KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KA35
Full Name:
Keratin, type I cytoskeletal 39
Alias:
K1C39; Keratin 39; Type I hair keratin KA35
Type:
Cytoskeletal protein
Mass (Da):
55623
Number AA:
491
UniProt ID:
Q6A163
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
D
T
K
G
C
T
T
T
N
S
P
S
T
Site 2
T9
D
T
K
G
C
T
T
T
N
S
P
S
T
P
C
Site 3
S11
K
G
C
T
T
T
N
S
P
S
T
P
C
Q
N
Site 4
T14
T
T
T
N
S
P
S
T
P
C
Q
N
C
S
R
Site 5
S20
S
T
P
C
Q
N
C
S
R
I
T
N
V
S
T
Site 6
T23
C
Q
N
C
S
R
I
T
N
V
S
T
I
S
S
Site 7
S26
C
S
R
I
T
N
V
S
T
I
S
S
N
N
G
Site 8
T27
S
R
I
T
N
V
S
T
I
S
S
N
N
G
C
Site 9
S30
T
N
V
S
T
I
S
S
N
N
G
C
H
P
G
Site 10
T40
G
C
H
P
G
G
L
T
V
N
N
C
Q
P
A
Site 11
Y71
R
F
C
R
K
P
I
Y
L
M
N
N
F
N
A
Site 12
Y88
S
L
D
D
C
S
W
Y
G
E
G
I
N
S
N
Site 13
T99
I
N
S
N
E
K
E
T
M
Q
I
L
N
E
R
Site 14
Y110
L
N
E
R
L
A
N
Y
L
Q
K
V
R
M
L
Site 15
Y143
L
P
V
L
C
P
D
Y
L
S
Y
Y
T
T
I
Site 16
Y146
L
C
P
D
Y
L
S
Y
Y
T
T
I
E
E
L
Site 17
Y147
C
P
D
Y
L
S
Y
Y
T
T
I
E
E
L
Q
Site 18
T149
D
Y
L
S
Y
Y
T
T
I
E
E
L
Q
Q
K
Site 19
S165
L
C
T
K
A
E
N
S
R
L
V
S
Q
I
D
Site 20
S169
A
E
N
S
R
L
V
S
Q
I
D
N
T
K
L
Site 21
Y185
A
D
D
L
R
A
K
Y
E
A
E
V
S
L
R
Site 22
S190
A
K
Y
E
A
E
V
S
L
R
Q
L
V
E
S
Site 23
S197
S
L
R
Q
L
V
E
S
D
A
N
G
L
K
Q
Site 24
S240
N
H
K
E
E
I
N
S
L
Q
C
Q
L
G
E
Site 25
T254
E
R
L
D
I
E
V
T
A
A
P
S
A
D
L
Site 26
Y272
L
Q
E
M
R
C
Q
Y
E
P
I
M
E
T
N
Site 27
S318
E
I
I
E
L
R
R
S
V
N
T
L
E
V
E
Site 28
T321
E
L
R
R
S
V
N
T
L
E
V
E
L
Q
A
Site 29
S335
A
Q
H
R
M
R
D
S
Q
E
C
I
L
T
E
Site 30
T341
D
S
Q
E
C
I
L
T
E
T
E
A
R
Y
T
Site 31
T348
T
E
T
E
A
R
Y
T
A
L
L
T
Q
I
Q
Site 32
Y379
L
E
R
Q
N
Q
E
Y
E
I
L
L
D
V
K
Site 33
T394
S
R
L
E
C
E
I
T
T
Y
R
S
L
L
E
Site 34
T395
R
L
E
C
E
I
T
T
Y
R
S
L
L
E
S
Site 35
Y396
L
E
C
E
I
T
T
Y
R
S
L
L
E
S
S
Site 36
S398
C
E
I
T
T
Y
R
S
L
L
E
S
S
D
G
Site 37
S402
T
Y
R
S
L
L
E
S
S
D
G
K
R
P
C
Site 38
S403
Y
R
S
L
L
E
S
S
D
G
K
R
P
C
Y
Site 39
Y410
S
D
G
K
R
P
C
Y
P
R
A
T
K
C
E
Site 40
T414
R
P
C
Y
P
R
A
T
K
C
E
P
S
P
W
Site 41
S419
R
A
T
K
C
E
P
S
P
W
T
S
C
K
S
Site 42
T422
K
C
E
P
S
P
W
T
S
C
K
S
G
A
I
Site 43
S423
C
E
P
S
P
W
T
S
C
K
S
G
A
I
E
Site 44
S426
S
P
W
T
S
C
K
S
G
A
I
E
S
T
A
Site 45
S431
C
K
S
G
A
I
E
S
T
A
P
A
C
T
S
Site 46
S438
S
T
A
P
A
C
T
S
S
S
P
C
S
L
K
Site 47
S439
T
A
P
A
C
T
S
S
S
P
C
S
L
K
E
Site 48
S440
A
P
A
C
T
S
S
S
P
C
S
L
K
E
H
Site 49
S443
C
T
S
S
S
P
C
S
L
K
E
H
C
S
A
Site 50
S449
C
S
L
K
E
H
C
S
A
C
G
P
L
S
R
Site 51
Y477
D
G
K
V
I
S
S
Y
E
H
V
Q
P
C
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation