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Updated November 2019
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Protein Info
Short Name:
TSHZ3
Full Name:
Teashirt homolog 3
Alias:
TSH3; zinc finger protein 537; ZNF537
Type:
Transcription factor
Mass (Da):
118566
Number AA:
1081
UniProt ID:
Q63HK5
International Prot ID:
IPI00001743
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y15
A
P
R
R
A
A
A
Y
V
S
E
E
L
K
A
Site 2
Y45
D
G
E
P
S
A
K
Y
M
C
P
E
K
E
L
Site 3
S58
E
L
A
R
A
C
P
S
Y
Q
N
S
P
A
A
Site 4
Y59
L
A
R
A
C
P
S
Y
Q
N
S
P
A
A
E
Site 5
S62
A
C
P
S
Y
Q
N
S
P
A
A
E
F
S
C
Site 6
S68
N
S
P
A
A
E
F
S
C
H
E
M
D
S
E
Site 7
S74
F
S
C
H
E
M
D
S
E
S
H
I
S
E
T
Site 8
S76
C
H
E
M
D
S
E
S
H
I
S
E
T
S
D
Site 9
S79
M
D
S
E
S
H
I
S
E
T
S
D
R
M
A
Site 10
S82
E
S
H
I
S
E
T
S
D
R
M
A
D
F
E
Site 11
T109
V
T
V
P
L
E
D
T
T
V
S
D
S
L
E
Site 12
T110
T
V
P
L
E
D
T
T
V
S
D
S
L
E
Q
Site 13
S112
P
L
E
D
T
T
V
S
D
S
L
E
Q
M
K
Site 14
S114
E
D
T
T
V
S
D
S
L
E
Q
M
K
A
V
Site 15
Y122
L
E
Q
M
K
A
V
Y
N
N
F
L
S
N
S
Site 16
S143
L
N
L
H
Q
P
S
S
E
K
N
N
G
S
S
Site 17
S149
S
S
E
K
N
N
G
S
S
S
S
S
S
S
S
Site 18
S150
S
E
K
N
N
G
S
S
S
S
S
S
S
S
S
Site 19
S151
E
K
N
N
G
S
S
S
S
S
S
S
S
S
S
Site 20
S152
K
N
N
G
S
S
S
S
S
S
S
S
S
S
S
Site 21
S153
N
N
G
S
S
S
S
S
S
S
S
S
S
S
C
Site 22
S154
N
G
S
S
S
S
S
S
S
S
S
S
S
C
G
Site 23
S155
G
S
S
S
S
S
S
S
S
S
S
S
C
G
S
Site 24
S156
S
S
S
S
S
S
S
S
S
S
S
C
G
S
G
Site 25
S157
S
S
S
S
S
S
S
S
S
S
C
G
S
G
S
Site 26
S158
S
S
S
S
S
S
S
S
S
C
G
S
G
S
F
Site 27
S159
S
S
S
S
S
S
S
S
C
G
S
G
S
F
D
Site 28
S162
S
S
S
S
S
C
G
S
G
S
F
D
W
H
Q
Site 29
S164
S
S
S
C
G
S
G
S
F
D
W
H
Q
S
A
Site 30
T175
H
Q
S
A
M
A
K
T
L
Q
Q
V
S
Q
S
Site 31
S180
A
K
T
L
Q
Q
V
S
Q
S
R
M
L
P
E
Site 32
S189
S
R
M
L
P
E
P
S
L
F
S
T
V
Q
L
Site 33
T193
P
E
P
S
L
F
S
T
V
Q
L
Y
R
Q
S
Site 34
Y197
L
F
S
T
V
Q
L
Y
R
Q
S
S
K
L
Y
Site 35
S200
T
V
Q
L
Y
R
Q
S
S
K
L
Y
G
S
I
Site 36
S201
V
Q
L
Y
R
Q
S
S
K
L
Y
G
S
I
F
Site 37
Y204
Y
R
Q
S
S
K
L
Y
G
S
I
F
T
G
A
Site 38
S206
Q
S
S
K
L
Y
G
S
I
F
T
G
A
S
K
Site 39
T209
K
L
Y
G
S
I
F
T
G
A
S
K
F
R
C
Site 40
T230
Y
D
T
L
V
E
L
T
V
H
M
N
E
T
G
Site 41
Y239
H
M
N
E
T
G
H
Y
R
D
D
N
H
E
T
Site 42
S255
N
N
N
P
K
R
W
S
K
P
R
K
R
S
L
Site 43
S261
W
S
K
P
R
K
R
S
L
L
E
M
E
G
K
Site 44
Y279
Q
K
V
L
K
C
M
Y
C
G
H
S
F
E
S
Site 45
S286
Y
C
G
H
S
F
E
S
L
Q
D
L
S
V
H
Site 46
S291
F
E
S
L
Q
D
L
S
V
H
M
I
K
T
K
Site 47
S332
S
L
E
L
E
L
P
S
S
P
D
S
T
G
G
Site 48
S333
L
E
L
E
L
P
S
S
P
D
S
T
G
G
T
Site 49
S336
E
L
P
S
S
P
D
S
T
G
G
T
P
K
A
Site 50
T337
L
P
S
S
P
D
S
T
G
G
T
P
K
A
T
Site 51
T340
S
P
D
S
T
G
G
T
P
K
A
T
I
S
D
Site 52
S346
G
T
P
K
A
T
I
S
D
T
N
D
A
L
Q
Site 53
T348
P
K
A
T
I
S
D
T
N
D
A
L
Q
K
N
Site 54
Y359
L
Q
K
N
S
N
P
Y
I
T
P
N
N
R
Y
Site 55
T361
K
N
S
N
P
Y
I
T
P
N
N
R
Y
G
H
Site 56
Y374
G
H
Q
N
G
A
S
Y
A
W
H
F
E
A
R
Site 57
S393
L
K
C
M
E
C
G
S
S
H
D
T
L
Q
E
Site 58
S394
K
C
M
E
C
G
S
S
H
D
T
L
Q
E
L
Site 59
T397
E
C
G
S
S
H
D
T
L
Q
E
L
T
A
H
Site 60
S417
H
F
I
K
V
T
N
S
A
M
K
K
G
K
P
Site 61
T428
K
G
K
P
I
V
E
T
P
V
T
P
T
I
T
Site 62
T450
Q
S
V
P
L
A
A
T
T
F
T
S
P
S
N
Site 63
T451
S
V
P
L
A
A
T
T
F
T
S
P
S
N
T
Site 64
S454
L
A
A
T
T
F
T
S
P
S
N
T
P
A
S
Site 65
S456
A
T
T
F
T
S
P
S
N
T
P
A
S
I
S
Site 66
T458
T
F
T
S
P
S
N
T
P
A
S
I
S
P
K
Site 67
S461
S
P
S
N
T
P
A
S
I
S
P
K
L
N
V
Site 68
S463
S
N
T
P
A
S
I
S
P
K
L
N
V
E
V
Site 69
T481
V
D
K
E
K
A
V
T
D
E
K
P
K
Q
K
Site 70
Y504
K
C
D
I
S
S
K
Y
H
Y
L
T
E
N
D
Site 71
Y506
D
I
S
S
K
Y
H
Y
L
T
E
N
D
L
E
Site 72
T508
S
S
K
Y
H
Y
L
T
E
N
D
L
E
E
S
Site 73
S515
T
E
N
D
L
E
E
S
P
K
G
G
L
D
I
Site 74
S525
G
G
L
D
I
L
K
S
L
E
N
T
V
T
S
Site 75
T529
I
L
K
S
L
E
N
T
V
T
S
A
I
N
K
Site 76
T531
K
S
L
E
N
T
V
T
S
A
I
N
K
A
Q
Site 77
T541
I
N
K
A
Q
N
G
T
P
S
W
G
G
Y
P
Site 78
S543
K
A
Q
N
G
T
P
S
W
G
G
Y
P
S
I
Site 79
Y547
G
T
P
S
W
G
G
Y
P
S
I
H
A
A
Y
Site 80
S549
P
S
W
G
G
Y
P
S
I
H
A
A
Y
Q
L
Site 81
Y554
Y
P
S
I
H
A
A
Y
Q
L
P
N
M
M
K
Site 82
S563
L
P
N
M
M
K
L
S
L
G
S
S
G
K
S
Site 83
S566
M
M
K
L
S
L
G
S
S
G
K
S
T
P
L
Site 84
S567
M
K
L
S
L
G
S
S
G
K
S
T
P
L
K
Site 85
S570
S
L
G
S
S
G
K
S
T
P
L
K
P
M
F
Site 86
T571
L
G
S
S
G
K
S
T
P
L
K
P
M
F
G
Site 87
S580
L
K
P
M
F
G
N
S
E
I
V
S
P
T
K
Site 88
S584
F
G
N
S
E
I
V
S
P
T
K
N
Q
T
L
Site 89
T590
V
S
P
T
K
N
Q
T
L
V
S
P
P
S
S
Site 90
S593
T
K
N
Q
T
L
V
S
P
P
S
S
Q
T
S
Site 91
S596
Q
T
L
V
S
P
P
S
S
Q
T
S
P
M
P
Site 92
S597
T
L
V
S
P
P
S
S
Q
T
S
P
M
P
K
Site 93
T599
V
S
P
P
S
S
Q
T
S
P
M
P
K
T
N
Site 94
S600
S
P
P
S
S
Q
T
S
P
M
P
K
T
N
F
Site 95
T605
Q
T
S
P
M
P
K
T
N
F
H
A
M
E
E
Site 96
S636
K
E
P
D
G
K
L
S
P
P
K
R
A
T
P
Site 97
T642
L
S
P
P
K
R
A
T
P
S
P
C
S
S
E
Site 98
S644
P
P
K
R
A
T
P
S
P
C
S
S
E
V
G
Site 99
S647
R
A
T
P
S
P
C
S
S
E
V
G
E
P
I
Site 100
S648
A
T
P
S
P
C
S
S
E
V
G
E
P
I
K
Site 101
S660
P
I
K
M
E
A
S
S
D
G
G
F
R
S
Q
Site 102
S666
S
S
D
G
G
F
R
S
Q
E
N
S
P
S
P
Site 103
S670
G
F
R
S
Q
E
N
S
P
S
P
P
R
D
G
Site 104
S672
R
S
Q
E
N
S
P
S
P
P
R
D
G
C
K
Site 105
S682
R
D
G
C
K
D
G
S
P
L
A
E
P
V
E
Site 106
T710
S
G
S
T
A
I
I
T
D
H
P
P
E
Q
P
Site 107
T765
A
E
K
A
A
V
A
T
P
P
P
L
Q
S
K
Site 108
Y780
K
A
D
H
L
D
R
Y
F
Y
H
V
N
N
D
Site 109
Y782
D
H
L
D
R
Y
F
Y
H
V
N
N
D
Q
P
Site 110
T793
N
D
Q
P
I
D
L
T
K
G
K
S
D
K
G
Site 111
S797
I
D
L
T
K
G
K
S
D
K
G
C
S
L
G
Site 112
S802
G
K
S
D
K
G
C
S
L
G
S
V
L
L
S
Site 113
S809
S
L
G
S
V
L
L
S
P
T
S
T
A
P
A
Site 114
T817
P
T
S
T
A
P
A
T
S
S
S
T
V
T
T
Site 115
S818
T
S
T
A
P
A
T
S
S
S
T
V
T
T
A
Site 116
S819
S
T
A
P
A
T
S
S
S
T
V
T
T
A
K
Site 117
T823
A
T
S
S
S
T
V
T
T
A
K
T
S
A
V
Site 118
T824
T
S
S
S
T
V
T
T
A
K
T
S
A
V
V
Site 119
S835
S
A
V
V
S
F
M
S
N
S
P
L
R
E
N
Site 120
S837
V
V
S
F
M
S
N
S
P
L
R
E
N
A
L
Site 121
S845
P
L
R
E
N
A
L
S
D
I
S
D
M
L
K
Site 122
T855
S
D
M
L
K
N
L
T
E
S
H
T
S
K
S
Site 123
S857
M
L
K
N
L
T
E
S
H
T
S
K
S
S
T
Site 124
T859
K
N
L
T
E
S
H
T
S
K
S
S
T
P
S
Site 125
S860
N
L
T
E
S
H
T
S
K
S
S
T
P
S
S
Site 126
S862
T
E
S
H
T
S
K
S
S
T
P
S
S
I
S
Site 127
S863
E
S
H
T
S
K
S
S
T
P
S
S
I
S
E
Site 128
T864
S
H
T
S
K
S
S
T
P
S
S
I
S
E
K
Site 129
S866
T
S
K
S
S
T
P
S
S
I
S
E
K
S
D
Site 130
S867
S
K
S
S
T
P
S
S
I
S
E
K
S
D
I
Site 131
S869
S
S
T
P
S
S
I
S
E
K
S
D
I
D
G
Site 132
S872
P
S
S
I
S
E
K
S
D
I
D
G
A
T
L
Site 133
T878
K
S
D
I
D
G
A
T
L
E
E
A
E
E
S
Site 134
S885
T
L
E
E
A
E
E
S
T
P
A
Q
K
R
K
Site 135
T886
L
E
E
A
E
E
S
T
P
A
Q
K
R
K
G
Site 136
S896
Q
K
R
K
G
R
Q
S
N
W
N
P
Q
H
L
Site 137
S913
L
Q
A
Q
F
A
A
S
L
R
Q
T
S
E
G
Site 138
T917
F
A
A
S
L
R
Q
T
S
E
G
K
Y
I
M
Site 139
S918
A
A
S
L
R
Q
T
S
E
G
K
Y
I
M
S
Site 140
Y922
R
Q
T
S
E
G
K
Y
I
M
S
D
L
S
P
Site 141
S925
S
E
G
K
Y
I
M
S
D
L
S
P
Q
E
R
Site 142
S928
K
Y
I
M
S
D
L
S
P
Q
E
R
M
H
I
Site 143
T939
R
M
H
I
S
R
F
T
G
L
S
M
T
T
I
Site 144
Y955
H
W
L
A
N
V
K
Y
Q
L
R
R
T
G
G
Site 145
T960
V
K
Y
Q
L
R
R
T
G
G
T
K
F
L
K
Site 146
T971
K
F
L
K
N
L
D
T
G
H
P
V
F
F
C
Site 147
T987
D
C
A
S
Q
I
R
T
P
S
T
Y
I
S
H
Site 148
S989
A
S
Q
I
R
T
P
S
T
Y
I
S
H
L
E
Site 149
T990
S
Q
I
R
T
P
S
T
Y
I
S
H
L
E
S
Site 150
Y991
Q
I
R
T
P
S
T
Y
I
S
H
L
E
S
H
Site 151
S993
R
T
P
S
T
Y
I
S
H
L
E
S
H
L
G
Site 152
S997
T
Y
I
S
H
L
E
S
H
L
G
F
R
L
R
Site 153
S1007
G
F
R
L
R
D
L
S
K
L
S
T
E
Q
I
Site 154
S1010
L
R
D
L
S
K
L
S
T
E
Q
I
N
S
Q
Site 155
T1011
R
D
L
S
K
L
S
T
E
Q
I
N
S
Q
I
Site 156
S1016
L
S
T
E
Q
I
N
S
Q
I
A
Q
T
K
S
Site 157
T1021
I
N
S
Q
I
A
Q
T
K
S
P
S
E
K
M
Site 158
S1023
S
Q
I
A
Q
T
K
S
P
S
E
K
M
V
T
Site 159
S1025
I
A
Q
T
K
S
P
S
E
K
M
V
T
S
S
Site 160
T1030
S
P
S
E
K
M
V
T
S
S
P
E
E
D
L
Site 161
S1032
S
E
K
M
V
T
S
S
P
E
E
D
L
G
T
Site 162
T1039
S
P
E
E
D
L
G
T
S
Y
Q
C
K
L
C
Site 163
Y1041
E
E
D
L
G
T
S
Y
Q
C
K
L
C
N
R
Site 164
S1061
H
A
V
K
L
H
L
S
K
T
H
G
K
S
P
Site 165
T1063
V
K
L
H
L
S
K
T
H
G
K
S
P
E
D
Site 166
S1067
L
S
K
T
H
G
K
S
P
E
D
H
L
L
Y
Site 167
Y1074
S
P
E
D
H
L
L
Y
V
S
E
L
E
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation