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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPZ
Full Name:
Carboxypeptidase Z
Alias:
Type:
Mass (Da):
73655
Number AA:
652
UniProt ID:
Q66K79
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T42
P
P
A
A
D
S
A
T
C
V
D
L
Q
L
R
Site 2
S52
D
L
Q
L
R
T
C
S
D
A
A
Y
N
H
T
Site 3
Y56
R
T
C
S
D
A
A
Y
N
H
T
T
F
P
N
Site 4
T59
S
D
A
A
Y
N
H
T
T
F
P
N
L
L
Q
Site 5
S69
P
N
L
L
Q
H
R
S
W
E
V
V
E
A
S
Site 6
Y149
Y
F
L
D
C
H
R
Y
F
T
R
E
D
E
G
Site 7
S176
E
A
D
E
A
L
P
S
G
L
P
P
T
F
I
Site 8
T181
L
P
S
G
L
P
P
T
F
I
R
F
S
H
H
Site 9
Y190
I
R
F
S
H
H
S
Y
A
Q
M
V
R
V
L
Site 10
S202
R
V
L
R
R
T
A
S
R
C
A
H
V
A
R
Site 11
Y211
C
A
H
V
A
R
T
Y
S
I
G
R
S
F
D
Site 12
S212
A
H
V
A
R
T
Y
S
I
G
R
S
F
D
G
Site 13
S216
R
T
Y
S
I
G
R
S
F
D
G
R
E
L
L
Site 14
S228
E
L
L
V
I
E
F
S
S
R
P
G
Q
H
E
Site 15
Y269
A
Q
Y
L
C
S
E
Y
L
L
G
N
P
R
I
Site 16
T282
R
I
Q
R
L
L
N
T
T
R
I
H
L
L
P
Site 17
T283
I
Q
R
L
L
N
T
T
R
I
H
L
L
P
S
Site 18
Y296
P
S
M
N
P
D
G
Y
E
V
A
A
A
E
G
Site 19
Y306
A
A
A
E
G
A
G
Y
N
G
W
T
S
G
R
Site 20
T329
N
R
N
F
P
D
L
T
S
E
Y
Y
R
L
A
Site 21
S330
R
N
F
P
D
L
T
S
E
Y
Y
R
L
A
E
Site 22
Y332
F
P
D
L
T
S
E
Y
Y
R
L
A
E
T
R
Site 23
S387
H
G
G
D
L
V
V
S
Y
P
F
D
F
S
K
Site 24
Y388
G
G
D
L
V
V
S
Y
P
F
D
F
S
K
H
Site 25
S393
V
S
Y
P
F
D
F
S
K
H
P
Q
E
E
K
Site 26
S403
P
Q
E
E
K
M
F
S
P
T
P
D
E
K
M
Site 27
T405
E
E
K
M
F
S
P
T
P
D
E
K
M
F
K
Site 28
S415
E
K
M
F
K
L
L
S
R
A
Y
A
D
V
H
Site 29
S442
G
N
F
L
K
R
G
S
I
I
N
G
A
D
W
Site 30
Y461
G
G
M
S
D
F
N
Y
L
H
T
N
C
F
E
Site 31
Y485
F
P
P
E
E
A
L
Y
T
L
W
Q
H
N
K
Site 32
T486
P
P
E
E
A
L
Y
T
L
W
Q
H
N
K
E
Site 33
T511
R
G
I
K
G
V
V
T
D
K
F
G
K
P
V
Site 34
S524
P
V
K
N
A
R
I
S
V
K
G
I
R
H
D
Site 35
T533
K
G
I
R
H
D
I
T
T
A
P
D
G
D
Y
Site 36
T534
G
I
R
H
D
I
T
T
A
P
D
G
D
Y
W
Site 37
Y540
T
T
A
P
D
G
D
Y
W
R
L
L
P
P
G
Site 38
T598
F
I
H
G
L
R
R
T
G
P
H
D
P
L
G
Site 39
S609
D
P
L
G
G
A
S
S
L
G
E
A
T
E
P
Site 40
S626
L
R
A
R
R
Q
P
S
A
D
G
S
K
P
W
Site 41
T643
S
Y
F
T
S
L
S
T
H
R
P
R
W
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation