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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANKS6
Full Name:
Ankyrin repeat and SAM domain-containing protein 6
Alias:
ANKRD14; SAMD6; Sterile alpha motif domain-containing 6
Type:
Mass (Da):
92219
Number AA:
871
UniProt ID:
Q68DC2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
C
D
Q
G
D
T
E
T
A
R
R
L
L
E
P
Site 2
S74
A
P
V
P
V
D
C
S
D
E
A
G
N
T
A
Site 3
S103
F
L
L
R
R
G
A
S
V
N
S
R
N
H
Y
Site 4
Y110
S
V
N
S
R
N
H
Y
G
W
S
A
L
M
Q
Site 5
S176
F
V
D
H
H
H
P
S
G
E
Q
L
G
L
G
Site 6
S185
E
Q
L
G
L
G
G
S
R
D
E
P
L
D
I
Site 7
T223
D
P
N
H
A
A
R
T
V
G
W
S
P
L
M
Site 8
S255
G
A
N
P
D
H
L
S
V
L
E
K
T
A
F
Site 9
Y276
K
H
R
D
L
V
D
Y
L
D
P
L
T
T
V
Site 10
T281
V
D
Y
L
D
P
L
T
T
V
R
P
K
T
D
Site 11
T282
D
Y
L
D
P
L
T
T
V
R
P
K
T
D
E
Site 12
T287
L
T
T
V
R
P
K
T
D
E
E
K
R
R
P
Site 13
S317
E
I
A
D
E
D
P
S
H
V
N
L
V
N
G
Site 14
S357
A
D
V
D
K
Q
D
S
V
H
G
W
T
A
L
Site 15
Y378
G
N
K
E
I
V
K
Y
L
L
N
Q
G
A
D
Site 16
T387
L
N
Q
G
A
D
V
T
L
R
A
K
N
G
Y
Site 17
S429
N
K
D
K
G
R
P
S
H
Q
P
P
L
P
H
Site 18
S437
H
Q
P
P
L
P
H
S
K
V
R
Q
P
W
S
Site 19
S444
S
K
V
R
Q
P
W
S
I
P
V
L
P
D
D
Site 20
T474
R
K
L
K
L
M
Q
T
L
P
R
G
L
S
S
Site 21
S480
Q
T
L
P
R
G
L
S
S
N
Q
P
L
P
F
Site 22
S481
T
L
P
R
G
L
S
S
N
Q
P
L
P
F
S
Site 23
S488
S
N
Q
P
L
P
F
S
D
E
P
E
P
A
L
Site 24
S497
E
P
E
P
A
L
D
S
T
M
R
A
A
P
Q
Site 25
T498
P
E
P
A
L
D
S
T
M
R
A
A
P
Q
D
Site 26
T507
R
A
A
P
Q
D
K
T
S
R
S
A
L
P
D
Site 27
T519
L
P
D
A
A
P
V
T
K
D
N
G
P
G
S
Site 28
S526
T
K
D
N
G
P
G
S
T
R
G
E
K
E
D
Site 29
T534
T
R
G
E
K
E
D
T
L
L
T
T
M
L
R
Site 30
T547
L
R
N
G
A
P
L
T
R
L
P
S
D
K
L
Site 31
S551
A
P
L
T
R
L
P
S
D
K
L
K
A
V
I
Site 32
S565
I
P
P
F
L
P
P
S
S
F
E
L
W
S
S
Site 33
S566
P
P
F
L
P
P
S
S
F
E
L
W
S
S
D
Site 34
S571
P
S
S
F
E
L
W
S
S
D
R
S
R
T
R
Site 35
S572
S
S
F
E
L
W
S
S
D
R
S
R
T
R
H
Site 36
S575
E
L
W
S
S
D
R
S
R
T
R
H
N
G
K
Site 37
T577
W
S
S
D
R
S
R
T
R
H
N
G
K
A
D
Site 38
T588
G
K
A
D
P
M
K
T
A
L
P
Q
R
A
S
Site 39
S595
T
A
L
P
Q
R
A
S
R
G
H
P
V
G
G
Site 40
T607
V
G
G
G
G
T
D
T
T
P
V
R
P
V
K
Site 41
T608
G
G
G
G
T
D
T
T
P
V
R
P
V
K
F
Site 42
S617
V
R
P
V
K
F
P
S
L
P
R
S
P
A
S
Site 43
S621
K
F
P
S
L
P
R
S
P
A
S
S
A
N
S
Site 44
S624
S
L
P
R
S
P
A
S
S
A
N
S
G
N
F
Site 45
S625
L
P
R
S
P
A
S
S
A
N
S
G
N
F
N
Site 46
S628
S
P
A
S
S
A
N
S
G
N
F
N
H
S
P
Site 47
S634
N
S
G
N
F
N
H
S
P
H
S
S
G
G
S
Site 48
S637
N
F
N
H
S
P
H
S
S
G
G
S
S
G
V
Site 49
S638
F
N
H
S
P
H
S
S
G
G
S
S
G
V
G
Site 50
S641
S
P
H
S
S
G
G
S
S
G
V
G
V
S
R
Site 51
S642
P
H
S
S
G
G
S
S
G
V
G
V
S
R
H
Site 52
S657
G
G
E
L
L
N
R
S
G
G
S
I
D
N
V
Site 53
S660
L
L
N
R
S
G
G
S
I
D
N
V
L
S
Q
Site 54
S666
G
S
I
D
N
V
L
S
Q
I
A
A
Q
R
K
Site 55
S684
G
L
L
E
Q
K
P
S
H
R
S
S
P
V
G
Site 56
S687
E
Q
K
P
S
H
R
S
S
P
V
G
P
A
P
Site 57
S688
Q
K
P
S
H
R
S
S
P
V
G
P
A
P
G
Site 58
S696
P
V
G
P
A
P
G
S
S
P
S
E
L
P
A
Site 59
S697
V
G
P
A
P
G
S
S
P
S
E
L
P
A
S
Site 60
S699
P
A
P
G
S
S
P
S
E
L
P
A
S
P
A
Site 61
S704
S
P
S
E
L
P
A
S
P
A
G
G
S
A
P
Site 62
T718
P
V
G
K
K
L
E
T
S
K
R
P
P
S
G
Site 63
S719
V
G
K
K
L
E
T
S
K
R
P
P
S
G
T
Site 64
S724
E
T
S
K
R
P
P
S
G
T
S
T
T
S
K
Site 65
T726
S
K
R
P
P
S
G
T
S
T
T
S
K
S
T
Site 66
S727
K
R
P
P
S
G
T
S
T
T
S
K
S
T
S
Site 67
T728
R
P
P
S
G
T
S
T
T
S
K
S
T
S
P
Site 68
S730
P
S
G
T
S
T
T
S
K
S
T
S
P
T
L
Site 69
S732
G
T
S
T
T
S
K
S
T
S
P
T
L
T
P
Site 70
S734
S
T
T
S
K
S
T
S
P
T
L
T
P
S
P
Site 71
T736
T
S
K
S
T
S
P
T
L
T
P
S
P
S
P
Site 72
T738
K
S
T
S
P
T
L
T
P
S
P
S
P
K
G
Site 73
S740
T
S
P
T
L
T
P
S
P
S
P
K
G
H
T
Site 74
S742
P
T
L
T
P
S
P
S
P
K
G
H
T
A
E
Site 75
T747
S
P
S
P
K
G
H
T
A
E
S
S
V
S
S
Site 76
S750
P
K
G
H
T
A
E
S
S
V
S
S
S
S
S
Site 77
S751
K
G
H
T
A
E
S
S
V
S
S
S
S
S
H
Site 78
S753
H
T
A
E
S
S
V
S
S
S
S
S
H
R
Q
Site 79
S754
T
A
E
S
S
V
S
S
S
S
S
H
R
Q
S
Site 80
S755
A
E
S
S
V
S
S
S
S
S
H
R
Q
S
K
Site 81
S756
E
S
S
V
S
S
S
S
S
H
R
Q
S
K
S
Site 82
S757
S
S
V
S
S
S
S
S
H
R
Q
S
K
S
S
Site 83
S761
S
S
S
S
H
R
Q
S
K
S
S
G
G
S
S
Site 84
S763
S
S
H
R
Q
S
K
S
S
G
G
S
S
S
G
Site 85
S764
S
H
R
Q
S
K
S
S
G
G
S
S
S
G
T
Site 86
S767
Q
S
K
S
S
G
G
S
S
S
G
T
I
T
D
Site 87
S768
S
K
S
S
G
G
S
S
S
G
T
I
T
D
E
Site 88
S769
K
S
S
G
G
S
S
S
G
T
I
T
D
E
D
Site 89
T771
S
G
G
S
S
S
G
T
I
T
D
E
D
E
L
Site 90
T773
G
S
S
S
G
T
I
T
D
E
D
E
L
T
G
Site 91
T779
I
T
D
E
D
E
L
T
G
I
L
K
K
L
S
Site 92
S786
T
G
I
L
K
K
L
S
L
E
K
Y
Q
P
I
Site 93
Y790
K
K
L
S
L
E
K
Y
Q
P
I
F
E
E
Q
Site 94
S822
L
G
I
K
T
D
G
S
R
Q
Q
I
L
A
A
Site 95
S853
E
T
I
H
N
F
H
S
S
F
E
S
S
A
S
Site 96
S854
T
I
H
N
F
H
S
S
F
E
S
S
A
S
N
Site 97
S857
N
F
H
S
S
F
E
S
S
A
S
N
T
R
A
Site 98
S858
F
H
S
S
F
E
S
S
A
S
N
T
R
A
P
Site 99
S860
S
S
F
E
S
S
A
S
N
T
R
A
P
G
N
Site 100
T862
F
E
S
S
A
S
N
T
R
A
P
G
N
S
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation