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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DENND2C
Full Name:
DENN domain-containing protein 2C
Alias:
DEN2C; DENN/MADD domain containing 2C
Type:
Uncharacterized protein
Mass (Da):
106865
Number AA:
928
UniProt ID:
Q68D51
International Prot ID:
IPI00470838
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
D
V
G
F
S
R
T
T
V
Q
T
L
S
R
S
Site 2
T12
F
S
R
T
T
V
Q
T
L
S
R
S
H
C
K
Site 3
S14
R
T
T
V
Q
T
L
S
R
S
H
C
K
N
I
Site 4
S26
K
N
I
K
Q
K
I
S
Q
W
E
G
R
A
N
Site 5
S36
E
G
R
A
N
G
I
S
N
P
E
K
W
C
P
Site 6
Y50
P
K
D
F
G
V
R
Y
N
C
H
Q
E
I
R
Site 7
S68
N
P
I
A
E
R
K
S
K
N
L
D
V
T
S
Site 8
T74
K
S
K
N
L
D
V
T
S
R
E
N
V
G
L
Site 9
S75
S
K
N
L
D
V
T
S
R
E
N
V
G
L
D
Site 10
S89
D
I
N
E
N
T
K
S
H
D
Q
S
E
N
E
Site 11
S93
N
T
K
S
H
D
Q
S
E
N
E
N
K
K
H
Site 12
T105
K
K
H
E
Y
D
D
T
H
F
F
K
N
E
S
Site 13
S119
S
E
S
N
W
V
C
S
R
V
K
E
I
E
S
Site 14
T136
E
D
V
L
D
P
E
T
S
L
P
P
G
N
F
Site 15
S137
D
V
L
D
P
E
T
S
L
P
P
G
N
F
Y
Site 16
Y144
S
L
P
P
G
N
F
Y
T
S
Q
I
L
W
K
Site 17
S171
L
A
L
E
H
C
D
S
S
E
K
E
L
N
F
Site 18
S183
L
N
F
R
V
L
D
S
S
Y
G
I
T
K
S
Site 19
S184
N
F
R
V
L
D
S
S
Y
G
I
T
K
S
L
Site 20
Y185
F
R
V
L
D
S
S
Y
G
I
T
K
S
L
E
Site 21
T188
L
D
S
S
Y
G
I
T
K
S
L
E
N
I
Y
Site 22
S190
S
S
Y
G
I
T
K
S
L
E
N
I
Y
S
E
Site 23
Y195
T
K
S
L
E
N
I
Y
S
E
P
E
G
Q
E
Site 24
S196
K
S
L
E
N
I
Y
S
E
P
E
G
Q
E
C
Site 25
S206
E
G
Q
E
C
G
P
S
I
N
P
L
P
K
P
Site 26
T216
P
L
P
K
P
R
R
T
F
R
Y
L
S
E
S
Site 27
Y219
K
P
R
R
T
F
R
Y
L
S
E
S
G
V
T
Site 28
S221
R
R
T
F
R
Y
L
S
E
S
G
V
T
P
Y
Site 29
S223
T
F
R
Y
L
S
E
S
G
V
T
P
Y
K
E
Site 30
T226
Y
L
S
E
S
G
V
T
P
Y
K
E
R
N
C
Site 31
Y228
S
E
S
G
V
T
P
Y
K
E
R
N
C
D
K
Site 32
Y237
E
R
N
C
D
K
K
Y
C
E
N
N
S
C
A
Site 33
S242
K
K
Y
C
E
N
N
S
C
A
Q
S
S
L
A
Site 34
S246
E
N
N
S
C
A
Q
S
S
L
A
S
S
Q
E
Site 35
S247
N
N
S
C
A
Q
S
S
L
A
S
S
Q
E
P
Site 36
S250
C
A
Q
S
S
L
A
S
S
Q
E
P
E
P
K
Site 37
S251
A
Q
S
S
L
A
S
S
Q
E
P
E
P
K
K
Site 38
Y259
Q
E
P
E
P
K
K
Y
G
G
K
I
R
G
R
Site 39
S267
G
G
K
I
R
G
R
S
K
R
K
S
F
E
F
Site 40
S271
R
G
R
S
K
R
K
S
F
E
F
E
D
I
Q
Site 41
S285
Q
H
F
R
N
R
N
S
Q
T
I
R
E
E
L
Site 42
T287
F
R
N
R
N
S
Q
T
I
R
E
E
L
G
R
Site 43
S296
R
E
E
L
G
R
N
S
G
S
A
L
Y
Y
T
Site 44
Y301
R
N
S
G
S
A
L
Y
Y
T
Q
S
E
D
N
Site 45
Y302
N
S
G
S
A
L
Y
Y
T
Q
S
E
D
N
I
Site 46
T303
S
G
S
A
L
Y
Y
T
Q
S
E
D
N
I
Y
Site 47
S305
S
A
L
Y
Y
T
Q
S
E
D
N
I
Y
E
D
Site 48
Y310
T
Q
S
E
D
N
I
Y
E
D
I
I
Y
P
T
Site 49
Y315
N
I
Y
E
D
I
I
Y
P
T
K
E
N
P
Y
Site 50
Y322
Y
P
T
K
E
N
P
Y
E
D
I
P
V
Q
P
Site 51
S335
Q
P
L
P
M
W
R
S
P
S
A
W
K
L
P
Site 52
S337
L
P
M
W
R
S
P
S
A
W
K
L
P
P
A
Site 53
S346
W
K
L
P
P
A
K
S
A
F
K
A
P
K
L
Site 54
T364
P
Q
F
L
H
R
K
T
M
E
V
K
N
S
Q
Site 55
S370
K
T
M
E
V
K
N
S
Q
A
Y
L
R
S
K
Site 56
Y373
E
V
K
N
S
Q
A
Y
L
R
S
K
L
T
K
Site 57
T382
R
S
K
L
T
K
D
T
T
L
P
V
T
L
T
Site 58
T383
S
K
L
T
K
D
T
T
L
P
V
T
L
T
E
Site 59
T387
K
D
T
T
L
P
V
T
L
T
E
W
K
L
F
Site 60
T402
R
A
G
E
V
A
N
T
K
R
K
N
L
P
R
Site 61
S420
K
I
D
D
I
F
E
S
K
R
G
K
K
K
V
Site 62
S431
K
K
K
V
K
L
H
S
Y
T
G
K
E
L
P
Site 63
T440
T
G
K
E
L
P
P
T
K
G
E
T
S
G
N
Site 64
S445
P
P
T
K
G
E
T
S
G
N
E
S
D
A
E
Site 65
S449
G
E
T
S
G
N
E
S
D
A
E
Y
L
P
K
Site 66
Y453
G
N
E
S
D
A
E
Y
L
P
K
N
R
H
K
Site 67
S468
R
L
A
Q
L
Q
P
S
S
K
R
N
P
H
Y
Site 68
S469
L
A
Q
L
Q
P
S
S
K
R
N
P
H
Y
Q
Site 69
Y475
S
S
K
R
N
P
H
Y
Q
T
L
E
R
D
L
Site 70
S504
V
S
L
Q
K
K
P
S
G
I
S
Y
I
P
Q
Site 71
Y508
K
K
P
S
G
I
S
Y
I
P
Q
V
I
Q
Q
Site 72
Y524
P
G
K
D
D
H
G
Y
K
Q
S
K
D
M
E
Site 73
S552
S
K
D
W
M
P
T
S
E
L
K
S
E
T
F
Site 74
T558
T
S
E
L
K
S
E
T
F
S
F
V
L
T
G
Site 75
S560
E
L
K
S
E
T
F
S
F
V
L
T
G
E
D
Site 76
T564
E
T
F
S
F
V
L
T
G
E
D
G
S
R
W
Site 77
Y574
D
G
S
R
W
F
G
Y
C
K
K
L
L
P
V
Site 78
Y591
G
K
R
L
P
E
V
Y
C
M
V
S
R
L
G
Site 79
S617
V
E
K
R
R
E
M
S
P
A
L
V
Y
P
F
Site 80
T639
P
F
P
A
P
G
R
T
I
T
V
K
S
Y
L
Site 81
T641
P
A
P
G
R
T
I
T
V
K
S
Y
L
P
G
Site 82
S644
G
R
T
I
T
V
K
S
Y
L
P
G
A
G
D
Site 83
Y645
R
T
I
T
V
K
S
Y
L
P
G
A
G
D
E
Site 84
S653
L
P
G
A
G
D
E
S
I
E
L
C
R
P
L
Site 85
S662
E
L
C
R
P
L
D
S
R
L
E
H
V
D
F
Site 86
Y724
P
F
T
W
Q
H
T
Y
I
P
V
L
P
A
S
Site 87
S777
D
K
F
L
Q
E
V
S
D
E
D
E
I
L
P
Site 88
T803
E
E
R
N
E
I
L
T
Q
E
Q
N
F
S
Q
Site 89
S809
L
T
Q
E
Q
N
F
S
Q
D
V
T
L
N
S
Site 90
T813
Q
N
F
S
Q
D
V
T
L
N
S
L
V
S
E
Site 91
T838
G
H
Y
S
L
N
M
T
V
T
E
R
G
E
R
Site 92
T840
Y
S
L
N
M
T
V
T
E
R
G
E
R
V
F
Site 93
S855
Q
R
E
P
F
R
K
S
H
T
S
R
S
V
R
Site 94
T857
E
P
F
R
K
S
H
T
S
R
S
V
R
H
F
Site 95
S858
P
F
R
K
S
H
T
S
R
S
V
R
H
F
L
Site 96
S860
R
K
S
H
T
S
R
S
V
R
H
F
L
D
L
Site 97
S886
Q
D
R
E
L
R
K
S
G
V
K
G
L
F
E
Site 98
Y899
F
E
I
R
A
I
Q
Y
L
E
T
I
P
E
S
Site 99
T902
R
A
I
Q
Y
L
E
T
I
P
E
S
E
P
S
Site 100
S906
Y
L
E
T
I
P
E
S
E
P
S
G
M
N
R
Site 101
S909
T
I
P
E
S
E
P
S
G
M
N
R
I
L
R
Site 102
S917
G
M
N
R
I
L
R
S
L
G
S
K
M
K
F
Site 103
S920
R
I
L
R
S
L
G
S
K
M
K
F
L
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation