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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANO1
Full Name:
Anoctamin-1
Alias:
Discovered on gastrointestinal stromal tumors protein 1; oral cancer overexpressed 2; ORAOV2; TAOS2; TM16A; TMEM16A; transmembrane protein 16A; transmembrane protein 16A (eight membrane-spanning domains); tumor amplified and over2
Type:
Membrane protein, integral
Mass (Da):
114078
Number AA:
986
UniProt ID:
Q5XXA6
International Prot ID:
IPI00384668
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0031404
GO:0005229
PhosphoSite+
KinaseNET
Biological Process:
GO:0006821
GO:0007424
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
R
V
N
E
K
Y
S
T
L
P
A
E
D
Site 2
T9
R
V
N
E
K
Y
S
T
L
P
A
E
D
R
S
Site 3
S33
E
D
I
G
Y
L
P
S
E
G
T
L
L
N
S
Site 4
S40
S
E
G
T
L
L
N
S
L
S
V
D
P
D
A
Site 5
S42
G
T
L
L
N
S
L
S
V
D
P
D
A
E
C
Site 6
Y51
D
P
D
A
E
C
K
Y
G
L
Y
F
R
D
G
Site 7
Y54
A
E
C
K
Y
G
L
Y
F
R
D
G
R
R
K
Site 8
Y64
D
G
R
R
K
V
D
Y
I
L
V
Y
H
H
K
Site 9
Y68
K
V
D
Y
I
L
V
Y
H
H
K
R
P
S
G
Site 10
S74
V
Y
H
H
K
R
P
S
G
N
R
T
L
V
R
Site 11
T78
K
R
P
S
G
N
R
T
L
V
R
R
V
Q
H
Site 12
S86
L
V
R
R
V
Q
H
S
D
T
P
S
G
A
R
Site 13
T88
R
R
V
Q
H
S
D
T
P
S
G
A
R
S
V
Site 14
S90
V
Q
H
S
D
T
P
S
G
A
R
S
V
K
Q
Site 15
S94
D
T
P
S
G
A
R
S
V
K
Q
D
H
P
L
Site 16
S107
P
L
P
G
K
G
A
S
L
D
A
G
S
G
E
Site 17
S112
G
A
S
L
D
A
G
S
G
E
P
P
M
D
Y
Site 18
Y119
S
G
E
P
P
M
D
Y
H
E
D
D
K
R
F
Site 19
Y131
K
R
F
R
R
E
E
Y
E
G
N
L
L
E
A
Site 20
T148
E
L
E
R
D
E
D
T
K
I
H
G
V
G
F
Site 21
Y182
K
M
P
T
K
K
M
Y
H
I
N
E
T
R
G
Site 22
T187
K
M
Y
H
I
N
E
T
R
G
L
L
K
K
I
Site 23
S196
G
L
L
K
K
I
N
S
V
L
Q
K
I
T
D
Site 24
T216
V
A
E
H
R
P
Q
T
M
K
R
L
S
Y
P
Site 25
S221
P
Q
T
M
K
R
L
S
Y
P
F
S
R
E
K
Site 26
Y222
Q
T
M
K
R
L
S
Y
P
F
S
R
E
K
Q
Site 27
S225
K
R
L
S
Y
P
F
S
R
E
K
Q
H
L
F
Site 28
S235
K
Q
H
L
F
D
L
S
D
K
D
S
F
F
D
Site 29
S239
F
D
L
S
D
K
D
S
F
F
D
S
K
T
R
Site 30
S243
D
K
D
S
F
F
D
S
K
T
R
S
T
I
V
Site 31
T245
D
S
F
F
D
S
K
T
R
S
T
I
V
Y
E
Site 32
T248
F
D
S
K
T
R
S
T
I
V
Y
E
I
L
K
Site 33
Y251
K
T
R
S
T
I
V
Y
E
I
L
K
R
T
T
Site 34
T258
Y
E
I
L
K
R
T
T
C
T
K
A
K
Y
S
Site 35
Y264
T
T
C
T
K
A
K
Y
S
M
G
I
T
S
L
Site 36
Y281
N
G
V
Y
A
A
A
Y
P
L
H
D
G
D
Y
Site 37
Y288
Y
P
L
H
D
G
D
Y
N
G
E
N
V
E
F
Site 38
Y302
F
N
D
R
K
L
L
Y
E
E
W
A
R
Y
G
Site 39
Y308
L
Y
E
E
W
A
R
Y
G
V
F
Y
K
Y
Q
Site 40
Y312
W
A
R
Y
G
V
F
Y
K
Y
Q
P
I
D
L
Site 41
Y314
R
Y
G
V
F
Y
K
Y
Q
P
I
D
L
V
R
Site 42
S401
A
C
A
T
A
R
A
S
H
L
F
D
N
P
A
Site 43
Y436
R
K
Q
M
R
L
N
Y
R
W
D
L
T
G
F
Site 44
T441
L
N
Y
R
W
D
L
T
G
F
E
E
E
E
E
Site 45
Y458
K
D
H
P
R
A
E
Y
E
A
R
V
L
E
K
Site 46
S466
E
A
R
V
L
E
K
S
L
K
K
E
S
R
N
Site 47
T494
K
W
K
Q
R
V
K
T
A
M
A
G
V
K
L
Site 48
T508
L
T
D
K
V
K
L
T
W
R
D
R
F
P
A
Site 49
Y516
W
R
D
R
F
P
A
Y
L
T
N
L
V
S
I
Site 50
S553
A
A
L
A
M
N
S
S
P
S
V
R
S
N
I
Site 51
S555
L
A
M
N
S
S
P
S
V
R
S
N
I
R
V
Site 52
S558
N
S
S
P
S
V
R
S
N
I
R
V
T
V
T
Site 53
T598
T
K
I
E
V
P
K
T
E
K
S
F
E
E
R
Site 54
S601
E
V
P
K
T
E
K
S
F
E
E
R
L
I
F
Site 55
Y624
N
S
Y
T
P
I
F
Y
V
A
F
F
K
G
R
Site 56
Y641
G
R
P
G
D
Y
V
Y
I
F
R
S
F
R
M
Site 57
Y692
K
M
K
K
L
I
R
Y
L
K
L
K
Q
Q
S
Site 58
S699
Y
L
K
L
K
Q
Q
S
P
P
D
H
E
E
C
Site 59
Y717
K
Q
R
Y
E
V
D
Y
N
L
E
P
F
A
G
Site 60
Y817
D
F
I
P
R
L
V
Y
L
Y
M
Y
S
K
N
Site 61
Y819
I
P
R
L
V
Y
L
Y
M
Y
S
K
N
G
T
Site 62
Y821
R
L
V
Y
L
Y
M
Y
S
K
N
G
T
M
H
Site 63
T834
M
H
G
F
V
N
H
T
L
S
S
F
N
V
S
Site 64
S837
F
V
N
H
T
L
S
S
F
N
V
S
D
F
Q
Site 65
S841
T
L
S
S
F
N
V
S
D
F
Q
N
G
T
A
Site 66
Y857
N
D
P
L
D
L
G
Y
E
V
Q
I
C
R
Y
Site 67
Y867
Q
I
C
R
Y
K
D
Y
R
E
P
P
W
S
E
Site 68
S873
D
Y
R
E
P
P
W
S
E
N
K
Y
D
I
S
Site 69
Y877
P
P
W
S
E
N
K
Y
D
I
S
K
D
F
W
Site 70
S920
P
D
I
P
K
D
I
S
Q
Q
I
H
K
E
K
Site 71
S971
N
T
K
A
C
P
D
S
L
G
S
P
A
P
S
Site 72
S974
A
C
P
D
S
L
G
S
P
A
P
S
H
A
Y
Site 73
S978
S
L
G
S
P
A
P
S
H
A
Y
H
G
G
V
Site 74
Y981
S
P
A
P
S
H
A
Y
H
G
G
V
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation