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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USPL1
Full Name:
Ubiquitin-specific peptidase-like protein 1
Alias:
Type:
Mass (Da):
120440
Number AA:
1092
UniProt ID:
Q5W0Q7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y30
S
S
L
H
M
V
G
Y
L
G
K
N
F
D
S
Site 2
S42
F
D
S
A
K
V
P
S
D
E
Y
C
P
A
C
Site 3
Y45
A
K
V
P
S
D
E
Y
C
P
A
C
R
E
K
Site 4
T60
G
K
L
K
A
L
K
T
Y
R
I
S
F
Q
E
Site 5
Y79
C
E
D
L
Q
C
I
Y
P
L
G
S
K
S
L
Site 6
S85
I
Y
P
L
G
S
K
S
L
N
N
L
I
S
P
Site 7
S91
K
S
L
N
N
L
I
S
P
D
L
E
E
C
H
Site 8
T99
P
D
L
E
E
C
H
T
P
H
K
P
Q
K
R
Site 9
S108
H
K
P
Q
K
R
K
S
L
E
S
S
Y
K
D
Site 10
S111
Q
K
R
K
S
L
E
S
S
Y
K
D
S
L
L
Site 11
S112
K
R
K
S
L
E
S
S
Y
K
D
S
L
L
L
Site 12
S116
L
E
S
S
Y
K
D
S
L
L
L
A
N
S
K
Site 13
S122
D
S
L
L
L
A
N
S
K
K
T
R
N
Y
I
Site 14
Y128
N
S
K
K
T
R
N
Y
I
A
I
D
G
G
K
Site 15
S139
D
G
G
K
V
L
N
S
K
H
N
G
E
V
Y
Site 16
Y146
S
K
H
N
G
E
V
Y
D
E
T
S
S
N
L
Site 17
T149
N
G
E
V
Y
D
E
T
S
S
N
L
P
D
S
Site 18
S151
E
V
Y
D
E
T
S
S
N
L
P
D
S
S
G
Site 19
S156
T
S
S
N
L
P
D
S
S
G
Q
Q
N
P
I
Site 20
S157
S
S
N
L
P
D
S
S
G
Q
Q
N
P
I
R
Site 21
S168
N
P
I
R
T
A
D
S
L
E
R
N
E
I
L
Site 22
T179
N
E
I
L
E
A
D
T
V
D
M
A
T
T
K
Site 23
T184
A
D
T
V
D
M
A
T
T
K
D
P
A
T
V
Site 24
T185
D
T
V
D
M
A
T
T
K
D
P
A
T
V
D
Site 25
T190
A
T
T
K
D
P
A
T
V
D
V
S
G
T
G
Site 26
S194
D
P
A
T
V
D
V
S
G
T
G
R
P
S
P
Site 27
T196
A
T
V
D
V
S
G
T
G
R
P
S
P
Q
N
Site 28
S200
V
S
G
T
G
R
P
S
P
Q
N
E
G
C
T
Site 29
S208
P
Q
N
E
G
C
T
S
K
L
E
M
P
L
E
Site 30
S216
K
L
E
M
P
L
E
S
K
C
T
S
F
P
Q
Site 31
T254
H
S
E
E
L
K
N
T
V
T
G
L
C
S
K
Site 32
T256
E
E
L
K
N
T
V
T
G
L
C
S
K
E
E
Site 33
S260
N
T
V
T
G
L
C
S
K
E
E
S
I
F
W
Site 34
T271
S
I
F
W
R
L
L
T
K
Y
N
Q
A
N
T
Site 35
Y273
F
W
R
L
L
T
K
Y
N
Q
A
N
T
L
L
Site 36
Y281
N
Q
A
N
T
L
L
Y
T
S
Q
L
S
G
V
Site 37
S283
A
N
T
L
L
Y
T
S
Q
L
S
G
V
K
D
Site 38
T297
D
G
D
C
K
K
L
T
S
E
I
F
A
E
I
Site 39
S318
V
R
D
E
I
F
I
S
L
Q
P
Q
L
R
C
Site 40
T326
L
Q
P
Q
L
R
C
T
L
G
D
M
E
S
P
Site 41
Y353
H
I
E
K
L
F
L
Y
S
F
S
W
D
F
E
Site 42
T378
R
H
M
K
S
L
V
T
F
T
N
V
I
P
E
Site 43
S415
K
M
V
L
E
K
V
S
P
I
F
M
L
H
F
Site 44
Y434
P
Q
N
D
L
Q
H
Y
A
F
H
F
E
G
C
Site 45
Y451
Q
I
T
S
V
I
Q
Y
R
A
N
N
H
F
I
Site 46
S479
D
D
L
K
G
P
C
S
E
R
H
K
K
F
E
Site 47
S502
V
I
W
E
R
K
I
S
Q
V
T
D
K
E
A
Site 48
T517
A
C
L
P
L
K
K
T
N
D
Q
H
A
L
S
Site 49
S524
T
N
D
Q
H
A
L
S
N
E
K
P
V
S
L
Site 50
S530
L
S
N
E
K
P
V
S
L
T
S
C
S
V
G
Site 51
S533
E
K
P
V
S
L
T
S
C
S
V
G
D
A
A
Site 52
S546
A
A
S
A
E
T
A
S
V
T
H
P
K
D
I
Site 53
S554
V
T
H
P
K
D
I
S
V
A
P
R
T
L
S
Site 54
T559
D
I
S
V
A
P
R
T
L
S
Q
D
T
A
V
Site 55
S561
S
V
A
P
R
T
L
S
Q
D
T
A
V
T
H
Site 56
S574
T
H
G
D
H
L
L
S
G
P
K
G
L
V
D
Site 57
T587
V
D
N
I
L
P
L
T
L
E
E
T
I
Q
K
Site 58
T595
L
E
E
T
I
Q
K
T
A
S
V
S
Q
L
N
Site 59
S597
E
T
I
Q
K
T
A
S
V
S
Q
L
N
S
E
Site 60
S599
I
Q
K
T
A
S
V
S
Q
L
N
S
E
A
F
Site 61
S603
A
S
V
S
Q
L
N
S
E
A
F
L
L
E
N
Site 62
T624
T
G
I
L
K
T
N
T
L
L
S
Q
E
S
L
Site 63
S627
L
K
T
N
T
L
L
S
Q
E
S
L
M
A
S
Site 64
S630
N
T
L
L
S
Q
E
S
L
M
A
S
S
V
S
Site 65
S634
S
Q
E
S
L
M
A
S
S
V
S
A
P
C
N
Site 66
S635
Q
E
S
L
M
A
S
S
V
S
A
P
C
N
E
Site 67
S653
Q
D
Q
F
V
D
I
S
F
P
S
Q
V
V
N
Site 68
T673
V
Q
L
N
T
E
D
T
V
N
T
K
S
V
N
Site 69
S678
E
D
T
V
N
T
K
S
V
N
N
T
D
A
T
Site 70
T682
N
T
K
S
V
N
N
T
D
A
T
G
L
I
Q
Site 71
T685
S
V
N
N
T
D
A
T
G
L
I
Q
G
V
K
Site 72
S693
G
L
I
Q
G
V
K
S
V
E
I
E
K
D
A
Site 73
T707
A
Q
L
K
Q
F
L
T
P
K
T
E
Q
L
K
Site 74
T710
K
Q
F
L
T
P
K
T
E
Q
L
K
P
E
R
Site 75
T719
Q
L
K
P
E
R
V
T
S
Q
V
S
N
L
K
Site 76
S720
L
K
P
E
R
V
T
S
Q
V
S
N
L
K
K
Site 77
T730
S
N
L
K
K
K
E
T
T
A
D
S
Q
T
T
Site 78
S734
K
K
E
T
T
A
D
S
Q
T
T
T
S
K
S
Site 79
T736
E
T
T
A
D
S
Q
T
T
T
S
K
S
L
Q
Site 80
T737
T
T
A
D
S
Q
T
T
T
S
K
S
L
Q
N
Site 81
T738
T
A
D
S
Q
T
T
T
S
K
S
L
Q
N
Q
Site 82
S739
A
D
S
Q
T
T
T
S
K
S
L
Q
N
Q
S
Site 83
S741
S
Q
T
T
T
S
K
S
L
Q
N
Q
S
L
K
Site 84
S758
Q
K
K
P
F
V
G
S
W
V
K
G
L
I
S
Site 85
T782
V
S
A
H
N
R
N
T
I
T
D
L
Q
P
S
Site 86
S789
T
I
T
D
L
Q
P
S
V
K
G
V
N
N
F
Site 87
S818
V
S
K
K
A
R
K
S
A
S
K
P
P
P
I
Site 88
S820
K
K
A
R
K
S
A
S
K
P
P
P
I
S
K
Site 89
S826
A
S
K
P
P
P
I
S
K
P
P
A
G
P
P
Site 90
S834
K
P
P
A
G
P
P
S
S
N
G
T
A
A
H
Site 91
S835
P
P
A
G
P
P
S
S
N
G
T
A
A
H
P
Site 92
T838
G
P
P
S
S
N
G
T
A
A
H
P
H
A
H
Site 93
S854
A
S
E
V
L
E
K
S
G
S
T
S
C
G
A
Site 94
S856
E
V
L
E
K
S
G
S
T
S
C
G
A
Q
L
Site 95
S858
L
E
K
S
G
S
T
S
C
G
A
Q
L
N
H
Site 96
S866
C
G
A
Q
L
N
H
S
S
Y
G
N
G
I
S
Site 97
S867
G
A
Q
L
N
H
S
S
Y
G
N
G
I
S
S
Site 98
Y868
A
Q
L
N
H
S
S
Y
G
N
G
I
S
S
A
Site 99
S873
S
S
Y
G
N
G
I
S
S
A
N
H
E
D
L
Site 100
S908
K
K
L
A
A
L
M
S
S
P
Q
S
R
T
V
Site 101
S909
K
L
A
A
L
M
S
S
P
Q
S
R
T
V
R
Site 102
S912
A
L
M
S
S
P
Q
S
R
T
V
R
S
E
N
Site 103
T914
M
S
S
P
Q
S
R
T
V
R
S
E
N
L
E
Site 104
S928
E
Q
V
P
Q
D
G
S
P
N
D
C
E
S
I
Site 105
S934
G
S
P
N
D
C
E
S
I
E
D
L
L
N
E
Site 106
Y944
D
L
L
N
E
L
P
Y
P
I
D
I
A
S
E
Site 107
S961
C
T
T
V
P
G
V
S
L
Y
S
S
Q
T
H
Site 108
Y963
T
V
P
G
V
S
L
Y
S
S
Q
T
H
E
E
Site 109
S965
P
G
V
S
L
Y
S
S
Q
T
H
E
E
I
L
Site 110
S982
L
L
S
P
T
P
V
S
T
E
L
S
E
N
G
Site 111
S986
T
P
V
S
T
E
L
S
E
N
G
E
G
D
F
Site 112
Y995
N
G
E
G
D
F
R
Y
L
G
M
G
D
S
H
Site 113
S1001
R
Y
L
G
M
G
D
S
H
I
P
P
P
V
P
Site 114
S1009
H
I
P
P
P
V
P
S
E
F
N
D
V
S
Q
Site 115
S1015
P
S
E
F
N
D
V
S
Q
N
T
H
L
R
Q
Site 116
Y1026
H
L
R
Q
D
H
N
Y
C
S
P
T
K
K
N
Site 117
S1041
P
C
E
V
Q
P
D
S
L
T
N
N
A
C
V
Site 118
T1043
E
V
Q
P
D
S
L
T
N
N
A
C
V
R
T
Site 119
S1055
V
R
T
L
N
L
E
S
P
M
K
T
D
I
F
Site 120
T1059
N
L
E
S
P
M
K
T
D
I
F
D
E
F
F
Site 121
T1078
L
N
A
L
A
N
D
T
L
D
L
P
H
F
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation