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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXW10
Full Name:
F-box/WD repeat-containing protein 10
Alias:
C17orf1; C17orf1A; F-box and WD repeat domain containing 10; F-box and WD-40 domain 10; F-box and WD-40 domain-containing protein 10; F-box protein; Fbw10; HREP; SM25H2; SM2SH2; Ubiquitin ligase specificity factor; Ubiquitin ligase-specificity factor
Type:
Mass (Da):
119741
Number AA:
1052
UniProt ID:
Q5XX13
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
S
R
L
K
N
A
P
Y
F
R
C
E
K
G
T
Site 2
T20
Y
F
R
C
E
K
G
T
D
S
I
P
L
C
R
Site 3
S22
R
C
E
K
G
T
D
S
I
P
L
C
R
K
C
Site 4
Y68
L
K
Q
L
N
S
L
Y
L
L
H
Y
F
Q
N
Site 5
Y72
N
S
L
Y
L
L
H
Y
F
Q
N
I
L
Q
T
Site 6
Y87
T
Q
G
K
D
F
I
Y
N
R
S
R
I
N
L
Site 7
S90
K
D
F
I
Y
N
R
S
R
I
N
L
S
K
K
Site 8
S104
K
E
G
K
V
V
K
S
S
L
N
Q
M
L
D
Site 9
S105
E
G
K
V
V
K
S
S
L
N
Q
M
L
D
K
Site 10
T113
L
N
Q
M
L
D
K
T
V
E
Q
K
M
K
E
Site 11
Y123
Q
K
M
K
E
I
L
Y
W
F
A
N
S
T
Q
Site 12
T132
F
A
N
S
T
Q
W
T
K
A
N
Y
T
L
L
Site 13
S168
L
R
E
E
N
N
I
S
G
L
N
Q
D
I
T
Site 14
T175
S
G
L
N
Q
D
I
T
D
V
C
F
S
P
E
Site 15
S180
D
I
T
D
V
C
F
S
P
E
K
D
H
S
S
Site 16
S186
F
S
P
E
K
D
H
S
S
K
S
A
T
S
Q
Site 17
S187
S
P
E
K
D
H
S
S
K
S
A
T
S
Q
V
Site 18
S189
E
K
D
H
S
S
K
S
A
T
S
Q
V
Y
W
Site 19
T191
D
H
S
S
K
S
A
T
S
Q
V
Y
W
T
A
Site 20
S192
H
S
S
K
S
A
T
S
Q
V
Y
W
T
A
K
Site 21
T200
Q
V
Y
W
T
A
K
T
Q
H
T
S
L
P
L
Site 22
S204
T
A
K
T
Q
H
T
S
L
P
L
S
K
A
P
Site 23
S208
Q
H
T
S
L
P
L
S
K
A
P
E
N
E
H
Site 24
S221
E
H
L
L
G
A
A
S
N
P
E
E
P
W
R
Site 25
S230
P
E
E
P
W
R
N
S
L
R
C
I
S
E
M
Site 26
S235
R
N
S
L
R
C
I
S
E
M
N
R
L
F
S
Site 27
S242
S
E
M
N
R
L
F
S
G
K
G
D
I
T
K
Site 28
T248
F
S
G
K
G
D
I
T
K
P
G
Y
D
P
C
Site 29
Y252
G
D
I
T
K
P
G
Y
D
P
C
N
L
L
V
Site 30
S268
L
D
D
I
R
D
L
S
S
G
F
S
K
Y
L
Site 31
S269
D
D
I
R
D
L
S
S
G
F
S
K
Y
L
D
Site 32
S272
R
D
L
S
S
G
F
S
K
Y
L
D
F
I
R
Site 33
Y280
K
Y
L
D
F
I
R
Y
L
P
I
H
L
S
K
Site 34
S286
R
Y
L
P
I
H
L
S
K
Y
I
L
S
M
L
Site 35
T297
L
R
M
L
D
R
H
T
L
N
K
C
A
S
V
Site 36
T330
G
F
I
Q
N
Q
I
T
F
L
Q
G
S
Y
T
Site 37
S335
Q
I
T
F
L
Q
G
S
Y
T
R
G
I
D
P
Site 38
T337
T
F
L
Q
G
S
Y
T
R
G
I
D
P
N
Y
Site 39
Y344
T
R
G
I
D
P
N
Y
A
N
K
V
S
I
P
Site 40
S361
K
M
V
D
D
G
K
S
M
R
V
K
H
P
K
Site 41
Y377
K
L
R
T
K
N
E
Y
N
L
W
T
A
Y
Q
Site 42
Y383
E
Y
N
L
W
T
A
Y
Q
N
E
E
T
Q
Q
Site 43
Y403
R
N
V
F
C
G
T
Y
N
V
R
I
L
S
D
Site 44
T411
N
V
R
I
L
S
D
T
W
D
Q
N
R
V
I
Site 45
S429
G
G
D
L
I
A
V
S
S
N
R
K
I
H
L
Site 46
S470
E
E
E
N
F
L
L
S
G
S
Y
D
L
S
I
Site 47
S472
E
N
F
L
L
S
G
S
Y
D
L
S
I
R
Y
Site 48
S476
L
S
G
S
Y
D
L
S
I
R
Y
W
D
L
K
Site 49
Y479
S
Y
D
L
S
I
R
Y
W
D
L
K
S
G
V
Site 50
T488
D
L
K
S
G
V
C
T
R
I
F
G
G
H
Q
Site 51
S510
L
C
K
N
R
L
V
S
G
G
R
D
C
Q
V
Site 52
T524
V
K
V
W
D
V
D
T
G
K
C
L
K
T
F
Site 53
T530
D
T
G
K
C
L
K
T
F
R
H
K
D
P
I
Site 54
T545
L
A
T
R
I
N
D
T
Y
I
V
S
S
C
E
Site 55
Y546
A
T
R
I
N
D
T
Y
I
V
S
S
C
E
R
Site 56
S550
N
D
T
Y
I
V
S
S
C
E
R
G
L
V
K
Site 57
S571
A
Q
L
V
K
T
L
S
G
H
E
G
A
V
K
Site 58
S589
F
D
Q
W
H
L
L
S
G
S
T
D
G
L
V
Site 59
S662
G
R
G
D
P
V
L
S
F
F
I
Q
G
N
R
Site 60
S711
E
E
E
K
E
E
N
S
L
M
E
I
L
S
K
Site 61
S725
K
C
N
I
Q
V
H
S
P
R
E
S
V
S
S
Site 62
S729
Q
V
H
S
P
R
E
S
V
S
S
K
Q
T
V
Site 63
S732
S
P
R
E
S
V
S
S
K
Q
T
V
I
Q
E
Site 64
T735
E
S
V
S
S
K
Q
T
V
I
Q
E
L
L
P
Site 65
S748
L
P
G
K
P
P
K
S
R
V
L
L
K
P
A
Site 66
S768
V
L
I
E
E
L
Q
S
Q
G
K
S
K
S
P
Site 67
S772
E
L
Q
S
Q
G
K
S
K
S
P
R
R
D
A
Site 68
S774
Q
S
Q
G
K
S
K
S
P
R
R
D
A
D
D
Site 69
T793
Q
K
Q
G
Q
L
E
T
P
G
K
L
P
S
H
Site 70
S799
E
T
P
G
K
L
P
S
H
P
K
K
K
S
W
Site 71
S805
P
S
H
P
K
K
K
S
W
K
I
P
M
S
P
Site 72
S811
K
S
W
K
I
P
M
S
P
D
Q
F
L
L
T
Site 73
Y833
H
N
S
G
E
F
A
Y
P
C
R
P
Q
T
E
Site 74
T842
C
R
P
Q
T
E
I
T
D
V
W
G
P
S
I
Site 75
S850
D
V
W
G
P
S
I
S
Y
P
R
K
V
L
N
Site 76
Y851
V
W
G
P
S
I
S
Y
P
R
K
V
L
N
F
Site 77
S862
V
L
N
F
K
G
K
S
I
Q
R
A
V
D
R
Site 78
S873
A
V
D
R
L
R
L
S
N
P
P
I
D
V
K
Site 79
S883
P
I
D
V
K
R
T
S
I
P
L
E
I
Q
K
Site 80
S898
L
Q
P
N
L
K
I
S
L
H
S
P
R
V
Q
Site 81
S901
N
L
K
I
S
L
H
S
P
R
V
Q
S
T
I
Site 82
S906
L
H
S
P
R
V
Q
S
T
I
P
Q
P
M
I
Site 83
S916
P
Q
P
M
I
I
R
S
R
F
S
G
S
L
K
Site 84
S919
M
I
I
R
S
R
F
S
G
S
L
K
G
G
D
Site 85
S921
I
R
S
R
F
S
G
S
L
K
G
G
D
Q
V
Site 86
T929
L
K
G
G
D
Q
V
T
S
S
I
E
R
A
V
Site 87
S931
G
G
D
Q
V
T
S
S
I
E
R
A
V
C
S
Site 88
S944
C
S
T
G
P
L
T
S
M
Q
V
I
K
P
N
Site 89
T960
M
L
A
P
Q
V
G
T
A
T
L
S
L
K
K
Site 90
S964
Q
V
G
T
A
T
L
S
L
K
K
E
R
P
R
Site 91
Y973
K
K
E
R
P
R
I
Y
T
A
L
D
P
F
R
Site 92
T974
K
E
R
P
R
I
Y
T
A
L
D
P
F
R
V
Site 93
T989
N
T
E
F
V
L
L
T
V
K
E
E
K
E
H
Site 94
Y1004
Q
E
A
K
M
K
E
Y
Q
A
R
E
S
T
G
Site 95
S1009
K
E
Y
Q
A
R
E
S
T
G
V
V
D
P
G
Site 96
T1010
E
Y
Q
A
R
E
S
T
G
V
V
D
P
G
K
Site 97
T1036
G
L
P
I
D
N
F
T
K
Q
G
K
T
A
A
Site 98
T1041
N
F
T
K
Q
G
K
T
A
A
P
E
L
G
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation