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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INTS3
Full Name:
Integrator complex subunit 3
Alias:
C1orf60; FLJ21919; Int3; INT3
Type:
Mass (Da):
118070
Number AA:
1043
UniProt ID:
Q68E01
International Prot ID:
IPI00792312
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070876
GO:0032039
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0031576
GO:0010212
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
A
A
A
A
A
A
S
G
A
A
G
G
G
G
Site 2
S39
G
G
G
R
L
L
L
S
T
S
L
D
A
K
D
Site 3
T40
G
G
R
L
L
L
S
T
S
L
D
A
K
D
E
Site 4
S41
G
R
L
L
L
S
T
S
L
D
A
K
D
E
L
Site 5
S57
E
R
L
E
R
C
M
S
I
V
T
S
M
T
A
Site 6
Y78
A
N
D
A
L
N
A
Y
V
C
K
G
L
P
Q
Site 7
Y134
N
Q
I
L
M
E
K
Y
L
K
L
Q
D
T
C
Site 8
T166
G
A
D
G
V
C
M
T
F
M
K
Q
I
A
G
Site 9
T193
E
S
V
L
D
I
L
T
E
Q
R
E
W
V
L
Site 10
S295
G
I
L
Q
L
L
Q
S
R
T
S
R
K
F
L
Site 11
T297
L
Q
L
L
Q
S
R
T
S
R
K
F
L
A
C
Site 12
S298
Q
L
L
Q
S
R
T
S
R
K
F
L
A
C
R
Site 13
T307
K
F
L
A
C
R
L
T
P
D
M
E
T
K
L
Site 14
T318
E
T
K
L
L
F
M
T
S
R
V
R
F
G
Q
Site 15
S319
T
K
L
L
F
M
T
S
R
V
R
F
G
Q
Q
Site 16
Y329
R
F
G
Q
Q
K
R
Y
Q
D
W
F
Q
R
Q
Site 17
Y337
Q
D
W
F
Q
R
Q
Y
L
S
T
P
D
S
Q
Site 18
S339
W
F
Q
R
Q
Y
L
S
T
P
D
S
Q
S
L
Site 19
T340
F
Q
R
Q
Y
L
S
T
P
D
S
Q
S
L
R
Site 20
S343
Q
Y
L
S
T
P
D
S
Q
S
L
R
C
D
L
Site 21
S345
L
S
T
P
D
S
Q
S
L
R
C
D
L
I
R
Site 22
Y353
L
R
C
D
L
I
R
Y
I
C
G
V
V
H
P
Site 23
S366
H
P
S
N
E
V
L
S
S
D
I
L
P
R
W
Site 24
S367
P
S
N
E
V
L
S
S
D
I
L
P
R
W
A
Site 25
S409
F
F
S
P
D
K
D
S
I
M
N
I
E
P
A
Site 26
Y446
C
R
I
I
P
N
F
Y
P
P
L
E
G
H
V
Site 27
S459
H
V
R
Q
G
V
F
S
S
L
N
H
I
V
E
Site 28
S460
V
R
Q
G
V
F
S
S
L
N
H
I
V
E
K
Site 29
S499
E
K
F
P
E
F
C
S
S
P
S
P
P
V
E
Site 30
S500
K
F
P
E
F
C
S
S
P
S
P
P
V
E
V
Site 31
S502
P
E
F
C
S
S
P
S
P
P
V
E
V
K
I
Site 32
S522
M
E
M
D
N
H
M
S
D
K
D
E
S
C
Y
Site 33
Y529
S
D
K
D
E
S
C
Y
D
N
A
E
A
A
F
Site 34
S537
D
N
A
E
A
A
F
S
D
D
E
E
D
L
N
Site 35
S545
D
D
E
E
D
L
N
S
K
G
K
K
R
E
F
Site 36
T560
R
F
H
P
I
K
E
T
V
V
E
E
P
V
D
Site 37
T569
V
E
E
P
V
D
I
T
P
Y
L
D
Q
L
D
Site 38
Y571
E
P
V
D
I
T
P
Y
L
D
Q
L
D
E
S
Site 39
S578
Y
L
D
Q
L
D
E
S
L
R
D
K
V
L
Q
Site 40
T592
Q
L
Q
K
G
S
D
T
E
A
Q
C
E
V
M
Site 41
S613
V
L
E
E
D
F
D
S
E
Q
L
S
V
L
A
Site 42
S617
D
F
D
S
E
Q
L
S
V
L
A
S
C
L
Q
Site 43
S644
P
E
E
I
T
E
E
S
L
E
E
S
V
G
K
Site 44
S648
T
E
E
S
L
E
E
S
V
G
K
P
L
Y
L
Site 45
S668
C
Q
M
Q
E
D
N
S
S
F
S
L
L
L
D
Site 46
S669
Q
M
Q
E
D
N
S
S
F
S
L
L
L
D
L
Site 47
S671
Q
E
D
N
S
S
F
S
L
L
L
D
L
L
S
Site 48
S678
S
L
L
L
D
L
L
S
E
L
Y
Q
K
Q
P
Site 49
Y681
L
D
L
L
S
E
L
Y
Q
K
Q
P
K
I
G
Site 50
Y693
K
I
G
Y
H
L
L
Y
Y
L
R
A
S
K
A
Site 51
Y708
A
A
G
K
M
N
L
Y
E
S
F
A
Q
A
T
Site 52
S710
G
K
M
N
L
Y
E
S
F
A
Q
A
T
Q
L
Site 53
T754
Y
T
E
F
P
D
E
T
L
R
S
G
E
L
L
Site 54
S757
F
P
D
E
T
L
R
S
G
E
L
L
N
M
I
Site 55
Y834
P
I
L
Q
H
L
K
Y
K
E
H
P
E
A
L
Site 56
S854
Q
L
R
R
E
K
P
S
E
E
M
V
K
M
V
Site 57
S863
E
M
V
K
M
V
L
S
R
P
C
H
P
D
D
Site 58
S901
S
L
L
I
K
N
N
S
L
P
R
K
R
Q
S
Site 59
S908
S
L
P
R
K
R
Q
S
L
R
S
S
S
S
K
Site 60
S911
R
K
R
Q
S
L
R
S
S
S
S
K
L
A
Q
Site 61
S912
K
R
Q
S
L
R
S
S
S
S
K
L
A
Q
L
Site 62
S913
R
Q
S
L
R
S
S
S
S
K
L
A
Q
L
T
Site 63
S914
Q
S
L
R
S
S
S
S
K
L
A
Q
L
T
L
Site 64
T920
S
S
K
L
A
Q
L
T
L
E
Q
I
L
E
H
Site 65
T936
D
N
L
R
L
N
L
T
N
T
K
Q
N
F
F
Site 66
T938
L
R
L
N
L
T
N
T
K
Q
N
F
F
S
Q
Site 67
S944
N
T
K
Q
N
F
F
S
Q
T
P
I
L
Q
A
Site 68
T946
K
Q
N
F
F
S
Q
T
P
I
L
Q
A
L
Q
Site 69
S968
E
A
H
K
M
K
F
S
D
L
F
S
L
A
E
Site 70
S972
M
K
F
S
D
L
F
S
L
A
E
E
Y
E
D
Site 71
Y977
L
F
S
L
A
E
E
Y
E
D
S
S
T
K
P
Site 72
S980
L
A
E
E
Y
E
D
S
S
T
K
P
P
K
S
Site 73
S981
A
E
E
Y
E
D
S
S
T
K
P
P
K
S
R
Site 74
T982
E
E
Y
E
D
S
S
T
K
P
P
K
S
R
R
Site 75
S987
S
S
T
K
P
P
K
S
R
R
K
A
A
L
S
Site 76
S994
S
R
R
K
A
A
L
S
S
P
R
S
R
K
N
Site 77
S995
R
R
K
A
A
L
S
S
P
R
S
R
K
N
A
Site 78
S998
A
A
L
S
S
P
R
S
R
K
N
A
T
Q
P
Site 79
T1003
P
R
S
R
K
N
A
T
Q
P
P
N
A
E
E
Site 80
S1012
P
P
N
A
E
E
E
S
G
S
S
S
A
S
E
Site 81
S1014
N
A
E
E
E
S
G
S
S
S
A
S
E
E
E
Site 82
S1015
A
E
E
E
S
G
S
S
S
A
S
E
E
E
D
Site 83
S1016
E
E
E
S
G
S
S
S
A
S
E
E
E
D
T
Site 84
S1018
E
S
G
S
S
S
A
S
E
E
E
D
T
K
P
Site 85
T1023
S
A
S
E
E
E
D
T
K
P
K
P
T
K
R
Site 86
T1028
E
D
T
K
P
K
P
T
K
R
K
R
K
G
S
Site 87
S1035
T
K
R
K
R
K
G
S
S
A
V
G
S
D
S
Site 88
S1036
T
K
R
K
R
K
G
S
S
A
V
G
S
D
S
Site 89
S1040
K
G
S
S
A
V
G
S
D
S
D
_
_
_
_
Site 90
S1042
S
S
A
V
G
S
D
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation