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Updated November 2019
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Protein Info
Short Name:
MSL1
Full Name:
Male-specific lethal 1 homolog
Alias:
Male-specific lethal 1-like 1;Male-specific lethal-1 homolog 1
Type:
Mass (Da):
67139
Number AA:
614
UniProt ID:
Q68DK7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
N
P
E
Q
R
L
D
Y
E
R
A
A
A
L
G
Site 2
S61
E
P
G
P
P
L
A
S
S
Q
G
G
S
P
A
Site 3
S62
P
G
P
P
L
A
S
S
Q
G
G
S
P
A
P
Site 4
S66
L
A
S
S
Q
G
G
S
P
A
P
S
P
A
G
Site 5
S70
Q
G
G
S
P
A
P
S
P
A
G
C
G
G
K
Site 6
S95
A
P
G
Q
Q
E
E
S
W
G
G
S
V
P
L
Site 7
S99
Q
E
E
S
W
G
G
S
V
P
L
P
C
P
P
Site 8
S126
A
A
A
G
A
G
C
S
P
R
P
K
Y
Q
A
Site 9
Y131
G
C
S
P
R
P
K
Y
Q
A
V
L
P
I
Q
Site 10
T150
V
A
A
A
K
E
P
T
P
W
A
G
D
K
G
Site 11
S161
G
D
K
G
G
A
A
S
P
A
A
T
A
S
D
Site 12
T165
G
A
A
S
P
A
A
T
A
S
D
P
A
G
P
Site 13
S167
A
S
P
A
A
T
A
S
D
P
A
G
P
P
P
Site 14
S195
T
A
G
T
L
A
A
S
E
G
R
W
K
S
M
Site 15
S201
A
S
E
G
R
W
K
S
M
R
K
S
P
L
G
Site 16
S205
R
W
K
S
M
R
K
S
P
L
G
G
G
G
G
Site 17
S213
P
L
G
G
G
G
G
S
G
A
S
S
Q
A
A
Site 18
S216
G
G
G
G
S
G
A
S
S
Q
A
A
C
L
K
Site 19
S217
G
G
G
S
G
A
S
S
Q
A
A
C
L
K
Q
Site 20
S252
K
E
I
E
E
L
K
S
E
R
D
T
L
L
A
Site 21
T256
E
L
K
S
E
R
D
T
L
L
A
R
I
E
R
Site 22
Y286
R
H
K
L
F
Q
G
Y
E
T
E
E
R
E
E
Site 23
T288
K
L
F
Q
G
Y
E
T
E
E
R
E
E
T
E
Site 24
T294
E
T
E
E
R
E
E
T
E
L
S
E
K
I
K
Site 25
S297
E
R
E
E
T
E
L
S
E
K
I
K
L
E
C
Site 26
S309
L
E
C
Q
P
E
L
S
E
T
S
Q
T
L
P
Site 27
T311
C
Q
P
E
L
S
E
T
S
Q
T
L
P
P
K
Site 28
T314
E
L
S
E
T
S
Q
T
L
P
P
K
P
F
S
Site 29
S321
T
L
P
P
K
P
F
S
C
G
R
S
G
K
G
Site 30
S325
K
P
F
S
C
G
R
S
G
K
G
H
K
R
K
Site 31
S333
G
K
G
H
K
R
K
S
P
F
G
S
T
E
R
Site 32
S337
K
R
K
S
P
F
G
S
T
E
R
K
T
P
V
Site 33
T338
R
K
S
P
F
G
S
T
E
R
K
T
P
V
K
Site 34
T342
F
G
S
T
E
R
K
T
P
V
K
K
L
A
P
Site 35
T356
P
E
F
S
K
V
K
T
K
T
P
K
H
S
P
Site 36
T358
F
S
K
V
K
T
K
T
P
K
H
S
P
I
K
Site 37
S362
K
T
K
T
P
K
H
S
P
I
K
E
E
P
C
Site 38
S371
I
K
E
E
P
C
G
S
L
S
E
T
V
C
K
Site 39
S373
E
E
P
C
G
S
L
S
E
T
V
C
K
R
E
Site 40
T375
P
C
G
S
L
S
E
T
V
C
K
R
E
L
R
Site 41
T386
R
E
L
R
S
Q
E
T
P
E
K
P
R
S
S
Site 42
S392
E
T
P
E
K
P
R
S
S
V
D
T
P
P
R
Site 43
S393
T
P
E
K
P
R
S
S
V
D
T
P
P
R
L
Site 44
T396
K
P
R
S
S
V
D
T
P
P
R
L
S
T
P
Site 45
S401
V
D
T
P
P
R
L
S
T
P
Q
K
G
P
S
Site 46
T402
D
T
P
P
R
L
S
T
P
Q
K
G
P
S
T
Site 47
S408
S
T
P
Q
K
G
P
S
T
H
P
K
E
K
A
Site 48
T409
T
P
Q
K
G
P
S
T
H
P
K
E
K
A
F
Site 49
S417
H
P
K
E
K
A
F
S
S
E
I
E
D
L
P
Site 50
S418
P
K
E
K
A
F
S
S
E
I
E
D
L
P
Y
Site 51
Y425
S
E
I
E
D
L
P
Y
L
P
T
T
E
M
Y
Site 52
T428
E
D
L
P
Y
L
P
T
T
E
M
Y
L
C
R
Site 53
S442
R
W
H
Q
P
P
P
S
P
L
P
L
R
E
S
Site 54
S449
S
P
L
P
L
R
E
S
S
P
K
K
E
E
T
Site 55
S450
P
L
P
L
R
E
S
S
P
K
K
E
E
T
V
Site 56
T456
S
S
P
K
K
E
E
T
V
A
R
C
L
M
P
Site 57
S477
T
S
V
L
A
V
P
S
W
R
D
H
S
V
E
Site 58
S482
V
P
S
W
R
D
H
S
V
E
P
L
R
D
P
Site 59
S492
P
L
R
D
P
N
P
S
D
L
L
E
N
L
D
Site 60
S501
L
L
E
N
L
D
D
S
V
F
S
K
R
H
A
Site 61
Y539
Q
R
L
Q
L
R
M
Y
K
K
K
G
I
Q
E
Site 62
S547
K
K
K
G
I
Q
E
S
E
P
E
V
T
S
F
Site 63
S553
E
S
E
P
E
V
T
S
F
F
P
E
P
D
D
Site 64
S563
P
E
P
D
D
V
E
S
L
M
I
T
P
F
L
Site 65
T583
G
R
P
L
P
K
L
T
P
Q
N
F
E
L
P
Site 66
S596
L
P
W
L
D
E
R
S
R
C
R
L
E
I
Q
Site 67
T607
L
E
I
Q
K
K
Q
T
P
H
R
T
C
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation