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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ISM2
Full Name:
Isthmin-2
Alias:
Thrombospondin and AMOP domain-containing isthmin-like protein 1;Thrombospondin type-1 domain-containing protein 3
Type:
Mass (Da):
63906
Number AA:
571
UniProt ID:
Q6H9L7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S41
L
R
G
P
R
P
G
S
L
T
R
L
A
E
V
Site 2
T43
G
P
R
P
G
S
L
T
R
L
A
E
V
S
A
Site 3
S49
L
T
R
L
A
E
V
S
A
S
P
D
P
R
P
Site 4
S51
R
L
A
E
V
S
A
S
P
D
P
R
P
L
K
Site 5
T90
V
T
E
P
A
A
M
T
P
G
N
A
T
P
P
Site 6
T95
A
M
T
P
G
N
A
T
P
P
R
T
P
E
V
Site 7
T99
G
N
A
T
P
P
R
T
P
E
V
T
P
L
R
Site 8
T103
P
P
R
T
P
E
V
T
P
L
R
L
E
L
Q
Site 9
S121
G
L
A
N
T
T
L
S
T
P
N
P
D
T
Q
Site 10
T122
L
A
N
T
T
L
S
T
P
N
P
D
T
Q
A
Site 11
T127
L
S
T
P
N
P
D
T
Q
A
S
A
S
P
D
Site 12
S130
P
N
P
D
T
Q
A
S
A
S
P
D
P
R
P
Site 13
S132
P
D
T
Q
A
S
A
S
P
D
P
R
P
L
R
Site 14
T150
E
A
R
L
L
P
R
T
H
L
Q
A
E
L
H
Site 15
T163
L
H
Q
H
G
C
W
T
V
T
E
P
A
A
L
Site 16
T171
V
T
E
P
A
A
L
T
P
G
N
A
T
P
P
Site 17
T176
A
L
T
P
G
N
A
T
P
P
R
T
Q
E
V
Site 18
T180
G
N
A
T
P
P
R
T
Q
E
V
T
P
L
L
Site 19
T184
P
P
R
T
Q
E
V
T
P
L
L
L
E
L
Q
Site 20
S202
E
L
V
H
A
T
L
S
T
P
N
P
D
N
Q
Site 21
T203
L
V
H
A
T
L
S
T
P
N
P
D
N
Q
V
Site 22
S231
I
D
L
L
A
E
P
S
N
P
P
P
Q
D
T
Site 23
T238
S
N
P
P
P
Q
D
T
L
S
W
L
P
A
L
Site 24
S240
P
P
P
Q
D
T
L
S
W
L
P
A
L
W
S
Site 25
Y253
W
S
F
L
W
G
D
Y
K
G
E
E
K
D
R
Site 26
Y275
E
K
E
E
D
E
D
Y
P
S
E
D
I
E
G
Site 27
S277
E
E
D
E
D
Y
P
S
E
D
I
E
G
E
D
Site 28
S323
W
V
F
K
D
S
V
S
Y
D
Y
E
P
Q
K
Site 29
Y326
K
D
S
V
S
Y
D
Y
E
P
Q
K
E
W
S
Site 30
S333
Y
E
P
Q
K
E
W
S
P
W
S
P
C
S
G
Site 31
S336
Q
K
E
W
S
P
W
S
P
C
S
G
N
C
S
Site 32
S339
W
S
P
W
S
P
C
S
G
N
C
S
T
G
K
Site 33
S343
S
P
C
S
G
N
C
S
T
G
K
Q
Q
R
T
Site 34
T344
P
C
S
G
N
C
S
T
G
K
Q
Q
R
T
R
Site 35
S369
T
R
T
C
D
L
P
S
C
P
G
T
E
D
K
Site 36
T373
D
L
P
S
C
P
G
T
E
D
K
D
T
L
G
Site 37
T378
P
G
T
E
D
K
D
T
L
G
L
P
S
E
E
Site 38
T394
K
L
L
A
R
N
A
T
D
M
H
D
Q
D
V
Site 39
Y418
K
S
D
F
L
I
K
Y
L
S
Q
M
L
R
D
Site 40
S440
Y
P
L
E
A
M
D
S
P
V
S
L
Q
D
E
Site 41
S443
E
A
M
D
S
P
V
S
L
Q
D
E
H
Q
G
Site 42
S452
Q
D
E
H
Q
G
R
S
F
R
W
R
D
A
S
Site 43
S459
S
F
R
W
R
D
A
S
G
P
R
E
R
L
D
Site 44
Y468
P
R
E
R
L
D
I
Y
Q
P
T
A
R
F
C
Site 45
T471
R
L
D
I
Y
Q
P
T
A
R
F
C
L
R
S
Site 46
S478
T
A
R
F
C
L
R
S
M
L
S
G
E
S
S
Site 47
S485
S
M
L
S
G
E
S
S
T
L
A
A
Q
H
C
Site 48
Y494
L
A
A
Q
H
C
C
Y
D
E
D
S
R
L
L
Site 49
T502
D
E
D
S
R
L
L
T
R
G
K
G
A
G
M
Site 50
S514
A
G
M
P
N
L
I
S
T
D
F
S
P
K
L
Site 51
S518
N
L
I
S
T
D
F
S
P
K
L
H
F
K
F
Site 52
T553
P
N
N
G
R
A
C
T
D
N
P
L
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation