PhosphoNET

           
Protein Info 
   
Short Name:  SIGIRR
Full Name:  Single Ig IL-1-related receptor
Alias:  SIGIR; Single Ig IL-1R-related molecule; Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; Single immunoglobulin domain IL1R1 related; Single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8
Type:  Receptor, misc.
Mass (Da):  45707
Number AA:  410
UniProt ID:  Q6IA17
International Prot ID:  IPI00029155
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021     Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0004888   PhosphoSite+ KinaseNET
Biological Process:  GO:0006953  GO:0045087  GO:0045079 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y150RLNVLLWYQDAYGEV
Site 2Y154LLWYQDAYGEVEIND
Site 3Y165EINDGKLYDAYVSYS
Site 4Y168DGKLYDAYVSYSDCP
Site 5S170KLYDAYVSYSDCPED
Site 6S172YDAYVSYSDCPEDRK
Site 7Y195QLERRRGYKLFLDDR
Site 8S211LLPRAEPSADLLVNL
Site 9S219ADLLVNLSRCRRLIV
Site 10S241SRAWCSHSFREGLCR
Site 11T260TRRPIFITFEGQRRD
Site 12S292LLLWRPGSVTPSSDF
Site 13T294LWRPGSVTPSSDFWK
Site 14S296RPGSVTPSSDFWKEV
Site 15S297PGSVTPSSDFWKEVQ
Site 16T322PVEGDPQTQLQDDKD
Site 17S346PEGRALDSEVDPDPE
Site 18S367GPVFGEPSAPPHTSG
Site 19T372EPSAPPHTSGVSLGE
Site 20S373PSAPPHTSGVSLGES
Site 21S376PPHTSGVSLGESRSS
Site 22S380SGVSLGESRSSEVDV
Site 23S382VSLGESRSSEVDVSD
Site 24S383SLGESRSSEVDVSDL
Site 25S388RSSEVDVSDLGSRNY
Site 26S392VDVSDLGSRNYSART
Site 27Y395SDLGSRNYSARTDFY
Site 28S396DLGSRNYSARTDFYC
Site 29Y402YSARTDFYCLVSKDD
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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