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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OVOS2
Full Name:
Ovostatin homolog 2
Alias:
ovostatin 2
Type:
Inhibitor protein
Mass (Da):
155720
Number AA:
UniProt ID:
Q6IE36
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
S
H
L
S
H
D
S
W
Q
Y
V
L
L
I
Site 2
S25
P
S
V
L
Q
E
G
S
L
D
K
A
C
A
Q
Site 3
T61
K
I
F
E
E
N
V
T
G
E
N
F
F
K
C
Site 4
S70
E
N
F
F
K
C
I
S
F
E
V
P
Q
A
R
Site 5
S100
L
N
L
E
E
R
R
S
V
A
I
R
S
R
E
Site 6
S105
R
R
S
V
A
I
R
S
R
E
N
V
V
F
V
Site 7
T118
F
V
Q
T
D
K
P
T
Y
K
P
G
Q
K
D
Site 8
Y141
L
D
T
Y
T
F
T
Y
P
N
I
T
L
K
D
Site 9
S170
F
R
N
I
T
Q
L
S
F
Q
L
I
S
E
P
Site 10
S175
Q
L
S
F
Q
L
I
S
E
P
M
F
G
D
Y
Site 11
Y182
S
E
P
M
F
G
D
Y
W
I
V
V
K
R
N
Site 12
T193
V
K
R
N
S
R
K
T
V
T
H
Q
F
A
V
Site 13
Y203
H
Q
F
A
V
K
R
Y
V
L
P
K
F
E
V
Site 14
T217
V
T
V
N
A
P
Q
T
V
T
I
S
D
D
E
Site 15
S221
A
P
Q
T
V
T
I
S
D
D
E
F
Q
V
D
Site 16
Y233
Q
V
D
V
C
A
K
Y
T
F
G
Q
P
V
Q
Site 17
T243
G
Q
P
V
Q
G
K
T
Q
I
R
V
C
R
E
Site 18
Y251
Q
I
R
V
C
R
E
Y
F
S
S
S
N
C
E
Site 19
S278
Q
L
E
N
G
C
V
S
Q
I
V
N
T
K
V
Site 20
Y289
N
T
K
V
F
Q
L
Y
R
S
G
L
F
M
T
Site 21
Y311
T
E
F
G
T
G
N
Y
C
M
Q
I
S
E
K
Site 22
Y339
F
E
N
M
D
T
F
Y
R
R
G
I
S
Y
F
Site 23
S344
T
F
Y
R
R
G
I
S
Y
F
G
T
L
K
F
Site 24
Y345
F
Y
R
R
G
I
S
Y
F
G
T
L
K
F
S
Site 25
T348
R
G
I
S
Y
F
G
T
L
K
F
S
D
P
N
Site 26
S352
Y
F
G
T
L
K
F
S
D
P
N
N
V
P
M
Site 27
Y376
N
D
E
F
I
G
N
Y
T
T
D
E
N
G
E
Site 28
S387
E
N
G
E
A
Q
F
S
I
D
T
S
D
I
F
Site 29
S391
A
Q
F
S
I
D
T
S
D
I
F
D
P
E
F
Site 30
Y404
E
F
N
L
K
A
T
Y
V
R
P
K
S
C
Y
Site 31
S409
A
T
Y
V
R
P
K
S
C
Y
L
P
S
W
L
Site 32
Y411
Y
V
R
P
K
S
C
Y
L
P
S
W
L
T
P
Site 33
Y420
P
S
W
L
T
P
Q
Y
L
D
A
H
F
L
V
Site 34
S428
L
D
A
H
F
L
V
S
R
F
Y
S
R
T
N
Site 35
Y431
H
F
L
V
S
R
F
Y
S
R
T
N
S
F
L
Site 36
S432
F
L
V
S
R
F
Y
S
R
T
N
S
F
L
K
Site 37
T434
V
S
R
F
Y
S
R
T
N
S
F
L
K
I
V
Site 38
S436
R
F
Y
S
R
T
N
S
F
L
K
I
V
P
E
Site 39
T456
C
N
H
Q
K
V
V
T
V
H
Y
S
L
N
S
Site 40
S460
K
V
V
T
V
H
Y
S
L
N
S
E
A
Y
E
Site 41
Y466
Y
S
L
N
S
E
A
Y
E
D
D
S
N
V
K
Site 42
S470
S
E
A
Y
E
D
D
S
N
V
K
F
F
Y
L
Site 43
Y476
D
S
N
V
K
F
F
Y
L
V
S
L
S
H
D
Site 44
S481
F
F
Y
L
V
S
L
S
H
D
S
G
N
F
Q
Site 45
S492
G
N
F
Q
H
R
I
S
S
S
P
I
Y
T
A
Site 46
S494
F
Q
H
R
I
S
S
S
P
I
Y
T
A
W
N
Site 47
Y497
R
I
S
S
S
P
I
Y
T
A
W
N
G
N
F
Site 48
T498
I
S
S
S
P
I
Y
T
A
W
N
G
N
F
S
Site 49
S535
S
G
E
I
V
A
D
S
V
R
F
Q
V
D
K
Site 50
S553
H
K
V
N
I
K
F
S
N
E
Q
G
L
P
G
Site 51
S561
N
E
Q
G
L
P
G
S
N
A
S
L
Y
L
Q
Site 52
S589
G
N
V
L
L
L
K
S
E
Q
Q
L
S
A
E
Site 53
S594
L
K
S
E
Q
Q
L
S
A
E
S
V
Y
N
M
Site 54
Y610
P
S
I
E
P
Y
G
Y
F
Y
H
G
L
N
L
Site 55
Y633
I
P
Q
R
D
M
F
Y
N
G
L
Y
Y
T
P
Site 56
Y637
D
M
F
Y
N
G
L
Y
Y
T
P
V
S
N
Y
Site 57
Y638
M
F
Y
N
G
L
Y
Y
T
P
V
S
N
Y
G
Site 58
T639
F
Y
N
G
L
Y
Y
T
P
V
S
N
Y
G
D
Site 59
S642
G
L
Y
Y
T
P
V
S
N
Y
G
D
G
D
I
Site 60
Y650
N
Y
G
D
G
D
I
Y
N
I
V
R
N
M
G
Site 61
Y666
K
V
F
T
N
L
H
Y
R
K
P
E
V
C
V
Site 62
Y685
L
P
L
P
K
P
L
Y
L
E
T
E
N
Y
G
Site 63
T688
P
K
P
L
Y
L
E
T
E
N
Y
G
P
M
H
Site 64
Y691
L
Y
L
E
T
E
N
Y
G
P
M
H
S
V
P
Site 65
S696
E
N
Y
G
P
M
H
S
V
P
S
R
I
A
C
Site 66
Y710
C
R
G
E
N
A
D
Y
V
E
Q
A
I
I
Q
Site 67
T718
V
E
Q
A
I
I
Q
T
V
R
T
N
F
P
E
Site 68
S733
T
W
M
W
D
L
V
S
V
D
S
S
G
S
A
Site 69
S736
W
D
L
V
S
V
D
S
S
G
S
A
N
L
S
Site 70
Y822
Q
V
E
E
S
Q
N
Y
E
A
N
I
N
T
W
Site 71
S834
N
T
W
K
I
N
G
S
E
V
I
Q
A
G
G
Site 72
T848
G
R
K
T
N
I
W
T
I
I
P
K
K
L
G
Site 73
T860
K
L
G
K
V
N
I
T
V
V
A
E
S
K
Q
Site 74
S868
V
V
A
E
S
K
Q
S
S
A
C
P
N
E
G
Site 75
S869
V
A
E
S
K
Q
S
S
A
C
P
N
E
G
M
Site 76
T886
Q
K
L
N
W
K
D
T
V
V
K
S
F
L
V
Site 77
S890
W
K
D
T
V
V
K
S
F
L
V
E
P
E
G
Site 78
T903
E
G
I
E
K
E
R
T
Q
S
F
L
I
C
T
Site 79
S905
I
E
K
E
R
T
Q
S
F
L
I
C
T
E
G
Site 80
S931
P
N
D
V
V
E
G
S
A
R
G
F
F
T
V
Site 81
Y976
S
D
T
Y
V
L
D
Y
L
K
S
T
E
Q
L
Site 82
S979
Y
V
L
D
Y
L
K
S
T
E
Q
L
T
E
E
Site 83
T980
V
L
D
Y
L
K
S
T
E
Q
L
T
E
E
V
Site 84
S989
Q
L
T
E
E
V
Q
S
K
A
F
F
L
L
S
Site 85
S996
S
K
A
F
F
L
L
S
N
G
Y
Q
R
Q
L
Site 86
Y999
F
F
L
L
S
N
G
Y
Q
R
Q
L
S
F
K
Site 87
S1004
N
G
Y
Q
R
Q
L
S
F
K
N
S
D
G
S
Site 88
S1008
R
Q
L
S
F
K
N
S
D
G
S
Y
S
V
F
Site 89
S1011
S
F
K
N
S
D
G
S
Y
S
V
F
W
Q
Q
Site 90
Y1012
F
K
N
S
D
G
S
Y
S
V
F
W
Q
Q
N
Site 91
T1033
L
S
A
L
T
F
K
T
L
E
R
M
K
K
F
Site 92
S1056
K
Q
T
L
I
W
L
S
S
Q
Q
K
T
S
G
Site 93
S1057
Q
T
L
I
W
L
S
S
Q
Q
K
T
S
G
C
Site 94
T1061
W
L
S
S
Q
Q
K
T
S
G
C
F
K
N
D
Site 95
S1062
L
S
S
Q
Q
K
T
S
G
C
F
K
N
D
G
Site 96
S1085
G
G
D
E
E
D
I
S
L
T
A
Y
V
V
G
Site 97
S1101
F
F
E
A
G
L
N
S
T
F
P
A
L
R
N
Site 98
S1119
C
L
E
A
A
L
D
S
G
V
T
N
G
Y
N
Site 99
Y1125
D
S
G
V
T
N
G
Y
N
H
A
I
L
A
Y
Site 100
S1145
G
K
E
K
Q
V
E
S
L
L
Q
T
L
D
Q
Site 101
T1149
Q
V
E
S
L
L
Q
T
L
D
Q
S
A
T
K
Site 102
Y1162
T
K
L
N
N
V
I
Y
W
E
R
E
R
K
P
Site 103
T1171
E
R
E
R
K
P
K
T
E
E
F
P
S
F
I
Site 104
S1176
P
K
T
E
E
F
P
S
F
I
P
W
A
P
S
Site 105
S1183
S
F
I
P
W
A
P
S
A
Q
T
E
K
S
C
Site 106
T1205
S
R
K
I
P
D
L
T
Y
A
S
K
I
V
Q
Site 107
Y1206
R
K
I
P
D
L
T
Y
A
S
K
I
V
Q
W
Site 108
S1226
N
S
H
G
G
F
S
S
N
Q
V
I
N
V
G
Site 109
S1247
C
G
E
E
G
L
F
S
K
N
Q
N
T
V
T
Site 110
T1252
L
F
S
K
N
Q
N
T
V
T
F
S
S
E
G
Site 111
T1254
S
K
N
Q
N
T
V
T
F
S
S
E
G
S
S
Site 112
S1256
N
Q
N
T
V
T
F
S
S
E
G
S
S
E
I
Site 113
S1257
Q
N
T
V
T
F
S
S
E
G
S
S
E
I
Q
Site 114
S1260
V
T
F
S
S
E
G
S
S
E
I
Q
F
N
G
Site 115
S1261
T
F
S
S
E
G
S
S
E
I
Q
F
N
G
H
Site 116
S1276
N
R
L
L
V
Q
R
S
E
V
T
Q
A
P
G
Site 117
T1279
L
V
Q
R
S
E
V
T
Q
A
P
G
Q
Y
T
Site 118
T1286
T
Q
A
P
G
Q
Y
T
V
D
V
E
G
R
G
Site 119
T1295
D
V
E
G
R
G
C
T
F
I
Q
A
T
L
K
Site 120
S1315
P
K
K
A
S
G
F
S
L
S
L
E
I
V
K
Site 121
S1317
K
A
S
G
F
S
L
S
L
E
I
V
K
N
Y
Site 122
S1362
S
G
F
T
P
T
M
S
S
I
E
E
L
E
N
Site 123
S1363
G
F
T
P
T
M
S
S
I
E
E
L
E
N
K
Site 124
T1376
N
K
G
Q
V
M
K
T
E
V
K
N
D
H
V
Site 125
Y1386
K
N
D
H
V
L
F
Y
L
E
N
V
F
G
R
Site 126
S1396
N
V
F
G
R
A
D
S
F
T
F
S
V
E
Q
Site 127
T1398
F
G
R
A
D
S
F
T
F
S
V
E
Q
S
N
Site 128
S1400
R
A
D
S
F
T
F
S
V
E
Q
S
N
L
V
Site 129
Y1420
A
P
G
M
V
Y
D
Y
Y
E
K
D
G
E
A
Site 130
Y1421
P
G
M
V
Y
D
Y
Y
E
K
D
G
E
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation