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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NXN
Full Name:
Nucleoredoxin
Alias:
EC 1.8.1.8; NRX; Nucleoredoxin; TRG-4
Type:
Mass (Da):
48392
Number AA:
435
UniProt ID:
Q6DKJ4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0047134
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0045454
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
L
L
G
E
K
L
V
T
G
G
G
E
E
V
D
Site 2
S25
G
E
E
V
D
V
H
S
L
G
A
R
G
I
S
Site 3
Y57
S
A
S
L
A
A
F
Y
G
R
L
R
G
D
A
Site 4
S93
L
E
I
V
F
V
S
S
D
Q
D
Q
R
Q
W
Site 5
S185
L
L
R
N
N
G
Q
S
L
E
S
S
S
L
E
Site 6
S188
N
N
G
Q
S
L
E
S
S
S
L
E
G
S
H
Site 7
S189
N
G
Q
S
L
E
S
S
S
L
E
G
S
H
V
Site 8
S190
G
Q
S
L
E
S
S
S
L
E
G
S
H
V
G
Site 9
S194
E
S
S
S
L
E
G
S
H
V
G
V
Y
F
S
Site 10
Y199
E
G
S
H
V
G
V
Y
F
S
A
H
W
C
P
Site 11
S210
H
W
C
P
P
C
R
S
L
T
R
V
L
V
E
Site 12
T212
C
P
P
C
R
S
L
T
R
V
L
V
E
S
Y
Site 13
S218
L
T
R
V
L
V
E
S
Y
R
K
I
K
E
A
Site 14
S235
N
F
E
I
I
F
V
S
A
D
R
S
E
E
S
Site 15
S239
I
F
V
S
A
D
R
S
E
E
S
F
K
Q
Y
Site 16
S242
S
A
D
R
S
E
E
S
F
K
Q
Y
F
S
E
Site 17
Y246
S
E
E
S
F
K
Q
Y
F
S
E
M
P
W
L
Site 18
T258
P
W
L
A
V
P
Y
T
D
E
A
R
R
S
R
Site 19
S264
Y
T
D
E
A
R
R
S
R
L
N
R
L
Y
G
Site 20
Y270
R
S
R
L
N
R
L
Y
G
I
Q
G
I
P
T
Site 21
S316
P
K
P
V
L
E
L
S
D
S
N
A
A
Q
L
Site 22
S318
P
V
L
E
L
S
D
S
N
A
A
Q
L
N
E
Site 23
S335
C
L
V
L
F
V
D
S
E
D
D
G
E
S
E
Site 24
T379
V
A
G
E
D
D
M
T
D
S
L
R
D
Y
T
Site 25
S381
G
E
D
D
M
T
D
S
L
R
D
Y
T
N
L
Site 26
Y385
M
T
D
S
L
R
D
Y
T
N
L
P
E
A
A
Site 27
T386
T
D
S
L
R
D
Y
T
N
L
P
E
A
A
P
Site 28
S401
L
L
T
I
L
D
M
S
A
R
A
K
Y
V
M
Site 29
Y406
D
M
S
A
R
A
K
Y
V
M
D
V
E
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation