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Updated November 2019
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Protein Info
Short Name:
RGPD1
Full Name:
RANBP2-like and GRIP domain-containing protein 1/2
Alias:
Ran-binding protein 2-like 6; RANBP2-like and GRIP domain containing 1; rgp1
Type:
Mass (Da):
196687
Number AA:
1748
UniProt ID:
Q68DN6
International Prot ID:
IPI00470913
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0046907
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
R
N
K
L
R
G
F
Y
F
A
K
L
Y
Y
E
Site 2
Y27
G
F
Y
F
A
K
L
Y
Y
E
A
K
E
Y
D
Site 3
Y33
L
Y
Y
E
A
K
E
Y
D
L
A
K
K
Y
V
Site 4
Y39
E
Y
D
L
A
K
K
Y
V
C
T
Y
L
S
V
Site 5
Y43
A
K
K
Y
V
C
T
Y
L
S
V
Q
E
R
D
Site 6
S45
K
Y
V
C
T
Y
L
S
V
Q
E
R
D
P
R
Site 7
S77
A
V
E
C
Y
R
R
S
L
E
L
N
P
P
Q
Site 8
Y107
V
T
D
G
R
A
K
Y
W
V
E
R
A
A
K
Site 9
Y123
F
P
G
S
P
A
I
Y
K
L
K
E
H
L
L
Site 10
Y150
D
W
I
Q
S
E
L
Y
V
R
P
D
D
V
H
Site 11
Y166
N
I
R
L
V
E
L
Y
R
S
N
K
R
L
K
Site 12
S168
R
L
V
E
L
Y
R
S
N
K
R
L
K
D
A
Site 13
S190
E
R
N
I
A
L
R
S
S
L
E
W
N
S
C
Site 14
S191
R
N
I
A
L
R
S
S
L
E
W
N
S
C
V
Site 15
S196
R
S
S
L
E
W
N
S
C
V
V
Q
T
L
K
Site 16
S208
T
L
K
E
Y
L
E
S
L
Q
C
L
E
S
D
Site 17
S214
E
S
L
Q
C
L
E
S
D
K
S
D
W
R
A
Site 18
S217
Q
C
L
E
S
D
K
S
D
W
R
A
T
N
T
Site 19
T222
D
K
S
D
W
R
A
T
N
T
D
L
L
L
A
Site 20
S239
N
L
M
L
L
T
L
S
T
R
D
V
Q
E
S
Site 21
S246
S
T
R
D
V
Q
E
S
R
E
L
L
E
S
F
Site 22
S252
E
S
R
E
L
L
E
S
F
D
S
A
L
Q
S
Site 23
S255
E
L
L
E
S
F
D
S
A
L
Q
S
A
K
S
Site 24
S259
S
F
D
S
A
L
Q
S
A
K
S
S
L
G
G
Site 25
S262
S
A
L
Q
S
A
K
S
S
L
G
G
N
D
E
Site 26
S263
A
L
Q
S
A
K
S
S
L
G
G
N
D
E
L
Site 27
S271
L
G
G
N
D
E
L
S
A
T
F
L
E
M
K
Site 28
T273
G
N
D
E
L
S
A
T
F
L
E
M
K
G
H
Site 29
S346
A
C
D
R
L
S
Q
S
G
H
M
L
L
N
L
Site 30
T367
F
L
K
E
V
V
E
T
F
A
N
K
S
G
Q
Site 31
S372
V
E
T
F
A
N
K
S
G
Q
S
V
L
Y
N
Site 32
Y378
K
S
G
Q
S
V
L
Y
N
A
L
F
S
S
Q
Site 33
S383
V
L
Y
N
A
L
F
S
S
Q
S
S
K
D
T
Site 34
S384
L
Y
N
A
L
F
S
S
Q
S
S
K
D
T
S
Site 35
S386
N
A
L
F
S
S
Q
S
S
K
D
T
S
F
L
Site 36
S387
A
L
F
S
S
Q
S
S
K
D
T
S
F
L
G
Site 37
T390
S
S
Q
S
S
K
D
T
S
F
L
G
S
D
D
Site 38
S391
S
Q
S
S
K
D
T
S
F
L
G
S
D
D
I
Site 39
S395
K
D
T
S
F
L
G
S
D
D
I
G
N
I
D
Site 40
T465
Q
E
T
S
R
L
E
T
N
A
P
E
S
I
C
Site 41
S497
Q
L
K
E
K
C
N
S
H
H
S
S
Y
Q
P
Site 42
S583
K
M
G
R
G
L
N
S
S
Y
D
Q
Q
E
Y
Site 43
S584
M
G
R
G
L
N
S
S
Y
D
Q
Q
E
Y
I
Site 44
Y585
G
R
G
L
N
S
S
Y
D
Q
Q
E
Y
I
G
Site 45
Y590
S
S
Y
D
Q
Q
E
Y
I
G
R
S
V
H
Y
Site 46
Y637
Q
A
S
E
I
V
E
Y
E
E
D
A
H
I
T
Site 47
T660
G
N
I
E
D
A
V
T
A
F
E
S
I
K
S
Site 48
Y701
E
Q
E
E
C
K
N
Y
L
R
K
T
R
D
Y
Site 49
Y708
Y
L
R
K
T
R
D
Y
L
I
K
I
I
D
D
Site 50
S718
K
I
I
D
D
S
D
S
N
L
S
V
V
K
K
Site 51
S721
D
D
S
D
S
N
L
S
V
V
K
K
L
P
V
Site 52
S732
K
L
P
V
P
L
E
S
V
K
E
M
L
K
S
Site 53
S739
S
V
K
E
M
L
K
S
V
M
Q
E
L
E
D
Site 54
Y747
V
M
Q
E
L
E
D
Y
S
E
G
G
P
L
Y
Site 55
S748
M
Q
E
L
E
D
Y
S
E
G
G
P
L
Y
K
Site 56
Y754
Y
S
E
G
G
P
L
Y
K
N
G
S
L
R
N
Site 57
S758
G
P
L
Y
K
N
G
S
L
R
N
A
D
S
E
Site 58
S764
G
S
L
R
N
A
D
S
E
I
K
H
S
T
P
Site 59
S769
A
D
S
E
I
K
H
S
T
P
S
P
T
K
Y
Site 60
T770
D
S
E
I
K
H
S
T
P
S
P
T
K
Y
S
Site 61
S772
E
I
K
H
S
T
P
S
P
T
K
Y
S
L
S
Site 62
T774
K
H
S
T
P
S
P
T
K
Y
S
L
S
P
S
Site 63
Y776
S
T
P
S
P
T
K
Y
S
L
S
P
S
K
S
Site 64
S777
T
P
S
P
T
K
Y
S
L
S
P
S
K
S
Y
Site 65
S779
S
P
T
K
Y
S
L
S
P
S
K
S
Y
K
Y
Site 66
S781
T
K
Y
S
L
S
P
S
K
S
Y
K
Y
S
P
Site 67
S783
Y
S
L
S
P
S
K
S
Y
K
Y
S
P
K
T
Site 68
S787
P
S
K
S
Y
K
Y
S
P
K
T
P
P
R
W
Site 69
T790
S
Y
K
Y
S
P
K
T
P
P
R
W
A
E
D
Site 70
S817
K
A
I
T
K
L
N
S
S
K
S
A
S
R
H
Site 71
S818
A
I
T
K
L
N
S
S
K
S
A
S
R
H
R
Site 72
S820
T
K
L
N
S
S
K
S
A
S
R
H
R
W
P
Site 73
S822
L
N
S
S
K
S
A
S
R
H
R
W
P
T
E
Site 74
T828
A
S
R
H
R
W
P
T
E
N
Y
G
P
D
S
Site 75
Y831
H
R
W
P
T
E
N
Y
G
P
D
S
V
P
D
Site 76
S835
T
E
N
Y
G
P
D
S
V
P
D
G
Y
Q
G
Site 77
Y840
P
D
S
V
P
D
G
Y
Q
G
S
Q
T
F
H
Site 78
S843
V
P
D
G
Y
Q
G
S
Q
T
F
H
G
A
P
Site 79
T845
D
G
Y
Q
G
S
Q
T
F
H
G
A
P
L
T
Site 80
S859
T
V
A
T
T
G
P
S
V
Y
Y
S
Q
S
P
Site 81
Y861
A
T
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
Site 82
S863
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
N
S
Site 83
S865
P
S
V
Y
Y
S
Q
S
P
A
Y
N
S
Q
Y
Site 84
Y868
Y
Y
S
Q
S
P
A
Y
N
S
Q
Y
L
L
R
Site 85
S870
S
Q
S
P
A
Y
N
S
Q
Y
L
L
R
P
A
Site 86
Y872
S
P
A
Y
N
S
Q
Y
L
L
R
P
A
A
N
Site 87
T881
L
R
P
A
A
N
V
T
P
T
K
G
S
S
N
Site 88
T889
P
T
K
G
S
S
N
T
E
F
K
S
T
K
E
Site 89
S893
S
S
N
T
E
F
K
S
T
K
E
G
F
S
I
Site 90
T894
S
N
T
E
F
K
S
T
K
E
G
F
S
I
A
Site 91
S899
K
S
T
K
E
G
F
S
I
A
V
S
A
D
G
Site 92
S912
D
G
F
K
F
G
I
S
E
P
G
N
Q
E
K
Site 93
S921
P
G
N
Q
E
K
K
S
E
K
P
L
E
N
D
Site 94
S937
G
F
Q
A
Q
D
I
S
G
Q
K
N
G
R
G
Site 95
T955
G
Q
T
S
S
T
F
T
F
A
D
V
A
K
S
Site 96
S962
T
F
A
D
V
A
K
S
T
S
G
E
G
F
Q
Site 97
S964
A
D
V
A
K
S
T
S
G
E
G
F
Q
F
G
Site 98
S989
G
A
G
E
K
L
F
S
S
Q
C
G
K
M
A
Site 99
S990
I
N
T
M
L
Q
L
S
P
E
E
K
G
K
L
Site 100
T1014
K
D
D
D
A
C
K
T
E
D
S
D
D
I
H
Site 101
S1017
D
A
C
K
T
E
D
S
D
D
I
H
F
E
P
Site 102
Y1045
E
E
G
E
K
V
L
Y
S
Q
G
V
K
L
F
Site 103
S1046
E
G
E
K
V
L
Y
S
Q
G
V
K
L
F
R
Site 104
S1059
F
R
F
D
A
E
I
S
Q
W
K
E
R
G
L
Site 105
S1108
T
M
N
L
K
P
L
S
G
S
D
R
A
W
M
Site 106
S1110
N
L
K
P
L
S
G
S
D
R
A
W
M
W
L
Site 107
S1122
M
W
L
A
S
D
F
S
D
G
D
A
K
L
E
Site 108
T1137
R
L
A
A
Q
F
K
T
P
E
L
A
E
E
F
Site 109
T1169
T
P
H
K
L
V
D
T
G
R
A
A
K
L
I
Site 110
S1184
Q
R
A
E
E
M
K
S
G
L
K
D
F
K
T
Site 111
T1191
S
G
L
K
D
F
K
T
F
L
T
N
D
Q
T
Site 112
T1194
K
D
F
K
T
F
L
T
N
D
Q
T
K
V
T
Site 113
T1198
T
F
L
T
N
D
Q
T
K
V
T
E
E
E
N
Site 114
S1208
T
E
E
E
N
K
G
S
G
T
G
S
A
G
A
Site 115
S1212
N
K
G
S
G
T
G
S
A
G
A
S
D
T
T
Site 116
S1216
G
T
G
S
A
G
A
S
D
T
T
I
K
P
N
Site 117
T1219
S
A
G
A
S
D
T
T
I
K
P
N
P
E
N
Site 118
Y1236
P
T
L
E
W
D
N
Y
D
L
R
E
D
A
L
Site 119
S1248
D
A
L
D
D
N
V
S
S
S
S
V
H
D
S
Site 120
S1249
A
L
D
D
N
V
S
S
S
S
V
H
D
S
P
Site 121
S1250
L
D
D
N
V
S
S
S
S
V
H
D
S
P
L
Site 122
S1251
D
D
N
V
S
S
S
S
V
H
D
S
P
L
A
Site 123
S1255
S
S
S
S
V
H
D
S
P
L
A
S
S
P
V
Site 124
S1259
V
H
D
S
P
L
A
S
S
P
V
R
K
N
I
Site 125
S1260
H
D
S
P
L
A
S
S
P
V
R
K
N
I
F
Site 126
T1273
I
F
R
F
D
E
S
T
T
G
F
N
F
S
F
Site 127
S1282
G
F
N
F
S
F
K
S
A
L
S
L
S
K
S
Site 128
S1285
F
S
F
K
S
A
L
S
L
S
K
S
P
A
K
Site 129
S1287
F
K
S
A
L
S
L
S
K
S
P
A
K
L
N
Site 130
S1289
S
A
L
S
L
S
K
S
P
A
K
L
N
Q
S
Site 131
S1296
S
P
A
K
L
N
Q
S
G
T
S
V
G
T
D
Site 132
S1306
S
V
G
T
D
E
E
S
D
V
T
Q
E
E
E
Site 133
T1309
T
D
E
E
S
D
V
T
Q
E
E
E
R
D
G
Site 134
Y1318
E
E
E
R
D
G
Q
Y
F
E
P
V
V
P
L
Site 135
S1333
P
D
L
V
E
V
S
S
G
E
E
N
E
Q
V
Site 136
S1343
E
N
E
Q
V
V
F
S
H
R
A
E
L
Y
R
Site 137
Y1351
H
R
A
E
L
Y
R
Y
D
K
D
V
G
Q
W
Site 138
Y1372
D
I
K
I
L
Q
N
Y
D
N
K
Q
V
R
I
Site 139
T1396
L
C
A
N
H
R
I
T
P
D
M
S
L
Q
N
Site 140
S1400
H
R
I
T
P
D
M
S
L
Q
N
M
K
G
T
Site 141
S1440
K
L
Q
D
V
A
D
S
F
K
K
I
F
D
E
Site 142
S1456
K
T
A
Q
E
K
D
S
L
I
T
P
H
V
S
Site 143
T1459
Q
E
K
D
S
L
I
T
P
H
V
S
R
S
S
Site 144
S1463
S
L
I
T
P
H
V
S
R
S
S
T
P
R
E
Site 145
S1465
I
T
P
H
V
S
R
S
S
T
P
R
E
S
P
Site 146
S1466
T
P
H
V
S
R
S
S
T
P
R
E
S
P
C
Site 147
T1467
P
H
V
S
R
S
S
T
P
R
E
S
P
C
G
Site 148
S1471
R
S
S
T
P
R
E
S
P
C
G
K
I
A
V
Site 149
T1489
E
E
T
T
R
E
R
T
D
V
I
Q
G
D
D
Site 150
S1502
D
D
V
A
D
A
A
S
E
V
E
V
S
S
T
Site 151
S1507
A
A
S
E
V
E
V
S
S
T
S
E
T
T
T
Site 152
T1509
S
E
V
E
V
S
S
T
S
E
T
T
T
K
A
Site 153
S1510
E
V
E
V
S
S
T
S
E
T
T
T
K
A
V
Site 154
T1512
E
V
S
S
T
S
E
T
T
T
K
A
V
V
S
Site 155
T1513
V
S
S
T
S
E
T
T
T
K
A
V
V
S
P
Site 156
T1514
S
S
T
S
E
T
T
T
K
A
V
V
S
P
P
Site 157
S1527
P
P
K
F
V
F
G
S
E
S
V
K
R
I
F
Site 158
S1529
K
F
V
F
G
S
E
S
V
K
R
I
F
S
S
Site 159
S1535
E
S
V
K
R
I
F
S
S
E
K
S
N
P
F
Site 160
S1536
S
V
K
R
I
F
S
S
E
K
S
N
P
F
A
Site 161
S1539
R
I
F
S
S
E
K
S
N
P
F
A
F
G
N
Site 162
S1552
G
N
S
S
A
T
G
S
L
F
G
F
S
F
N
Site 163
S1564
S
F
N
A
P
L
K
S
N
D
S
E
T
S
S
Site 164
S1567
A
P
L
K
S
N
D
S
E
T
S
S
V
A
Q
Site 165
T1569
L
K
S
N
D
S
E
T
S
S
V
A
Q
S
G
Site 166
S1571
S
N
D
S
E
T
S
S
V
A
Q
S
G
S
E
Site 167
S1575
E
T
S
S
V
A
Q
S
G
S
E
S
K
V
E
Site 168
S1577
S
S
V
A
Q
S
G
S
E
S
K
V
E
P
K
Site 169
S1579
V
A
Q
S
G
S
E
S
K
V
E
P
K
K
C
Site 170
S1589
E
P
K
K
C
E
L
S
K
N
S
D
I
E
H
Site 171
S1592
K
C
E
L
S
K
N
S
D
I
E
H
S
S
D
Site 172
S1598
N
S
D
I
E
H
S
S
D
S
K
V
K
N
L
Site 173
S1600
D
I
E
H
S
S
D
S
K
V
K
N
L
S
A
Site 174
S1606
D
S
K
V
K
N
L
S
A
S
F
P
M
E
E
Site 175
S1608
K
V
K
N
L
S
A
S
F
P
M
E
E
S
S
Site 176
Y1618
M
E
E
S
S
I
N
Y
T
F
K
T
P
E
K
Site 177
T1619
E
E
S
S
I
N
Y
T
F
K
T
P
E
K
E
Site 178
T1622
S
I
N
Y
T
F
K
T
P
E
K
E
P
P
L
Site 179
S1644
E
E
L
V
Q
K
L
S
S
T
T
K
S
A
D
Site 180
S1645
E
L
V
Q
K
L
S
S
T
T
K
S
A
D
Q
Site 181
S1649
K
L
S
S
T
T
K
S
A
D
Q
L
N
G
L
Site 182
T1663
L
L
R
E
T
E
A
T
S
A
V
L
M
E
Q
Site 183
S1676
E
Q
I
K
L
L
K
S
E
I
R
R
L
E
R
Site 184
S1688
L
E
R
N
Q
E
E
S
A
A
N
V
E
H
L
Site 185
S1709
F
I
F
L
K
P
G
S
E
R
E
S
L
L
P
Site 186
S1713
K
P
G
S
E
R
E
S
L
L
P
V
I
N
T
Site 187
S1725
I
N
T
M
L
Q
L
S
P
E
E
K
G
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation