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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DEF
Full Name:
Digestive organ expansion factor homolog
Alias:
Type:
Mass (Da):
87055
Number AA:
756
UniProt ID:
Q68CQ4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
G
K
R
G
S
R
S
Q
S
Q
L
L
Site 2
S8
M
G
K
R
G
S
R
S
Q
S
Q
L
L
N
T
Site 3
S10
K
R
G
S
R
S
Q
S
Q
L
L
N
T
L
T
Site 4
T15
S
Q
S
Q
L
L
N
T
L
T
K
K
Q
K
K
Site 5
T17
S
Q
L
L
N
T
L
T
K
K
Q
K
K
H
L
Site 6
Y34
F
G
E
E
H
P
F
Y
D
R
V
S
R
K
E
Site 7
S38
H
P
F
Y
D
R
V
S
R
K
E
A
K
P
Q
Site 8
S50
K
P
Q
I
C
Q
L
S
E
S
S
D
S
S
D
Site 9
S52
Q
I
C
Q
L
S
E
S
S
D
S
S
D
S
E
Site 10
S53
I
C
Q
L
S
E
S
S
D
S
S
D
S
E
S
Site 11
S55
Q
L
S
E
S
S
D
S
S
D
S
E
S
D
S
Site 12
S56
L
S
E
S
S
D
S
S
D
S
E
S
D
S
E
Site 13
S58
E
S
S
D
S
S
D
S
E
S
D
S
E
S
E
Site 14
S60
S
D
S
S
D
S
E
S
D
S
E
S
E
P
Q
Site 15
S62
S
S
D
S
E
S
D
S
E
S
E
P
Q
Q
V
Site 16
S64
D
S
E
S
D
S
E
S
E
P
Q
Q
V
S
G
Site 17
Y72
E
P
Q
Q
V
S
G
Y
H
R
L
L
A
T
L
Site 18
S98
E
E
E
E
E
E
D
S
I
V
D
D
A
E
M
Site 19
S112
M
N
D
E
D
G
G
S
D
V
S
V
E
E
E
Site 20
S115
E
D
G
G
S
D
V
S
V
E
E
E
M
A
A
Site 21
S127
M
A
A
E
S
T
E
S
P
E
N
V
A
L
S
Site 22
S134
S
P
E
N
V
A
L
S
A
D
P
E
G
K
E
Site 23
T149
D
G
E
E
P
P
G
T
S
Q
T
S
P
E
E
Site 24
S153
P
P
G
T
S
Q
T
S
P
E
E
F
T
D
A
Site 25
S164
F
T
D
A
K
H
E
S
L
F
S
L
E
T
N
Site 26
S167
A
K
H
E
S
L
F
S
L
E
T
N
F
L
E
Site 27
S177
T
N
F
L
E
E
E
S
G
D
N
S
S
L
K
Site 28
S181
E
E
E
S
G
D
N
S
S
L
K
A
S
Q
D
Site 29
S182
E
E
S
G
D
N
S
S
L
K
A
S
Q
D
P
Site 30
S186
D
N
S
S
L
K
A
S
Q
D
P
F
L
Q
H
Site 31
T212
A
V
A
T
N
P
K
T
T
H
E
L
K
W
P
Site 32
T235
S
K
F
Q
K
L
E
T
F
K
P
P
K
D
I
Site 33
S246
P
K
D
I
D
L
K
S
L
H
L
Q
K
P
L
Site 34
T258
K
P
L
E
S
T
W
T
K
T
N
S
Q
F
L
Site 35
T260
L
E
S
T
W
T
K
T
N
S
Q
F
L
S
G
Site 36
S262
S
T
W
T
K
T
N
S
Q
F
L
S
G
P
Q
Site 37
S266
K
T
N
S
Q
F
L
S
G
P
Q
K
S
S
S
Site 38
S271
F
L
S
G
P
Q
K
S
S
S
P
F
T
P
L
Site 39
S272
L
S
G
P
Q
K
S
S
S
P
F
T
P
L
Q
Site 40
S273
S
G
P
Q
K
S
S
S
P
F
T
P
L
Q
K
Site 41
T276
Q
K
S
S
S
P
F
T
P
L
Q
K
E
L
F
Site 42
Y294
N
S
Y
R
D
L
F
Y
P
E
R
T
A
L
K
Site 43
Y310
G
E
E
I
R
H
V
Y
C
L
H
V
I
N
H
Site 44
S330
A
Q
V
L
G
N
N
S
R
R
R
S
Q
K
F
Site 45
S334
G
N
N
S
R
R
R
S
Q
K
F
G
V
G
D
Site 46
T351
D
F
R
D
Q
G
L
T
R
P
K
V
L
I
V
Site 47
S387
S
K
K
K
I
I
V
S
N
K
K
R
F
Q
G
Site 48
Y396
K
K
R
F
Q
G
E
Y
G
S
D
P
E
E
R
Site 49
S398
R
F
Q
G
E
Y
G
S
D
P
E
E
R
P
P
Site 50
Y413
N
L
K
R
P
E
D
Y
E
A
V
F
V
G
N
Site 51
Y439
L
Q
R
S
I
R
L
Y
A
P
F
Y
S
S
D
Site 52
S508
M
N
L
L
P
L
D
S
H
G
V
D
F
S
R
Site 53
S514
D
S
H
G
V
D
F
S
R
V
R
M
W
S
L
Site 54
Y527
S
L
N
N
W
S
K
Y
Y
R
Q
T
L
L
F
Site 55
T531
W
S
K
Y
Y
R
Q
T
L
L
F
G
A
L
Q
Site 56
Y549
I
N
S
V
F
N
K
Y
C
V
N
M
Q
G
Q
Site 57
S589
M
E
A
E
N
L
A
S
V
I
D
A
R
F
N
Site 58
Y606
V
N
K
I
L
P
Q
Y
R
D
A
V
M
S
H
Site 59
Y630
D
F
V
R
L
R
N
Y
F
K
K
E
E
L
N
Site 60
T639
K
K
E
E
L
N
F
T
H
I
C
E
Y
T
Q
Site 61
Y644
N
F
T
H
I
C
E
Y
T
Q
K
S
G
V
S
Site 62
S648
I
C
E
Y
T
Q
K
S
G
V
S
R
A
R
H
Site 63
Y674
F
T
E
R
F
H
F
Y
K
R
Y
T
I
K
G
Site 64
Y677
R
F
H
F
Y
K
R
Y
T
I
K
G
I
R
N
Site 65
Y688
G
I
R
N
L
I
F
Y
E
L
P
T
Y
P
H
Site 66
Y693
I
F
Y
E
L
P
T
Y
P
H
F
Y
S
E
I
Site 67
T707
I
C
N
M
L
R
A
T
N
R
G
E
E
A
T
Site 68
T714
T
N
R
G
E
E
A
T
W
T
C
T
V
L
Y
Site 69
T716
R
G
E
E
A
T
W
T
C
T
V
L
Y
S
K
Site 70
Y724
C
T
V
L
Y
S
K
Y
D
A
Q
R
L
A
A
Site 71
S744
R
A
A
Q
M
L
Q
S
N
K
N
V
H
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation