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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DIP
Full Name:
GRAM domain-containing protein 4
Alias:
Death-inducinG protein; Death-inducing-protein; GRAM domain containing 4; KIAA0767
Type:
Membrane, Mitochondrial membrane, Mitochondrion, Integral membrane protein
Mass (Da):
66408
Number AA:
578
UniProt ID:
Q6IC98
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005739
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
D
F
L
D
L
A
E
S
P
N
A
S
D
T
E
Site 2
S28
L
A
E
S
P
N
A
S
D
T
E
C
S
D
E
Site 3
T30
E
S
P
N
A
S
D
T
E
C
S
D
E
I
P
Site 4
S33
N
A
S
D
T
E
C
S
D
E
I
P
L
K
V
Site 5
T43
I
P
L
K
V
P
R
T
S
P
R
D
S
E
E
Site 6
S44
D
F
L
D
L
A
E
S
P
N
A
S
D
T
E
Site 7
S48
L
A
E
S
P
N
A
S
D
T
E
C
S
D
E
Site 8
T105
L
R
K
L
R
E
E
T
N
A
E
M
L
R
Q
Site 9
S152
P
K
G
Q
A
Q
A
S
N
G
A
E
R
R
S
Site 10
S159
S
N
G
A
E
R
R
S
Q
G
L
S
S
R
L
Site 11
S163
E
R
R
S
Q
G
L
S
S
R
L
Q
K
W
F
Site 12
Y171
S
R
L
Q
K
W
F
Y
E
R
F
G
E
Y
V
Site 13
Y177
F
Y
E
R
F
G
E
Y
V
E
D
F
R
F
Q
Site 14
T189
R
F
Q
P
E
E
N
T
V
E
T
E
E
P
L
Site 15
T192
P
E
E
N
T
V
E
T
E
E
P
L
S
A
R
Site 16
S197
V
E
T
E
E
P
L
S
A
R
R
L
T
E
N
Site 17
T202
P
L
S
A
R
R
L
T
E
N
M
R
R
L
K
Site 18
T216
K
R
G
A
K
P
V
T
N
F
V
K
N
L
S
Site 19
S223
T
N
F
V
K
N
L
S
A
L
S
D
W
Y
S
Site 20
S226
V
K
N
L
S
A
L
S
D
W
Y
S
V
Y
T
Site 21
S277
R
G
W
R
I
Q
W
S
I
V
P
E
V
S
E
Site 22
S283
W
S
I
V
P
E
V
S
E
P
V
E
P
P
K
Site 23
T294
E
P
P
K
E
D
L
T
V
S
E
K
F
Q
L
Site 24
Y386
C
P
R
L
R
A
K
Y
D
T
P
Y
I
I
W
Site 25
T388
R
L
R
A
K
Y
D
T
P
Y
I
I
W
R
S
Site 26
Y390
R
A
K
Y
D
T
P
Y
I
I
W
R
S
L
P
Site 27
S395
T
P
Y
I
I
W
R
S
L
P
T
D
P
Q
L
Site 28
S406
D
P
Q
L
K
E
R
S
S
A
A
V
S
R
R
Site 29
S407
P
Q
L
K
E
R
S
S
A
A
V
S
R
R
L
Site 30
S411
E
R
S
S
A
A
V
S
R
R
L
Q
T
T
S
Site 31
T416
A
V
S
R
R
L
Q
T
T
S
S
R
S
Y
V
Site 32
T417
V
S
R
R
L
Q
T
T
S
S
R
S
Y
V
P
Site 33
S418
S
R
R
L
Q
T
T
S
S
R
S
Y
V
P
S
Site 34
S419
R
R
L
Q
T
T
S
S
R
S
Y
V
P
S
A
Site 35
S421
L
Q
T
T
S
S
R
S
Y
V
P
S
A
P
A
Site 36
Y422
Q
T
T
S
S
R
S
Y
V
P
S
A
P
A
G
Site 37
S425
S
S
R
S
Y
V
P
S
A
P
A
G
L
G
K
Site 38
S441
E
D
A
G
R
F
H
S
T
K
K
G
N
F
H
Site 39
T442
D
A
G
R
F
H
S
T
K
K
G
N
F
H
E
Site 40
Y482
D
R
K
M
P
T
D
Y
I
R
N
G
V
L
Y
Site 41
Y494
V
L
Y
V
T
E
N
Y
L
C
F
E
S
S
K
Site 42
S499
E
N
Y
L
C
F
E
S
S
K
S
G
S
S
K
Site 43
S500
N
Y
L
C
F
E
S
S
K
S
G
S
S
K
R
Site 44
S502
L
C
F
E
S
S
K
S
G
S
S
K
R
N
K
Site 45
S504
F
E
S
S
K
S
G
S
S
K
R
N
K
V
I
Site 46
S505
E
S
S
K
S
G
S
S
K
R
N
K
V
I
K
Site 47
S538
S
G
M
G
I
A
V
S
T
P
S
T
Q
K
P
Site 48
T539
G
M
G
I
A
V
S
T
P
S
T
Q
K
P
L
Site 49
T560
H
R
D
E
A
F
E
T
I
L
S
Q
Y
I
K
Site 50
S570
S
Q
Y
I
K
I
T
S
A
A
A
S
G
G
D
Site 51
S574
K
I
T
S
A
A
A
S
G
G
D
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation