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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DMPK2
Full Name:
Serine/threonine-protein kinase MRCK gamma
Alias:
EC 2.7.11.1; MRCKG; Myotonic dystrophy protein kinase like protein
Type:
Protein-serine kinase, AGC family. DMPK subfamily
Mass (Da):
172518
Number AA:
1551
UniProt ID:
Q6DT37
International Prot ID:
IPI00454910
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031252
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031532
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Myotonic dystrophy protein kinase 2; Serine-threonine-protein kinase MRCK gamma pan-specific antibody AB-NK265-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK265-1#Myotonic dystrophy protein kinase 2 / Serine-threonine-protein kinase MRCK gamma (M1-C19, human) peptide - Powder PE-01BCS80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BCS80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
L
A
L
H
H
E
L
S
S
G
P
L
R
R
E
Site 2
S46
G
P
L
R
R
E
R
S
V
A
Q
F
L
S
W
Site 3
S59
S
W
A
S
P
F
V
S
K
V
K
E
L
R
L
Site 4
T86
R
G
A
F
G
E
V
T
V
V
R
Q
R
D
T
Site 5
T93
T
V
V
R
Q
R
D
T
G
Q
I
F
A
M
K
Site 6
T113
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
Site 7
S128
D
V
L
V
K
G
D
S
R
W
V
T
T
L
H
Site 8
T132
K
G
D
S
R
W
V
T
T
L
H
Y
A
F
Q
Site 9
Y143
Y
A
F
Q
D
E
E
Y
L
Y
L
V
M
D
Y
Site 10
Y145
F
Q
D
E
E
Y
L
Y
L
V
M
D
Y
Y
A
Site 11
T158
Y
A
G
G
D
L
L
T
L
L
S
R
F
E
D
Site 12
S161
G
D
L
L
T
L
L
S
R
F
E
D
R
L
P
Site 13
Y191
H
S
L
H
Q
L
G
Y
V
H
R
D
V
K
P
Site 14
T222
G
S
C
L
R
L
N
T
N
G
M
V
D
S
S
Site 15
S228
N
T
N
G
M
V
D
S
S
V
A
V
G
T
P
Site 16
S229
T
N
G
M
V
D
S
S
V
A
V
G
T
P
D
Site 17
T234
D
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
Site 18
S239
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
Site 19
S280
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
Site 20
T284
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
Site 21
S307
D
V
P
D
V
P
A
S
A
Q
D
L
I
R
Q
Site 22
S347
V
D
W
E
R
L
A
S
S
T
A
P
Y
I
P
Site 23
T349
W
E
R
L
A
S
S
T
A
P
Y
I
P
E
L
Site 24
Y352
L
A
S
S
T
A
P
Y
I
P
E
L
R
G
P
Site 25
T362
E
L
R
G
P
M
D
T
S
N
F
D
V
D
D
Site 26
S363
L
R
G
P
M
D
T
S
N
F
D
V
D
D
D
Site 27
T371
N
F
D
V
D
D
D
T
L
N
H
P
G
T
L
Site 28
T377
D
T
L
N
H
P
G
T
L
P
P
P
S
H
G
Site 29
S382
P
G
T
L
P
P
P
S
H
G
A
F
S
G
H
Site 30
S387
P
P
S
H
G
A
F
S
G
H
H
L
P
F
V
Site 31
T397
H
L
P
F
V
G
F
T
Y
T
S
G
S
H
S
Site 32
Y398
L
P
F
V
G
F
T
Y
T
S
G
S
H
S
P
Site 33
S400
F
V
G
F
T
Y
T
S
G
S
H
S
P
E
S
Site 34
S402
G
F
T
Y
T
S
G
S
H
S
P
E
S
S
S
Site 35
S404
T
Y
T
S
G
S
H
S
P
E
S
S
S
E
A
Site 36
S407
S
G
S
H
S
P
E
S
S
S
E
A
W
A
A
Site 37
S408
G
S
H
S
P
E
S
S
S
E
A
W
A
A
L
Site 38
S409
S
H
S
P
E
S
S
S
E
A
W
A
A
L
E
Site 39
T455
Q
L
R
K
E
V
Q
T
L
R
D
R
L
P
E
Site 40
S469
E
M
L
R
D
K
A
S
L
S
Q
T
D
G
P
Site 41
S471
L
R
D
K
A
S
L
S
Q
T
D
G
P
P
A
Site 42
T473
D
K
A
S
L
S
Q
T
D
G
P
P
A
G
S
Site 43
S480
T
D
G
P
P
A
G
S
P
G
Q
D
S
D
L
Site 44
S485
A
G
S
P
G
Q
D
S
D
L
R
Q
E
L
D
Site 45
S538
E
R
E
A
A
T
A
S
Q
T
R
A
L
S
S
Site 46
S544
A
S
Q
T
R
A
L
S
S
Q
L
E
E
A
R
Site 47
S545
S
Q
T
R
A
L
S
S
Q
L
E
E
A
R
A
Site 48
S562
R
E
L
E
A
Q
V
S
S
L
S
R
Q
V
T
Site 49
S563
E
L
E
A
Q
V
S
S
L
S
R
Q
V
T
Q
Site 50
T569
S
S
L
S
R
Q
V
T
Q
L
Q
G
Q
W
E
Site 51
S583
E
Q
R
L
E
E
S
S
Q
A
K
T
I
H
T
Site 52
T587
E
E
S
S
Q
A
K
T
I
H
T
A
S
E
T
Site 53
S592
A
K
T
I
H
T
A
S
E
T
N
G
M
G
P
Site 54
S625
E
Q
L
E
Q
A
H
S
H
R
R
S
G
K
E
Site 55
S629
Q
A
H
S
H
R
R
S
G
K
E
E
A
L
C
Site 56
S646
Q
E
E
N
R
R
L
S
R
E
Q
E
R
L
E
Site 57
T673
L
E
G
E
R
R
E
T
E
S
N
W
E
A
Q
Site 58
S675
G
E
R
R
E
T
E
S
N
W
E
A
Q
L
A
Site 59
S686
A
Q
L
A
D
I
L
S
W
V
N
D
E
K
V
Site 60
Y697
D
E
K
V
S
R
G
Y
L
Q
A
L
A
T
K
Site 61
S711
K
M
A
E
E
L
E
S
L
R
N
V
G
T
Q
Site 62
T719
L
R
N
V
G
T
Q
T
L
P
A
R
P
L
D
Site 63
S740
R
L
Q
K
M
E
A
S
A
R
L
E
L
Q
S
Site 64
S747
S
A
R
L
E
L
Q
S
A
L
E
A
E
I
R
Site 65
T764
Q
G
L
Q
E
R
L
T
Q
V
Q
E
A
Q
L
Site 66
T806
R
A
R
G
P
V
D
T
K
P
S
N
S
L
I
Site 67
S809
G
P
V
D
T
K
P
S
N
S
L
I
P
F
L
Site 68
S817
N
S
L
I
P
F
L
S
F
R
S
S
E
K
D
Site 69
S820
I
P
F
L
S
F
R
S
S
E
K
D
S
A
K
Site 70
S821
P
F
L
S
F
R
S
S
E
K
D
S
A
K
D
Site 71
S825
F
R
S
S
E
K
D
S
A
K
D
P
G
I
S
Site 72
S832
S
A
K
D
P
G
I
S
G
E
A
T
R
H
G
Site 73
T836
P
G
I
S
G
E
A
T
R
H
G
G
E
P
D
Site 74
S851
L
R
P
E
G
R
R
S
L
R
M
G
A
V
F
Site 75
T863
A
V
F
P
R
A
P
T
A
N
T
A
S
T
E
Site 76
S868
A
P
T
A
N
T
A
S
T
E
G
L
P
A
K
Site 77
S878
G
L
P
A
K
P
G
S
H
T
L
R
P
R
S
Site 78
T880
P
A
K
P
G
S
H
T
L
R
P
R
S
F
P
Site 79
S885
S
H
T
L
R
P
R
S
F
P
S
P
T
K
C
Site 80
S888
L
R
P
R
S
F
P
S
P
T
K
C
L
R
C
Site 81
T890
P
R
S
F
P
S
P
T
K
C
L
R
C
T
S
Site 82
Y950
E
T
G
T
G
T
A
Y
E
G
F
L
S
V
P
Site 83
S955
T
A
Y
E
G
F
L
S
V
P
R
P
S
G
V
Site 84
S960
F
L
S
V
P
R
P
S
G
V
R
R
G
W
Q
Site 85
S989
D
A
P
D
L
R
L
S
P
P
S
G
A
L
L
Site 86
S1007
D
L
R
D
P
Q
F
S
A
T
P
V
L
A
S
Site 87
T1009
R
D
P
Q
F
S
A
T
P
V
L
A
S
D
V
Site 88
T1043
A
V
P
P
T
T
C
T
V
L
L
L
A
E
S
Site 89
S1050
T
V
L
L
L
A
E
S
E
G
E
R
E
R
W
Site 90
Y1079
R
P
R
P
R
P
V
Y
T
L
K
E
A
Y
D
Site 91
S1121
L
F
V
I
H
L
R
S
N
D
I
F
Q
V
G
Site 92
T1137
C
R
R
V
Q
Q
L
T
L
S
P
S
A
G
L
Site 93
Y1206
V
K
R
Q
V
L
C
Y
Q
L
G
P
G
P
G
Site 94
S1272
V
P
E
E
L
P
P
S
R
G
G
L
G
E
A
Site 95
S1308
V
D
G
A
G
R
K
S
R
G
H
E
L
L
W
Site 96
Y1328
G
W
G
Y
A
A
P
Y
L
T
V
F
S
E
N
Site 97
T1350
R
R
A
E
W
V
Q
T
V
P
L
K
K
V
R
Site 98
S1364
R
P
L
N
P
E
G
S
L
F
L
Y
G
T
E
Site 99
Y1368
P
E
G
S
L
F
L
Y
G
T
E
K
V
R
L
Site 100
T1370
G
S
L
F
L
Y
G
T
E
K
V
R
L
T
Y
Site 101
T1376
G
T
E
K
V
R
L
T
Y
L
R
N
Q
L
A
Site 102
Y1377
T
E
K
V
R
L
T
Y
L
R
N
Q
L
A
E
Site 103
T1394
E
F
D
I
P
D
L
T
D
N
S
R
R
Q
L
Site 104
S1397
I
P
D
L
T
D
N
S
R
R
Q
L
F
R
T
Site 105
T1404
S
R
R
Q
L
F
R
T
K
S
K
R
R
F
F
Site 106
S1406
R
Q
L
F
R
T
K
S
K
R
R
F
F
F
R
Site 107
S1415
R
R
F
F
F
R
V
S
E
E
Q
Q
K
Q
Q
Site 108
S1434
L
K
D
P
F
V
R
S
K
L
I
S
P
P
T
Site 109
S1438
F
V
R
S
K
L
I
S
P
P
T
N
F
N
H
Site 110
T1441
S
K
L
I
S
P
P
T
N
F
N
H
L
V
H
Site 111
S1462
R
P
G
A
R
D
K
S
P
A
P
E
E
K
G
Site 112
S1475
K
G
R
V
A
R
G
S
G
P
Q
R
P
H
S
Site 113
S1482
S
G
P
Q
R
P
H
S
F
S
E
A
L
R
R
Site 114
S1484
P
Q
R
P
H
S
F
S
E
A
L
R
R
P
A
Site 115
S1492
E
A
L
R
R
P
A
S
M
G
S
E
G
L
G
Site 116
T1511
P
M
K
R
K
P
W
T
S
L
S
S
E
S
V
Site 117
S1512
M
K
R
K
P
W
T
S
L
S
S
E
S
V
S
Site 118
S1514
R
K
P
W
T
S
L
S
S
E
S
V
S
C
P
Site 119
S1515
K
P
W
T
S
L
S
S
E
S
V
S
C
P
Q
Site 120
S1517
W
T
S
L
S
S
E
S
V
S
C
P
Q
G
S
Site 121
S1519
S
L
S
S
E
S
V
S
C
P
Q
G
S
L
S
Site 122
S1524
S
V
S
C
P
Q
G
S
L
S
P
A
T
S
L
Site 123
S1526
S
C
P
Q
G
S
L
S
P
A
T
S
L
M
Q
Site 124
S1530
G
S
L
S
P
A
T
S
L
M
Q
V
S
E
R
Site 125
S1535
A
T
S
L
M
Q
V
S
E
R
P
R
S
L
P
Site 126
S1540
Q
V
S
E
R
P
R
S
L
P
L
S
P
E
L
Site 127
S1544
R
P
R
S
L
P
L
S
P
E
L
E
S
S
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation