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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASTL
Full Name:
Astacin-like metalloendopeptidase
Alias:
Oocyte astacin;Ovastacin
Type:
Mass (Da):
45964
Number AA:
431
UniProt ID:
Q6HA08
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
T
S
F
P
D
G
L
T
P
E
G
T
Q
A
S
Site 2
T47
D
G
L
T
P
E
G
T
Q
A
S
G
D
K
D
Site 3
S70
I
L
E
E
T
P
E
S
S
F
L
I
E
G
D
Site 4
S71
L
E
E
T
P
E
S
S
F
L
I
E
G
D
I
Site 5
S82
E
G
D
I
I
R
P
S
P
F
R
L
L
S
A
Site 6
S88
P
S
P
F
R
L
L
S
A
T
S
N
K
W
P
Site 7
T90
P
F
R
L
L
S
A
T
S
N
K
W
P
M
G
Site 8
S91
F
R
L
L
S
A
T
S
N
K
W
P
M
G
G
Site 9
S99
N
K
W
P
M
G
G
S
G
V
V
E
V
P
F
Site 10
S110
E
V
P
F
L
L
S
S
K
Y
D
E
P
S
R
Site 11
Y112
P
F
L
L
S
S
K
Y
D
E
P
S
R
Q
V
Site 12
S116
S
S
K
Y
D
E
P
S
R
Q
V
I
L
E
A
Site 13
S156
P
M
Y
G
C
F
S
S
V
G
R
S
G
G
M
Site 14
T171
Q
V
V
S
L
A
P
T
C
L
Q
K
G
R
G
Site 15
Y202
T
R
A
D
R
D
R
Y
I
R
V
N
W
N
E
Site 16
S221
F
E
I
N
F
I
K
S
R
S
S
N
M
L
T
Site 17
S223
I
N
F
I
K
S
R
S
S
N
M
L
T
P
Y
Site 18
S224
N
F
I
K
S
R
S
S
N
M
L
T
P
Y
D
Site 19
T228
S
R
S
S
N
M
L
T
P
Y
D
Y
S
S
V
Site 20
Y230
S
S
N
M
L
T
P
Y
D
Y
S
S
V
M
H
Site 21
Y232
N
M
L
T
P
Y
D
Y
S
S
V
M
H
Y
G
Site 22
Y238
D
Y
S
S
V
M
H
Y
G
R
L
A
F
S
R
Site 23
S244
H
Y
G
R
L
A
F
S
R
R
G
L
P
T
I
Site 24
T250
F
S
R
R
G
L
P
T
I
T
P
L
W
A
P
Site 25
T252
R
R
G
L
P
T
I
T
P
L
W
A
P
S
V
Site 26
S268
I
G
Q
R
W
N
L
S
A
S
D
I
T
R
V
Site 27
S282
V
L
K
L
Y
G
C
S
P
S
G
P
R
P
R
Site 28
S284
K
L
Y
G
C
S
P
S
G
P
R
P
R
G
R
Site 29
S293
P
R
P
R
G
R
G
S
H
A
H
S
T
G
R
Site 30
S297
G
R
G
S
H
A
H
S
T
G
R
S
P
A
P
Site 31
T298
R
G
S
H
A
H
S
T
G
R
S
P
A
P
A
Site 32
S301
H
A
H
S
T
G
R
S
P
A
P
A
S
L
S
Site 33
S306
G
R
S
P
A
P
A
S
L
S
L
Q
R
L
L
Site 34
S317
Q
R
L
L
E
A
L
S
A
E
S
R
S
P
D
Site 35
S320
L
E
A
L
S
A
E
S
R
S
P
D
P
S
G
Site 36
S322
A
L
S
A
E
S
R
S
P
D
P
S
G
S
S
Site 37
S326
E
S
R
S
P
D
P
S
G
S
S
A
G
G
Q
Site 38
S328
R
S
P
D
P
S
G
S
S
A
G
G
Q
P
V
Site 39
S329
S
P
D
P
S
G
S
S
A
G
G
Q
P
V
P
Site 40
S342
V
P
A
G
P
G
E
S
P
H
G
W
E
S
P
Site 41
S348
E
S
P
H
G
W
E
S
P
A
L
K
K
L
S
Site 42
S355
S
P
A
L
K
K
L
S
A
E
A
S
A
R
Q
Site 43
S359
K
K
L
S
A
E
A
S
A
R
Q
P
Q
T
L
Site 44
T365
A
S
A
R
Q
P
Q
T
L
A
S
S
P
R
S
Site 45
S368
R
Q
P
Q
T
L
A
S
S
P
R
S
R
P
G
Site 46
S369
Q
P
Q
T
L
A
S
S
P
R
S
R
P
G
A
Site 47
S372
T
L
A
S
S
P
R
S
R
P
G
A
G
A
P
Site 48
S386
P
G
V
A
Q
E
Q
S
W
L
A
G
V
S
T
Site 49
S392
Q
S
W
L
A
G
V
S
T
K
P
T
V
P
S
Site 50
T393
S
W
L
A
G
V
S
T
K
P
T
V
P
S
S
Site 51
T396
A
G
V
S
T
K
P
T
V
P
S
S
E
A
G
Site 52
S400
T
K
P
T
V
P
S
S
E
A
G
I
Q
P
V
Site 53
S412
Q
P
V
P
V
Q
G
S
P
A
L
P
G
G
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation