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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GARNL1
Full Name:
Ral GTPase-activating protein subunit alpha-1
Alias:
GAP-related-interacting partner to E12; GRIPE; Tuberin-like protein 1
Type:
Intracellular, Cytoplasm, Nucleus, Mitochondrion protein
Mass (Da):
229832
Number AA:
2036
UniProt ID:
Q6GYQ0
International Prot ID:
IPI00472044
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005096
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
P
H
G
D
V
K
K
S
T
Q
K
V
L
D
T
Site 2
T14
H
G
D
V
K
K
S
T
Q
K
V
L
D
T
K
Site 3
T20
S
T
Q
K
V
L
D
T
K
K
D
A
L
T
R
Site 4
T26
D
T
K
K
D
A
L
T
R
L
K
H
L
R
I
Site 5
S52
Q
F
F
D
Q
H
F
S
H
I
Y
Y
V
F
F
Site 6
S68
N
F
V
T
I
E
A
S
L
K
Q
K
G
H
K
Site 7
S76
L
K
Q
K
G
H
K
S
Q
R
E
E
L
D
A
Site 8
S121
K
L
L
H
T
G
N
S
L
K
I
R
R
E
G
Site 9
S159
S
C
L
I
P
G
F
S
A
P
Q
S
E
H
G
Site 10
S163
P
G
F
S
A
P
Q
S
E
H
G
P
R
T
L
Site 11
T169
Q
S
E
H
G
P
R
T
L
D
N
L
I
N
P
Site 12
T186
N
L
Q
E
T
Q
V
T
I
E
E
I
T
P
L
Site 13
T191
Q
V
T
I
E
E
I
T
P
L
V
P
P
Q
S
Site 14
S198
T
P
L
V
P
P
Q
S
G
D
K
G
Q
E
D
Site 15
T207
D
K
G
Q
E
D
L
T
S
Y
F
L
E
A
L
Site 16
S208
K
G
Q
E
D
L
T
S
Y
F
L
E
A
L
L
Site 17
Y209
G
Q
E
D
L
T
S
Y
F
L
E
A
L
L
K
Site 18
S238
E
N
Q
E
R
G
F
S
F
L
F
S
H
F
K
Site 19
Y248
F
S
H
F
K
K
Y
Y
L
P
Y
I
F
P
N
Site 20
Y251
F
K
K
Y
Y
L
P
Y
I
F
P
N
I
C
K
Site 21
Y263
I
C
K
E
N
S
L
Y
H
P
I
L
D
I
P
Site 22
Y278
Q
M
R
P
K
P
H
Y
V
V
I
K
K
D
A
Site 23
Y292
A
E
T
N
E
A
I
Y
C
T
K
E
P
F
I
Site 24
T294
T
N
E
A
I
Y
C
T
K
E
P
F
I
K
A
Site 25
T320
W
L
E
P
K
P
H
T
G
P
H
I
P
G
M
Site 26
S342
N
I
Q
R
A
A
A
S
L
V
S
R
E
E
S
Site 27
S345
R
A
A
A
S
L
V
S
R
E
E
S
K
N
D
Site 28
S349
S
L
V
S
R
E
E
S
K
N
D
N
A
D
K
Site 29
T357
K
N
D
N
A
D
K
T
D
R
T
T
E
P
E
Site 30
T360
N
A
D
K
T
D
R
T
T
E
P
E
Q
S
H
Site 31
T361
A
D
K
T
D
R
T
T
E
P
E
Q
S
H
S
Site 32
S366
R
T
T
E
P
E
Q
S
H
S
N
T
S
T
L
Site 33
S368
T
E
P
E
Q
S
H
S
N
T
S
T
L
T
E
Site 34
T370
P
E
Q
S
H
S
N
T
S
T
L
T
E
R
E
Site 35
S371
E
Q
S
H
S
N
T
S
T
L
T
E
R
E
P
Site 36
T372
Q
S
H
S
N
T
S
T
L
T
E
R
E
P
S
Site 37
T374
H
S
N
T
S
T
L
T
E
R
E
P
S
S
S
Site 38
S379
T
L
T
E
R
E
P
S
S
S
S
L
C
S
I
Site 39
S380
L
T
E
R
E
P
S
S
S
S
L
C
S
I
D
Site 40
S381
T
E
R
E
P
S
S
S
S
L
C
S
I
D
E
Site 41
S382
E
R
E
P
S
S
S
S
L
C
S
I
D
E
E
Site 42
S385
P
S
S
S
S
L
C
S
I
D
E
E
H
L
T
Site 43
T392
S
I
D
E
E
H
L
T
D
I
E
I
V
R
R
Site 44
S402
E
I
V
R
R
V
F
S
S
K
R
S
N
V
N
Site 45
S403
I
V
R
R
V
F
S
S
K
R
S
N
V
N
F
Site 46
S406
R
V
F
S
S
K
R
S
N
V
N
F
V
T
E
Site 47
S474
N
V
T
D
H
D
I
S
M
E
E
G
E
K
R
Site 48
T487
K
R
E
E
E
N
G
T
N
T
A
D
H
V
R
Site 49
S496
T
A
D
H
V
R
N
S
S
W
A
K
N
G
S
Site 50
S497
A
D
H
V
R
N
S
S
W
A
K
N
G
S
Y
Site 51
S503
S
S
W
A
K
N
G
S
Y
Q
G
A
L
H
N
Site 52
T524
E
Q
N
I
R
A
G
T
Q
A
V
L
Q
V
F
Site 53
T555
K
N
L
L
D
E
H
T
D
M
C
K
R
I
L
Site 54
T578
Q
V
S
M
D
K
K
T
W
E
Q
M
L
L
V
Site 55
S598
E
S
V
L
K
M
P
S
Q
A
F
L
Q
F
Q
Site 56
T611
F
Q
G
K
K
N
M
T
L
A
G
R
L
A
G
Site 57
Y636
I
K
A
N
L
N
V
Y
I
S
R
E
L
W
D
Site 58
S638
A
N
L
N
V
Y
I
S
R
E
L
W
D
D
L
Site 59
S650
D
D
L
L
S
V
L
S
S
L
T
Y
W
E
E
Site 60
Y654
S
V
L
S
S
L
T
Y
W
E
E
L
A
T
E
Site 61
S663
E
E
L
A
T
E
W
S
L
T
M
E
T
L
T
Site 62
S683
N
L
Y
S
L
D
L
S
D
L
P
L
D
K
L
Site 63
S691
D
L
P
L
D
K
L
S
E
Q
K
Q
K
K
H
Site 64
S711
G
H
E
F
Q
K
V
S
V
D
K
S
F
S
R
Site 65
S715
Q
K
V
S
V
D
K
S
F
S
R
G
W
S
R
Site 66
S717
V
S
V
D
K
S
F
S
R
G
W
S
R
D
Q
Site 67
S721
K
S
F
S
R
G
W
S
R
D
Q
P
G
Q
A
Site 68
S734
Q
A
P
M
R
Q
R
S
A
T
T
T
G
S
P
Site 69
T736
P
M
R
Q
R
S
A
T
T
T
G
S
P
G
T
Site 70
T738
R
Q
R
S
A
T
T
T
G
S
P
G
T
E
K
Site 71
S740
R
S
A
T
T
T
G
S
P
G
T
E
K
A
R
Site 72
S748
P
G
T
E
K
A
R
S
I
V
R
Q
K
T
V
Site 73
T754
R
S
I
V
R
Q
K
T
V
D
I
D
D
A
Q
Site 74
S766
D
A
Q
I
L
P
R
S
T
R
V
R
H
F
S
Site 75
T767
A
Q
I
L
P
R
S
T
R
V
R
H
F
S
Q
Site 76
S773
S
T
R
V
R
H
F
S
Q
S
E
E
T
G
N
Site 77
S775
R
V
R
H
F
S
Q
S
E
E
T
G
N
E
V
Site 78
T778
H
F
S
Q
S
E
E
T
G
N
E
V
F
G
A
Site 79
S795
E
E
Q
P
L
P
R
S
S
S
T
S
D
I
L
Site 80
S796
E
Q
P
L
P
R
S
S
S
T
S
D
I
L
E
Site 81
S797
Q
P
L
P
R
S
S
S
T
S
D
I
L
E
P
Site 82
T798
P
L
P
R
S
S
S
T
S
D
I
L
E
P
F
Site 83
S799
L
P
R
S
S
S
T
S
D
I
L
E
P
F
T
Site 84
T806
S
D
I
L
E
P
F
T
V
E
R
A
K
V
N
Site 85
S818
K
V
N
K
E
D
M
S
Q
K
L
P
P
L
N
Site 86
S826
Q
K
L
P
P
L
N
S
D
I
G
G
S
S
A
Site 87
S849
F
I
A
E
R
L
R
S
G
N
A
S
T
M
T
Site 88
S853
R
L
R
S
G
N
A
S
T
M
T
R
R
G
S
Site 89
T854
L
R
S
G
N
A
S
T
M
T
R
R
G
S
S
Site 90
T856
S
G
N
A
S
T
M
T
R
R
G
S
S
P
G
Site 91
S860
S
T
M
T
R
R
G
S
S
P
G
S
L
E
I
Site 92
S861
T
M
T
R
R
G
S
S
P
G
S
L
E
I
P
Site 93
S864
R
R
G
S
S
P
G
S
L
E
I
P
K
D
L
Site 94
S891
I
D
D
P
G
V
P
S
E
W
T
S
P
A
S
Site 95
T894
P
G
V
P
S
E
W
T
S
P
A
S
A
G
S
Site 96
S895
G
V
P
S
E
W
T
S
P
A
S
A
G
S
S
Site 97
S898
S
E
W
T
S
P
A
S
A
G
S
S
D
L
I
Site 98
S901
T
S
P
A
S
A
G
S
S
D
L
I
S
S
D
Site 99
S902
S
P
A
S
A
G
S
S
D
L
I
S
S
D
S
Site 100
S906
A
G
S
S
D
L
I
S
S
D
S
H
S
D
S
Site 101
S907
G
S
S
D
L
I
S
S
D
S
H
S
D
S
F
Site 102
S909
S
D
L
I
S
S
D
S
H
S
D
S
F
S
A
Site 103
S911
L
I
S
S
D
S
H
S
D
S
F
S
A
F
Q
Site 104
S913
S
S
D
S
H
S
D
S
F
S
A
F
Q
Y
D
Site 105
S915
D
S
H
S
D
S
F
S
A
F
Q
Y
D
G
R
Site 106
Y919
D
S
F
S
A
F
Q
Y
D
G
R
K
F
D
N
Site 107
T933
N
F
G
F
G
T
D
T
G
V
T
S
S
A
D
Site 108
S937
G
T
D
T
G
V
T
S
S
A
D
V
D
S
G
Site 109
S938
T
D
T
G
V
T
S
S
A
D
V
D
S
G
S
Site 110
S943
T
S
S
A
D
V
D
S
G
S
G
H
H
Q
S
Site 111
S945
S
A
D
V
D
S
G
S
G
H
H
Q
S
A
E
Site 112
S950
S
G
S
G
H
H
Q
S
A
E
E
Q
E
V
A
Site 113
S966
L
T
T
L
H
I
D
S
E
T
S
S
L
N
Q
Site 114
S970
H
I
D
S
E
T
S
S
L
N
Q
Q
A
F
S
Site 115
T984
S
A
E
V
A
T
I
T
G
S
E
S
A
S
P
Site 116
S986
E
V
A
T
I
T
G
S
E
S
A
S
P
V
H
Site 117
S988
A
T
I
T
G
S
E
S
A
S
P
V
H
S
P
Site 118
S990
I
T
G
S
E
S
A
S
P
V
H
S
P
L
G
Site 119
S994
E
S
A
S
P
V
H
S
P
L
G
S
R
S
Q
Site 120
S998
P
V
H
S
P
L
G
S
R
S
Q
T
P
S
P
Site 121
S1000
H
S
P
L
G
S
R
S
Q
T
P
S
P
S
T
Site 122
T1002
P
L
G
S
R
S
Q
T
P
S
P
S
T
L
N
Site 123
S1004
G
S
R
S
Q
T
P
S
P
S
T
L
N
I
D
Site 124
S1006
R
S
Q
T
P
S
P
S
T
L
N
I
D
H
M
Site 125
T1007
S
Q
T
P
S
P
S
T
L
N
I
D
H
M
E
Site 126
S1027
L
D
E
K
L
H
H
S
V
L
Q
T
P
D
D
Site 127
T1031
L
H
H
S
V
L
Q
T
P
D
D
L
E
I
S
Site 128
S1038
T
P
D
D
L
E
I
S
E
F
P
S
E
C
C
Site 129
T1113
G
I
S
T
D
N
L
T
S
P
S
P
P
V
L
Site 130
S1116
T
D
N
L
T
S
P
S
P
P
V
L
I
P
P
Site 131
Y1141
A
T
M
L
T
D
K
Y
K
Q
G
K
L
H
A
Site 132
S1163
M
K
R
R
Q
D
V
S
P
N
R
D
F
L
T
Site 133
S1279
L
I
I
K
T
V
L
S
S
A
R
D
E
P
S
Site 134
S1280
I
I
K
T
V
L
S
S
A
R
D
E
P
S
G
Site 135
T1331
S
L
K
F
T
N
K
T
V
A
H
V
A
C
N
Site 136
Y1353
Y
V
P
R
L
Q
I
Y
Q
P
D
S
P
L
K
Site 137
S1375
T
I
T
H
L
L
P
S
T
E
A
S
S
Y
E
Site 138
T1376
I
T
H
L
L
P
S
T
E
A
S
S
Y
E
M
Site 139
S1379
L
L
P
S
T
E
A
S
S
Y
E
M
D
K
R
Site 140
Y1381
P
S
T
E
A
S
S
Y
E
M
D
K
R
L
V
Site 141
T1421
T
G
A
E
S
D
K
T
E
K
S
V
L
N
C
Site 142
S1424
E
S
D
K
T
E
K
S
V
L
N
C
I
Y
K
Site 143
Y1448
Q
C
F
S
N
P
R
Y
F
P
M
S
L
S
D
Site 144
S1452
N
P
R
Y
F
P
M
S
L
S
D
L
A
S
V
Site 145
S1454
R
Y
F
P
M
S
L
S
D
L
A
S
V
D
Y
Site 146
Y1461
S
D
L
A
S
V
D
Y
D
P
F
M
H
L
E
Site 147
S1469
D
P
F
M
H
L
E
S
L
K
E
P
E
P
L
Site 148
S1478
K
E
P
E
P
L
H
S
P
D
S
E
R
S
S
Site 149
S1481
E
P
L
H
S
P
D
S
E
R
S
S
K
L
Q
Site 150
S1485
S
P
D
S
E
R
S
S
K
L
Q
P
V
T
E
Site 151
T1491
S
S
K
L
Q
P
V
T
E
V
K
T
Q
M
Q
Site 152
Y1520
L
V
N
H
L
G
H
Y
P
M
S
G
G
P
A
Site 153
S1523
H
L
G
H
Y
P
M
S
G
G
P
A
M
L
T
Site 154
T1530
S
G
G
P
A
M
L
T
S
Q
V
C
E
N
H
Site 155
S1531
G
G
P
A
M
L
T
S
Q
V
C
E
N
H
D
Site 156
Y1541
C
E
N
H
D
N
H
Y
S
E
S
T
E
L
S
Site 157
S1542
E
N
H
D
N
H
Y
S
E
S
T
E
L
S
P
Site 158
S1544
H
D
N
H
Y
S
E
S
T
E
L
S
P
E
L
Site 159
S1548
Y
S
E
S
T
E
L
S
P
E
L
F
E
S
P
Site 160
S1554
L
S
P
E
L
F
E
S
P
N
I
Q
F
F
V
Site 161
T1565
Q
F
F
V
L
N
N
T
T
L
V
S
C
I
Q
Site 162
S1569
L
N
N
T
T
L
V
S
C
I
Q
I
R
S
E
Site 163
S1575
V
S
C
I
Q
I
R
S
E
E
N
M
P
G
G
Site 164
S1585
N
M
P
G
G
G
L
S
A
G
L
A
S
A
N
Site 165
S1590
G
L
S
A
G
L
A
S
A
N
S
N
V
R
I
Site 166
S1593
A
G
L
A
S
A
N
S
N
V
R
I
I
V
R
Site 167
S1603
R
I
I
V
R
D
L
S
G
K
Y
S
W
D
S
Site 168
Y1606
V
R
D
L
S
G
K
Y
S
W
D
S
A
I
L
Site 169
S1607
R
D
L
S
G
K
Y
S
W
D
S
A
I
L
Y
Site 170
S1610
S
G
K
Y
S
W
D
S
A
I
L
Y
G
P
P
Site 171
Y1614
S
W
D
S
A
I
L
Y
G
P
P
P
V
S
G
Site 172
S1620
L
Y
G
P
P
P
V
S
G
L
S
E
P
T
S
Site 173
S1627
S
G
L
S
E
P
T
S
F
M
L
S
L
S
H
Site 174
S1631
E
P
T
S
F
M
L
S
L
S
H
Q
E
K
P
Site 175
S1633
T
S
F
M
L
S
L
S
H
Q
E
K
P
E
E
Site 176
T1643
E
K
P
E
E
P
P
T
S
N
E
C
L
E
D
Site 177
S1644
K
P
E
E
P
P
T
S
N
E
C
L
E
D
I
Site 178
T1652
N
E
C
L
E
D
I
T
V
K
D
G
L
S
L
Site 179
S1658
I
T
V
K
D
G
L
S
L
Q
F
K
R
F
R
Site 180
T1667
Q
F
K
R
F
R
E
T
V
P
T
W
D
T
I
Site 181
T1670
R
F
R
E
T
V
P
T
W
D
T
I
R
D
E
Site 182
T1673
E
T
V
P
T
W
D
T
I
R
D
E
E
D
V
Site 183
S1692
L
Q
Y
L
G
V
T
S
P
E
C
L
Q
R
T
Site 184
S1714
A
P
Q
P
V
C
I
S
E
K
Q
E
N
D
V
Site 185
Y1763
Q
K
P
Q
S
A
F
Y
Y
C
R
L
L
L
S
Site 186
S1776
L
S
I
L
G
M
N
S
W
D
K
R
R
S
F
Site 187
S1782
N
S
W
D
K
R
R
S
F
H
L
L
K
K
N
Site 188
S1801
R
E
L
R
N
L
D
S
R
Q
C
R
E
T
H
Site 189
T1807
D
S
R
Q
C
R
E
T
H
K
I
A
V
F
Y
Site 190
Y1814
T
H
K
I
A
V
F
Y
V
A
E
G
Q
E
D
Site 191
S1824
E
G
Q
E
D
K
H
S
I
L
T
N
T
G
G
Site 192
S1863
G
G
L
Q
K
N
K
S
T
G
L
T
T
P
Y
Site 193
T1867
K
N
K
S
T
G
L
T
T
P
Y
F
A
T
S
Site 194
T1868
N
K
S
T
G
L
T
T
P
Y
F
A
T
S
T
Site 195
Y1870
S
T
G
L
T
T
P
Y
F
A
T
S
T
V
E
Site 196
S1883
V
E
V
I
F
H
V
S
T
R
M
P
S
D
S
Site 197
T1884
E
V
I
F
H
V
S
T
R
M
P
S
D
S
D
Site 198
S1888
H
V
S
T
R
M
P
S
D
S
D
D
S
L
T
Site 199
S1890
S
T
R
M
P
S
D
S
D
D
S
L
T
K
K
Site 200
S1893
M
P
S
D
S
D
D
S
L
T
K
K
L
R
H
Site 201
T1895
S
D
S
D
D
S
L
T
K
K
L
R
H
L
G
Site 202
Y1917
W
S
E
H
T
R
D
Y
R
R
G
I
I
P
T
Site 203
S1985
N
A
S
R
A
L
K
S
L
I
P
L
Y
Q
N
Site 204
Y1990
L
K
S
L
I
P
L
Y
Q
N
F
Y
E
E
R
Site 205
Y1994
I
P
L
Y
Q
N
F
Y
E
E
R
A
R
Y
L
Site 206
Y2000
F
Y
E
E
R
A
R
Y
L
Q
T
I
V
Q
H
Site 207
T2013
Q
H
H
L
E
P
T
T
F
E
D
F
A
A
Q
Site 208
S2023
D
F
A
A
Q
V
F
S
P
A
P
Y
H
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation