Q
V
S
S
I
S
G
G
Q
S
D
Site 52
S675
R
S
Q
V
S
S
I
S
G
G
Q
S
D
Q
G
Site 53
S679
V
A
K
H
S
Q
P
S
P
E
P
H
S
P
T
Site 54
Y683
G
G
Q
S
D
Q
G
Y
G
S
K
D
E
L
I
Site 55
S685
Q
S
D
Q
G
Y
G
S
K
D
E
L
I
K
D
Site 56
T709
Q
A
A
R
E
L
I
T
K
T
K
M
Q
T
E
Site 57
T711
A
R
E
L
I
T
K
T
K
M
Q
T
E
E
V
Site 58
S722
T
E
E
V
C
D
A
S
A
I
V
A
K
H
S
Site 59
S729
S
A
I
V
A
K
H
S
Q
P
S
P
E
P
H
Site 60
S732
V
A
K
H
S
Q
P
S
P
E
P
H
S
P
T
Site 61
S737
Q
P
S
P
E
P
H
S
P
T
E
P
P
A
W
Site 62
T739
S
P
E
P
H
S
P
T
E
P
P
A
W
G
S
Site 63
S747
E
P
P
A
W
G
S
S
I
V
K
V
P
S
G
Site 64
S753
S
S
I
V
K
V
P
S
G
I
F
D
V
N
S
Site 65
S760
S
G
I
F
D
V
N
S
R
K
S
S
T
G
S
Site 66
S763
F
D
V
N
S
R
K
S
S
T
G
S
I
S
N
Site 67
S764
D
V
N
S
R
K
S
S
T
G
S
I
S
N
V
Site 68
T765
V
N
S
R
K
S
S
T
G
S
I
S
N
V
L
Site 69
S767
S
R
K
S
S
T
G
S
I
S
N
V
L
F
S
Site 70
S769
K
S
S
T
G
S
I
S
N
V
L
F
S
T
Q
Site 71
S808
Q
K
H
F
P
E
R
S
C
S
F
S
S
E
S
Site 72
S810
H
F
P
E
R
S
C
S
F
S
S
E
S
R
A
Site 73
S812
P
E
R
S
C
S
F
S
S
E
S
R
A
G
M
Site 74
S813
E
R
S
C
S
F
S
S
E
S
R
A
G
M
L
Site 75
S815
S
C
S
F
S
S
E
S
R
A
G
M
L
L
K
Site 76
S824
A
G
M
L
L
K
K
S
S
L
D
S
N
S
S
Site 77
S825
G
M
L
L
K
K
S
S
L
D
S
N
S
S
E
Site 78
S828
L
K
K
S
S
L
D
S
N
S
S
E
M
A
I
Site 79
S830
K
S
S
L
D
S
N
S
S
E
M
A
I
M
M
Site 80
S831
S
S
L
D
S
N
S
S
E
M
A
I
M
M
G
Site 81
T849
K
I
L
T
A
A
L
T
C
P
K
T
S
L
L
Site 82
T861
S
L
L
H
I
A
R
T
H
S
F
E
N
V
S
Site 83
S863
L
H
I
A
R
T
H
S
F
E
N
V
S
C
H
Site 84
S868
T
H
S
F
E
N
V
S
C
H
L
P
D
S
R
Site 85
S874
V
S
C
H
L
P
D
S
R
T
C
M
S
E
S
Site 86
S889
T
W
N
P
E
H
R
S
S
P
V
P
E
M
L
Site 87
S890
W
N
P
E
H
R
S
S
P
V
P
E
M
L
E
Site 88
T913
V
V
D
D
V
P
K
T
T
A
T
V
D
T
Y
Site 89
T916
D
V
P
K
T
T
A
T
V
D
T
Y
E
S
L
Site 90
T919
K
T
T
A
T
V
D
T
Y
E
S
L
L
S
D
Site 91
Y920
T
T
A
T
V
D
T
Y
E
S
L
L
S
D
S
Site 92
S922
A
T
V
D
T
Y
E
S
L
L
S
D
S
N
S
Site 93
S925
D
T
Y
E
S
L
L
S
D
S
N
S
N
Q
S
Site 94
S927
Y
E
S
L
L
S
D
S
N
S
N
Q
S
R
D
Site 95
S929
S
L
L
S
D
S
N
S
N
Q
S
R
D
L
K
Site 96
T937
N
Q
S
R
D
L
K
T
V
S
K
D
L
R
N
Site 97
S947
K
D
L
R
N
K
R
S
S
L
Y
G
I
A
K
Site 98
S948
D
L
R
N
K
R
S
S
L
Y
G
I
A
K
V
Site 99
Y950
R
N
K
R
S
S
L
Y
G
I
A
K
V
V
Q
Site 100
T963
V
Q
R
E
D
V
E
T
G
L
D
P
L
S
L
Site 101
T973
D
P
L
S
L
L
A
T
E
C
T
G
G
K
T
Site 102
T980
T
E
C
T
G
G
K
T
P
D
S
E
D
K
L
Site 103
S983
T
G
G
K
T
P
D
S
E
D
K
L
F
S
P
Site 104
S989
D
S
E
D
K
L
F
S
P
V
I
A
R
N
L
Site 105
S1002
N
L
A
D
E
I
E
S
Y
M
N
L
K
S
P
Site 106
Y1003
L
A
D
E
I
E
S
Y
M
N
L
K
S
P
L
Site 107
S1008
E
S
Y
M
N
L
K
S
P
L
G
S
K
S
S
Site 108
S1012
N
L
K
S
P
L
G
S
K
S
S
S
M
E
L
Site 109
S1014
K
S
P
L
G
S
K
S
S
S
M
E
L
H
R
Site 110
S1015
S
P
L
G
S
K
S
S
S
M
E
L
H
R
E
Site 111
S1016
P
L
G
S
K
S
S
S
M
E
L
H
R
E
E
Site 112
S1027
H
R
E
E
N
R
E
S
G
M
T
T
A
F
I
Site 113
T1030
E
N
R
E
S
G
M
T
T
A
F
I
H
A
L
Site 114
S1041
I
H
A
L
E
R
R
S
S
L
P
L
D
H
G
Site 115
S1042
H
A
L
E
R
R
S
S
L
P
L
D
H
G
S
Site 116
S1049
S
L
P
L
D
H
G
S
P
A
Q
E
N
P
E
Site 117
S1057
P
A
Q
E
N
P
E
S
E
K
S
S
P
A
V
Site 118
S1060
E
N
P
E
S
E
K
S
S
P
A
V
S
R
S
Site 119
S1061
N
P
E
S
E
K
S
S
P
A
V
S
R
S
K
Site 120
S1065
E
K
S
S
P
A
V
S
R
S
K
T
F
T
G
Site 121
S1067
S
S
P
A
V
S
R
S
K
T
F
T
G
R
F
Site 122
T1069
P
A
V
S
R
S
K
T
F
T
G
R
F
K
Q
Site 123
T1071
V
S
R
S
K
T
F
T
G
R
F
K
Q
Q
T
Site 124
T1078
T
G
R
F
K
Q
Q
T
P
S
R
T
H
K
E
Site 125
S1080
R
F
K
Q
Q
T
P
S
R
T
H
K
E
R
S
Site 126
S1087
S
R
T
H
K
E
R
S
T
S
L
S
A
L
V
Site 127
T1088
R
T
H
K
E
R
S
T
S
L
S
A
L
V
R
Site 128
S1089
T
H
K
E
R
S
T
S
L
S
A
L
V
R
S
Site 129
S1091
K
E
R
S
T
S
L
S
A
L
V
R
S
S
P
Site 130
S1096
S
L
S
A
L
V
R
S
S
P
H
G
S
L
G
Site 131
S1097
L
S
A
L
V
R
S
S
P
H
G
S
L
G
S
Site 132
S1101
V
R
S
S
P
H
G
S
L
G
S
V
V
N
S
Site 133
S1104
S
P
H
G
S
L
G
S
V
V
N
S
L
S
G
Site 134
S1110
G
S
V
V
N
S
L
S
G
L
K
L
D
N
I
Site 135
S1128
P
K
I
D
V
L
K
S
G
M
K
Q
A
A
T
Site 136
S1138
K
Q
A
A
T
V
A
S
K
M
W
V
A
V
A
Site 137
Y1150
A
V
A
S
A
Y
S
Y
S
D
D
E
E
E
T
Site 138
S1151
V
A
S
A
Y
S
Y
S
D
D
E
E
E
T
N
Site 139
T1157
Y
S
D
D
E
E
E
T
N
R
D
Y
S
F
P
Site 140
Y1161
E
E
E
T
N
R
D
Y
S
F
P
A
G
L
E
Site 141
S1162
E
E
T
N
R
D
Y
S
F
P
A
G
L
E
D
Site 142
S1177
H
I
L
G
E
N
I
S
P
N
T
S
I
S
G
Site 143
S1181
E
N
I
S
P
N
T
S
I
S
G
L
V
P
S
Site 144
S1188
S
I
S
G
L
V
P
S
E
L
T
Q
S
N
T
Site 145
T1191
G
L
V
P
S
E
L
T
Q
S
N
T
S
L
G
Site 146
S1193
V
P
S
E
L
T
Q
S
N
T
S
L
G
S
S
Site 147
T1195
S
E
L
T
Q
S
N
T
S
L
G
S
S
S
S
Site 148
S1196
E
L
T
Q
S
N
T
S
L
G
S
S
S
S
S
Site 149
S1199
Q
S
N
T
S
L
G
S
S
S
S
S
G
D
V
Site 150
S1200
S
N
T
S
L
G
S
S
S
S
S
G
D
V
G
Site 151
S1201
N
T
S
L
G
S
S
S
S
S
G
D
V
G
K
Site 152
S1202
T
S
L
G
S
S
S
S
S
G
D
V
G
K
L
Site 153
S1203
S
L
G
S
S
S
S
S
G
D
V
G
K
L
H
Site 154
Y1211
G
D
V
G
K
L
H
Y
P
T
G
E
V
P
F
Site 155
S1230
K
G
Q
D
F
E
K
S
D
H
G
S
S
Q
N
Site 156
S1234
F
E
K
S
D
H
G
S
S
Q
N
T
S
M
S
Site 157
S1235
E
K
S
D
H
G
S
S
Q
N
T
S
M
S
S
Site 158
T1238
D
H
G
S
S
Q
N
T
S
M
S
S
I
Y
Q
Site 159
S1239
H
G
S
S
Q
N
T
S
M
S
S
I
Y
Q
N
Site 160
S1241
S
S
Q
N
T
S
M
S
S
I
Y
Q
N
C
A
Site 161
S1254
C
A
M
E
V
L
M
S
S
C
S
Q
C
R
A
Site 162
T1284
A
D
D
S
N
L
N
T
A
C
P
F
C
K
S
Site 163
S1307
E
F
K
D
L
R
G
S
A
S
F
F
L
K
P
Site 164
S1309
K
D
L
R
G
S
A
S
F
F
L
K
P
S
T
Site 165
S1315
A
S
F
F
L
K
P
S
T
S
G
D
S
L
Q
Site 166
T1316
S
F
F
L
K
P
S
T
S
G
D
S
L
Q
S
Site 167
S1317
F
F
L
K
P
S
T
S
G
D
S
L
Q
S
G
Site 168
S1320
K
P
S
T
S
G
D
S
L
Q
S
G
S
I
P
Site 169
S1323
T
S
G
D
S
L
Q
S
G
S
I
P
L
A
N
Site 170
S1325
G
D
S
L
Q
S
G
S
I
P
L
A
N
E
S
Site 171
S1332
S
I
P
L
A
N
E
S
L
E
H
K
P
V
S
Site 172
S1339
S
L
E
H
K
P
V
S
S
L
A
E
P
D
L
Site 173
T1360
P
K
H
N
Q
I
I
T
E
E
T
G
S
A
V
Site 174
S1365
I
I
T
E
E
T
G
S
A
V
E
P
S
D
E
Site 175
S1370
T
G
S
A
V
E
P
S
D
E
I
K
R
A
S
Site 176
S1377
S
D
E
I
K
R
A
S
G
D
V
Q
T
M
K
Site 177
T1382
R
A
S
G
D
V
Q
T
M
K
I
S
S
V
P
Site 178
S1387
V
Q
T
M
K
I
S
S
V
P
N
S
L
S
K
Site 179
S1391
K
I
S
S
V
P
N
S
L
S
K
R
N
V
S
Site 180
S1393
S
S
V
P
N
S
L
S
K
R
N
V
S
L
T
Site 181
S1398
S
L
S
K
R
N
V
S
L
T
R
S
H
S
V
Site 182
T1400
S
K
R
N
V
S
L
T
R
S
H
S
V
G
G
Site 183
S1402
R
N
V
S
L
T
R
S
H
S
V
G
G
P
L
Site 184
S1404
V
S
L
T
R
S
H
S
V
G
G
P
L
Q
N
Site 185
T1415
P
L
Q
N
I
D
F
T
Q
R
P
F
H
G
I
Site 186
S1423
Q
R
P
F
H
G
I
S
T
V
S
L
P
N
S
Site 187
T1424
R
P
F
H
G
I
S
T
V
S
L
P
N
S
L
Site 188
S1426
F
H
G
I
S
T
V
S
L
P
N
S
L
Q
E
Site 189
S1430
S
T
V
S
L
P
N
S
L
Q
E
V
V
D
P
Site 190
S1448
R
P
N
P
P
P
V
S
V
P
Y
L
S
P
L
Site 191
S1463
V
L
R
K
E
L
E
S
L
L
E
N
E
G
D
Site 192
T1475
E
G
D
Q
V
I
H
T
S
S
F
I
N
Q
H
Site 193
S1521
E
G
V
Q
L
P
L
S
S
L
S
Q
D
S
K
Site 194
S1522
G
V
Q
L
P
L
S
S
L
S
Q
D
S
K
L
Site 195
S1524
Q
L
P
L
S
S
L
S
Q
D
S
K
L
V
Y
Site 196
Y1531
S
Q
D
S
K
L
V
Y
I
Q
L
L
W
D
N
Site 197
Y1550
Q
E
P
R
E
P
L
Y
V
S
W
R
N
F
N
Site 198
S1552
P
R
E
P
L
Y
V
S
W
R
N
F
N
S
E
Site 199
S1558
V
S
W
R
N
F
N
S
E
K
K
S
S
L
L
Site 200
S1562
N
F
N
S
E
K
K
S
S
L
L
S
E
E
Q
Site 201
S1563
F
N
S
E
K
K
S
S
L
L
S
E
E
Q
Q
Site 202
S1566
E
K
K
S
S
L
L
S
E
E
Q
Q
E
T
S
Site 203
T1578
E
T
S
T
L
V
E
T
I
R
Q
S
I
Q
H
Site 204
S1582
L
V
E
T
I
R
Q
S
I
Q
H
N
N
V
L
Site 205
S1596
L
K
P
I
N
L
L
S
Q
Q
M
K
P
G
M
Site 206
S1608
P
G
M
K
R
Q
R
S
L
Y
R
E
I
L
F
Site 207
Y1610
M
K
R
Q
R
S
L
Y
R
E
I
L
F
L
S
Site 208
Y1635
I
E
A
F
D
N
E
Y
G
I
A
Y
N
S
L
Site 209
Y1639
D
N
E
Y
G
I
A
Y
N
S
L
S
S
E
I
Site 210
S1641
E
Y
G
I
A
Y
N
S
L
S
S
E
I
L
E
Site 211
S1658
Q
K
I
D
A
P
P
S
A
S
V
E
W
C
R
Site 212
S1660
I
D
A
P
P
S
A
S
V
E
W
C
R
K
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation