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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF219
Full Name:
RING finger protein 219
Alias:
C13orf7
Type:
Uncharacterized
Mass (Da):
81116
Number AA:
726
UniProt ID:
Q5W0B1
International Prot ID:
IPI00465370
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T60
P
A
C
R
V
P
I
T
P
E
N
P
C
K
E
Site 2
S73
K
E
I
I
G
G
T
S
E
S
E
P
M
L
S
Site 3
S75
I
I
G
G
T
S
E
S
E
P
M
L
S
H
T
Site 4
S80
S
E
S
E
P
M
L
S
H
T
V
R
K
H
L
Site 5
T82
S
E
P
M
L
S
H
T
V
R
K
H
L
R
K
Site 6
T90
V
R
K
H
L
R
K
T
R
L
E
L
L
H
K
Site 7
Y99
L
E
L
L
H
K
E
Y
E
D
E
I
D
C
L
Site 8
S115
K
E
V
E
E
L
K
S
K
N
L
S
L
E
S
Site 9
S119
E
L
K
S
K
N
L
S
L
E
S
Q
I
K
T
Site 10
S122
S
K
N
L
S
L
E
S
Q
I
K
T
I
L
D
Site 11
T132
K
T
I
L
D
P
L
T
L
V
Q
G
N
Q
N
Site 12
T146
N
E
D
K
H
L
V
T
D
N
P
S
K
I
N
Site 13
T156
P
S
K
I
N
P
E
T
V
A
E
W
K
K
K
Site 14
S210
K
A
E
V
D
N
R
S
P
Q
K
F
G
R
F
Site 15
Y229
L
Q
S
K
V
E
Q
Y
E
R
E
T
N
R
L
Site 16
T233
V
E
Q
Y
E
R
E
T
N
R
L
K
K
A
L
Site 17
S243
L
K
K
A
L
E
R
S
D
K
Y
I
E
E
L
Site 18
Y246
A
L
E
R
S
D
K
Y
I
E
E
L
E
S
Q
Site 19
S252
K
Y
I
E
E
L
E
S
Q
V
A
Q
L
K
N
Site 20
S260
Q
V
A
Q
L
K
N
S
S
E
E
K
E
A
M
Site 21
S261
V
A
Q
L
K
N
S
S
E
E
K
E
A
M
N
Site 22
S269
E
E
K
E
A
M
N
S
I
C
Q
T
A
L
S
Site 23
T273
A
M
N
S
I
C
Q
T
A
L
S
A
D
G
K
Site 24
S276
S
I
C
Q
T
A
L
S
A
D
G
K
G
S
K
Site 25
S285
D
G
K
G
S
K
G
S
E
E
D
V
V
S
K
Site 26
S291
G
S
E
E
D
V
V
S
K
N
Q
G
D
S
A
Site 27
S297
V
S
K
N
Q
G
D
S
A
R
K
Q
P
G
S
Site 28
S304
S
A
R
K
Q
P
G
S
S
T
S
S
S
S
H
Site 29
S305
A
R
K
Q
P
G
S
S
T
S
S
S
S
H
L
Site 30
T306
R
K
Q
P
G
S
S
T
S
S
S
S
H
L
A
Site 31
S307
K
Q
P
G
S
S
T
S
S
S
S
H
L
A
K
Site 32
S308
Q
P
G
S
S
T
S
S
S
S
H
L
A
K
P
Site 33
S309
P
G
S
S
T
S
S
S
S
H
L
A
K
P
S
Site 34
S310
G
S
S
T
S
S
S
S
H
L
A
K
P
S
S
Site 35
S316
S
S
H
L
A
K
P
S
S
S
R
L
C
D
T
Site 36
S317
S
H
L
A
K
P
S
S
S
R
L
C
D
T
S
Site 37
S318
H
L
A
K
P
S
S
S
R
L
C
D
T
S
S
Site 38
T323
S
S
S
R
L
C
D
T
S
S
A
R
Q
E
S
Site 39
S324
S
S
R
L
C
D
T
S
S
A
R
Q
E
S
T
Site 40
S325
S
R
L
C
D
T
S
S
A
R
Q
E
S
T
S
Site 41
S330
T
S
S
A
R
Q
E
S
T
S
K
A
D
L
N
Site 42
T331
S
S
A
R
Q
E
S
T
S
K
A
D
L
N
C
Site 43
S332
S
A
R
Q
E
S
T
S
K
A
D
L
N
C
S
Site 44
S339
S
K
A
D
L
N
C
S
K
N
K
D
L
Y
Q
Site 45
Y345
C
S
K
N
K
D
L
Y
Q
E
Q
V
E
V
M
Site 46
S359
M
L
D
V
T
D
T
S
M
D
T
Y
L
E
R
Site 47
Y363
T
D
T
S
M
D
T
Y
L
E
R
E
W
G
N
Site 48
Y384
P
Y
K
D
E
E
L
Y
D
L
P
A
P
C
T
Site 49
S401
S
L
S
C
L
Q
L
S
T
P
E
N
R
E
S
Site 50
T402
L
S
C
L
Q
L
S
T
P
E
N
R
E
S
S
Site 51
S408
S
T
P
E
N
R
E
S
S
V
V
Q
A
G
G
Site 52
S409
T
P
E
N
R
E
S
S
V
V
Q
A
G
G
S
Site 53
S416
S
V
V
Q
A
G
G
S
K
K
H
S
N
H
L
Site 54
S420
A
G
G
S
K
K
H
S
N
H
L
R
K
L
V
Site 55
S434
V
F
D
D
F
C
D
S
S
N
V
S
N
K
D
Site 56
S435
F
D
D
F
C
D
S
S
N
V
S
N
K
D
S
Site 57
S438
F
C
D
S
S
N
V
S
N
K
D
S
S
E
D
Site 58
S442
S
N
V
S
N
K
D
S
S
E
D
D
I
S
R
Site 59
S443
N
V
S
N
K
D
S
S
E
D
D
I
S
R
S
Site 60
S448
D
S
S
E
D
D
I
S
R
S
E
N
E
K
K
Site 61
S450
S
E
D
D
I
S
R
S
E
N
E
K
K
S
E
Site 62
S456
R
S
E
N
E
K
K
S
E
C
F
S
S
P
K
Site 63
S460
E
K
K
S
E
C
F
S
S
P
K
T
G
F
W
Site 64
S461
K
K
S
E
C
F
S
S
P
K
T
G
F
W
D
Site 65
S482
A
Q
N
L
D
F
E
S
S
E
G
N
T
I
A
Site 66
T487
F
E
S
S
E
G
N
T
I
A
N
S
V
G
E
Site 67
S491
E
G
N
T
I
A
N
S
V
G
E
I
S
S
K
Site 68
S496
A
N
S
V
G
E
I
S
S
K
L
S
E
K
S
Site 69
S497
N
S
V
G
E
I
S
S
K
L
S
E
K
S
G
Site 70
S500
G
E
I
S
S
K
L
S
E
K
S
G
L
C
L
Site 71
S503
S
S
K
L
S
E
K
S
G
L
C
L
S
K
R
Site 72
S508
E
K
S
G
L
C
L
S
K
R
L
N
S
I
R
Site 73
S513
C
L
S
K
R
L
N
S
I
R
S
F
E
M
N
Site 74
S516
K
R
L
N
S
I
R
S
F
E
M
N
R
T
R
Site 75
T522
R
S
F
E
M
N
R
T
R
T
S
S
E
A
S
Site 76
T524
F
E
M
N
R
T
R
T
S
S
E
A
S
M
D
Site 77
S525
E
M
N
R
T
R
T
S
S
E
A
S
M
D
A
Site 78
S526
M
N
R
T
R
T
S
S
E
A
S
M
D
A
A
Site 79
S529
T
R
T
S
S
E
A
S
M
D
A
A
Y
L
D
Site 80
Y534
E
A
S
M
D
A
A
Y
L
D
K
I
S
E
L
Site 81
S539
A
A
Y
L
D
K
I
S
E
L
D
S
M
M
S
Site 82
S543
D
K
I
S
E
L
D
S
M
M
S
E
S
D
N
Site 83
S546
S
E
L
D
S
M
M
S
E
S
D
N
S
K
S
Site 84
S548
L
D
S
M
M
S
E
S
D
N
S
K
S
P
C
Site 85
S551
M
M
S
E
S
D
N
S
K
S
P
C
N
N
G
Site 86
S553
S
E
S
D
N
S
K
S
P
C
N
N
G
F
K
Site 87
S561
P
C
N
N
G
F
K
S
L
D
L
D
G
L
S
Site 88
S568
S
L
D
L
D
G
L
S
K
S
S
Q
G
S
E
Site 89
S570
D
L
D
G
L
S
K
S
S
Q
G
S
E
F
L
Site 90
S571
L
D
G
L
S
K
S
S
Q
G
S
E
F
L
E
Site 91
S574
L
S
K
S
S
Q
G
S
E
F
L
E
E
P
D
Site 92
T587
P
D
K
L
E
E
K
T
E
L
N
L
S
K
G
Site 93
S592
E
K
T
E
L
N
L
S
K
G
S
L
T
N
D
Site 94
T610
N
G
S
E
W
K
P
T
S
F
F
L
L
S
P
Site 95
S611
G
S
E
W
K
P
T
S
F
F
L
L
S
P
S
Site 96
S616
P
T
S
F
F
L
L
S
P
S
D
Q
E
M
N
Site 97
S618
S
F
F
L
L
S
P
S
D
Q
E
M
N
E
D
Site 98
S627
Q
E
M
N
E
D
F
S
L
H
S
S
S
C
P
Site 99
S631
E
D
F
S
L
H
S
S
S
C
P
V
T
N
E
Site 100
S632
D
F
S
L
H
S
S
S
C
P
V
T
N
E
I
Site 101
T636
H
S
S
S
C
P
V
T
N
E
I
K
P
P
S
Site 102
S643
T
N
E
I
K
P
P
S
C
L
F
Q
T
E
F
Site 103
S657
F
S
Q
G
I
L
L
S
S
S
H
R
L
F
E
Site 104
S658
S
Q
G
I
L
L
S
S
S
H
R
L
F
E
D
Site 105
S659
Q
G
I
L
L
S
S
S
H
R
L
F
E
D
Q
Site 106
S670
F
E
D
Q
R
F
G
S
S
L
F
K
M
S
S
Site 107
S671
E
D
Q
R
F
G
S
S
L
F
K
M
S
S
E
Site 108
S676
G
S
S
L
F
K
M
S
S
E
M
H
S
L
H
Site 109
S677
S
S
L
F
K
M
S
S
E
M
H
S
L
H
N
Site 110
S681
K
M
S
S
E
M
H
S
L
H
N
H
L
Q
S
Site 111
S688
S
L
H
N
H
L
Q
S
P
W
S
T
S
F
V
Site 112
S691
N
H
L
Q
S
P
W
S
T
S
F
V
P
E
K
Site 113
S693
L
Q
S
P
W
S
T
S
F
V
P
E
K
R
N
Site 114
S706
R
N
K
N
V
N
Q
S
T
K
R
K
I
Q
S
Site 115
T707
N
K
N
V
N
Q
S
T
K
R
K
I
Q
S
S
Site 116
S713
S
T
K
R
K
I
Q
S
S
L
S
S
A
S
P
Site 117
S714
T
K
R
K
I
Q
S
S
L
S
S
A
S
P
S
Site 118
S716
R
K
I
Q
S
S
L
S
S
A
S
P
S
K
A
Site 119
S717
K
I
Q
S
S
L
S
S
A
S
P
S
K
A
T
Site 120
S719
Q
S
S
L
S
S
A
S
P
S
K
A
T
K
S
Site 121
S721
S
L
S
S
A
S
P
S
K
A
T
K
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation