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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PHF17
Full Name:
Protein Jade-1
Alias:
Gene for apoptosis and differentiation in epithelia; Jade1; PHD finger protein 17; PHD protein Jade-1
Type:
Cytoplasm, Nucleus protein
Mass (Da):
95533
Number AA:
842
UniProt ID:
Q6IE81
International Prot ID:
IPI00399252
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000123
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0043966
GO:0043983
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
K
R
G
R
L
P
S
S
S
E
D
S
D
D
Site 2
S9
K
R
G
R
L
P
S
S
S
E
D
S
D
D
N
Site 3
S10
R
G
R
L
P
S
S
S
E
D
S
D
D
N
G
Site 4
S13
L
P
S
S
S
E
D
S
D
D
N
G
S
L
S
Site 5
S18
E
D
S
D
D
N
G
S
L
S
T
T
W
S
Q
Site 6
S20
S
D
D
N
G
S
L
S
T
T
W
S
Q
N
S
Site 7
T22
D
N
G
S
L
S
T
T
W
S
Q
N
S
R
S
Site 8
S24
G
S
L
S
T
T
W
S
Q
N
S
R
S
Q
H
Site 9
S29
T
W
S
Q
N
S
R
S
Q
H
R
R
S
S
C
Site 10
S34
S
R
S
Q
H
R
R
S
S
C
S
R
H
E
D
Site 11
S35
R
S
Q
H
R
R
S
S
C
S
R
H
E
D
R
Site 12
S37
Q
H
R
R
S
S
C
S
R
H
E
D
R
K
P
Site 13
S45
R
H
E
D
R
K
P
S
E
V
F
R
T
D
L
Site 14
T50
K
P
S
E
V
F
R
T
D
L
I
T
A
M
K
Site 15
Y62
A
M
K
L
H
D
S
Y
Q
L
N
P
D
E
Y
Site 16
Y69
Y
Q
L
N
P
D
E
Y
Y
V
L
A
D
P
W
Site 17
Y70
Q
L
N
P
D
E
Y
Y
V
L
A
D
P
W
R
Site 18
S89
K
G
V
Q
V
P
V
S
P
G
T
I
P
Q
P
Site 19
T92
Q
V
P
V
S
P
G
T
I
P
Q
P
V
A
R
Site 20
S102
Q
P
V
A
R
V
V
S
E
E
K
S
L
M
F
Site 21
S106
R
V
V
S
E
E
K
S
L
M
F
I
R
P
K
Site 22
Y115
M
F
I
R
P
K
K
Y
I
V
S
S
G
S
E
Site 23
S119
P
K
K
Y
I
V
S
S
G
S
E
P
P
E
L
Site 24
S121
K
Y
I
V
S
S
G
S
E
P
P
E
L
G
Y
Site 25
Y128
S
E
P
P
E
L
G
Y
V
D
I
R
T
L
A
Site 26
S137
D
I
R
T
L
A
D
S
V
C
R
Y
D
L
N
Site 27
Y141
L
A
D
S
V
C
R
Y
D
L
N
D
M
D
A
Site 28
Y169
G
M
P
E
L
D
E
Y
T
M
E
R
V
L
E
Site 29
T170
M
P
E
L
D
E
Y
T
M
E
R
V
L
E
E
Site 30
Y183
E
E
F
E
Q
R
C
Y
D
N
M
N
H
A
I
Site 31
Y200
E
E
G
L
G
I
E
Y
D
E
D
V
V
C
D
Site 32
S211
V
V
C
D
V
C
Q
S
P
D
G
E
D
G
N
Site 33
T271
K
G
G
A
M
K
P
T
R
S
G
T
K
W
V
Site 34
S273
G
A
M
K
P
T
R
S
G
T
K
W
V
H
V
Site 35
T275
M
K
P
T
R
S
G
T
K
W
V
H
V
S
C
Site 36
S293
I
P
E
V
S
I
G
S
P
E
K
M
E
P
I
Site 37
T301
P
E
K
M
E
P
I
T
K
V
S
H
I
P
S
Site 38
S304
M
E
P
I
T
K
V
S
H
I
P
S
S
R
W
Site 39
S309
K
V
S
H
I
P
S
S
R
W
A
L
V
C
S
Site 40
S363
N
D
E
V
K
F
K
S
Y
C
P
K
H
S
S
Site 41
Y364
D
E
V
K
F
K
S
Y
C
P
K
H
S
S
H
Site 42
S369
K
S
Y
C
P
K
H
S
S
H
R
K
P
E
E
Site 43
S370
S
Y
C
P
K
H
S
S
H
R
K
P
E
E
S
Site 44
S377
S
H
R
K
P
E
E
S
L
G
K
G
A
A
Q
Site 45
S392
E
N
G
A
P
E
C
S
P
R
N
P
L
E
P
Site 46
S402
N
P
L
E
P
F
A
S
L
E
Q
N
R
E
E
Site 47
S414
R
E
E
A
H
R
V
S
V
R
K
Q
K
L
Q
Site 48
Y428
Q
Q
L
E
D
E
F
Y
T
F
V
N
L
L
D
Site 49
Y451
E
E
V
V
D
F
L
Y
Q
Y
W
K
L
K
R
Site 50
Y453
V
V
D
F
L
Y
Q
Y
W
K
L
K
R
K
V
Site 51
T468
N
F
N
K
P
L
I
T
P
K
K
D
E
E
D
Site 52
T493
F
R
R
L
Q
L
F
T
H
L
R
Q
D
L
E
Site 53
T506
L
E
R
V
R
N
L
T
Y
M
V
T
R
R
E
Site 54
Y507
E
R
V
R
N
L
T
Y
M
V
T
R
R
E
K
Site 55
T510
R
N
L
T
Y
M
V
T
R
R
E
K
I
K
R
Site 56
S518
R
R
E
K
I
K
R
S
V
C
K
V
Q
E
Q
Site 57
S540
L
L
E
Q
E
R
V
S
G
V
P
S
S
C
S
Site 58
S544
E
R
V
S
G
V
P
S
S
C
S
S
S
S
L
Site 59
S545
R
V
S
G
V
P
S
S
C
S
S
S
S
L
E
Site 60
S547
S
G
V
P
S
S
C
S
S
S
S
L
E
N
M
Site 61
S548
G
V
P
S
S
C
S
S
S
S
L
E
N
M
L
Site 62
S550
P
S
S
C
S
S
S
S
L
E
N
M
L
L
F
Site 63
S559
E
N
M
L
L
F
N
S
P
S
V
G
P
D
A
Site 64
S561
M
L
L
F
N
S
P
S
V
G
P
D
A
P
K
Site 65
T585
F
F
R
K
Q
M
G
T
S
L
V
H
S
L
K
Site 66
S586
F
R
K
Q
M
G
T
S
L
V
H
S
L
K
K
Site 67
S590
M
G
T
S
L
V
H
S
L
K
K
P
H
K
R
Site 68
S603
K
R
D
P
L
Q
N
S
P
G
S
E
G
K
T
Site 69
S606
P
L
Q
N
S
P
G
S
E
G
K
T
L
L
K
Site 70
T610
S
P
G
S
E
G
K
T
L
L
K
Q
P
D
L
Site 71
S644
F
A
E
A
R
L
I
S
A
Q
Q
K
N
G
V
Site 72
S677
K
G
D
L
K
D
K
S
F
K
Q
S
H
K
P
Site 73
S681
K
D
K
S
F
K
Q
S
H
K
P
L
R
S
T
Site 74
S687
Q
S
H
K
P
L
R
S
T
D
V
S
Q
R
H
Site 75
T688
S
H
K
P
L
R
S
T
D
V
S
Q
R
H
L
Site 76
S691
P
L
R
S
T
D
V
S
Q
R
H
L
D
N
T
Site 77
T698
S
Q
R
H
L
D
N
T
R
A
A
T
S
P
G
Site 78
T702
L
D
N
T
R
A
A
T
S
P
G
V
G
Q
S
Site 79
S703
D
N
T
R
A
A
T
S
P
G
V
G
Q
S
A
Site 80
T713
V
G
Q
S
A
P
G
T
R
K
E
I
V
P
K
Site 81
Y730
G
S
L
I
K
V
N
Y
N
Q
T
A
V
K
V
Site 82
T739
Q
T
A
V
K
V
P
T
T
P
A
S
P
V
K
Site 83
T740
T
A
V
K
V
P
T
T
P
A
S
P
V
K
N
Site 84
S743
K
V
P
T
T
P
A
S
P
V
K
N
W
G
G
Site 85
Y776
A
C
H
Q
H
S
D
Y
P
Y
L
G
L
G
R
Site 86
Y778
H
Q
H
S
D
Y
P
Y
L
G
L
G
R
V
P
Site 87
S792
P
A
K
E
R
A
K
S
K
L
K
S
D
N
E
Site 88
S796
R
A
K
S
K
L
K
S
D
N
E
N
D
G
Y
Site 89
Y803
S
D
N
E
N
D
G
Y
V
P
D
V
E
M
S
Site 90
S810
Y
V
P
D
V
E
M
S
D
S
E
S
E
A
S
Site 91
S812
P
D
V
E
M
S
D
S
E
S
E
A
S
E
K
Site 92
S814
V
E
M
S
D
S
E
S
E
A
S
E
K
K
C
Site 93
S817
S
D
S
E
S
E
A
S
E
K
K
C
I
H
T
Site 94
S825
E
K
K
C
I
H
T
S
S
T
I
S
R
R
T
Site 95
T827
K
C
I
H
T
S
S
T
I
S
R
R
T
D
I
Site 96
S829
I
H
T
S
S
T
I
S
R
R
T
D
I
I
R
Site 97
T832
S
S
T
I
S
R
R
T
D
I
I
R
R
S
I
Site 98
S838
R
T
D
I
I
R
R
S
I
L
A
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation