KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TRIM68
Full Name:
E3 ubiquitin-protein ligase TRIM68
Alias:
RING finger protein 137;SSA protein SS-56;Tripartite motif-containing protein 68
Type:
Mass (Da):
56259
Number AA:
485
UniProt ID:
Q6AZZ1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
T
F
L
R
E
P
M
S
I
D
C
G
H
S
F
Site 2
Y55
G
E
S
Q
N
W
G
Y
T
C
P
L
C
R
A
Site 3
S121
L
I
M
C
E
A
C
S
Q
S
P
E
H
E
A
Site 4
S123
M
C
E
A
C
S
Q
S
P
E
H
E
A
H
S
Site 5
S130
S
P
E
H
E
A
H
S
V
V
P
M
E
D
V
Site 6
T170
E
V
G
E
R
K
R
T
A
T
W
K
I
Q
V
Site 7
T172
G
E
R
K
R
T
A
T
W
K
I
Q
V
E
T
Site 8
S183
Q
V
E
T
R
K
Q
S
I
V
W
E
F
E
K
Site 9
Y191
I
V
W
E
F
E
K
Y
Q
R
L
L
E
K
K
Site 10
T223
L
Q
R
E
A
A
E
T
M
Q
K
L
E
L
N
Site 11
S232
Q
K
L
E
L
N
H
S
E
L
I
Q
Q
S
Q
Site 12
S238
H
S
E
L
I
Q
Q
S
Q
V
L
W
R
M
I
Site 13
S252
I
A
E
L
K
E
R
S
Q
R
P
V
R
W
M
Site 14
S270
I
Q
E
V
L
N
R
S
K
S
W
S
L
Q
Q
Site 15
S272
E
V
L
N
R
S
K
S
W
S
L
Q
Q
P
E
Site 16
S274
L
N
R
S
K
S
W
S
L
Q
Q
P
E
P
I
Site 17
S282
L
Q
Q
P
E
P
I
S
L
E
L
K
T
D
C
Site 18
T311
D
V
R
L
D
P
D
T
A
Y
S
R
L
I
V
Site 19
Y313
R
L
D
P
D
T
A
Y
S
R
L
I
V
S
E
Site 20
S319
A
Y
S
R
L
I
V
S
E
D
R
K
R
V
H
Site 21
Y327
E
D
R
K
R
V
H
Y
G
D
T
N
Q
K
L
Site 22
T330
K
R
V
H
Y
G
D
T
N
Q
K
L
P
D
N
Site 23
Y342
P
D
N
P
E
R
F
Y
R
Y
N
I
V
L
G
Site 24
Y344
N
P
E
R
F
Y
R
Y
N
I
V
L
G
S
Q
Site 25
S350
R
Y
N
I
V
L
G
S
Q
C
I
S
S
G
R
Site 26
Y359
C
I
S
S
G
R
H
Y
W
E
V
E
V
G
D
Site 27
S368
E
V
E
V
G
D
R
S
E
W
G
L
G
V
C
Site 28
Y386
V
D
R
K
E
V
V
Y
L
S
P
H
Y
G
F
Site 29
S388
R
K
E
V
V
Y
L
S
P
H
Y
G
F
W
V
Site 30
Y404
R
L
R
K
G
N
E
Y
R
A
G
T
D
E
Y
Site 31
T408
G
N
E
Y
R
A
G
T
D
E
Y
P
I
L
S
Site 32
Y411
Y
R
A
G
T
D
E
Y
P
I
L
S
L
P
V
Site 33
S415
T
D
E
Y
P
I
L
S
L
P
V
P
P
R
R
Site 34
Y437
E
A
H
D
I
S
F
Y
N
V
T
D
C
G
S
Site 35
T448
D
C
G
S
H
I
F
T
F
P
R
Y
P
F
P
Site 36
Y466
L
P
Y
F
S
P
C
Y
S
I
G
T
N
N
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation