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Updated November 2019
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Protein Info
Short Name:
TNS3
Full Name:
Tensin-3
Alias:
FLJ13732; H_NH0549I23.2; TEM6; TENS1; TENS3; Tensin 3; Tensin-like SH2 domain-containing protein 1; Tumor endothelial marker 6
Type:
Adapter/scaffold protein
Mass (Da):
155266
Number AA:
1445
UniProt ID:
Q68CZ2
International Prot ID:
IPI00658152
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005925
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
E
G
H
G
L
D
L
T
Y
I
T
E
R
I
I
Site 2
S26
V
S
F
P
A
G
C
S
E
E
S
Y
L
H
N
Site 3
Y30
A
G
C
S
E
E
S
Y
L
H
N
L
Q
E
V
Site 4
S43
E
V
T
R
M
L
K
S
K
H
G
D
N
Y
L
Site 5
Y49
K
S
K
H
G
D
N
Y
L
V
L
N
L
S
E
Site 6
S55
N
Y
L
V
L
N
L
S
E
K
R
Y
D
L
T
Site 7
Y59
L
N
L
S
E
K
R
Y
D
L
T
K
L
N
P
Site 8
T62
S
E
K
R
Y
D
L
T
K
L
N
P
K
I
M
Site 9
T86
P
P
L
D
K
M
C
T
I
C
K
A
Q
E
S
Site 10
S97
A
Q
E
S
W
L
N
S
N
L
Q
H
V
V
V
Site 11
S130
H
F
T
N
V
S
A
S
A
D
Q
A
L
D
R
Site 12
Y144
R
F
A
M
K
K
F
Y
D
D
K
V
S
A
L
Site 13
S155
V
S
A
L
M
Q
P
S
Q
K
R
Y
V
Q
F
Site 14
Y159
M
Q
P
S
Q
K
R
Y
V
Q
F
L
S
G
L
Site 15
T188
H
F
V
I
L
H
G
T
P
N
F
D
T
G
G
Site 16
T193
H
G
T
P
N
F
D
T
G
G
V
C
R
P
F
Site 17
Y204
C
R
P
F
L
K
L
Y
Q
A
M
Q
P
V
Y
Site 18
Y211
Y
Q
A
M
Q
P
V
Y
T
S
G
I
Y
N
V
Site 19
Y216
P
V
Y
T
S
G
I
Y
N
V
G
P
E
N
P
Site 20
T253
H
K
K
Y
R
S
A
T
R
D
V
I
F
R
L
Site 21
Y270
H
T
G
A
V
Q
G
Y
G
L
V
F
G
K
E
Site 22
Y291
K
D
D
R
F
P
D
Y
G
K
V
E
L
V
F
Site 23
S299
G
K
V
E
L
V
F
S
A
T
P
E
K
I
Q
Site 24
Y312
I
Q
G
S
E
H
L
Y
N
D
H
G
V
I
V
Site 25
Y321
D
H
G
V
I
V
D
Y
N
T
T
D
P
L
I
Site 26
T324
V
I
V
D
Y
N
T
T
D
P
L
I
R
W
D
Site 27
S332
D
P
L
I
R
W
D
S
Y
E
N
L
S
A
D
Site 28
Y333
P
L
I
R
W
D
S
Y
E
N
L
S
A
D
G
Site 29
S337
W
D
S
Y
E
N
L
S
A
D
G
E
V
L
H
Site 30
T345
A
D
G
E
V
L
H
T
Q
G
P
V
D
G
S
Site 31
S352
T
Q
G
P
V
D
G
S
L
Y
A
K
V
R
K
Site 32
Y354
G
P
V
D
G
S
L
Y
A
K
V
R
K
K
S
Site 33
S361
Y
A
K
V
R
K
K
S
S
S
D
P
G
I
P
Site 34
S362
A
K
V
R
K
K
S
S
S
D
P
G
I
P
G
Site 35
S363
K
V
R
K
K
S
S
S
D
P
G
I
P
G
G
Site 36
T377
G
P
Q
A
I
P
A
T
N
S
P
D
H
S
D
Site 37
S379
Q
A
I
P
A
T
N
S
P
D
H
S
D
H
T
Site 38
S383
A
T
N
S
P
D
H
S
D
H
T
L
S
V
S
Site 39
T386
S
P
D
H
S
D
H
T
L
S
V
S
S
D
S
Site 40
S388
D
H
S
D
H
T
L
S
V
S
S
D
S
G
H
Site 41
S390
S
D
H
T
L
S
V
S
S
D
S
G
H
S
T
Site 42
S393
T
L
S
V
S
S
D
S
G
H
S
T
A
S
A
Site 43
T397
S
S
D
S
G
H
S
T
A
S
A
R
T
D
K
Site 44
S399
D
S
G
H
S
T
A
S
A
R
T
D
K
T
E
Site 45
T402
H
S
T
A
S
A
R
T
D
K
T
E
E
R
L
Site 46
T405
A
S
A
R
T
D
K
T
E
E
R
L
A
P
G
Site 47
T413
E
E
R
L
A
P
G
T
R
R
G
L
S
A
Q
Site 48
S418
P
G
T
R
R
G
L
S
A
Q
E
K
A
E
L
Site 49
S430
A
E
L
D
Q
L
L
S
G
F
G
L
E
D
P
Site 50
S439
F
G
L
E
D
P
G
S
S
L
K
E
M
T
D
Site 51
S440
G
L
E
D
P
G
S
S
L
K
E
M
T
D
A
Site 52
T445
G
S
S
L
K
E
M
T
D
A
R
S
K
Y
S
Site 53
S449
K
E
M
T
D
A
R
S
K
Y
S
G
T
R
H
Site 54
Y451
M
T
D
A
R
S
K
Y
S
G
T
R
H
V
V
Site 55
T475
A
A
L
K
D
R
E
T
D
I
L
D
D
E
M
Site 56
S489
M
P
H
H
D
L
H
S
V
D
S
L
G
T
L
Site 57
S492
H
D
L
H
S
V
D
S
L
G
T
L
S
S
S
Site 58
T495
H
S
V
D
S
L
G
T
L
S
S
S
E
G
P
Site 59
S497
V
D
S
L
G
T
L
S
S
S
E
G
P
Q
S
Site 60
S498
D
S
L
G
T
L
S
S
S
E
G
P
Q
S
A
Site 61
S499
S
L
G
T
L
S
S
S
E
G
P
Q
S
A
H
Site 62
S504
S
S
S
E
G
P
Q
S
A
H
L
G
P
F
T
Site 63
T511
S
A
H
L
G
P
F
T
C
H
K
S
S
Q
N
Site 64
S515
G
P
F
T
C
H
K
S
S
Q
N
S
L
L
S
Site 65
S516
P
F
T
C
H
K
S
S
Q
N
S
L
L
S
D
Site 66
S519
C
H
K
S
S
Q
N
S
L
L
S
D
G
F
G
Site 67
S522
S
S
Q
N
S
L
L
S
D
G
F
G
S
N
V
Site 68
Y549
G
L
G
M
D
G
P
Y
E
R
E
R
T
F
G
Site 69
T554
G
P
Y
E
R
E
R
T
F
G
S
R
E
P
K
Site 70
S571
Q
P
L
L
R
K
P
S
V
S
A
Q
M
Q
A
Site 71
S573
L
L
R
K
P
S
V
S
A
Q
M
Q
A
Y
G
Site 72
Y579
V
S
A
Q
M
Q
A
Y
G
Q
S
S
Y
S
T
Site 73
S582
Q
M
Q
A
Y
G
Q
S
S
Y
S
T
Q
T
W
Site 74
Y584
Q
A
Y
G
Q
S
S
Y
S
T
Q
T
W
V
R
Site 75
T586
Y
G
Q
S
S
Y
S
T
Q
T
W
V
R
Q
Q
Site 76
T588
Q
S
S
Y
S
T
Q
T
W
V
R
Q
Q
Q
M
Site 77
Y601
Q
M
V
V
A
H
Q
Y
S
F
A
P
D
G
E
Site 78
S602
M
V
V
A
H
Q
Y
S
F
A
P
D
G
E
A
Site 79
S613
D
G
E
A
R
L
V
S
R
C
P
A
D
N
P
Site 80
T632
A
Q
P
R
V
P
L
T
P
T
R
G
T
S
S
Site 81
T634
P
R
V
P
L
T
P
T
R
G
T
S
S
R
V
Site 82
T637
P
L
T
P
T
R
G
T
S
S
R
V
A
V
Q
Site 83
S638
L
T
P
T
R
G
T
S
S
R
V
A
V
Q
R
Site 84
S639
T
P
T
R
G
T
S
S
R
V
A
V
Q
R
G
Site 85
S649
A
V
Q
R
G
V
G
S
G
P
H
P
P
D
T
Site 86
T656
S
G
P
H
P
P
D
T
Q
Q
P
S
P
S
K
Site 87
S660
P
P
D
T
Q
Q
P
S
P
S
K
A
F
K
P
Site 88
S662
D
T
Q
Q
P
S
P
S
K
A
F
K
P
R
F
Site 89
S683
N
G
A
G
P
E
L
S
T
G
P
S
P
G
S
Site 90
T684
G
A
G
P
E
L
S
T
G
P
S
P
G
S
P
Site 91
S687
P
E
L
S
T
G
P
S
P
G
S
P
T
L
D
Site 92
S690
S
T
G
P
S
P
G
S
P
T
L
D
I
D
Q
Site 93
T692
G
P
S
P
G
S
P
T
L
D
I
D
Q
S
I
Site 94
S698
P
T
L
D
I
D
Q
S
I
E
Q
L
N
R
L
Site 95
T718
P
T
F
E
P
I
P
T
H
M
N
A
L
G
S
Site 96
S725
T
H
M
N
A
L
G
S
Q
A
N
G
S
V
S
Site 97
S730
L
G
S
Q
A
N
G
S
V
S
P
D
S
V
G
Site 98
S732
S
Q
A
N
G
S
V
S
P
D
S
V
G
G
G
Site 99
S735
N
G
S
V
S
P
D
S
V
G
G
G
L
R
A
Site 100
S743
V
G
G
G
L
R
A
S
S
R
L
P
D
T
G
Site 101
S744
G
G
G
L
R
A
S
S
R
L
P
D
T
G
E
Site 102
T749
A
S
S
R
L
P
D
T
G
E
G
P
S
R
A
Site 103
T757
G
E
G
P
S
R
A
T
G
R
Q
G
S
S
A
Site 104
S762
R
A
T
G
R
Q
G
S
S
A
E
Q
P
L
G
Site 105
S763
A
T
G
R
Q
G
S
S
A
E
Q
P
L
G
G
Site 106
S776
G
G
R
L
R
K
L
S
L
G
Q
Y
D
N
D
Site 107
Y780
R
K
L
S
L
G
Q
Y
D
N
D
A
G
G
Q
Site 108
S791
A
G
G
Q
L
P
F
S
K
C
A
W
G
K
A
Site 109
Y802
W
G
K
A
G
V
D
Y
A
P
N
L
P
P
F
Site 110
S811
P
N
L
P
P
F
P
S
P
A
D
V
K
E
T
Site 111
T818
S
P
A
D
V
K
E
T
M
T
P
G
Y
P
Q
Site 112
T820
A
D
V
K
E
T
M
T
P
G
Y
P
Q
D
L
Site 113
Y823
K
E
T
M
T
P
G
Y
P
Q
D
L
D
I
I
Site 114
S836
I
I
D
G
R
I
L
S
S
K
E
S
M
C
S
Site 115
S837
I
D
G
R
I
L
S
S
K
E
S
M
C
S
T
Site 116
S840
R
I
L
S
S
K
E
S
M
C
S
T
P
A
F
Site 117
S843
S
S
K
E
S
M
C
S
T
P
A
F
P
V
S
Site 118
T844
S
K
E
S
M
C
S
T
P
A
F
P
V
S
P
Site 119
S850
S
T
P
A
F
P
V
S
P
E
T
P
Y
V
K
Site 120
T853
A
F
P
V
S
P
E
T
P
Y
V
K
T
A
L
Site 121
Y855
P
V
S
P
E
T
P
Y
V
K
T
A
L
R
H
Site 122
T858
P
E
T
P
Y
V
K
T
A
L
R
H
P
P
F
Site 123
S866
A
L
R
H
P
P
F
S
P
P
E
P
P
L
S
Site 124
S873
S
P
P
E
P
P
L
S
S
P
A
S
Q
H
K
Site 125
S874
P
P
E
P
P
L
S
S
P
A
S
Q
H
K
G
Site 126
S877
P
P
L
S
S
P
A
S
Q
H
K
G
G
R
E
Site 127
S887
K
G
G
R
E
P
R
S
C
P
E
T
L
T
H
Site 128
T891
E
P
R
S
C
P
E
T
L
T
H
A
V
G
M
Site 129
T893
R
S
C
P
E
T
L
T
H
A
V
G
M
S
E
Site 130
S899
L
T
H
A
V
G
M
S
E
S
P
I
G
P
K
Site 131
S901
H
A
V
G
M
S
E
S
P
I
G
P
K
S
T
Site 132
S907
E
S
P
I
G
P
K
S
T
M
L
R
A
D
A
Site 133
S915
T
M
L
R
A
D
A
S
S
T
P
S
F
Q
Q
Site 134
S916
M
L
R
A
D
A
S
S
T
P
S
F
Q
Q
A
Site 135
T917
L
R
A
D
A
S
S
T
P
S
F
Q
Q
A
F
Site 136
S919
A
D
A
S
S
T
P
S
F
Q
Q
A
F
A
S
Site 137
S926
S
F
Q
Q
A
F
A
S
S
C
T
I
S
S
N
Site 138
S927
F
Q
Q
A
F
A
S
S
C
T
I
S
S
N
G
Site 139
S931
F
A
S
S
C
T
I
S
S
N
G
P
G
Q
R
Site 140
S932
A
S
S
C
T
I
S
S
N
G
P
G
Q
R
R
Site 141
S941
G
P
G
Q
R
R
E
S
S
S
S
A
E
R
Q
Site 142
S942
P
G
Q
R
R
E
S
S
S
S
A
E
R
Q
W
Site 143
S943
G
Q
R
R
E
S
S
S
S
A
E
R
Q
W
V
Site 144
S944
Q
R
R
E
S
S
S
S
A
E
R
Q
W
V
E
Site 145
S952
A
E
R
Q
W
V
E
S
S
P
K
P
M
V
S
Site 146
S953
E
R
Q
W
V
E
S
S
P
K
P
M
V
S
L
Site 147
S959
S
S
P
K
P
M
V
S
L
L
G
S
G
R
P
Site 148
S963
P
M
V
S
L
L
G
S
G
R
P
T
G
S
P
Site 149
T967
L
L
G
S
G
R
P
T
G
S
P
L
S
A
E
Site 150
S969
G
S
G
R
P
T
G
S
P
L
S
A
E
F
S
Site 151
S972
R
P
T
G
S
P
L
S
A
E
F
S
G
T
R
Site 152
S976
S
P
L
S
A
E
F
S
G
T
R
K
D
S
P
Site 153
T978
L
S
A
E
F
S
G
T
R
K
D
S
P
V
L
Site 154
S982
F
S
G
T
R
K
D
S
P
V
L
S
C
F
P
Site 155
S986
R
K
D
S
P
V
L
S
C
F
P
P
S
E
L
Site 156
S999
E
L
Q
A
P
F
H
S
H
E
L
S
L
A
E
Site 157
S1003
P
F
H
S
H
E
L
S
L
A
E
P
P
D
S
Site 158
S1010
S
L
A
E
P
P
D
S
L
A
P
P
S
S
Q
Site 159
S1015
P
D
S
L
A
P
P
S
S
Q
A
F
L
G
F
Site 160
S1029
F
G
T
A
P
V
G
S
G
L
P
P
E
E
D
Site 161
S1048
L
A
N
S
H
G
A
S
P
T
P
S
I
P
L
Site 162
T1050
N
S
H
G
A
S
P
T
P
S
I
P
L
T
A
Site 163
S1052
H
G
A
S
P
T
P
S
I
P
L
T
A
T
G
Site 164
T1056
P
T
P
S
I
P
L
T
A
T
G
A
A
D
N
Site 165
S1078
L
T
V
A
P
G
H
S
S
H
H
S
P
G
L
Site 166
S1079
T
V
A
P
G
H
S
S
H
H
S
P
G
L
Q
Site 167
S1082
P
G
H
S
S
H
H
S
P
G
L
Q
G
Q
G
Site 168
S1105
L
P
E
K
K
R
A
S
E
G
D
R
S
L
G
Site 169
S1110
R
A
S
E
G
D
R
S
L
G
S
V
S
P
S
Site 170
S1113
E
G
D
R
S
L
G
S
V
S
P
S
S
S
G
Site 171
S1115
D
R
S
L
G
S
V
S
P
S
S
S
G
F
S
Site 172
S1117
S
L
G
S
V
S
P
S
S
S
G
F
S
S
P
Site 173
S1118
L
G
S
V
S
P
S
S
S
G
F
S
S
P
H
Site 174
S1119
G
S
V
S
P
S
S
S
G
F
S
S
P
H
S
Site 175
S1122
S
P
S
S
S
G
F
S
S
P
H
S
G
S
T
Site 176
S1123
P
S
S
S
G
F
S
S
P
H
S
G
S
T
I
Site 177
S1126
S
G
F
S
S
P
H
S
G
S
T
I
S
I
P
Site 178
S1128
F
S
S
P
H
S
G
S
T
I
S
I
P
F
P
Site 179
S1142
P
N
V
L
P
D
F
S
K
A
S
E
A
A
S
Site 180
S1145
L
P
D
F
S
K
A
S
E
A
A
S
P
L
P
Site 181
S1149
S
K
A
S
E
A
A
S
P
L
P
D
S
P
G
Site 182
S1154
A
A
S
P
L
P
D
S
P
G
D
K
L
V
I
Site 183
Y1173
Q
D
T
S
K
F
W
Y
K
A
D
I
S
R
E
Site 184
S1193
L
K
D
K
E
P
G
S
F
I
V
R
D
S
H
Site 185
S1199
G
S
F
I
V
R
D
S
H
S
F
R
G
A
Y
Site 186
S1201
F
I
V
R
D
S
H
S
F
R
G
A
Y
G
L
Site 187
Y1206
S
H
S
F
R
G
A
Y
G
L
A
M
K
V
A
Site 188
S1218
K
V
A
T
P
P
P
S
V
L
Q
L
N
K
K
Site 189
T1242
R
H
F
L
I
E
C
T
P
K
G
V
R
L
K
Site 190
S1252
G
V
R
L
K
G
C
S
N
E
P
Y
F
G
S
Site 191
Y1256
K
G
C
S
N
E
P
Y
F
G
S
L
T
A
L
Site 192
S1259
S
N
E
P
Y
F
G
S
L
T
A
L
V
C
Q
Site 193
S1292
P
L
E
E
I
A
E
S
S
P
Q
T
A
A
N
Site 194
S1293
L
E
E
I
A
E
S
S
P
Q
T
A
A
N
S
Site 195
T1296
I
A
E
S
S
P
Q
T
A
A
N
S
A
A
E
Site 196
S1300
S
P
Q
T
A
A
N
S
A
A
E
L
L
K
Q
Site 197
S1323
L
N
S
V
E
M
E
S
L
T
G
H
Q
A
I
Site 198
T1347
Q
E
P
P
P
V
S
T
V
V
H
F
K
V
S
Site 199
S1354
T
V
V
H
F
K
V
S
A
Q
G
I
T
L
T
Site 200
T1359
K
V
S
A
Q
G
I
T
L
T
D
N
Q
R
K
Site 201
T1361
S
A
Q
G
I
T
L
T
D
N
Q
R
K
L
F
Site 202
S1396
K
W
I
K
D
G
P
S
S
K
V
F
G
F
V
Site 203
S1428
H
D
P
E
Q
P
A
S
A
I
V
N
F
V
S
Site 204
S1441
V
S
K
V
M
I
G
S
P
K
K
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation