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Updated November 2019
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Protein Info
Short Name:
LRRC16A
Full Name:
Leucine-rich repeat-containing protein 16A
Alias:
DJ501N12.1; DJ501N12.5; DJ501N12.5.1; FLJ20048; Leucine rich repeat containing 16A; Leucine-rich repeat-containing protein 16A: CARMIL homolog: Leucine-rich repeat-containing protein 16A: CARMIL homolog; LRRC16
Type:
Unknown function
Mass (Da):
151557
Number AA:
1371
UniProt ID:
Q5VZK9
International Prot ID:
IPI00014843
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
T
E
E
S
S
D
V
P
R
E
L
I
Site 2
S15
V
P
R
E
L
I
E
S
I
K
D
V
I
G
R
Site 3
S27
I
G
R
K
I
K
I
S
V
K
K
K
V
K
L
Site 4
S94
E
T
E
K
C
S
I
S
M
K
M
A
S
P
E
Site 5
S99
S
I
S
M
K
M
A
S
P
E
D
V
S
E
V
Site 6
S104
M
A
S
P
E
D
V
S
E
V
L
A
H
I
G
Site 7
T112
E
V
L
A
H
I
G
T
C
L
R
K
I
F
P
Site 8
S122
R
K
I
F
P
G
L
S
P
V
R
I
M
K
K
Site 9
S131
V
R
I
M
K
K
V
S
M
E
P
S
E
R
L
Site 10
S135
K
K
V
S
M
E
P
S
E
R
L
A
S
L
Q
Site 11
S140
E
P
S
E
R
L
A
S
L
Q
A
L
W
D
S
Site 12
S147
S
L
Q
A
L
W
D
S
Q
T
V
A
E
Q
G
Site 13
T149
Q
A
L
W
D
S
Q
T
V
A
E
Q
G
P
C
Site 14
Y186
Q
W
D
V
D
T
I
Y
L
T
Q
D
T
R
E
Site 15
S224
N
Q
W
F
T
K
L
S
S
K
D
L
K
L
S
Site 16
S231
S
S
K
D
L
K
L
S
T
D
V
C
E
Q
I
Site 17
T232
S
K
D
L
K
L
S
T
D
V
C
E
Q
I
L
Site 18
S243
E
Q
I
L
R
V
V
S
R
S
N
R
L
E
E
Site 19
T280
N
P
N
S
G
L
H
T
I
N
L
A
G
N
P
Site 20
S294
P
L
E
D
R
G
V
S
S
L
S
I
Q
F
A
Site 21
S295
L
E
D
R
G
V
S
S
L
S
I
Q
F
A
K
Site 22
S297
D
R
G
V
S
S
L
S
I
Q
F
A
K
L
P
Site 23
S313
G
L
K
H
L
N
L
S
K
T
S
L
S
P
K
Site 24
T315
K
H
L
N
L
S
K
T
S
L
S
P
K
G
V
Site 25
S316
H
L
N
L
S
K
T
S
L
S
P
K
G
V
N
Site 26
S318
N
L
S
K
T
S
L
S
P
K
G
V
N
S
L
Site 27
S324
L
S
P
K
G
V
N
S
L
S
Q
S
L
S
A
Site 28
S326
P
K
G
V
N
S
L
S
Q
S
L
S
A
N
P
Site 29
S328
G
V
N
S
L
S
Q
S
L
S
A
N
P
L
T
Site 30
S330
N
S
L
S
Q
S
L
S
A
N
P
L
T
A
S
Site 31
T402
A
V
L
N
L
S
R
T
V
F
S
H
R
K
G
Site 32
S405
N
L
S
R
T
V
F
S
H
R
K
G
K
E
V
Site 33
S415
K
G
K
E
V
P
P
S
F
K
Q
F
F
S
S
Site 34
S432
A
L
M
H
I
N
L
S
G
T
K
L
S
P
E
Site 35
S437
N
L
S
G
T
K
L
S
P
E
P
L
K
A
L
Site 36
S458
N
H
N
L
K
G
V
S
L
D
L
S
N
C
E
Site 37
S462
K
G
V
S
L
D
L
S
N
C
E
L
R
S
G
Site 38
S486
A
E
I
H
N
I
T
S
L
D
I
S
D
N
G
Site 39
S490
N
I
T
S
L
D
I
S
D
N
G
L
E
S
D
Site 40
S506
S
T
L
I
V
W
L
S
K
N
R
S
I
Q
H
Site 41
S510
V
W
L
S
K
N
R
S
I
Q
H
L
A
L
G
Site 42
S525
K
N
F
N
N
M
K
S
K
N
L
T
P
V
L
Site 43
T529
N
M
K
S
K
N
L
T
P
V
L
D
N
L
V
Site 44
S544
Q
M
I
Q
D
E
E
S
P
L
Q
S
L
S
L
Site 45
S548
D
E
E
S
P
L
Q
S
L
S
L
A
D
S
K
Site 46
S550
E
S
P
L
Q
S
L
S
L
A
D
S
K
L
K
Site 47
S554
Q
S
L
S
L
A
D
S
K
L
K
T
E
V
T
Site 48
S572
N
A
L
G
S
N
T
S
L
T
K
V
D
I
S
Site 49
T574
L
G
S
N
T
S
L
T
K
V
D
I
S
G
N
Site 50
S579
S
L
T
K
V
D
I
S
G
N
G
M
G
D
M
Site 51
T599
A
K
A
L
Q
I
N
T
K
L
R
T
V
I
W
Site 52
T628
V
A
M
E
K
N
Y
T
L
R
F
M
P
I
P
Site 53
Y637
R
F
M
P
I
P
M
Y
D
A
S
Q
A
L
K
Site 54
S640
P
I
P
M
Y
D
A
S
Q
A
L
K
T
N
P
Site 55
T645
D
A
S
Q
A
L
K
T
N
P
E
K
T
E
D
Site 56
Y660
A
L
Q
K
I
E
N
Y
L
L
R
N
H
E
T
Site 57
Y670
R
N
H
E
T
R
K
Y
L
Q
E
Q
A
Y
R
Site 58
Y676
K
Y
L
Q
E
Q
A
Y
R
L
Q
Q
G
I
V
Site 59
S685
L
Q
Q
G
I
V
T
S
T
T
Q
Q
M
I
D
Site 60
S704
K
V
Q
D
H
L
N
S
L
R
N
C
G
G
D
Site 61
S719
A
I
Q
E
D
L
K
S
A
E
R
L
M
R
D
Site 62
S730
L
M
R
D
A
K
N
S
K
T
L
L
P
N
L
Site 63
T732
R
D
A
K
N
S
K
T
L
L
P
N
L
Y
H
Site 64
Y738
K
T
L
L
P
N
L
Y
H
V
G
G
A
S
W
Site 65
S754
G
A
S
G
L
L
S
S
P
I
Q
E
T
L
E
Site 66
S762
P
I
Q
E
T
L
E
S
M
A
G
E
V
T
R
Site 67
S807
R
Q
D
L
I
H
A
S
T
E
K
I
S
I
P
Site 68
T808
Q
D
L
I
H
A
S
T
E
K
I
S
I
P
R
Site 69
S826
K
N
V
L
L
E
Q
S
G
I
D
I
L
N
K
Site 70
S869
H
K
L
A
D
H
F
S
R
R
G
K
T
L
P
Site 71
T874
H
F
S
R
R
G
K
T
L
P
Q
Q
E
S
L
Site 72
S880
K
T
L
P
Q
Q
E
S
L
E
I
E
L
A
E
Site 73
T912
E
R
L
E
D
L
D
T
C
M
M
T
P
K
S
Site 74
T916
D
L
D
T
C
M
M
T
P
K
S
K
R
K
S
Site 75
S919
T
C
M
M
T
P
K
S
K
R
K
S
I
H
S
Site 76
S923
T
P
K
S
K
R
K
S
I
H
S
R
M
L
R
Site 77
S926
S
K
R
K
S
I
H
S
R
M
L
R
P
V
S
Site 78
S933
S
R
M
L
R
P
V
S
R
A
F
E
M
E
F
Site 79
S960
I
E
D
P
P
F
P
S
L
R
Q
E
K
R
S
Site 80
S967
S
L
R
Q
E
K
R
S
S
G
F
I
S
E
L
Site 81
S968
L
R
Q
E
K
R
S
S
G
F
I
S
E
L
P
Site 82
S972
K
R
S
S
G
F
I
S
E
L
P
S
E
E
G
Site 83
S976
G
F
I
S
E
L
P
S
E
E
G
K
K
L
E
Site 84
S1010
V
C
A
A
N
I
V
S
Q
D
G
E
Q
N
G
Site 85
S1039
K
K
V
T
K
M
D
S
K
K
W
S
T
R
G
Site 86
S1043
K
M
D
S
K
K
W
S
T
R
G
S
E
S
H
Site 87
S1047
K
K
W
S
T
R
G
S
E
S
H
E
L
N
E
Site 88
S1064
D
E
K
K
K
R
D
S
R
K
S
S
G
F
L
Site 89
S1067
K
K
R
D
S
R
K
S
S
G
F
L
N
L
I
Site 90
S1068
K
R
D
S
R
K
S
S
G
F
L
N
L
I
K
Site 91
S1076
G
F
L
N
L
I
K
S
R
S
K
S
E
R
P
Site 92
S1078
L
N
L
I
K
S
R
S
K
S
E
R
P
P
T
Site 93
S1080
L
I
K
S
R
S
K
S
E
R
P
P
T
I
L
Site 94
T1085
S
K
S
E
R
P
P
T
I
L
M
T
E
E
P
Site 95
T1089
R
P
P
T
I
L
M
T
E
E
P
S
S
P
K
Site 96
S1093
I
L
M
T
E
E
P
S
S
P
K
G
A
V
R
Site 97
S1094
L
M
T
E
E
P
S
S
P
K
G
A
V
R
S
Site 98
S1101
S
P
K
G
A
V
R
S
P
P
V
D
C
P
R
Site 99
T1111
V
D
C
P
R
K
D
T
K
A
A
E
H
N
G
Site 100
S1120
A
A
E
H
N
G
N
S
E
R
I
E
E
I
K
Site 101
T1128
E
R
I
E
E
I
K
T
P
D
S
F
E
E
S
Site 102
S1131
E
E
I
K
T
P
D
S
F
E
E
S
Q
G
E
Site 103
S1135
T
P
D
S
F
E
E
S
Q
G
E
E
I
G
K
Site 104
S1146
E
I
G
K
V
E
R
S
D
S
K
S
S
P
Q
Site 105
S1148
G
K
V
E
R
S
D
S
K
S
S
P
Q
A
G
Site 106
S1150
V
E
R
S
D
S
K
S
S
P
Q
A
G
R
R
Site 107
S1151
E
R
S
D
S
K
S
S
P
Q
A
G
R
R
Y
Site 108
Y1158
S
P
Q
A
G
R
R
Y
G
V
Q
V
M
G
S
Site 109
S1192
K
L
G
N
D
A
V
S
Q
D
S
S
S
P
A
Site 110
S1195
N
D
A
V
S
Q
D
S
S
S
P
A
L
S
G
Site 111
S1196
D
A
V
S
Q
D
S
S
S
P
A
L
S
G
V
Site 112
S1197
A
V
S
Q
D
S
S
S
P
A
L
S
G
V
E
Site 113
S1201
D
S
S
S
P
A
L
S
G
V
E
R
S
D
G
Site 114
T1228
E
N
R
F
G
L
G
T
P
E
K
N
T
K
A
Site 115
S1243
E
P
K
A
E
A
G
S
R
S
R
S
S
S
S
Site 116
S1245
K
A
E
A
G
S
R
S
R
S
S
S
S
T
P
Site 117
S1247
E
A
G
S
R
S
R
S
S
S
S
T
P
T
S
Site 118
S1248
A
G
S
R
S
R
S
S
S
S
T
P
T
S
P
Site 119
S1249
G
S
R
S
R
S
S
S
S
T
P
T
S
P
K
Site 120
S1250
S
R
S
R
S
S
S
S
T
P
T
S
P
K
P
Site 121
T1251
R
S
R
S
S
S
S
T
P
T
S
P
K
P
L
Site 122
T1253
R
S
S
S
S
T
P
T
S
P
K
P
L
L
Q
Site 123
S1254
S
S
S
S
T
P
T
S
P
K
P
L
L
Q
S
Site 124
S1261
S
P
K
P
L
L
Q
S
P
K
P
S
L
A
A
Site 125
T1278
V
I
P
Q
K
P
R
T
A
S
R
P
D
D
I
Site 126
S1280
P
Q
K
P
R
T
A
S
R
P
D
D
I
P
D
Site 127
S1288
R
P
D
D
I
P
D
S
P
S
S
P
K
V
A
Site 128
S1290
D
D
I
P
D
S
P
S
S
P
K
V
A
L
L
Site 129
S1291
D
I
P
D
S
P
S
S
P
K
V
A
L
L
P
Site 130
S1306
P
V
L
K
K
V
P
S
D
K
E
R
D
G
Q
Site 131
S1314
D
K
E
R
D
G
Q
S
S
P
Q
P
S
P
R
Site 132
S1315
K
E
R
D
G
Q
S
S
P
Q
P
S
P
R
T
Site 133
S1319
G
Q
S
S
P
Q
P
S
P
R
T
F
S
Q
E
Site 134
T1322
S
P
Q
P
S
P
R
T
F
S
Q
E
V
S
R
Site 135
S1324
Q
P
S
P
R
T
F
S
Q
E
V
S
R
R
S
Site 136
S1328
R
T
F
S
Q
E
V
S
R
R
S
W
G
Q
Q
Site 137
S1331
S
Q
E
V
S
R
R
S
W
G
Q
Q
A
Q
E
Site 138
Y1339
W
G
Q
Q
A
Q
E
Y
Q
E
Q
K
Q
R
S
Site 139
S1346
Y
Q
E
Q
K
Q
R
S
S
S
K
D
G
H
Q
Site 140
S1347
Q
E
Q
K
Q
R
S
S
S
K
D
G
H
Q
G
Site 141
S1348
E
Q
K
Q
R
S
S
S
K
D
G
H
Q
G
S
Site 142
S1355
S
K
D
G
H
Q
G
S
K
S
N
D
S
G
E
Site 143
S1357
D
G
H
Q
G
S
K
S
N
D
S
G
E
E
A
Site 144
S1360
Q
G
S
K
S
N
D
S
G
E
E
A
E
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation