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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TENC1
Full Name:
Tensin-like C1 domain-containing phosphatase
Alias:
C1-TEN; EC 3.1.3.-; KIAA1075; Tensin 2; Tensin like C1 domain containing phosphatase; Tensin-2; TNS2
Type:
Cell cycle regulation; Phosphatase; EC 3.1.3.-; Adhesion
Mass (Da):
152580
Number AA:
1409
UniProt ID:
Q63HR2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0004721
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0008285
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
R
A
L
G
R
R
D
S
S
R
A
A
S
R
P
Site 2
S20
A
L
G
R
R
D
S
S
R
A
A
S
R
P
R
Site 3
S24
R
D
S
S
R
A
A
S
R
P
R
K
A
E
P
Site 4
S33
P
R
K
A
E
P
H
S
F
R
E
K
V
F
R
Site 5
T76
R
K
C
E
A
K
V
T
S
A
C
Q
A
L
P
Site 6
T91
P
V
E
L
R
R
N
T
A
P
V
R
R
I
E
Site 7
S102
R
R
I
E
H
L
G
S
T
K
S
L
N
H
S
Site 8
S105
E
H
L
G
S
T
K
S
L
N
H
S
K
Q
R
Site 9
S109
S
T
K
S
L
N
H
S
K
Q
R
S
T
L
P
Site 10
S113
L
N
H
S
K
Q
R
S
T
L
P
R
S
F
S
Site 11
T114
N
H
S
K
Q
R
S
T
L
P
R
S
F
S
L
Site 12
S118
Q
R
S
T
L
P
R
S
F
S
L
D
P
L
M
Site 13
S120
S
T
L
P
R
S
F
S
L
D
P
L
M
E
R
Site 14
T134
R
R
W
D
L
D
L
T
Y
V
T
E
R
I
L
Site 15
Y135
R
W
D
L
D
L
T
Y
V
T
E
R
I
L
A
Site 16
Y173
Q
S
K
H
R
D
K
Y
L
L
F
N
L
S
E
Site 17
S179
K
Y
L
L
F
N
L
S
E
K
R
H
D
L
T
Site 18
T186
S
E
K
R
H
D
L
T
R
L
N
P
K
V
Q
Site 19
S210
P
P
L
D
K
L
C
S
I
C
K
A
M
E
T
Site 20
S220
K
A
M
E
T
W
L
S
A
D
P
Q
H
V
V
Site 21
Y230
P
Q
H
V
V
V
L
Y
C
K
G
N
K
G
K
Site 22
Y245
L
G
V
I
V
S
A
Y
M
H
Y
S
K
I
S
Site 23
Y248
I
V
S
A
Y
M
H
Y
S
K
I
S
A
G
A
Site 24
S249
V
S
A
Y
M
H
Y
S
K
I
S
A
G
A
D
Site 25
T263
D
Q
A
L
A
T
L
T
M
R
K
F
C
E
D
Site 26
S279
V
A
T
E
L
Q
P
S
Q
R
R
Y
I
S
Y
Site 27
Y283
L
Q
P
S
Q
R
R
Y
I
S
Y
F
S
G
L
Site 28
S285
P
S
Q
R
R
Y
I
S
Y
F
S
G
L
L
S
Site 29
Y286
S
Q
R
R
Y
I
S
Y
F
S
G
L
L
S
G
Site 30
S292
S
Y
F
S
G
L
L
S
G
S
I
R
M
N
S
Site 31
S294
F
S
G
L
L
S
G
S
I
R
M
N
S
S
P
Site 32
S299
S
G
S
I
R
M
N
S
S
P
L
F
L
H
Y
Site 33
Y335
Y
Q
S
M
Q
L
V
Y
T
S
G
V
Y
H
I
Site 34
Y369
G
D
V
M
V
T
C
Y
H
K
G
G
R
G
T
Site 35
T376
Y
H
K
G
G
R
G
T
D
R
T
L
V
F
R
Site 36
T379
G
G
R
G
T
D
R
T
L
V
F
R
V
Q
F
Site 37
T397
T
I
H
G
P
Q
L
T
F
P
K
D
Q
L
D
Site 38
T408
D
Q
L
D
E
A
W
T
D
E
R
F
P
F
Q
Site 39
S417
E
R
F
P
F
Q
A
S
V
E
F
V
F
S
S
Site 40
S423
A
S
V
E
F
V
F
S
S
S
P
E
K
I
K
Site 41
S425
V
E
F
V
F
S
S
S
P
E
K
I
K
G
S
Site 42
S432
S
P
E
K
I
K
G
S
T
P
R
N
D
P
S
Site 43
T433
P
E
K
I
K
G
S
T
P
R
N
D
P
S
V
Site 44
S439
S
T
P
R
N
D
P
S
V
S
V
D
Y
N
T
Site 45
S441
P
R
N
D
P
S
V
S
V
D
Y
N
T
T
E
Site 46
Y444
D
P
S
V
S
V
D
Y
N
T
T
E
P
A
V
Site 47
T446
S
V
S
V
D
Y
N
T
T
E
P
A
V
R
W
Site 48
S455
E
P
A
V
R
W
D
S
Y
E
N
F
N
Q
H
Site 49
Y456
P
A
V
R
W
D
S
Y
E
N
F
N
Q
H
H
Site 50
S466
F
N
Q
H
H
E
D
S
V
D
G
S
L
T
H
Site 51
S470
H
E
D
S
V
D
G
S
L
T
H
T
R
G
P
Site 52
T472
D
S
V
D
G
S
L
T
H
T
R
G
P
L
D
Site 53
T474
V
D
G
S
L
T
H
T
R
G
P
L
D
G
S
Site 54
S481
T
R
G
P
L
D
G
S
P
Y
A
Q
V
Q
R
Site 55
Y483
G
P
L
D
G
S
P
Y
A
Q
V
Q
R
P
P
Site 56
T493
V
Q
R
P
P
R
Q
T
P
P
A
P
S
P
E
Site 57
S498
R
Q
T
P
P
A
P
S
P
E
P
P
P
P
P
Site 58
S508
P
P
P
P
P
M
L
S
V
S
S
D
S
G
H
Site 59
S510
P
P
P
M
L
S
V
S
S
D
S
G
H
S
S
Site 60
S511
P
P
M
L
S
V
S
S
D
S
G
H
S
S
T
Site 61
S513
M
L
S
V
S
S
D
S
G
H
S
S
T
L
T
Site 62
S517
S
S
D
S
G
H
S
S
T
L
T
T
E
P
A
Site 63
T518
S
D
S
G
H
S
S
T
L
T
T
E
P
A
A
Site 64
T520
S
G
H
S
S
T
L
T
T
E
P
A
A
E
S
Site 65
T521
G
H
S
S
T
L
T
T
E
P
A
A
E
S
P
Site 66
S527
T
T
E
P
A
A
E
S
P
G
R
P
P
P
T
Site 67
T534
S
P
G
R
P
P
P
T
A
A
E
R
Q
E
L
Site 68
T561
G
R
G
A
G
R
E
T
A
I
L
D
D
E
E
Site 69
T571
L
D
D
E
E
Q
P
T
V
G
G
G
P
H
L
Site 70
Y581
G
G
P
H
L
G
V
Y
P
G
H
R
P
G
L
Site 71
S589
P
G
H
R
P
G
L
S
R
H
C
S
C
R
Q
Site 72
S593
P
G
L
S
R
H
C
S
C
R
Q
G
Y
R
E
Site 73
Y598
H
C
S
C
R
Q
G
Y
R
E
P
C
G
V
P
Site 74
Y609
C
G
V
P
N
G
G
Y
Y
R
P
E
G
T
L
Site 75
Y610
G
V
P
N
G
G
Y
Y
R
P
E
G
T
L
E
Site 76
Y623
L
E
R
R
R
L
A
Y
G
G
Y
E
G
S
P
Site 77
Y626
R
R
L
A
Y
G
G
Y
E
G
S
P
Q
G
Y
Site 78
S629
A
Y
G
G
Y
E
G
S
P
Q
G
Y
A
E
A
Site 79
Y633
Y
E
G
S
P
Q
G
Y
A
E
A
S
M
E
K
Site 80
S637
P
Q
G
Y
A
E
A
S
M
E
K
R
R
L
C
Site 81
S646
E
K
R
R
L
C
R
S
L
S
E
G
L
Y
P
Site 82
S648
R
R
L
C
R
S
L
S
E
G
L
Y
P
Y
P
Site 83
Y652
R
S
L
S
E
G
L
Y
P
Y
P
P
E
M
G
Site 84
Y654
L
S
E
G
L
Y
P
Y
P
P
E
M
G
K
P
Site 85
Y668
P
A
T
G
D
F
G
Y
R
A
P
G
Y
R
E
Site 86
Y673
F
G
Y
R
A
P
G
Y
R
E
V
V
I
L
E
Site 87
Y688
D
P
G
L
P
A
L
Y
P
C
P
A
C
E
E
Site 88
Y705
A
L
P
T
A
A
L
Y
G
L
R
L
E
R
E
Site 89
S719
E
A
G
E
G
W
A
S
E
A
G
K
P
L
L
Site 90
Y752
H
H
A
P
M
P
D
Y
S
C
L
K
P
P
K
Site 91
S753
H
A
P
M
P
D
Y
S
C
L
K
P
P
K
A
Site 92
Y770
E
G
H
E
G
C
S
Y
T
M
C
P
E
G
R
Site 93
Y778
T
M
C
P
E
G
R
Y
G
H
P
G
Y
P
A
Site 94
Y783
G
R
Y
G
H
P
G
Y
P
A
L
V
T
Y
S
Site 95
Y789
G
Y
P
A
L
V
T
Y
S
Y
G
G
A
V
P
Site 96
S797
S
Y
G
G
A
V
P
S
Y
C
P
A
Y
G
R
Site 97
Y798
Y
G
G
A
V
P
S
Y
C
P
A
Y
G
R
V
Site 98
Y802
V
P
S
Y
C
P
A
Y
G
R
V
P
H
S
C
Site 99
S808
A
Y
G
R
V
P
H
S
C
G
S
P
G
E
G
Site 100
S811
R
V
P
H
S
C
G
S
P
G
E
G
R
G
Y
Site 101
Y818
S
P
G
E
G
R
G
Y
P
S
P
G
A
H
S
Site 102
S820
G
E
G
R
G
Y
P
S
P
G
A
H
S
P
R
Site 103
S825
Y
P
S
P
G
A
H
S
P
R
A
G
S
I
S
Site 104
S830
A
H
S
P
R
A
G
S
I
S
P
G
S
P
P
Site 105
S832
S
P
R
A
G
S
I
S
P
G
S
P
P
Y
P
Site 106
S835
A
G
S
I
S
P
G
S
P
P
Y
P
Q
S
R
Site 107
Y838
I
S
P
G
S
P
P
Y
P
Q
S
R
K
L
S
Site 108
S841
G
S
P
P
Y
P
Q
S
R
K
L
S
Y
E
I
Site 109
S845
Y
P
Q
S
R
K
L
S
Y
E
I
P
T
E
E
Site 110
Y846
P
Q
S
R
K
L
S
Y
E
I
P
T
E
E
G
Site 111
Y857
T
E
E
G
G
D
R
Y
P
L
P
G
H
L
A
Site 112
S874
G
P
L
A
S
A
E
S
L
E
P
V
S
W
R
Site 113
S879
A
E
S
L
E
P
V
S
W
R
E
G
P
S
G
Site 114
S885
V
S
W
R
E
G
P
S
G
H
S
T
L
P
R
Site 115
S888
R
E
G
P
S
G
H
S
T
L
P
R
S
P
R
Site 116
T889
E
G
P
S
G
H
S
T
L
P
R
S
P
R
D
Site 117
S893
G
H
S
T
L
P
R
S
P
R
D
A
P
C
S
Site 118
S900
S
P
R
D
A
P
C
S
A
S
S
E
L
S
G
Site 119
S902
R
D
A
P
C
S
A
S
S
E
L
S
G
P
S
Site 120
S903
D
A
P
C
S
A
S
S
E
L
S
G
P
S
T
Site 121
S906
C
S
A
S
S
E
L
S
G
P
S
T
P
L
H
Site 122
S909
S
S
E
L
S
G
P
S
T
P
L
H
T
S
S
Site 123
T910
S
E
L
S
G
P
S
T
P
L
H
T
S
S
P
Site 124
T914
G
P
S
T
P
L
H
T
S
S
P
V
Q
G
K
Site 125
S915
P
S
T
P
L
H
T
S
S
P
V
Q
G
K
E
Site 126
S916
S
T
P
L
H
T
S
S
P
V
Q
G
K
E
S
Site 127
S923
S
P
V
Q
G
K
E
S
T
R
R
Q
D
T
R
Site 128
T929
E
S
T
R
R
Q
D
T
R
S
P
T
S
A
P
Site 129
S931
T
R
R
Q
D
T
R
S
P
T
S
A
P
T
Q
Site 130
T933
R
Q
D
T
R
S
P
T
S
A
P
T
Q
R
L
Site 131
S934
Q
D
T
R
S
P
T
S
A
P
T
Q
R
L
S
Site 132
T937
R
S
P
T
S
A
P
T
Q
R
L
S
P
G
E
Site 133
S941
S
A
P
T
Q
R
L
S
P
G
E
A
L
P
P
Site 134
S950
G
E
A
L
P
P
V
S
Q
A
G
T
G
K
A
Site 135
S962
G
K
A
P
E
L
P
S
G
S
G
P
E
P
L
Site 136
S964
A
P
E
L
P
S
G
S
G
P
E
P
L
A
P
Site 137
S972
G
P
E
P
L
A
P
S
P
V
S
P
T
F
P
Site 138
S975
P
L
A
P
S
P
V
S
P
T
F
P
P
S
S
Site 139
T977
A
P
S
P
V
S
P
T
F
P
P
S
S
P
S
Site 140
S981
V
S
P
T
F
P
P
S
S
P
S
D
W
P
Q
Site 141
S982
S
P
T
F
P
P
S
S
P
S
D
W
P
Q
E
Site 142
S984
T
F
P
P
S
S
P
S
D
W
P
Q
E
R
S
Site 143
S991
S
D
W
P
Q
E
R
S
P
G
G
H
S
D
G
Site 144
S996
E
R
S
P
G
G
H
S
D
G
A
S
P
R
S
Site 145
S1000
G
G
H
S
D
G
A
S
P
R
S
P
V
P
T
Site 146
S1003
S
D
G
A
S
P
R
S
P
V
P
T
T
L
P
Site 147
T1007
S
P
R
S
P
V
P
T
T
L
P
G
L
R
H
Site 148
T1008
P
R
S
P
V
P
T
T
L
P
G
L
R
H
A
Site 149
S1026
G
P
R
G
P
P
D
S
P
D
G
S
P
L
T
Site 150
S1030
P
P
D
S
P
D
G
S
P
L
T
P
V
P
S
Site 151
T1033
S
P
D
G
S
P
L
T
P
V
P
S
Q
M
P
Site 152
S1045
Q
M
P
W
L
V
A
S
P
E
P
P
Q
S
S
Site 153
S1051
A
S
P
E
P
P
Q
S
S
P
T
P
A
F
P
Site 154
S1052
S
P
E
P
P
Q
S
S
P
T
P
A
F
P
L
Site 155
T1054
E
P
P
Q
S
S
P
T
P
A
F
P
L
A
A
Site 156
Y1063
A
F
P
L
A
A
S
Y
D
T
N
G
L
S
Q
Site 157
S1069
S
Y
D
T
N
G
L
S
Q
P
P
L
P
E
K
Site 158
S1095
P
W
G
P
E
Q
A
S
S
P
A
R
G
I
S
Site 159
S1096
W
G
P
E
Q
A
S
S
P
A
R
G
I
S
H
Site 160
S1102
S
S
P
A
R
G
I
S
H
H
V
T
F
A
P
Site 161
T1118
L
S
D
N
V
P
Q
T
P
E
P
P
T
Q
E
Site 162
T1123
P
Q
T
P
E
P
P
T
Q
E
S
Q
S
N
V
Site 163
S1126
P
E
P
P
T
Q
E
S
Q
S
N
V
K
F
V
Site 164
S1128
P
P
T
Q
E
S
Q
S
N
V
K
F
V
Q
D
Site 165
Y1141
Q
D
T
S
K
F
W
Y
K
P
H
L
S
R
D
Site 166
S1167
G
A
F
L
I
R
D
S
H
S
F
Q
G
A
Y
Site 167
S1169
F
L
I
R
D
S
H
S
F
Q
G
A
Y
G
L
Site 168
S1186
K
V
A
T
P
P
P
S
A
Q
P
W
K
G
D
Site 169
S1218
V
K
I
K
G
C
P
S
E
P
Y
F
G
S
L
Site 170
Y1221
K
G
C
P
S
E
P
Y
F
G
S
L
S
A
L
Site 171
S1224
P
S
E
P
Y
F
G
S
L
S
A
L
V
S
Q
Site 172
S1226
E
P
Y
F
G
S
L
S
A
L
V
S
Q
H
S
Site 173
S1247
P
C
C
L
R
I
P
S
K
D
P
L
E
E
T
Site 174
T1254
S
K
D
P
L
E
E
T
P
E
A
P
V
P
T
Site 175
S1288
L
T
S
V
E
T
E
S
L
T
G
P
Q
A
V
Site 176
S1304
R
A
S
S
A
A
L
S
C
S
P
R
P
T
P
Site 177
S1306
S
S
A
A
L
S
C
S
P
R
P
T
P
A
V
Site 178
T1310
L
S
C
S
P
R
P
T
P
A
V
V
H
F
K
Site 179
T1326
S
A
Q
G
I
T
L
T
D
N
Q
R
K
L
F
Site 180
Y1338
K
L
F
F
R
R
H
Y
P
V
N
S
I
T
F
Site 181
S1342
R
R
H
Y
P
V
N
S
I
T
F
S
S
T
D
Site 182
T1344
H
Y
P
V
N
S
I
T
F
S
S
T
D
P
Q
Site 183
S1346
P
V
N
S
I
T
F
S
S
T
D
P
Q
D
R
Site 184
T1356
D
P
Q
D
R
R
W
T
N
P
D
G
T
T
S
Site 185
T1361
R
W
T
N
P
D
G
T
T
S
K
I
F
G
F
Site 186
S1375
F
V
A
K
K
P
G
S
P
W
E
N
V
C
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation