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Updated November 2019
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Protein Info
Short Name:
WWC2
Full Name:
Protein WWC2
Alias:
BH-3-only member B; BOMB; FLJ22029; WW and C2 domain containing 2; WW domain-containing protein 2
Type:
Uncharacterized protein
Mass (Da):
133891
Number AA:
1192
UniProt ID:
Q6AWC2
International Prot ID:
IPI00550853
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
P
R
R
A
G
S
G
Q
L
P
L
P
R
Site 2
Y22
G
W
E
E
A
R
D
Y
D
G
K
V
F
Y
I
Site 3
Y28
D
Y
D
G
K
V
F
Y
I
D
H
N
T
R
R
Site 4
T36
I
D
H
N
T
R
R
T
S
W
I
D
P
R
D
Site 5
S37
D
H
N
T
R
R
T
S
W
I
D
P
R
D
R
Site 6
T46
I
D
P
R
D
R
L
T
K
P
L
S
F
A
D
Site 7
S50
D
R
L
T
K
P
L
S
F
A
D
C
V
G
D
Site 8
Y74
F
D
P
Q
I
G
V
Y
Y
I
D
H
I
N
K
Site 9
Y75
D
P
Q
I
G
V
Y
Y
I
D
H
I
N
K
T
Site 10
Y103
Q
E
K
M
L
K
D
Y
L
S
V
A
Q
D
A
Site 11
S105
K
M
L
K
D
Y
L
S
V
A
Q
D
A
L
R
Site 12
Y118
L
R
T
Q
K
E
L
Y
H
V
K
E
Q
R
L
Site 13
Y132
L
A
L
A
L
D
E
Y
V
R
L
N
D
A
Y
Site 14
Y139
Y
V
R
L
N
D
A
Y
K
E
K
S
S
S
H
Site 15
S143
N
D
A
Y
K
E
K
S
S
S
H
T
S
L
F
Site 16
S144
D
A
Y
K
E
K
S
S
S
H
T
S
L
F
S
Site 17
S145
A
Y
K
E
K
S
S
S
H
T
S
L
F
S
G
Site 18
T147
K
E
K
S
S
S
H
T
S
L
F
S
G
S
S
Site 19
S148
E
K
S
S
S
H
T
S
L
F
S
G
S
S
S
Site 20
S151
S
S
H
T
S
L
F
S
G
S
S
S
S
T
K
Site 21
S153
H
T
S
L
F
S
G
S
S
S
S
T
K
Y
D
Site 22
S154
T
S
L
F
S
G
S
S
S
S
T
K
Y
D
P
Site 23
S155
S
L
F
S
G
S
S
S
S
T
K
Y
D
P
D
Site 24
S156
L
F
S
G
S
S
S
S
T
K
Y
D
P
D
I
Site 25
T157
F
S
G
S
S
S
S
T
K
Y
D
P
D
I
L
Site 26
Y159
G
S
S
S
S
T
K
Y
D
P
D
I
L
K
A
Site 27
S169
D
I
L
K
A
E
I
S
T
T
R
L
R
V
K
Site 28
S183
K
K
L
K
R
E
L
S
Q
M
K
Q
E
L
L
Site 29
Y191
Q
M
K
Q
E
L
L
Y
K
E
Q
G
F
E
T
Site 30
S211
K
K
M
S
G
G
Q
S
G
Y
E
L
S
E
A
Site 31
S216
G
Q
S
G
Y
E
L
S
E
A
K
A
I
L
T
Site 32
T223
S
E
A
K
A
I
L
T
E
L
K
S
I
R
K
Site 33
S234
S
I
R
K
A
I
S
S
G
E
K
E
K
Q
D
Site 34
S245
E
K
Q
D
L
M
Q
S
L
A
K
L
Q
E
R
Site 35
S262
L
D
Q
N
I
G
R
S
E
P
D
L
R
C
S
Site 36
S269
S
E
P
D
L
R
C
S
P
V
N
S
H
L
C
Site 37
S273
L
R
C
S
P
V
N
S
H
L
C
L
S
R
Q
Site 38
S278
V
N
S
H
L
C
L
S
R
Q
T
L
D
A
G
Site 39
T281
H
L
C
L
S
R
Q
T
L
D
A
G
S
Q
T
Site 40
S286
R
Q
T
L
D
A
G
S
Q
T
S
I
S
G
D
Site 41
S289
L
D
A
G
S
Q
T
S
I
S
G
D
I
G
V
Site 42
S291
A
G
S
Q
T
S
I
S
G
D
I
G
V
R
S
Site 43
S298
S
G
D
I
G
V
R
S
R
S
N
L
A
E
K
Site 44
S300
D
I
G
V
R
S
R
S
N
L
A
E
K
V
R
Site 45
S309
L
A
E
K
V
R
L
S
L
Q
Y
E
E
A
K
Site 46
Y312
K
V
R
L
S
L
Q
Y
E
E
A
K
R
S
M
Site 47
S318
Q
Y
E
E
A
K
R
S
M
A
N
L
K
I
E
Site 48
S327
A
N
L
K
I
E
L
S
K
L
D
S
E
A
W
Site 49
S331
I
E
L
S
K
L
D
S
E
A
W
P
G
A
L
Site 50
T362
L
K
E
L
Q
F
V
T
P
Q
K
R
T
Q
D
Site 51
S387
R
L
E
E
E
L
L
S
V
R
G
T
P
S
R
Site 52
T391
E
L
L
S
V
R
G
T
P
S
R
A
L
A
E
Site 53
Y422
E
T
T
K
L
T
T
Y
L
H
S
Q
L
K
S
Site 54
S425
K
L
T
T
Y
L
H
S
Q
L
K
S
L
S
A
Site 55
S429
Y
L
H
S
Q
L
K
S
L
S
A
S
T
L
S
Site 56
S431
H
S
Q
L
K
S
L
S
A
S
T
L
S
M
S
Site 57
S433
Q
L
K
S
L
S
A
S
T
L
S
M
S
S
G
Site 58
T434
L
K
S
L
S
A
S
T
L
S
M
S
S
G
S
Site 59
S438
S
A
S
T
L
S
M
S
S
G
S
S
L
G
S
Site 60
S445
S
S
G
S
S
L
G
S
L
A
S
S
R
G
S
Site 61
S448
S
S
L
G
S
L
A
S
S
R
G
S
L
N
T
Site 62
S449
S
L
G
S
L
A
S
S
R
G
S
L
N
T
S
Site 63
S452
S
L
A
S
S
R
G
S
L
N
T
S
S
R
G
Site 64
T455
S
S
R
G
S
L
N
T
S
S
R
G
S
L
N
Site 65
S456
S
R
G
S
L
N
T
S
S
R
G
S
L
N
S
Site 66
S457
R
G
S
L
N
T
S
S
R
G
S
L
N
S
L
Site 67
S460
L
N
T
S
S
R
G
S
L
N
S
L
S
S
T
Site 68
S463
S
S
R
G
S
L
N
S
L
S
S
T
E
L
Y
Site 69
S465
R
G
S
L
N
S
L
S
S
T
E
L
Y
Y
S
Site 70
S466
G
S
L
N
S
L
S
S
T
E
L
Y
Y
S
S
Site 71
T467
S
L
N
S
L
S
S
T
E
L
Y
Y
S
S
Q
Site 72
Y470
S
L
S
S
T
E
L
Y
Y
S
S
Q
S
D
Q
Site 73
Y471
L
S
S
T
E
L
Y
Y
S
S
Q
S
D
Q
I
Site 74
S472
S
S
T
E
L
Y
Y
S
S
Q
S
D
Q
I
D
Site 75
S473
S
T
E
L
Y
Y
S
S
Q
S
D
Q
I
D
V
Site 76
Y482
S
D
Q
I
D
V
D
Y
Q
Y
K
L
D
F
L
Site 77
Y484
Q
I
D
V
D
Y
Q
Y
K
L
D
F
L
L
Q
Site 78
S494
D
F
L
L
Q
E
K
S
G
Y
I
P
S
G
P
Site 79
Y496
L
L
Q
E
K
S
G
Y
I
P
S
G
P
I
T
Site 80
S499
E
K
S
G
Y
I
P
S
G
P
I
T
T
I
H
Site 81
T503
Y
I
P
S
G
P
I
T
T
I
H
E
N
E
V
Site 82
S513
H
E
N
E
V
V
K
S
P
S
Q
P
G
Q
S
Site 83
S515
N
E
V
V
K
S
P
S
Q
P
G
Q
S
G
L
Site 84
T533
A
A
A
A
T
G
H
T
P
P
L
A
E
A
P
Site 85
S542
P
L
A
E
A
P
K
S
V
A
S
L
S
S
R
Site 86
S545
E
A
P
K
S
V
A
S
L
S
S
R
S
S
L
Site 87
S547
P
K
S
V
A
S
L
S
S
R
S
S
L
S
S
Site 88
S548
K
S
V
A
S
L
S
S
R
S
S
L
S
S
L
Site 89
S550
V
A
S
L
S
S
R
S
S
L
S
S
L
S
P
Site 90
S551
A
S
L
S
S
R
S
S
L
S
S
L
S
P
P
Site 91
S553
L
S
S
R
S
S
L
S
S
L
S
P
P
G
S
Site 92
S554
S
S
R
S
S
L
S
S
L
S
P
P
G
S
P
Site 93
S556
R
S
S
L
S
S
L
S
P
P
G
S
P
L
V
Site 94
S560
S
S
L
S
P
P
G
S
P
L
V
L
E
G
T
Site 95
T567
S
P
L
V
L
E
G
T
F
P
M
S
S
S
H
Site 96
S571
L
E
G
T
F
P
M
S
S
S
H
D
A
S
L
Site 97
S572
E
G
T
F
P
M
S
S
S
H
D
A
S
L
H
Site 98
S573
G
T
F
P
M
S
S
S
H
D
A
S
L
H
Q
Site 99
S577
M
S
S
S
H
D
A
S
L
H
Q
F
T
A
D
Site 100
S591
D
F
E
D
C
E
L
S
S
H
F
A
D
I
S
Site 101
S608
E
N
Q
I
L
L
D
S
D
S
G
G
A
S
Q
Site 102
S610
Q
I
L
L
D
S
D
S
G
G
A
S
Q
S
L
Site 103
S614
D
S
D
S
G
G
A
S
Q
S
L
S
E
D
K
Site 104
S616
D
S
G
G
A
S
Q
S
L
S
E
D
K
D
L
Site 105
S618
G
G
A
S
Q
S
L
S
E
D
K
D
L
N
E
Site 106
Y632
E
C
A
R
E
P
L
Y
E
G
T
A
D
V
E
Site 107
S641
G
T
A
D
V
E
K
S
L
P
K
R
R
V
I
Site 108
S659
G
E
K
T
T
C
V
S
A
A
V
S
D
E
S
Site 109
S663
T
C
V
S
A
A
V
S
D
E
S
V
A
G
D
Site 110
S666
S
A
A
V
S
D
E
S
V
A
G
D
S
G
V
Site 111
S682
E
A
F
V
K
Q
P
S
E
M
E
D
V
T
Y
Site 112
T688
P
S
E
M
E
D
V
T
Y
S
E
E
D
V
A
Site 113
Y689
S
E
M
E
D
V
T
Y
S
E
E
D
V
A
I
Site 114
S690
E
M
E
D
V
T
Y
S
E
E
D
V
A
I
V
Site 115
Y708
Q
V
Q
I
G
L
R
Y
N
A
K
S
S
S
F
Site 116
S714
R
Y
N
A
K
S
S
S
F
M
V
I
I
A
Q
Site 117
Y737
I
P
H
T
S
K
V
Y
F
R
V
A
V
L
P
Site 118
T761
R
T
K
V
H
P
P
T
E
S
I
L
F
N
D
Site 119
S775
D
V
F
R
V
A
I
S
Q
T
A
L
Q
Q
K
Site 120
T783
Q
T
A
L
Q
Q
K
T
L
R
V
D
L
C
S
Site 121
S790
T
L
R
V
D
L
C
S
V
S
K
H
R
R
E
Site 122
S792
R
V
D
L
C
S
V
S
K
H
R
R
E
E
C
Site 123
Y821
S
E
V
F
T
L
W
Y
N
L
L
P
S
K
Q
Site 124
S840
K
N
E
E
N
E
D
S
V
F
Q
P
N
Q
P
Site 125
S883
A
Q
E
E
E
E
E
S
G
Q
E
E
P
R
G
Site 126
T897
G
P
D
G
D
W
L
T
M
L
R
E
A
S
D
Site 127
S903
L
T
M
L
R
E
A
S
D
E
I
V
A
E
K
Site 128
S920
E
V
K
L
P
E
D
S
S
C
T
E
D
L
S
Site 129
S921
V
K
L
P
E
D
S
S
C
T
E
D
L
S
S
Site 130
S927
S
S
C
T
E
D
L
S
S
C
T
S
V
P
E
Site 131
S928
S
C
T
E
D
L
S
S
C
T
S
V
P
E
M
Site 132
S931
E
D
L
S
S
C
T
S
V
P
E
M
N
E
D
Site 133
S944
E
D
G
N
R
K
E
S
N
C
A
K
D
L
R
Site 134
S952
N
C
A
K
D
L
R
S
Q
P
P
T
R
I
P
Site 135
T956
D
L
R
S
Q
P
P
T
R
I
P
T
L
V
D
Site 136
T960
Q
P
P
T
R
I
P
T
L
V
D
K
E
T
N
Site 137
T966
P
T
L
V
D
K
E
T
N
T
D
E
A
A
N
Site 138
S984
A
V
R
P
K
E
R
S
S
L
S
S
R
Q
H
Site 139
S985
V
R
P
K
E
R
S
S
L
S
S
R
Q
H
P
Site 140
S987
P
K
E
R
S
S
L
S
S
R
Q
H
P
F
V
Site 141
S988
K
E
R
S
S
L
S
S
R
Q
H
P
F
V
R
Site 142
S997
Q
H
P
F
V
R
S
S
V
I
V
R
S
Q
T
Site 143
S1002
R
S
S
V
I
V
R
S
Q
T
F
S
P
G
E
Site 144
T1004
S
V
I
V
R
S
Q
T
F
S
P
G
E
R
N
Site 145
S1006
I
V
R
S
Q
T
F
S
P
G
E
R
N
Q
Y
Site 146
Y1013
S
P
G
E
R
N
Q
Y
I
C
R
L
N
R
S
Site 147
S1020
Y
I
C
R
L
N
R
S
D
S
D
S
S
T
L
Site 148
S1022
C
R
L
N
R
S
D
S
D
S
S
T
L
A
K
Site 149
S1024
L
N
R
S
D
S
D
S
S
T
L
A
K
K
S
Site 150
S1025
N
R
S
D
S
D
S
S
T
L
A
K
K
S
L
Site 151
T1026
R
S
D
S
D
S
S
T
L
A
K
K
S
L
F
Site 152
S1031
S
S
T
L
A
K
K
S
L
F
V
R
N
S
T
Site 153
S1037
K
S
L
F
V
R
N
S
T
E
R
R
S
L
R
Site 154
T1038
S
L
F
V
R
N
S
T
E
R
R
S
L
R
V
Site 155
S1042
R
N
S
T
E
R
R
S
L
R
V
K
R
T
V
Site 156
T1048
R
S
L
R
V
K
R
T
V
C
Q
S
V
L
R
Site 157
S1052
V
K
R
T
V
C
Q
S
V
L
R
R
T
T
Q
Site 158
T1057
C
Q
S
V
L
R
R
T
T
Q
E
C
P
V
R
Site 159
T1058
Q
S
V
L
R
R
T
T
Q
E
C
P
V
R
T
Site 160
S1066
Q
E
C
P
V
R
T
S
L
D
L
E
L
D
L
Site 161
S1076
L
E
L
D
L
Q
A
S
L
T
R
Q
S
R
L
Site 162
T1078
L
D
L
Q
A
S
L
T
R
Q
S
R
L
N
D
Site 163
S1081
Q
A
S
L
T
R
Q
S
R
L
N
D
E
L
Q
Site 164
S1150
E
K
L
M
R
Q
V
S
K
D
V
C
R
L
R
Site 165
S1160
V
C
R
L
R
E
Q
S
Q
K
V
P
R
Q
V
Site 166
S1169
K
V
P
R
Q
V
Q
S
F
R
E
K
I
A
Y
Site 167
Y1176
S
F
R
E
K
I
A
Y
F
T
R
A
K
I
S
Site 168
S1183
Y
F
T
R
A
K
I
S
I
P
S
L
P
A
D
Site 169
S1186
R
A
K
I
S
I
P
S
L
P
A
D
D
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation