KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
E4F1
Full Name:
Transcription factor E4F1
Alias:
E4F; E4F transcription factor 1; P120E4F; Putative E3 ubiquitin-protein ligase E4F1
Type:
Ligase; EC 6.3.2.-; Transcription factor
Mass (Da):
83477
Number AA:
784
UniProt ID:
Q66K89
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0003713
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0008283
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S50
L
G
L
P
A
P
F
S
E
E
D
E
D
D
V
Site 2
S135
A
A
D
I
S
H
A
S
D
L
V
G
G
G
H
Site 3
S165
E
M
A
E
A
P
G
S
P
H
Q
Q
G
L
G
Site 4
Y192
L
V
N
K
D
G
R
Y
V
C
A
L
C
H
K
Site 5
S216
A
H
M
V
T
H
S
S
R
K
D
H
E
C
K
Site 6
S228
E
C
K
L
C
G
A
S
F
R
T
K
G
S
L
Site 7
S234
A
S
F
R
T
K
G
S
L
I
R
H
H
R
R
Site 8
T243
I
R
H
H
R
R
H
T
D
E
R
P
Y
K
C
Site 9
Y248
R
H
T
D
E
R
P
Y
K
C
S
K
C
G
K
Site 10
S251
D
E
R
P
Y
K
C
S
K
C
G
K
S
F
R
Site 11
S256
K
C
S
K
C
G
K
S
F
R
E
S
G
A
L
Site 12
S260
C
G
K
S
F
R
E
S
G
A
L
T
R
H
L
Site 13
T264
F
R
E
S
G
A
L
T
R
H
L
K
S
L
T
Site 14
S269
A
L
T
R
H
L
K
S
L
T
P
C
T
E
K
Site 15
T271
T
R
H
L
K
S
L
T
P
C
T
E
K
I
R
Site 16
T274
L
K
S
L
T
P
C
T
E
K
I
R
F
S
V
Site 17
S282
E
K
I
R
F
S
V
S
K
D
V
V
V
S
K
Site 18
S296
K
E
D
A
R
A
G
S
G
A
G
A
A
G
L
Site 19
S309
G
L
G
T
A
T
S
S
V
T
G
E
P
I
E
Site 20
T317
V
T
G
E
P
I
E
T
S
P
V
I
H
L
V
Site 21
S356
L
A
P
E
P
P
V
S
Q
E
L
P
C
S
S
Site 22
S362
V
S
Q
E
L
P
C
S
S
E
G
S
R
E
N
Site 23
S366
L
P
C
S
S
E
G
S
R
E
N
L
L
H
Q
Site 24
S401
P
A
P
A
A
G
S
S
P
Q
P
L
A
V
A
Site 25
S426
P
L
E
T
Q
V
A
S
E
A
S
A
V
P
R
Site 26
T434
E
A
S
A
V
P
R
T
H
P
C
P
Q
C
S
Site 27
T443
P
C
P
Q
C
S
E
T
F
P
T
A
A
T
L
Site 28
T446
Q
C
S
E
T
F
P
T
A
A
T
L
E
A
H
Site 29
T458
E
A
H
K
R
G
H
T
G
P
R
P
F
A
C
Site 30
Y500
C
G
D
C
G
K
L
Y
K
T
I
A
H
V
R
Site 31
S514
R
G
H
R
R
V
H
S
D
E
R
P
Y
P
C
Site 32
Y519
V
H
S
D
E
R
P
Y
P
C
P
K
C
G
K
Site 33
T530
K
C
G
K
R
Y
K
T
K
N
A
Q
Q
V
H
Site 34
S561
R
G
F
R
E
K
G
S
L
V
R
H
V
R
H
Site 35
T570
V
R
H
V
R
H
H
T
G
E
K
P
F
K
C
Site 36
Y578
G
E
K
P
F
K
C
Y
K
C
G
R
G
F
A
Site 37
T589
R
G
F
A
E
H
G
T
L
N
R
H
L
R
T
Site 38
S610
E
V
E
E
L
L
V
S
E
D
S
P
A
A
A
Site 39
T665
E
I
I
E
G
T
Q
T
E
V
D
S
H
I
M
Site 40
T715
A
D
T
I
T
I
A
T
P
E
S
L
T
E
Q
Site 41
T743
V
L
A
A
R
A
G
T
S
G
T
E
Q
A
T
Site 42
T750
T
S
G
T
E
Q
A
T
V
T
M
V
S
S
E
Site 43
T752
G
T
E
Q
A
T
V
T
M
V
S
S
E
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation