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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cezanne
Full Name:
OTU domain-containing protein 7B
Alias:
Cellular zinc finger anti-NF-kappa-B protein; CEZANNE; OTU domain containing 7B; OTU7B; ZA20D1; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne
Type:
Protease; Ubiquitin conjugating system; EC 3.-.-.-
Mass (Da):
92526
Number AA:
843
UniProt ID:
Q6GQQ9
International Prot ID:
IPI00024658
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008234
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0043124
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
L
S
D
F
V
R
S
T
G
A
E
P
G
L
A
Site 2
S39
W
D
V
N
A
A
L
S
D
F
E
Q
L
R
Q
Site 3
S55
H
A
G
N
L
P
P
S
F
S
E
G
S
G
G
Site 4
S57
G
N
L
P
P
S
F
S
E
G
S
G
G
S
R
Site 5
T65
E
G
S
G
G
S
R
T
P
E
K
G
F
S
D
Site 6
S71
R
T
P
E
K
G
F
S
D
R
E
P
T
R
P
Site 7
T76
G
F
S
D
R
E
P
T
R
P
P
R
P
I
L
Site 8
S96
I
V
Q
E
K
R
L
S
R
G
I
S
H
A
S
Site 9
S100
K
R
L
S
R
G
I
S
H
A
S
S
S
I
V
Site 10
S103
S
R
G
I
S
H
A
S
S
S
I
V
S
L
A
Site 11
S104
R
G
I
S
H
A
S
S
S
I
V
S
L
A
R
Site 12
S105
G
I
S
H
A
S
S
S
I
V
S
L
A
R
S
Site 13
S108
H
A
S
S
S
I
V
S
L
A
R
S
H
V
S
Site 14
S112
S
I
V
S
L
A
R
S
H
V
S
S
N
G
G
Site 15
S115
S
L
A
R
S
H
V
S
S
N
G
G
G
G
G
Site 16
S116
L
A
R
S
H
V
S
S
N
G
G
G
G
G
S
Site 17
S123
S
N
G
G
G
G
G
S
N
E
H
P
L
E
M
Site 18
T141
A
F
Q
L
P
D
L
T
V
Y
N
E
D
F
R
Site 19
Y143
Q
L
P
D
L
T
V
Y
N
E
D
F
R
S
F
Site 20
S149
V
Y
N
E
D
F
R
S
F
I
E
R
D
L
I
Site 21
S175
G
R
L
N
W
W
V
S
V
D
P
T
S
Q
R
Site 22
T179
W
W
V
S
V
D
P
T
S
Q
R
L
L
P
L
Site 23
Y218
L
M
L
R
K
A
L
Y
A
L
M
E
K
G
V
Site 24
Y249
N
K
E
S
G
L
V
Y
T
E
D
E
W
Q
K
Site 25
S266
N
E
L
I
K
L
A
S
S
E
P
R
M
H
L
Site 26
S267
E
L
I
K
L
A
S
S
E
P
R
M
H
L
G
Site 27
T275
E
P
R
M
H
L
G
T
N
G
A
N
C
G
G
Site 28
S286
N
C
G
G
V
E
S
S
E
E
P
V
Y
E
S
Site 29
Y291
E
S
S
E
E
P
V
Y
E
S
L
E
E
F
H
Site 30
S293
S
E
E
P
V
Y
E
S
L
E
E
F
H
V
F
Site 31
S321
A
D
T
M
L
R
D
S
G
G
E
A
F
A
P
Site 32
S343
L
P
L
E
V
P
A
S
Q
C
H
R
S
P
L
Site 33
S348
P
A
S
Q
C
H
R
S
P
L
V
L
A
Y
D
Site 34
S360
A
Y
D
Q
A
H
F
S
A
L
V
S
M
E
Q
Site 35
S364
A
H
F
S
A
L
V
S
M
E
Q
K
E
N
T
Site 36
T380
E
Q
A
V
I
P
L
T
D
S
E
Y
K
L
L
Site 37
S406
W
E
W
G
K
D
D
S
D
N
V
R
L
A
S
Site 38
Y428
K
L
H
L
L
H
S
Y
M
N
V
K
W
I
P
Site 39
S437
N
V
K
W
I
P
L
S
S
D
A
Q
A
P
L
Site 40
S449
A
P
L
A
Q
P
E
S
P
T
A
S
A
G
D
Site 41
T451
L
A
Q
P
E
S
P
T
A
S
A
G
D
E
P
Site 42
S453
Q
P
E
S
P
T
A
S
A
G
D
E
P
R
S
Site 43
S460
S
A
G
D
E
P
R
S
T
P
E
S
G
D
S
Site 44
T461
A
G
D
E
P
R
S
T
P
E
S
G
D
S
D
Site 45
S464
E
P
R
S
T
P
E
S
G
D
S
D
K
E
S
Site 46
S467
S
T
P
E
S
G
D
S
D
K
E
S
V
G
S
Site 47
S471
S
G
D
S
D
K
E
S
V
G
S
S
S
T
S
Site 48
S474
S
D
K
E
S
V
G
S
S
S
T
S
N
E
G
Site 49
S475
D
K
E
S
V
G
S
S
S
T
S
N
E
G
G
Site 50
S476
K
E
S
V
G
S
S
S
T
S
N
E
G
G
R
Site 51
S478
S
V
G
S
S
S
T
S
N
E
G
G
R
R
K
Site 52
S488
G
G
R
R
K
E
K
S
K
R
D
R
E
K
D
Site 53
S501
K
D
K
K
R
A
D
S
V
A
N
K
L
G
S
Site 54
S508
S
V
A
N
K
L
G
S
F
G
K
T
L
G
S
Site 55
T512
K
L
G
S
F
G
K
T
L
G
S
K
L
K
K
Site 56
S515
S
F
G
K
T
L
G
S
K
L
K
K
N
M
G
Site 57
S527
N
M
G
G
L
M
H
S
K
G
S
K
P
G
G
Site 58
T537
S
K
P
G
G
V
G
T
G
L
G
G
S
S
G
Site 59
S543
G
T
G
L
G
G
S
S
G
T
E
T
L
E
K
Site 60
T547
G
G
S
S
G
T
E
T
L
E
K
K
K
K
N
Site 61
S555
L
E
K
K
K
K
N
S
L
K
S
W
K
G
G
Site 62
S558
K
K
K
N
S
L
K
S
W
K
G
G
K
E
E
Site 63
S573
A
A
G
D
G
P
V
S
E
K
P
P
A
E
S
Site 64
S580
S
E
K
P
P
A
E
S
V
G
N
G
G
S
K
Site 65
Y588
V
G
N
G
G
S
K
Y
S
Q
E
V
M
Q
S
Site 66
S589
G
N
G
G
S
K
Y
S
Q
E
V
M
Q
S
L
Site 67
S595
Y
S
Q
E
V
M
Q
S
L
S
I
L
R
T
A
Site 68
T601
Q
S
L
S
I
L
R
T
A
M
Q
G
E
G
K
Site 69
Y623
K
M
G
H
R
H
Q
Y
Q
E
E
M
I
Q
R
Site 70
Y631
Q
E
E
M
I
Q
R
Y
L
S
D
A
E
E
R
Site 71
S633
E
M
I
Q
R
Y
L
S
D
A
E
E
R
F
L
Site 72
T677
D
A
R
E
E
Q
P
T
G
P
P
A
E
S
R
Site 73
S689
E
S
R
A
M
A
F
S
T
G
Y
P
G
D
F
Site 74
T697
T
G
Y
P
G
D
F
T
I
P
R
P
S
G
G
Site 75
S702
D
F
T
I
P
R
P
S
G
G
G
V
H
C
Q
Site 76
T729
G
G
L
P
P
Y
A
T
F
P
R
Q
C
P
P
Site 77
Y740
Q
C
P
P
G
R
P
Y
P
H
Q
D
S
I
P
Site 78
S745
R
P
Y
P
H
Q
D
S
I
P
S
L
E
P
G
Site 79
S748
P
H
Q
D
S
I
P
S
L
E
P
G
S
H
S
Site 80
S753
I
P
S
L
E
P
G
S
H
S
K
D
G
L
H
Site 81
S755
S
L
E
P
G
S
H
S
K
D
G
L
H
R
G
Site 82
Y769
G
A
L
L
P
P
P
Y
R
V
A
D
S
Y
S
Site 83
S774
P
P
Y
R
V
A
D
S
Y
S
N
G
Y
R
E
Site 84
Y775
P
Y
R
V
A
D
S
Y
S
N
G
Y
R
E
P
Site 85
S776
Y
R
V
A
D
S
Y
S
N
G
Y
R
E
P
P
Site 86
Y779
A
D
S
Y
S
N
G
Y
R
E
P
P
E
P
D
Site 87
T798
G
L
R
G
L
P
P
T
Q
T
K
C
K
Q
P
Site 88
T800
R
G
L
P
P
T
Q
T
K
C
K
Q
P
N
C
Site 89
Y810
K
Q
P
N
C
S
F
Y
G
H
P
E
T
N
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation