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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rap1GAP2
Full Name:
Rap1 GTPase-activating protein 2
Alias:
GARNL4; GTPase-activating Rap/Ran-GAP domain-like protein 4; KIAA1039; RAP1 GTPase activating protein 2; RAP1GA2; RPGP2
Type:
GTPase-activating protein for G protein
Mass (Da):
80056
Number AA:
730
UniProt ID:
Q684P5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
F
G
R
K
R
S
V
S
F
G
G
F
G
Site 2
S9
F
G
R
K
R
S
V
S
F
G
G
F
G
W
I
Site 3
S34
K
K
Q
E
L
A
N
S
S
D
A
T
L
P
D
Site 4
T38
L
A
N
S
S
D
A
T
L
P
D
R
P
L
S
Site 5
S45
T
L
P
D
R
P
L
S
P
P
L
T
A
P
P
Site 6
T49
R
P
L
S
P
P
L
T
A
P
P
T
M
K
S
Site 7
T53
P
P
L
T
A
P
P
T
M
K
S
S
E
F
F
Site 8
S56
T
A
P
P
T
M
K
S
S
E
F
F
E
M
L
Site 9
S57
A
P
P
T
M
K
S
S
E
F
F
E
M
L
E
Site 10
Y85
P
Q
K
N
K
D
D
Y
I
P
Y
P
S
I
D
Site 11
Y88
N
K
D
D
Y
I
P
Y
P
S
I
D
E
V
V
Site 12
S90
D
D
Y
I
P
Y
P
S
I
D
E
V
V
E
K
Site 13
Y101
V
V
E
K
G
G
P
Y
P
Q
V
I
L
P
Q
Site 14
T122
E
D
P
E
N
V
G
T
P
T
S
L
G
S
S
Site 15
T124
P
E
N
V
G
T
P
T
S
L
G
S
S
I
C
Site 16
S125
E
N
V
G
T
P
T
S
L
G
S
S
I
C
E
Site 17
S129
T
P
T
S
L
G
S
S
I
C
E
E
E
E
E
Site 18
S140
E
E
E
E
D
N
L
S
P
N
T
F
G
Y
K
Site 19
T143
E
D
N
L
S
P
N
T
F
G
Y
K
L
E
C
Site 20
Y157
C
K
G
E
A
R
A
Y
R
R
H
F
L
G
K
Site 21
Y170
G
K
D
H
L
N
F
Y
C
T
G
S
S
L
G
Site 22
T172
D
H
L
N
F
Y
C
T
G
S
S
L
G
N
L
Site 23
Y193
E
E
A
E
G
I
E
Y
L
R
V
I
L
R
S
Site 24
S200
Y
L
R
V
I
L
R
S
K
L
K
T
V
H
E
Site 25
T204
I
L
R
S
K
L
K
T
V
H
E
R
I
P
L
Site 26
S245
P
V
L
Y
P
K
A
S
Q
M
I
V
S
Y
D
Site 27
S250
K
A
S
Q
M
I
V
S
Y
D
E
H
E
V
N
Site 28
Y251
A
S
Q
M
I
V
S
Y
D
E
H
E
V
N
N
Site 29
T259
D
E
H
E
V
N
N
T
F
K
F
G
V
I
Y
Site 30
Y266
T
F
K
F
G
V
I
Y
Q
K
A
R
Q
T
L
Site 31
T272
I
Y
Q
K
A
R
Q
T
L
E
E
E
L
F
G
Site 32
S284
L
F
G
N
N
E
E
S
P
A
F
K
E
F
L
Site 33
T313
F
R
G
G
L
D
V
T
H
G
Q
T
G
V
E
Site 34
S321
H
G
Q
T
G
V
E
S
V
Y
T
T
F
R
D
Site 35
T324
T
G
V
E
S
V
Y
T
T
F
R
D
R
E
I
Site 36
T325
G
V
E
S
V
Y
T
T
F
R
D
R
E
I
M
Site 37
T391
Y
I
V
V
Q
V
E
T
P
G
T
E
T
P
S
Site 38
T394
V
Q
V
E
T
P
G
T
E
T
P
S
Y
K
V
Site 39
T396
V
E
T
P
G
T
E
T
P
S
Y
K
V
S
V
Site 40
S398
T
P
G
T
E
T
P
S
Y
K
V
S
V
T
A
Site 41
Y399
P
G
T
E
T
P
S
Y
K
V
S
V
T
A
R
Site 42
S402
E
T
P
S
Y
K
V
S
V
T
A
R
E
D
V
Site 43
T411
T
A
R
E
D
V
P
T
F
G
P
P
L
P
S
Site 44
S418
T
F
G
P
P
L
P
S
P
P
V
F
Q
K
G
Site 45
T434
E
F
R
E
F
L
L
T
K
L
T
N
A
E
N
Site 46
S446
A
E
N
A
C
C
K
S
D
K
F
A
K
L
E
Site 47
S496
G
H
G
G
F
L
E
S
F
K
R
A
I
R
V
Site 48
S505
K
R
A
I
R
V
R
S
H
S
M
E
T
M
V
Site 49
S507
A
I
R
V
R
S
H
S
M
E
T
M
V
G
G
Site 50
T510
V
R
S
H
S
M
E
T
M
V
G
G
Q
K
K
Site 51
S518
M
V
G
G
Q
K
K
S
H
S
G
G
I
P
G
Site 52
S520
G
G
Q
K
K
S
H
S
G
G
I
P
G
S
L
Site 53
S526
H
S
G
G
I
P
G
S
L
S
G
G
I
S
H
Site 54
S528
G
G
I
P
G
S
L
S
G
G
I
S
H
N
S
Site 55
S532
G
S
L
S
G
G
I
S
H
N
S
M
E
V
T
Site 56
S535
S
G
G
I
S
H
N
S
M
E
V
T
K
T
T
Site 57
T539
S
H
N
S
M
E
V
T
K
T
T
F
S
P
P
Site 58
T541
N
S
M
E
V
T
K
T
T
F
S
P
P
V
V
Site 59
S544
E
V
T
K
T
T
F
S
P
P
V
V
A
A
T
Site 60
T551
S
P
P
V
V
A
A
T
V
K
N
Q
S
R
S
Site 61
S558
T
V
K
N
Q
S
R
S
P
I
K
R
R
S
G
Site 62
S564
R
S
P
I
K
R
R
S
G
L
F
P
R
L
H
Site 63
T572
G
L
F
P
R
L
H
T
G
S
E
G
Q
G
D
Site 64
S574
F
P
R
L
H
T
G
S
E
G
Q
G
D
S
R
Site 65
S580
G
S
E
G
Q
G
D
S
R
A
R
C
D
S
T
Site 66
S586
D
S
R
A
R
C
D
S
T
S
S
T
P
K
T
Site 67
T587
S
R
A
R
C
D
S
T
S
S
T
P
K
T
P
Site 68
S588
R
A
R
C
D
S
T
S
S
T
P
K
T
P
D
Site 69
S589
A
R
C
D
S
T
S
S
T
P
K
T
P
D
G
Site 70
T590
R
C
D
S
T
S
S
T
P
K
T
P
D
G
G
Site 71
T593
S
T
S
S
T
P
K
T
P
D
G
G
H
S
S
Site 72
S600
T
P
D
G
G
H
S
S
Q
E
I
K
S
E
T
Site 73
S605
H
S
S
Q
E
I
K
S
E
T
S
S
N
P
S
Site 74
T607
S
Q
E
I
K
S
E
T
S
S
N
P
S
S
P
Site 75
S608
Q
E
I
K
S
E
T
S
S
N
P
S
S
P
E
Site 76
S609
E
I
K
S
E
T
S
S
N
P
S
S
P
E
I
Site 77
S612
S
E
T
S
S
N
P
S
S
P
E
I
C
P
N
Site 78
S613
E
T
S
S
N
P
S
S
P
E
I
C
P
N
K
Site 79
S635
K
E
N
G
R
A
I
S
R
S
S
S
S
T
S
Site 80
S637
N
G
R
A
I
S
R
S
S
S
S
T
S
S
V
Site 81
S638
G
R
A
I
S
R
S
S
S
S
T
S
S
V
S
Site 82
S639
R
A
I
S
R
S
S
S
S
T
S
S
V
S
S
Site 83
S640
A
I
S
R
S
S
S
S
T
S
S
V
S
S
T
Site 84
T641
I
S
R
S
S
S
S
T
S
S
V
S
S
T
A
Site 85
S642
S
R
S
S
S
S
T
S
S
V
S
S
T
A
G
Site 86
S643
R
S
S
S
S
T
S
S
V
S
S
T
A
G
E
Site 87
S646
S
S
T
S
S
V
S
S
T
A
G
E
G
E
A
Site 88
T647
S
T
S
S
V
S
S
T
A
G
E
G
E
A
M
Site 89
S659
E
A
M
E
E
G
D
S
G
G
S
Q
P
S
T
Site 90
S662
E
E
G
D
S
G
G
S
Q
P
S
T
T
S
P
Site 91
S665
D
S
G
G
S
Q
P
S
T
T
S
P
F
K
Q
Site 92
T666
S
G
G
S
Q
P
S
T
T
S
P
F
K
Q
E
Site 93
T667
G
G
S
Q
P
S
T
T
S
P
F
K
Q
E
V
Site 94
S668
G
S
Q
P
S
T
T
S
P
F
K
Q
E
V
F
Site 95
Y677
F
K
Q
E
V
F
V
Y
S
P
S
P
S
S
E
Site 96
S678
K
Q
E
V
F
V
Y
S
P
S
P
S
S
E
S
Site 97
S680
E
V
F
V
Y
S
P
S
P
S
S
E
S
P
S
Site 98
S682
F
V
Y
S
P
S
P
S
S
E
S
P
S
L
G
Site 99
S683
V
Y
S
P
S
P
S
S
E
S
P
S
L
G
A
Site 100
S685
S
P
S
P
S
S
E
S
P
S
L
G
A
A
A
Site 101
S687
S
P
S
S
E
S
P
S
L
G
A
A
A
T
P
Site 102
S700
T
P
I
I
M
S
R
S
P
T
D
A
K
S
R
Site 103
T702
I
I
M
S
R
S
P
T
D
A
K
S
R
N
S
Site 104
S706
R
S
P
T
D
A
K
S
R
N
S
P
R
S
N
Site 105
S709
T
D
A
K
S
R
N
S
P
R
S
N
L
K
F
Site 106
S712
K
S
R
N
S
P
R
S
N
L
K
F
R
F
D
Site 107
S722
K
F
R
F
D
K
L
S
H
A
S
S
G
A
G
Site 108
S726
D
K
L
S
H
A
S
S
G
A
G
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation