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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0746
Full Name:
Protein sel-1 homolog 3
Alias:
K0746; KIAA0746 protein; Sel-1 suppressor of lin-12-like 3; SEL1-like repeat-containing protein KIAA0746
Type:
Mass (Da):
128570
Number AA:
UniProt ID:
Q68CR1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S65
P
S
L
G
R
Q
T
S
L
T
T
S
V
I
P
Site 2
T67
L
G
R
Q
T
S
L
T
T
S
V
I
P
K
A
Site 3
S69
R
Q
T
S
L
T
T
S
V
I
P
K
A
E
Q
Site 4
S97
E
G
N
V
R
N
V
S
E
V
S
V
E
Y
L
Site 5
S100
V
R
N
V
S
E
V
S
V
E
Y
L
C
S
Q
Site 6
S119
N
L
E
A
V
V
S
S
E
F
R
S
S
I
P
Site 7
S123
V
V
S
S
E
F
R
S
S
I
P
V
Y
K
K
Site 8
S124
V
S
S
E
F
R
S
S
I
P
V
Y
K
K
R
Site 9
Y128
F
R
S
S
I
P
V
Y
K
K
R
W
K
N
E
Site 10
T143
K
H
L
H
T
S
R
T
Q
I
V
H
V
K
F
Site 11
Y156
K
F
P
S
I
M
V
Y
R
D
D
Y
F
I
R
Site 12
Y160
I
M
V
Y
R
D
D
Y
F
I
R
H
S
I
S
Site 13
T207
K
N
Y
T
L
L
Q
T
I
P
P
F
E
R
P
Site 14
T261
Y
A
S
S
G
E
N
T
G
I
V
K
K
F
P
Site 15
T278
R
N
R
E
L
E
A
T
R
R
Q
R
M
D
Y
Site 16
Y285
T
R
R
Q
R
M
D
Y
P
V
F
T
V
S
L
Site 17
T319
D
S
N
E
M
Y
G
T
P
S
V
F
L
T
E
Site 18
S321
N
E
M
Y
G
T
P
S
V
F
L
T
E
E
G
Site 19
T346
G
E
D
L
A
V
K
T
K
F
I
I
P
L
K
Site 20
S379
S
I
G
Q
D
L
K
S
Y
H
N
Q
T
I
S
Site 21
Y380
I
G
Q
D
L
K
S
Y
H
N
Q
T
I
S
F
Site 22
Y393
S
F
R
E
D
F
H
Y
N
D
T
A
G
Y
F
Site 23
Y399
H
Y
N
D
T
A
G
Y
F
I
I
G
G
S
R
Site 24
Y407
F
I
I
G
G
S
R
Y
V
A
G
I
E
G
F
Site 25
Y420
G
F
F
G
P
L
K
Y
Y
R
L
R
S
L
H
Site 26
Y421
F
F
G
P
L
K
Y
Y
R
L
R
S
L
H
P
Site 27
S425
L
K
Y
Y
R
L
R
S
L
H
P
A
Q
I
F
Site 28
Y447
L
A
E
Q
I
K
L
Y
Y
E
R
C
A
E
V
Site 29
Y448
A
E
Q
I
K
L
Y
Y
E
R
C
A
E
V
Q
Site 30
Y461
V
Q
E
I
V
S
V
Y
A
S
A
A
K
H
G
Site 31
S463
E
I
V
S
V
Y
A
S
A
A
K
H
G
G
E
Site 32
S480
E
A
C
H
L
H
N
S
Y
L
D
L
Q
R
R
Site 33
Y481
A
C
H
L
H
N
S
Y
L
D
L
Q
R
R
Y
Site 34
Y488
Y
L
D
L
Q
R
R
Y
G
R
P
S
M
C
R
Site 35
T521
L
L
E
M
D
L
L
T
V
P
R
N
Q
N
E
Site 36
S529
V
P
R
N
Q
N
E
S
V
S
E
I
G
G
K
Site 37
S531
R
N
Q
N
E
S
V
S
E
I
G
G
K
I
F
Site 38
S546
E
K
A
V
K
R
L
S
S
I
D
G
L
H
Q
Site 39
S547
K
A
V
K
R
L
S
S
I
D
G
L
H
Q
I
Site 40
Y569
T
D
S
S
C
C
G
Y
H
K
A
S
Y
Y
L
Site 41
Y574
C
G
Y
H
K
A
S
Y
Y
L
A
V
F
Y
E
Site 42
Y575
G
Y
H
K
A
S
Y
Y
L
A
V
F
Y
E
T
Site 43
Y596
D
Q
L
Q
G
M
L
Y
S
L
V
G
G
Q
G
Site 44
S604
S
L
V
G
G
Q
G
S
E
R
L
S
S
M
N
Site 45
S608
G
Q
G
S
E
R
L
S
S
M
N
L
G
Y
K
Site 46
S609
Q
G
S
E
R
L
S
S
M
N
L
G
Y
K
H
Site 47
Y614
L
S
S
M
N
L
G
Y
K
H
Y
Q
G
I
D
Site 48
Y623
H
Y
Q
G
I
D
N
Y
P
L
D
W
E
L
S
Site 49
Y631
P
L
D
W
E
L
S
Y
A
Y
Y
S
N
I
A
Site 50
Y634
W
E
L
S
Y
A
Y
Y
S
N
I
A
T
K
T
Site 51
T639
A
Y
Y
S
N
I
A
T
K
T
P
L
D
Q
H
Site 52
T641
Y
S
N
I
A
T
K
T
P
L
D
Q
H
T
L
Site 53
T647
K
T
P
L
D
Q
H
T
L
Q
G
D
Q
A
Y
Site 54
Y654
T
L
Q
G
D
Q
A
Y
V
E
T
I
R
L
K
Site 55
T724
Y
A
K
G
A
L
E
T
E
D
P
A
L
I
Y
Site 56
Y772
A
V
N
G
L
G
W
Y
Y
H
K
F
K
K
N
Site 57
Y773
V
N
G
L
G
W
Y
Y
H
K
F
K
K
N
Y
Site 58
S799
E
M
G
N
P
D
A
S
Y
N
L
G
V
L
H
Site 59
Y800
M
G
N
P
D
A
S
Y
N
L
G
V
L
H
L
Site 60
T820
G
V
P
G
R
N
Q
T
L
A
G
E
Y
F
H
Site 61
T852
Y
I
T
G
N
L
E
T
F
P
R
D
P
E
K
Site 62
Y873
H
V
A
E
K
N
G
Y
L
G
H
V
I
R
K
Site 63
Y885
I
R
K
G
L
N
A
Y
L
E
G
S
W
H
E
Site 64
S889
L
N
A
Y
L
E
G
S
W
H
E
A
L
L
Y
Site 65
S908
A
E
T
G
I
E
V
S
Q
T
N
L
A
H
I
Site 66
Y926
R
P
D
L
A
R
R
Y
L
G
V
N
C
V
W
Site 67
Y957
Y
L
K
M
G
D
L
Y
Y
Y
G
H
Q
N
Q
Site 68
Y958
L
K
M
G
D
L
Y
Y
Y
G
H
Q
N
Q
S
Site 69
Y959
K
M
G
D
L
Y
Y
Y
G
H
Q
N
Q
S
Q
Site 70
S965
Y
Y
G
H
Q
N
Q
S
Q
D
L
E
L
S
V
Site 71
S971
Q
S
Q
D
L
E
L
S
V
Q
M
Y
A
Q
A
Site 72
S984
Q
A
A
L
D
G
D
S
Q
G
F
F
N
L
A
Site 73
S1012
L
D
F
L
E
I
D
S
T
L
H
S
N
N
I
Site 74
T1013
D
F
L
E
I
D
S
T
L
H
S
N
N
I
S
Site 75
S1016
E
I
D
S
T
L
H
S
N
N
I
S
I
L
Q
Site 76
S1020
T
L
H
S
N
N
I
S
I
L
Q
E
L
Y
E
Site 77
Y1026
I
S
I
L
Q
E
L
Y
E
R
C
W
S
H
S
Site 78
S1031
E
L
Y
E
R
C
W
S
H
S
N
E
E
S
F
Site 79
S1033
Y
E
R
C
W
S
H
S
N
E
E
S
F
S
P
Site 80
S1037
W
S
H
S
N
E
E
S
F
S
P
C
S
L
A
Site 81
S1039
H
S
N
E
E
S
F
S
P
C
S
L
A
W
L
Site 82
S1042
E
E
S
F
S
P
C
S
L
A
W
L
Y
L
H
Site 83
S1084
W
T
V
Q
Y
F
Q
S
V
S
A
S
D
P
P
Site 84
S1086
V
Q
Y
F
Q
S
V
S
A
S
D
P
P
P
R
Site 85
S1088
Y
F
Q
S
V
S
A
S
D
P
P
P
R
P
S
Site 86
S1095
S
D
P
P
P
R
P
S
Q
A
S
P
D
T
A
Site 87
S1098
P
P
R
P
S
Q
A
S
P
D
T
A
T
S
T
Site 88
T1101
P
S
Q
A
S
P
D
T
A
T
S
T
A
S
P
Site 89
T1103
Q
A
S
P
D
T
A
T
S
T
A
S
P
A
V
Site 90
T1105
S
P
D
T
A
T
S
T
A
S
P
A
V
T
P
Site 91
S1107
D
T
A
T
S
T
A
S
P
A
V
T
P
A
A
Site 92
T1111
S
T
A
S
P
A
V
T
P
A
A
D
A
S
D
Site 93
S1117
V
T
P
A
A
D
A
S
D
Q
D
Q
P
T
V
Site 94
T1123
A
S
D
Q
D
Q
P
T
V
T
N
N
P
E
P
Site 95
T1125
D
Q
D
Q
P
T
V
T
N
N
P
E
P
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation