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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF123
Full Name:
E3 ubiquitin-protein ligase RNF123
Alias:
FLJ12565; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123; RN123
Type:
Ligase; Ubiquitin conjugating system; EC 6.3.2.-
Mass (Da):
148496
Number AA:
1314
UniProt ID:
Q5XPI4
International Prot ID:
IPI00335085
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
S
K
G
A
G
M
S
F
S
R
K
S
Y
R
Site 2
S11
K
G
A
G
M
S
F
S
R
K
S
Y
R
L
T
Site 3
S14
G
M
S
F
S
R
K
S
Y
R
L
T
S
D
A
Site 4
Y15
M
S
F
S
R
K
S
Y
R
L
T
S
D
A
E
Site 5
T18
S
R
K
S
Y
R
L
T
S
D
A
E
K
S
R
Site 6
S19
R
K
S
Y
R
L
T
S
D
A
E
K
S
R
V
Site 7
S24
L
T
S
D
A
E
K
S
R
V
T
G
I
V
Q
Site 8
T27
D
A
E
K
S
R
V
T
G
I
V
Q
E
K
L
Site 9
Y38
Q
E
K
L
L
N
D
Y
L
N
R
I
F
S
S
Site 10
S44
D
Y
L
N
R
I
F
S
S
S
E
H
A
P
P
Site 11
S46
L
N
R
I
F
S
S
S
E
H
A
P
P
A
A
Site 12
S81
V
D
N
E
E
E
E
S
Q
G
Q
V
E
G
R
Site 13
S92
V
E
G
R
L
G
P
S
T
V
V
L
D
H
T
Site 14
T93
E
G
R
L
G
P
S
T
V
V
L
D
H
T
G
Site 15
S126
S
N
F
G
T
I
R
S
T
T
C
V
Y
K
G
Site 16
T127
N
F
G
T
I
R
S
T
T
C
V
Y
K
G
K
Site 17
T128
F
G
T
I
R
S
T
T
C
V
Y
K
G
K
W
Site 18
Y131
I
R
S
T
T
C
V
Y
K
G
K
W
L
Y
E
Site 19
Y137
V
Y
K
G
K
W
L
Y
E
V
L
I
S
S
Q
Site 20
S170
G
V
G
D
T
H
N
S
Y
A
Y
D
G
N
R
Site 21
Y171
V
G
D
T
H
N
S
Y
A
Y
D
G
N
R
V
Site 22
T184
R
V
R
K
W
N
V
T
T
T
N
Y
G
K
A
Site 23
S226
G
T
A
F
E
N
L
S
R
G
L
G
M
A
Y
Site 24
Y256
F
G
S
R
P
L
R
Y
P
V
A
G
Y
R
P
Site 25
S269
R
P
L
Q
D
P
P
S
A
D
L
V
R
A
Q
Site 26
S302
G
R
L
L
D
K
E
S
S
K
W
R
L
R
G
Site 27
S303
R
L
L
D
K
E
S
S
K
W
R
L
R
G
Q
Site 28
T350
L
G
I
V
E
K
G
T
P
T
Q
A
Q
S
V
Site 29
T352
I
V
E
K
G
T
P
T
Q
A
Q
S
V
V
H
Site 30
Y372
L
W
L
F
M
E
D
Y
E
V
Q
D
C
L
K
Site 31
Y404
D
L
G
L
Q
I
H
Y
L
R
L
T
I
A
I
Site 32
S417
A
I
L
R
H
E
K
S
R
K
F
L
L
S
N
Site 33
S469
S
S
R
E
G
K
E
S
T
E
M
K
E
E
T
Site 34
Y486
E
R
L
R
R
R
A
Y
E
R
G
C
Q
R
L
Site 35
S523
D
D
N
G
G
E
A
S
R
Y
I
F
L
T
K
Site 36
Y525
N
G
G
E
A
S
R
Y
I
F
L
T
K
F
R
Site 37
T529
A
S
R
Y
I
F
L
T
K
F
R
K
F
L
Q
Site 38
S540
K
F
L
Q
E
N
A
S
G
R
G
N
M
P
M
Site 39
Y567
R
L
I
S
A
L
R
Y
Y
W
D
E
Y
K
A
Site 40
Y568
L
I
S
A
L
R
Y
Y
W
D
E
Y
K
A
S
Site 41
Y572
L
R
Y
Y
W
D
E
Y
K
A
S
N
P
H
A
Site 42
S580
K
A
S
N
P
H
A
S
F
S
E
E
A
Y
I
Site 43
S582
S
N
P
H
A
S
F
S
E
E
A
Y
I
P
P
Site 44
Y586
A
S
F
S
E
E
A
Y
I
P
P
Q
V
F
Y
Site 45
Y599
F
Y
N
G
K
V
D
Y
F
D
L
Q
R
L
G
Site 46
S610
Q
R
L
G
G
L
L
S
H
L
R
K
T
L
K
Site 47
T615
L
L
S
H
L
R
K
T
L
K
D
D
L
A
S
Site 48
T636
D
P
L
E
L
Q
S
T
A
M
D
D
L
D
E
Site 49
S674
L
P
R
P
G
W
L
S
S
P
T
L
G
R
A
Site 50
S675
P
R
P
G
W
L
S
S
P
T
L
G
R
A
N
Site 51
T677
P
G
W
L
S
S
P
T
L
G
R
A
N
R
F
Site 52
S686
G
R
A
N
R
F
L
S
T
A
A
V
S
L
M
Site 53
T694
T
A
A
V
S
L
M
T
P
R
R
P
L
S
T
Site 54
S700
M
T
P
R
R
P
L
S
T
S
E
K
V
K
V
Site 55
T701
T
P
R
R
P
L
S
T
S
E
K
V
K
V
R
Site 56
S702
P
R
R
P
L
S
T
S
E
K
V
K
V
R
T
Site 57
S711
K
V
K
V
R
T
L
S
V
E
Q
R
T
R
E
Site 58
S723
T
R
E
D
I
E
G
S
H
W
N
E
G
L
L
Site 59
T743
E
E
P
E
Q
P
L
T
E
N
S
L
L
E
V
Site 60
S746
E
Q
P
L
T
E
N
S
L
L
E
V
L
D
G
Site 61
S773
L
G
K
M
V
G
V
S
D
D
V
N
E
Y
A
Site 62
T786
Y
A
M
A
L
R
D
T
E
D
K
L
R
R
C
Site 63
S807
I
L
A
E
L
T
K
S
Q
K
V
F
S
E
K
Site 64
S819
S
E
K
L
D
H
L
S
R
R
L
A
W
V
H
Site 65
T828
R
L
A
W
V
H
A
T
V
Y
S
Q
E
K
M
Site 66
T848
L
L
R
V
C
L
R
T
I
E
H
G
D
R
T
Site 67
T855
T
I
E
H
G
D
R
T
G
S
L
F
A
F
M
Site 68
S857
E
H
G
D
R
T
G
S
L
F
A
F
M
P
E
Site 69
Y880
S
Y
S
A
L
K
N
Y
F
G
P
V
H
S
M
Site 70
S886
N
Y
F
G
P
V
H
S
M
E
E
L
P
G
Y
Site 71
Y893
S
M
E
E
L
P
G
Y
E
E
T
L
T
R
L
Site 72
S935
S
Y
V
C
Y
P
H
S
L
R
A
V
E
R
I
Site 73
Y983
G
C
G
F
G
Y
R
Y
T
R
L
P
H
L
L
Site 74
S1001
L
E
D
A
N
L
P
S
L
Q
K
P
C
P
S
Site 75
T1009
L
Q
K
P
C
P
S
T
L
L
Q
Q
H
M
A
Site 76
S1028
Q
G
P
D
V
A
P
S
F
L
N
S
V
L
N
Site 77
S1065
L
E
R
N
F
V
D
S
R
Q
L
K
V
C
A
Site 78
T1100
P
E
I
F
L
D
W
T
R
P
T
S
E
M
L
Site 79
T1103
F
L
D
W
T
R
P
T
S
E
M
L
L
R
R
Site 80
S1104
L
D
W
T
R
P
T
S
E
M
L
L
R
R
L
Site 81
T1123
N
Q
V
L
N
R
V
T
A
E
R
N
L
F
D
Site 82
S1166
L
L
V
R
G
P
A
S
E
R
E
Q
A
T
S
Site 83
S1173
S
E
R
E
Q
A
T
S
V
L
L
A
D
P
C
Site 84
Y1188
F
Q
L
R
S
I
C
Y
L
L
G
Q
P
E
P
Site 85
T1200
P
E
P
P
A
P
G
T
A
L
P
A
P
D
R
Site 86
S1211
A
P
D
R
K
R
F
S
L
Q
S
Y
A
D
Y
Site 87
S1214
R
K
R
F
S
L
Q
S
Y
A
D
Y
I
S
A
Site 88
Y1215
K
R
F
S
L
Q
S
Y
A
D
Y
I
S
A
D
Site 89
Y1218
S
L
Q
S
Y
A
D
Y
I
S
A
D
E
L
A
Site 90
S1245
S
A
Q
A
A
A
A
S
L
P
T
S
E
E
D
Site 91
S1308
W
E
K
G
A
N
T
S
T
T
S
S
A
A
_
Site 92
S1312
A
N
T
S
T
T
S
S
A
A
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation