KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CES8
Full Name:
Carboxylesterase 8
Alias:
Type:
Mass (Da):
63529
Number AA:
561
UniProt ID:
Q5XG92
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
R
W
I
L
C
W
S
L
T
L
C
L
M
A
Site 2
T24
T
A
L
G
A
L
H
T
K
R
P
Q
V
V
T
Site 3
T31
T
K
R
P
Q
V
V
T
K
Y
G
T
L
Q
G
Site 4
Y33
R
P
Q
V
V
T
K
Y
G
T
L
Q
G
K
Q
Site 5
T46
K
Q
M
H
V
G
K
T
P
I
Q
V
F
L
G
Site 6
T82
W
K
G
I
R
D
A
T
T
Y
P
P
G
C
L
Site 7
T83
K
G
I
R
D
A
T
T
Y
P
P
G
C
L
Q
Site 8
Y84
G
I
R
D
A
T
T
Y
P
P
G
C
L
Q
E
Site 9
S92
P
P
G
C
L
Q
E
S
W
G
Q
L
A
S
M
Site 10
S98
E
S
W
G
Q
L
A
S
M
Y
V
S
T
R
E
Site 11
Y100
W
G
Q
L
A
S
M
Y
V
S
T
R
E
R
Y
Site 12
S102
Q
L
A
S
M
Y
V
S
T
R
E
R
Y
K
W
Site 13
Y107
Y
V
S
T
R
E
R
Y
K
W
L
R
F
S
E
Site 14
Y118
R
F
S
E
D
C
L
Y
L
N
V
Y
A
P
A
Site 15
S155
A
A
S
S
Y
E
G
S
D
L
A
A
R
E
K
Site 16
S179
L
G
I
F
G
F
L
S
T
D
D
S
H
A
R
Site 17
S183
G
F
L
S
T
D
D
S
H
A
R
G
N
W
G
Site 18
T216
G
G
D
P
G
N
V
T
L
F
G
Q
S
A
G
Site 19
S297
G
T
K
V
M
R
V
S
N
K
M
R
F
L
Q
Site 20
S317
D
P
E
E
I
I
W
S
M
S
P
V
V
D
G
Site 21
T375
R
Q
A
M
R
K
E
T
I
T
K
M
L
W
S
Site 22
T377
A
M
R
K
E
T
I
T
K
M
L
W
S
T
R
Site 23
T385
K
M
L
W
S
T
R
T
L
L
N
I
T
K
E
Site 24
Y401
V
P
L
V
V
E
E
Y
L
D
N
V
N
E
H
Site 25
Y436
A
T
L
Q
T
A
H
Y
H
R
D
A
G
L
P
Site 26
Y445
R
D
A
G
L
P
V
Y
L
Y
E
F
E
H
H
Site 27
Y447
A
G
L
P
V
Y
L
Y
E
F
E
H
H
A
R
Site 28
T462
G
I
I
V
K
P
R
T
D
G
A
D
H
G
D
Site 29
Y472
A
D
H
G
D
E
M
Y
F
L
F
G
G
P
F
Site 30
S484
G
P
F
A
T
G
L
S
M
G
K
E
K
A
L
Site 31
Y498
L
S
L
Q
M
M
K
Y
W
A
N
F
A
R
T
Site 32
Y519
N
L
P
C
W
P
R
Y
N
K
D
E
K
Y
L
Site 33
Y525
R
Y
N
K
D
E
K
Y
L
Q
L
D
F
T
T
Site 34
T531
K
Y
L
Q
L
D
F
T
T
R
V
G
M
K
L
Site 35
Y550
M
A
F
W
M
S
L
Y
Q
S
Q
R
P
E
K
Site 36
S552
F
W
M
S
L
Y
Q
S
Q
R
P
E
K
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation