PhosphoNET

           
Protein Info 
   
Short Name:  POLS
Full Name:  DNA polymerase sigma
Alias:  DNA polymerase kappa; LAK-1; POLK; polymerase (DNA directed) sigma; polymerase (DNA-directed) sigma; Topoisomerase-related function protein 4-1; TRF4; TRF4-1
Type:  Transferase; DNA repair; DNA replication; EC 2.7.7.7
Mass (Da):  59874
Number AA:  542
UniProt ID:  Q5XG87
International Prot ID:  IPI00418630
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0003677  GO:0003887  GO:0043221 PhosphoSite+ KinaseNET
Biological Process:  GO:0006260  GO:0051301  GO:0006302 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T20EVVKRIETVVKDLWP
Site 2T39QIFGSFSTGLYLPTS
Site 3Y42GSFSTGLYLPTSDID
Site 4S46TGLYLPTSDIDLVVF
Site 5T97IKLTDQETEVKVDIS
Site 6S104TEVKVDISFNMETGV
Site 7Y120AAEFIKNYMKKYSLL
Site 8S125KNYMKKYSLLPYLIL
Site 9T148RDLNEVFTGGISSYS
Site 10Y196LYGRNFNYLKTGIRI
Site 11T199RNFNYLKTGIRIKEG
Site 12Y209RIKEGGAYIAKEEIM
Site 13S221EIMKAMTSGYRPSML
Site 14S226MTSGYRPSMLCIEDP
Site 15S243PGNDVGRSSYGAMQV
Site 16S244GNDVGRSSYGAMQVK
Site 17Y245NDVGRSSYGAMQVKQ
Site 18S271AVSPLARSYPNRDAE
Site 19Y272VSPLARSYPNRDAES
Site 20T280PNRDAESTLGRIIKV
Site 21T288LGRIIKVTQEVIDYR
Site 22Y294VTQEVIDYRRWIKEK
Site 23S304WIKEKWGSKAHPSPG
Site 24S309WGSKAHPSPGMDSRI
Site 25S314HPSPGMDSRIKIKER
Site 26T324KIKERIATCNGEQTQ
Site 27T330ATCNGEQTQNREPES
Site 28S337TQNREPESPYGQRLT
Site 29Y339NREPESPYGQRLTLS
Site 30T344SPYGQRLTLSLSSPQ
Site 31S346YGQRLTLSLSSPQLL
Site 32S348QRLTLSLSSPQLLSS
Site 33S349RLTLSLSSPQLLSSG
Site 34S354LSSPQLLSSGSSASS
Site 35S355SSPQLLSSGSSASSV
Site 36S357PQLLSSGSSASSVSS
Site 37S360LSSGSSASSVSSLSG
Site 38S361SSGSSASSVSSLSGS
Site 39S363GSSASSVSSLSGSDV
Site 40S364SSASSVSSLSGSDVD
Site 41S366ASSVSSLSGSDVDSD
Site 42S368SVSSLSGSDVDSDTP
Site 43S372LSGSDVDSDTPPCTT
Site 44T374GSDVDSDTPPCTTPS
Site 45T378DSDTPPCTTPSVYQF
Site 46T379SDTPPCTTPSVYQFS
Site 47S381TPPCTTPSVYQFSLQ
Site 48S405PTALPMPSGKPQPTT
Site 49T411PSGKPQPTTSRTLIM
Site 50T412SGKPQPTTSRTLIMT
Site 51S413GKPQPTTSRTLIMTT
Site 52T415PQPTTSRTLIMTTNN
Site 53T419TSRTLIMTTNNQTRF
Site 54T424IMTTNNQTRFTIPPP
Site 55T427TNNQTRFTIPPPTLG
Site 56S450AGVEGTASLKAVHHM
Site 57S458LKAVHHMSSPAIPSA
Site 58S459KAVHHMSSPAIPSAS
Site 59S464MSSPAIPSASPNPLS
Site 60S466SPAIPSASPNPLSSP
Site 61S471SASPNPLSSPHLYHK
Site 62S472ASPNPLSSPHLYHKQ
Site 63Y476PLSSPHLYHKQHNGM
Site 64S490MKLSMKGSHGHTQGG
Site 65T494MKGSHGHTQGGGYSS
Site 66Y499GHTQGGGYSSVGSGG
Site 67S500HTQGGGYSSVGSGGV
Site 68S501TQGGGYSSVGSGGVR
Site 69S504GGYSSVGSGGVRPPV
Site 70Y519GNRGHHQYNRTGWRR
Site 71T530GWRRKKHTHTRDSLP
Site 72S535KHTHTRDSLPVSLSR
Site 73S539TRDSLPVSLSR____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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