KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IQSEC1
Full Name:
IQ motif and SEC7 domain-containing protein 1
Alias:
ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARFGEP100; BRAG2; Brefeldin-resistant Arf-GEF 2 protein; IQ motif and Sec7 domain 1; IQ motif and Sec7 domain-containing protein 1; IQEC1; KIAA0763
Type:
Uncharacterized protein
Mass (Da):
108314
Number AA:
963
UniProt ID:
Q6DN90
International Prot ID:
IPI00457114
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005086
PhosphoSite+
KinaseNET
Biological Process:
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
C
N
S
E
R
T
Q
S
L
L
E
L
E
L
D
Site 2
S21
L
L
E
L
E
L
D
S
G
V
E
G
E
A
P
Site 3
S30
V
E
G
E
A
P
S
S
E
T
G
T
S
L
D
Site 4
T34
A
P
S
S
E
T
G
T
S
L
D
S
P
S
A
Site 5
S35
P
S
S
E
T
G
T
S
L
D
S
P
S
A
Y
Site 6
S38
E
T
G
T
S
L
D
S
P
S
A
Y
P
Q
G
Site 7
S40
G
T
S
L
D
S
P
S
A
Y
P
Q
G
P
L
Site 8
Y42
S
L
D
S
P
S
A
Y
P
Q
G
P
L
V
P
Site 9
S51
Q
G
P
L
V
P
G
S
S
L
S
P
D
H
Y
Site 10
S52
G
P
L
V
P
G
S
S
L
S
P
D
H
Y
E
Site 11
S54
L
V
P
G
S
S
L
S
P
D
H
Y
E
H
T
Site 12
Y58
S
S
L
S
P
D
H
Y
E
H
T
S
V
G
A
Site 13
Y66
E
H
T
S
V
G
A
Y
G
L
Y
S
G
P
P
Site 14
Y69
S
V
G
A
Y
G
L
Y
S
G
P
P
G
Q
Q
Site 15
S70
V
G
A
Y
G
L
Y
S
G
P
P
G
Q
Q
Q
Site 16
T79
P
P
G
Q
Q
Q
R
T
R
R
P
K
L
Q
H
Site 17
S87
R
R
P
K
L
Q
H
S
T
S
I
L
R
K
Q
Site 18
T88
R
P
K
L
Q
H
S
T
S
I
L
R
K
Q
A
Site 19
S89
P
K
L
Q
H
S
T
S
I
L
R
K
Q
A
E
Site 20
S103
E
E
E
A
I
K
R
S
R
S
L
S
E
S
Y
Site 21
S105
E
A
I
K
R
S
R
S
L
S
E
S
Y
E
L
Site 22
S107
I
K
R
S
R
S
L
S
E
S
Y
E
L
S
S
Site 23
S109
R
S
R
S
L
S
E
S
Y
E
L
S
S
D
L
Site 24
Y110
S
R
S
L
S
E
S
Y
E
L
S
S
D
L
Q
Site 25
S113
L
S
E
S
Y
E
L
S
S
D
L
Q
D
K
Q
Site 26
Y128
V
E
M
L
E
R
K
Y
G
G
R
L
V
T
R
Site 27
T134
K
Y
G
G
R
L
V
T
R
H
A
A
R
T
I
Site 28
T140
V
T
R
H
A
A
R
T
I
Q
T
A
F
R
Q
Site 29
Y148
I
Q
T
A
F
R
Q
Y
Q
M
N
K
N
F
E
Site 30
S159
K
N
F
E
R
L
R
S
S
M
S
E
N
R
M
Site 31
S160
N
F
E
R
L
R
S
S
M
S
E
N
R
M
S
Site 32
S162
E
R
L
R
S
S
M
S
E
N
R
M
S
R
R
Site 33
S167
S
M
S
E
N
R
M
S
R
R
I
V
L
S
N
Site 34
S173
M
S
R
R
I
V
L
S
N
M
R
M
Q
F
S
Site 35
S180
S
N
M
R
M
Q
F
S
F
E
G
P
E
K
V
Site 36
S189
E
G
P
E
K
V
H
S
S
Y
F
E
G
K
Q
Site 37
Y191
P
E
K
V
H
S
S
Y
F
E
G
K
Q
V
S
Site 38
S198
Y
F
E
G
K
Q
V
S
V
T
N
D
G
S
Q
Site 39
T200
E
G
K
Q
V
S
V
T
N
D
G
S
Q
L
G
Site 40
S204
V
S
V
T
N
D
G
S
Q
L
G
A
L
V
S
Site 41
S218
S
P
E
C
G
D
L
S
E
P
T
T
L
K
S
Site 42
T221
C
G
D
L
S
E
P
T
T
L
K
S
P
A
P
Site 43
T222
G
D
L
S
E
P
T
T
L
K
S
P
A
P
S
Site 44
S225
S
E
P
T
T
L
K
S
P
A
P
S
S
D
F
Site 45
S229
T
L
K
S
P
A
P
S
S
D
F
A
D
A
I
Site 46
S230
L
K
S
P
A
P
S
S
D
F
A
D
A
I
T
Site 47
S244
T
E
L
E
D
A
F
S
R
Q
V
K
S
L
A
Site 48
S249
A
F
S
R
Q
V
K
S
L
A
E
S
I
D
D
Site 49
S253
Q
V
K
S
L
A
E
S
I
D
D
A
L
N
C
Site 50
S262
D
D
A
L
N
C
R
S
L
H
T
E
E
A
P
Site 51
T279
D
A
A
R
A
R
D
T
E
P
Q
T
A
L
H
Site 52
T297
H
R
K
L
D
E
M
T
A
S
Y
S
D
V
T
Site 53
S299
K
L
D
E
M
T
A
S
Y
S
D
V
T
L
Y
Site 54
S301
D
E
M
T
A
S
Y
S
D
V
T
L
Y
I
D
Site 55
Y306
S
Y
S
D
V
T
L
Y
I
D
E
E
E
L
S
Site 56
S313
Y
I
D
E
E
E
L
S
P
P
L
P
L
S
Q
Site 57
S319
L
S
P
P
L
P
L
S
Q
A
G
D
R
P
S
Site 58
S326
S
Q
A
G
D
R
P
S
S
T
E
S
D
L
R
Site 59
S327
Q
A
G
D
R
P
S
S
T
E
S
D
L
R
L
Site 60
T328
A
G
D
R
P
S
S
T
E
S
D
L
R
L
R
Site 61
S330
D
R
P
S
S
T
E
S
D
L
R
L
R
A
G
Site 62
Y343
A
G
G
A
A
P
D
Y
W
A
L
A
H
K
E
Site 63
T355
H
K
E
D
K
A
D
T
D
T
S
C
R
S
T
Site 64
T357
E
D
K
A
D
T
D
T
S
C
R
S
T
P
S
Site 65
S358
D
K
A
D
T
D
T
S
C
R
S
T
P
S
L
Site 66
S361
D
T
D
T
S
C
R
S
T
P
S
L
E
R
Q
Site 67
T362
T
D
T
S
C
R
S
T
P
S
L
E
R
Q
E
Site 68
S364
T
S
C
R
S
T
P
S
L
E
R
Q
E
Q
R
Site 69
T381
V
E
H
L
P
L
L
T
I
E
P
P
S
D
S
Site 70
S386
L
L
T
I
E
P
P
S
D
S
S
V
D
L
S
Site 71
S388
T
I
E
P
P
S
D
S
S
V
D
L
S
D
R
Site 72
S389
I
E
P
P
S
D
S
S
V
D
L
S
D
R
S
Site 73
S393
S
D
S
S
V
D
L
S
D
R
S
E
R
G
S
Site 74
S396
S
V
D
L
S
D
R
S
E
R
G
S
L
K
R
Site 75
S400
S
D
R
S
E
R
G
S
L
K
R
Q
S
A
Y
Site 76
S405
R
G
S
L
K
R
Q
S
A
Y
E
R
S
L
G
Site 77
Y407
S
L
K
R
Q
S
A
Y
E
R
S
L
G
G
Q
Site 78
S410
R
Q
S
A
Y
E
R
S
L
G
G
Q
Q
G
S
Site 79
S417
S
L
G
G
Q
Q
G
S
P
K
H
G
P
H
S
Site 80
S424
S
P
K
H
G
P
H
S
G
A
P
K
S
L
P
Site 81
S429
P
H
S
G
A
P
K
S
L
P
R
E
E
P
E
Site 82
S447
R
P
P
R
P
L
D
S
H
L
A
I
N
G
S
Site 83
S454
S
H
L
A
I
N
G
S
A
N
R
Q
S
K
S
Site 84
S459
N
G
S
A
N
R
Q
S
K
S
E
S
D
Y
S
Site 85
S461
S
A
N
R
Q
S
K
S
E
S
D
Y
S
D
G
Site 86
S463
N
R
Q
S
K
S
E
S
D
Y
S
D
G
D
N
Site 87
Y465
Q
S
K
S
E
S
D
Y
S
D
G
D
N
D
S
Site 88
S466
S
K
S
E
S
D
Y
S
D
G
D
N
D
S
I
Site 89
S472
Y
S
D
G
D
N
D
S
I
N
S
T
S
N
S
Site 90
S475
G
D
N
D
S
I
N
S
T
S
N
S
N
D
T
Site 91
T476
D
N
D
S
I
N
S
T
S
N
S
N
D
T
I
Site 92
S479
S
I
N
S
T
S
N
S
N
D
T
I
N
C
S
Site 93
T482
S
T
S
N
S
N
D
T
I
N
C
S
S
E
S
Site 94
S486
S
N
D
T
I
N
C
S
S
E
S
S
S
R
D
Site 95
S487
N
D
T
I
N
C
S
S
E
S
S
S
R
D
S
Site 96
S489
T
I
N
C
S
S
E
S
S
S
R
D
S
L
R
Site 97
S490
I
N
C
S
S
E
S
S
S
R
D
S
L
R
E
Site 98
S491
N
C
S
S
E
S
S
S
R
D
S
L
R
E
Q
Site 99
S494
S
E
S
S
S
R
D
S
L
R
E
Q
T
L
S
Site 100
T499
R
D
S
L
R
E
Q
T
L
S
K
Q
T
Y
H
Site 101
S501
S
L
R
E
Q
T
L
S
K
Q
T
Y
H
K
E
Site 102
S512
Y
H
K
E
A
R
N
S
W
D
S
P
A
F
S
Site 103
S515
E
A
R
N
S
W
D
S
P
A
F
S
N
D
V
Site 104
S519
S
W
D
S
P
A
F
S
N
D
V
I
R
K
R
Site 105
Y528
D
V
I
R
K
R
H
Y
R
I
G
L
N
L
F
Site 106
Y545
K
P
E
K
G
V
Q
Y
L
I
E
R
G
F
V
Site 107
S600
V
V
D
E
M
D
F
S
T
M
E
L
D
E
A
Site 108
Y667
I
L
L
N
T
D
M
Y
S
P
N
V
K
P
E
Site 109
S668
L
L
N
T
D
M
Y
S
P
N
V
K
P
E
R
Site 110
Y704
R
E
M
L
M
G
I
Y
E
R
I
R
K
R
E
Site 111
S720
K
T
N
E
D
H
V
S
Q
V
Q
K
V
E
K
Site 112
S737
V
G
K
K
P
I
G
S
L
H
P
G
L
G
C
Site 113
Y756
P
H
R
R
L
V
C
Y
C
R
L
F
E
V
P
Site 114
S797
I
F
Q
K
K
K
N
S
V
T
Y
S
F
R
Q
Site 115
S801
K
K
N
S
V
T
Y
S
F
R
Q
S
F
S
L
Site 116
S805
V
T
Y
S
F
R
Q
S
F
S
L
Y
G
M
Q
Site 117
S807
Y
S
F
R
Q
S
F
S
L
Y
G
M
Q
V
L
Site 118
Y820
V
L
L
F
E
N
Q
Y
Y
P
N
G
I
R
L
Site 119
Y821
L
L
F
E
N
Q
Y
Y
P
N
G
I
R
L
T
Site 120
T828
Y
P
N
G
I
R
L
T
S
S
V
P
G
A
D
Site 121
S829
P
N
G
I
R
L
T
S
S
V
P
G
A
D
I
Site 122
S830
N
G
I
R
L
T
S
S
V
P
G
A
D
I
K
Site 123
S860
F
T
D
D
L
R
E
S
I
A
E
V
Q
E
M
Site 124
S874
M
E
K
H
R
I
E
S
E
L
E
K
Q
K
G
Site 125
S886
Q
K
G
V
V
R
P
S
M
S
Q
C
S
S
L
Site 126
S888
G
V
V
R
P
S
M
S
Q
C
S
S
L
K
K
Site 127
S891
R
P
S
M
S
Q
C
S
S
L
K
K
E
S
G
Site 128
S892
P
S
M
S
Q
C
S
S
L
K
K
E
S
G
N
Site 129
S897
C
S
S
L
K
K
E
S
G
N
G
T
L
S
R
Site 130
T901
K
K
E
S
G
N
G
T
L
S
R
A
C
L
D
Site 131
S903
E
S
G
N
G
T
L
S
R
A
C
L
D
D
S
Site 132
S910
S
R
A
C
L
D
D
S
Y
A
S
G
E
G
L
Site 133
Y911
R
A
C
L
D
D
S
Y
A
S
G
E
G
L
K
Site 134
S920
S
G
E
G
L
K
R
S
A
L
S
S
S
L
R
Site 135
S923
G
L
K
R
S
A
L
S
S
S
L
R
D
L
S
Site 136
S924
L
K
R
S
A
L
S
S
S
L
R
D
L
S
E
Site 137
S925
K
R
S
A
L
S
S
S
L
R
D
L
S
E
A
Site 138
S930
S
S
S
L
R
D
L
S
E
A
G
K
R
G
R
Site 139
S939
A
G
K
R
G
R
R
S
S
A
G
S
L
E
S
Site 140
S940
G
K
R
G
R
R
S
S
A
G
S
L
E
S
N
Site 141
S943
G
R
R
S
S
A
G
S
L
E
S
N
V
E
F
Site 142
S946
S
S
A
G
S
L
E
S
N
V
E
F
Q
P
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation