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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KDM4D
Full Name:
Lysine-specific demethylase 4D
Alias:
JmjC domain-containing histone demethylation protein 3D;Jumonji domain-containing protein 2D
Type:
Mass (Da):
58603
Number AA:
523
UniProt ID:
Q6B0I6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y34
E
F
N
D
F
D
K
Y
I
A
Y
M
E
S
Q
Site 2
Y37
D
F
D
K
Y
I
A
Y
M
E
S
Q
G
A
H
Site 3
S40
K
Y
I
A
Y
M
E
S
Q
G
A
H
R
A
G
Site 4
T62
K
E
W
K
A
R
E
T
Y
D
N
I
S
E
I
Site 5
Y63
E
W
K
A
R
E
T
Y
D
N
I
S
E
I
L
Site 6
T87
S
G
R
A
G
V
F
T
Q
Y
H
K
K
K
K
Site 7
Y89
R
A
G
V
F
T
Q
Y
H
K
K
K
K
A
M
Site 8
T97
H
K
K
K
K
A
M
T
V
G
E
Y
R
H
L
Site 9
S107
E
Y
R
H
L
A
N
S
K
K
Y
Q
T
P
P
Site 10
Y110
H
L
A
N
S
K
K
Y
Q
T
P
P
H
Q
N
Site 11
T112
A
N
S
K
K
Y
Q
T
P
P
H
Q
N
F
E
Site 12
Y125
F
E
D
L
E
R
K
Y
W
K
N
R
I
Y
N
Site 13
Y131
K
Y
W
K
N
R
I
Y
N
S
P
I
Y
G
A
Site 14
Y136
R
I
Y
N
S
P
I
Y
G
A
D
I
S
G
S
Site 15
S141
P
I
Y
G
A
D
I
S
G
S
L
F
D
E
N
Site 16
S143
Y
G
A
D
I
S
G
S
L
F
D
E
N
T
K
Site 17
Y179
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
Site 18
Y181
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
Site 19
Y199
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
L
Site 20
Y203
M
D
L
Y
S
I
N
Y
L
H
L
G
E
P
K
Site 21
T211
L
H
L
G
E
P
K
T
W
Y
V
V
P
P
E
Site 22
Y213
L
G
E
P
K
T
W
Y
V
V
P
P
E
H
G
Site 23
S234
A
R
E
L
F
P
G
S
S
R
G
C
G
A
F
Site 24
S250
R
H
K
V
A
L
I
S
P
T
V
L
K
E
N
Site 25
T265
G
I
P
F
N
R
I
T
Q
E
A
G
E
F
M
Site 26
T274
E
A
G
E
F
M
V
T
F
P
Y
G
Y
H
A
Site 27
T297
A
E
A
I
N
F
A
T
P
R
W
I
D
Y
G
Site 28
Y303
A
T
P
R
W
I
D
Y
G
K
M
A
S
Q
C
Site 29
Y333
R
I
L
Q
P
E
R
Y
D
L
W
K
R
G
Q
Site 30
S355
M
E
P
R
V
P
A
S
Q
E
L
S
T
Q
K
Site 31
S359
V
P
A
S
Q
E
L
S
T
Q
K
E
V
Q
L
Site 32
S379
L
G
L
R
Q
L
P
S
H
W
A
R
H
S
P
Site 33
S385
P
S
H
W
A
R
H
S
P
W
P
M
A
A
R
Site 34
T399
R
S
G
T
R
C
H
T
L
V
C
S
S
L
P
Site 35
S403
R
C
H
T
L
V
C
S
S
L
P
R
R
S
A
Site 36
S409
C
S
S
L
P
R
R
S
A
V
S
G
T
A
T
Site 37
S412
L
P
R
R
S
A
V
S
G
T
A
T
Q
P
R
Site 38
S426
R
A
A
A
V
H
S
S
K
K
P
S
S
T
P
Site 39
S430
V
H
S
S
K
K
P
S
S
T
P
S
S
T
P
Site 40
S431
H
S
S
K
K
P
S
S
T
P
S
S
T
P
G
Site 41
T432
S
S
K
K
P
S
S
T
P
S
S
T
P
G
P
Site 42
S434
K
K
P
S
S
T
P
S
S
T
P
G
P
S
A
Site 43
S435
K
P
S
S
T
P
S
S
T
P
G
P
S
A
Q
Site 44
T436
P
S
S
T
P
S
S
T
P
G
P
S
A
Q
I
Site 45
S440
P
S
S
T
P
G
P
S
A
Q
I
I
H
P
S
Site 46
S447
S
A
Q
I
I
H
P
S
N
G
R
R
G
R
G
Site 47
T466
K
L
R
A
Q
E
L
T
L
Q
T
P
A
K
R
Site 48
T469
A
Q
E
L
T
L
Q
T
P
A
K
R
P
L
L
Site 49
T480
R
P
L
L
A
G
T
T
C
T
A
S
G
P
E
Site 50
S505
M
D
K
P
V
P
L
S
P
G
L
Q
H
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation