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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTY2D1
Full Name:
Protein SPT2 homolog
Alias:
SPT2 domain-containing protein 1
Type:
Mass (Da):
75528
Number AA:
685
UniProt ID:
Q68D10
International Prot ID:
IPI00396008
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
E
I
L
M
I
A
S
K
G
Q
G
V
N
N
Site 2
S24
N
N
V
P
K
R
Y
S
L
A
V
G
L
Q
K
Site 3
S105
G
I
P
I
E
E
K
S
K
K
R
Q
A
T
E
Site 4
T111
K
S
K
K
R
Q
A
T
E
S
H
T
S
Q
G
Site 5
S113
K
K
R
Q
A
T
E
S
H
T
S
Q
G
T
D
Site 6
S116
Q
A
T
E
S
H
T
S
Q
G
T
D
R
G
Y
Site 7
Y123
S
Q
G
T
D
R
G
Y
E
M
E
E
E
N
E
Site 8
Y134
E
E
N
E
F
L
E
Y
N
H
A
E
S
E
Q
Site 9
Y143
H
A
E
S
E
Q
E
Y
E
E
E
Q
E
P
P
Site 10
S154
Q
E
P
P
K
V
E
S
K
P
K
V
P
L
K
Site 11
S162
K
P
K
V
P
L
K
S
A
P
P
P
M
N
F
Site 12
T170
A
P
P
P
M
N
F
T
D
L
L
R
L
A
E
Site 13
S192
E
I
K
V
V
K
K
S
E
E
R
P
M
T
A
Site 14
T198
K
S
E
E
R
P
M
T
A
E
E
L
R
E
R
Site 15
T219
H
R
R
K
K
L
E
T
D
G
K
L
P
P
T
Site 16
T226
T
D
G
K
L
P
P
T
V
S
K
K
A
P
S
Site 17
S228
G
K
L
P
P
T
V
S
K
K
A
P
S
Q
K
Site 18
S233
T
V
S
K
K
A
P
S
Q
K
E
S
V
G
T
Site 19
S237
K
A
P
S
Q
K
E
S
V
G
T
K
L
S
K
Site 20
T240
S
Q
K
E
S
V
G
T
K
L
S
K
G
S
G
Site 21
S243
E
S
V
G
T
K
L
S
K
G
S
G
D
R
H
Site 22
S246
G
T
K
L
S
K
G
S
G
D
R
H
P
S
S
Site 23
S252
G
S
G
D
R
H
P
S
S
K
G
M
P
L
P
Site 24
S253
S
G
D
R
H
P
S
S
K
G
M
P
L
P
H
Site 25
S268
A
E
K
K
S
R
P
S
M
A
N
E
K
H
L
Site 26
S278
N
E
K
H
L
A
L
S
S
S
K
S
M
P
G
Site 27
S280
K
H
L
A
L
S
S
S
K
S
M
P
G
E
R
Site 28
S282
L
A
L
S
S
S
K
S
M
P
G
E
R
I
K
Site 29
S292
G
E
R
I
K
A
G
S
G
N
S
S
Q
P
S
Site 30
S295
I
K
A
G
S
G
N
S
S
Q
P
S
L
R
E
Site 31
S296
K
A
G
S
G
N
S
S
Q
P
S
L
R
E
G
Site 32
S299
S
G
N
S
S
Q
P
S
L
R
E
G
H
D
K
Site 33
S317
N
G
A
G
K
P
H
S
S
T
S
S
P
S
V
Site 34
S318
G
A
G
K
P
H
S
S
T
S
S
P
S
V
P
Site 35
T319
A
G
K
P
H
S
S
T
S
S
P
S
V
P
K
Site 36
S320
G
K
P
H
S
S
T
S
S
P
S
V
P
K
T
Site 37
S321
K
P
H
S
S
T
S
S
P
S
V
P
K
T
S
Site 38
S323
H
S
S
T
S
S
P
S
V
P
K
T
S
A
S
Site 39
T327
S
S
P
S
V
P
K
T
S
A
S
R
T
Q
K
Site 40
S328
S
P
S
V
P
K
T
S
A
S
R
T
Q
K
S
Site 41
S330
S
V
P
K
T
S
A
S
R
T
Q
K
S
A
V
Site 42
T332
P
K
T
S
A
S
R
T
Q
K
S
A
V
E
H
Site 43
S344
V
E
H
K
A
K
K
S
L
S
H
P
S
H
S
Site 44
S346
H
K
A
K
K
S
L
S
H
P
S
H
S
R
P
Site 45
S349
K
K
S
L
S
H
P
S
H
S
R
P
G
P
M
Site 46
S351
S
L
S
H
P
S
H
S
R
P
G
P
M
V
T
Site 47
T358
S
R
P
G
P
M
V
T
P
H
N
K
A
K
S
Site 48
S365
T
P
H
N
K
A
K
S
P
G
V
R
Q
P
G
Site 49
S373
P
G
V
R
Q
P
G
S
S
S
S
S
A
P
G
Site 50
S374
G
V
R
Q
P
G
S
S
S
S
S
A
P
G
Q
Site 51
S375
V
R
Q
P
G
S
S
S
S
S
A
P
G
Q
P
Site 52
S376
R
Q
P
G
S
S
S
S
S
A
P
G
Q
P
S
Site 53
S377
Q
P
G
S
S
S
S
S
A
P
G
Q
P
S
T
Site 54
S383
S
S
A
P
G
Q
P
S
T
G
V
A
R
P
T
Site 55
T384
S
A
P
G
Q
P
S
T
G
V
A
R
P
T
V
Site 56
T390
S
T
G
V
A
R
P
T
V
S
S
G
P
V
P
Site 57
S392
G
V
A
R
P
T
V
S
S
G
P
V
P
R
R
Site 58
S393
V
A
R
P
T
V
S
S
G
P
V
P
R
R
Q
Site 59
S403
V
P
R
R
Q
N
G
S
S
S
S
G
P
E
R
Site 60
S404
P
R
R
Q
N
G
S
S
S
S
G
P
E
R
S
Site 61
S405
R
R
Q
N
G
S
S
S
S
G
P
E
R
S
I
Site 62
S406
R
Q
N
G
S
S
S
S
G
P
E
R
S
I
S
Site 63
S411
S
S
S
G
P
E
R
S
I
S
G
S
K
K
P
Site 64
S413
S
G
P
E
R
S
I
S
G
S
K
K
P
T
N
Site 65
S415
P
E
R
S
I
S
G
S
K
K
P
T
N
D
S
Site 66
T419
I
S
G
S
K
K
P
T
N
D
S
N
P
S
R
Site 67
S422
S
K
K
P
T
N
D
S
N
P
S
R
R
T
V
Site 68
S425
P
T
N
D
S
N
P
S
R
R
T
V
S
G
T
Site 69
T428
D
S
N
P
S
R
R
T
V
S
G
T
C
G
P
Site 70
S430
N
P
S
R
R
T
V
S
G
T
C
G
P
G
Q
Site 71
T432
S
R
R
T
V
S
G
T
C
G
P
G
Q
P
A
Site 72
S440
C
G
P
G
Q
P
A
S
S
S
G
G
P
G
R
Site 73
S441
G
P
G
Q
P
A
S
S
S
G
G
P
G
R
P
Site 74
S442
P
G
Q
P
A
S
S
S
G
G
P
G
R
P
I
Site 75
S450
G
G
P
G
R
P
I
S
G
S
V
S
S
A
R
Site 76
S452
P
G
R
P
I
S
G
S
V
S
S
A
R
P
L
Site 77
S454
R
P
I
S
G
S
V
S
S
A
R
P
L
G
S
Site 78
S455
P
I
S
G
S
V
S
S
A
R
P
L
G
S
S
Site 79
S461
S
S
A
R
P
L
G
S
S
R
G
P
G
R
P
Site 80
S462
S
A
R
P
L
G
S
S
R
G
P
G
R
P
V
Site 81
S470
R
G
P
G
R
P
V
S
S
P
H
E
L
R
R
Site 82
S471
G
P
G
R
P
V
S
S
P
H
E
L
R
R
P
Site 83
S480
H
E
L
R
R
P
V
S
G
L
G
P
P
G
R
Site 84
S488
G
L
G
P
P
G
R
S
V
S
G
P
G
R
S
Site 85
S490
G
P
P
G
R
S
V
S
G
P
G
R
S
I
S
Site 86
S495
S
V
S
G
P
G
R
S
I
S
G
S
I
P
A
Site 87
S497
S
G
P
G
R
S
I
S
G
S
I
P
A
G
R
Site 88
S499
P
G
R
S
I
S
G
S
I
P
A
G
R
T
V
Site 89
T505
G
S
I
P
A
G
R
T
V
S
N
S
V
P
G
Site 90
S507
I
P
A
G
R
T
V
S
N
S
V
P
G
R
P
Site 91
S509
A
G
R
T
V
S
N
S
V
P
G
R
P
V
S
Site 92
S516
S
V
P
G
R
P
V
S
S
L
G
P
G
Q
T
Site 93
S517
V
P
G
R
P
V
S
S
L
G
P
G
Q
T
V
Site 94
T523
S
S
L
G
P
G
Q
T
V
S
S
S
G
P
T
Site 95
S525
L
G
P
G
Q
T
V
S
S
S
G
P
T
I
K
Site 96
S526
G
P
G
Q
T
V
S
S
S
G
P
T
I
K
P
Site 97
S527
P
G
Q
T
V
S
S
S
G
P
T
I
K
P
K
Site 98
T530
T
V
S
S
S
G
P
T
I
K
P
K
C
T
V
Site 99
T536
P
T
I
K
P
K
C
T
V
V
S
E
T
I
S
Site 100
S539
K
P
K
C
T
V
V
S
E
T
I
S
S
K
N
Site 101
S543
T
V
V
S
E
T
I
S
S
K
N
I
I
S
R
Site 102
S544
V
V
S
E
T
I
S
S
K
N
I
I
S
R
S
Site 103
S549
I
S
S
K
N
I
I
S
R
S
S
N
G
Q
M
Site 104
S551
S
K
N
I
I
S
R
S
S
N
G
Q
M
N
G
Site 105
S552
K
N
I
I
S
R
S
S
N
G
Q
M
N
G
M
Site 106
S564
N
G
M
K
P
P
L
S
G
Y
R
A
A
Q
G
Site 107
T579
P
Q
R
L
P
F
P
T
G
Y
K
R
Q
R
E
Site 108
Y581
R
L
P
F
P
T
G
Y
K
R
Q
R
E
Y
E
Site 109
Y587
G
Y
K
R
Q
R
E
Y
E
E
E
D
D
D
D
Site 110
Y597
E
D
D
D
D
D
E
Y
D
S
E
M
E
D
F
Site 111
S599
D
D
D
D
E
Y
D
S
E
M
E
D
F
I
E
Site 112
Y625
H
I
R
E
I
F
G
Y
D
R
K
K
Y
K
D
Site 113
Y630
F
G
Y
D
R
K
K
Y
K
D
E
S
D
Y
A
Site 114
S634
R
K
K
Y
K
D
E
S
D
Y
A
L
R
Y
M
Site 115
Y636
K
Y
K
D
E
S
D
Y
A
L
R
Y
M
E
S
Site 116
Y640
E
S
D
Y
A
L
R
Y
M
E
S
S
W
K
E
Site 117
S644
A
L
R
Y
M
E
S
S
W
K
E
Q
Q
K
E
Site 118
S655
Q
Q
K
E
E
A
K
S
L
R
L
G
M
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation