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Updated November 2019
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Protein Info
Short Name:
PLEKHA7
Full Name:
Pleckstrin homology domain-containing family A member 7
Alias:
DKFZp686M22243; LOC144100; PKHA7; Pleckstriny domain containing, family A member 7
Type:
Unknown function
Mass (Da):
127135
Number AA:
1121
UniProt ID:
Q6IQ23
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
A
A
T
V
G
R
D
T
L
P
E
H
W
S
Y
Site 2
Y17
T
L
P
E
H
W
S
Y
G
V
C
R
D
G
R
Site 3
T36
N
D
Q
L
R
C
T
T
W
L
H
P
R
T
G
Site 4
T42
T
T
W
L
H
P
R
T
G
E
P
V
N
S
G
Site 5
S48
R
T
G
E
P
V
N
S
G
H
M
I
R
S
D
Site 6
S54
N
S
G
H
M
I
R
S
D
L
P
R
G
W
E
Site 7
T65
R
G
W
E
E
G
F
T
E
E
G
A
S
Y
F
Site 8
Y71
F
T
E
E
G
A
S
Y
F
I
D
H
N
Q
Q
Site 9
T87
T
A
F
R
H
P
V
T
G
Q
F
S
P
E
N
Site 10
S91
H
P
V
T
G
Q
F
S
P
E
N
S
E
F
I
Site 11
S95
G
Q
F
S
P
E
N
S
E
F
I
L
Q
E
E
Site 12
S117
Q
D
R
N
Q
R
P
S
S
M
V
S
E
T
S
Site 13
S118
D
R
N
Q
R
P
S
S
M
V
S
E
T
S
T
Site 14
S121
Q
R
P
S
S
M
V
S
E
T
S
T
A
G
T
Site 15
T123
P
S
S
M
V
S
E
T
S
T
A
G
T
A
S
Site 16
S124
S
S
M
V
S
E
T
S
T
A
G
T
A
S
T
Site 17
T125
S
M
V
S
E
T
S
T
A
G
T
A
S
T
L
Site 18
T128
S
E
T
S
T
A
G
T
A
S
T
L
E
A
K
Site 19
T131
S
T
A
G
T
A
S
T
L
E
A
K
P
G
P
Site 20
S143
P
G
P
K
I
I
K
S
S
S
K
V
H
S
F
Site 21
S145
P
K
I
I
K
S
S
S
K
V
H
S
F
G
K
Site 22
S149
K
S
S
S
K
V
H
S
F
G
K
R
D
Q
A
Site 23
Y196
L
A
D
Y
C
L
F
Y
Y
K
D
S
R
E
E
Site 24
Y197
A
D
Y
C
L
F
Y
Y
K
D
S
R
E
E
A
Site 25
S217
P
L
P
S
Y
V
I
S
P
V
A
P
E
D
R
Site 26
S226
V
A
P
E
D
R
I
S
R
K
Y
S
F
K
A
Site 27
Y229
E
D
R
I
S
R
K
Y
S
F
K
A
V
H
T
Site 28
S230
D
R
I
S
R
K
Y
S
F
K
A
V
H
T
G
Site 29
Y243
T
G
M
R
A
L
I
Y
N
S
S
T
A
G
S
Site 30
S245
M
R
A
L
I
Y
N
S
S
T
A
G
S
Q
A
Site 31
S246
R
A
L
I
Y
N
S
S
T
A
G
S
Q
A
E
Site 32
T247
A
L
I
Y
N
S
S
T
A
G
S
Q
A
E
Q
Site 33
S250
Y
N
S
S
T
A
G
S
Q
A
E
Q
S
G
M
Site 34
S255
A
G
S
Q
A
E
Q
S
G
M
R
T
Y
Y
F
Site 35
T259
A
E
Q
S
G
M
R
T
Y
Y
F
S
A
D
T
Site 36
Y260
E
Q
S
G
M
R
T
Y
Y
F
S
A
D
T
Q
Site 37
Y261
Q
S
G
M
R
T
Y
Y
F
S
A
D
T
Q
E
Site 38
S285
N
Q
A
A
Q
V
L
S
R
S
S
L
K
R
D
Site 39
S288
A
Q
V
L
S
R
S
S
L
K
R
D
M
E
K
Site 40
Y345
Q
E
Q
E
G
E
Q
Y
R
S
Q
R
D
P
L
Site 41
S347
Q
E
G
E
Q
Y
R
S
Q
R
D
P
L
E
G
Site 42
S359
L
E
G
K
R
D
R
S
K
A
R
S
P
Y
S
Site 43
S363
R
D
R
S
K
A
R
S
P
Y
S
P
A
E
E
Site 44
Y365
R
S
K
A
R
S
P
Y
S
P
A
E
E
D
A
Site 45
S366
S
K
A
R
S
P
Y
S
P
A
E
E
D
A
L
Site 46
T379
A
L
F
M
D
L
P
T
G
P
R
G
Q
Q
A
Site 47
S400
K
N
G
M
L
P
A
S
Y
G
P
G
E
Q
N
Site 48
Y401
N
G
M
L
P
A
S
Y
G
P
G
E
Q
N
G
Site 49
T409
G
P
G
E
Q
N
G
T
G
G
Y
Q
R
A
F
Site 50
Y412
E
Q
N
G
T
G
G
Y
Q
R
A
F
P
P
R
Site 51
T420
Q
R
A
F
P
P
R
T
N
P
E
K
H
S
Q
Site 52
S426
R
T
N
P
E
K
H
S
Q
R
K
S
N
L
A
Site 53
S430
E
K
H
S
Q
R
K
S
N
L
A
Q
V
E
H
Site 54
S446
A
R
A
Q
K
G
D
S
R
S
L
P
L
D
Q
Site 55
S448
A
Q
K
G
D
S
R
S
L
P
L
D
Q
T
L
Site 56
T454
R
S
L
P
L
D
Q
T
L
P
R
Q
G
P
G
Site 57
S463
P
R
Q
G
P
G
Q
S
L
S
F
P
E
N
Y
Site 58
S465
Q
G
P
G
Q
S
L
S
F
P
E
N
Y
Q
T
Site 59
Y470
S
L
S
F
P
E
N
Y
Q
T
L
P
K
S
T
Site 60
T472
S
F
P
E
N
Y
Q
T
L
P
K
S
T
R
H
Site 61
S476
N
Y
Q
T
L
P
K
S
T
R
H
P
S
G
G
Site 62
T477
Y
Q
T
L
P
K
S
T
R
H
P
S
G
G
S
Site 63
S481
P
K
S
T
R
H
P
S
G
G
S
S
P
P
P
Site 64
S485
R
H
P
S
G
G
S
S
P
P
P
R
N
L
P
Site 65
S493
P
P
P
R
N
L
P
S
D
Y
K
Y
A
Q
D
Site 66
Y495
P
R
N
L
P
S
D
Y
K
Y
A
Q
D
R
A
Site 67
Y497
N
L
P
S
D
Y
K
Y
A
Q
D
R
A
S
H
Site 68
S503
K
Y
A
Q
D
R
A
S
H
L
K
M
S
S
E
Site 69
S508
R
A
S
H
L
K
M
S
S
E
E
R
R
A
H
Site 70
S509
A
S
H
L
K
M
S
S
E
E
R
R
A
H
R
Site 71
T519
R
R
A
H
R
D
G
T
V
W
Q
L
Y
E
W
Site 72
Y524
D
G
T
V
W
Q
L
Y
E
W
Q
Q
R
Q
Q
Site 73
S536
R
Q
Q
F
R
H
G
S
P
T
A
P
I
C
L
Site 74
T538
Q
F
R
H
G
S
P
T
A
P
I
C
L
G
S
Site 75
S545
T
A
P
I
C
L
G
S
P
E
F
T
D
Q
G
Site 76
T549
C
L
G
S
P
E
F
T
D
Q
G
R
S
R
S
Site 77
S556
T
D
Q
G
R
S
R
S
M
L
E
V
P
R
S
Site 78
S563
S
M
L
E
V
P
R
S
I
S
V
P
P
S
P
Site 79
S565
L
E
V
P
R
S
I
S
V
P
P
S
P
S
D
Site 80
S569
R
S
I
S
V
P
P
S
P
S
D
I
P
P
P
Site 81
S571
I
S
V
P
P
S
P
S
D
I
P
P
P
G
P
Site 82
T589
F
P
P
R
R
P
H
T
P
A
E
R
V
T
V
Site 83
T595
H
T
P
A
E
R
V
T
V
K
P
P
D
Q
R
Site 84
S604
K
P
P
D
Q
R
R
S
V
D
I
S
L
G
D
Site 85
S608
Q
R
R
S
V
D
I
S
L
G
D
S
P
R
R
Site 86
S612
V
D
I
S
L
G
D
S
P
R
R
A
R
G
H
Site 87
S625
G
H
A
V
K
N
S
S
H
V
D
R
R
S
M
Site 88
S631
S
S
H
V
D
R
R
S
M
P
S
M
G
Y
M
Site 89
S634
V
D
R
R
S
M
P
S
M
G
Y
M
T
H
T
Site 90
T639
M
P
S
M
G
Y
M
T
H
T
V
S
A
P
S
Site 91
T641
S
M
G
Y
M
T
H
T
V
S
A
P
S
L
H
Site 92
S643
G
Y
M
T
H
T
V
S
A
P
S
L
H
G
K
Site 93
S646
T
H
T
V
S
A
P
S
L
H
G
K
S
A
D
Site 94
T655
H
G
K
S
A
D
D
T
Y
L
Q
L
K
K
D
Site 95
Y656
G
K
S
A
D
D
T
Y
L
Q
L
K
K
D
L
Site 96
Y665
Q
L
K
K
D
L
E
Y
L
D
L
K
M
T
G
Site 97
T671
E
Y
L
D
L
K
M
T
G
R
D
L
L
K
D
Site 98
S680
R
D
L
L
K
D
R
S
L
K
P
V
K
I
A
Site 99
S689
K
P
V
K
I
A
E
S
D
T
D
V
K
L
S
Site 100
S724
E
N
K
D
Q
L
E
S
V
L
E
V
L
H
R
Site 101
Y736
L
H
R
Q
M
E
Q
Y
R
D
Q
P
Q
H
L
Site 102
Y748
Q
H
L
E
K
I
A
Y
Q
Q
K
L
L
Q
E
Site 103
S765
V
H
I
R
A
E
L
S
R
E
S
T
E
M
E
Site 104
S768
R
A
E
L
S
R
E
S
T
E
M
E
N
A
W
Site 105
T769
A
E
L
S
R
E
S
T
E
M
E
N
A
W
N
Site 106
T819
L
W
R
I
E
D
V
T
A
G
L
S
A
N
K
Site 107
S823
E
D
V
T
A
G
L
S
A
N
K
E
N
F
R
Site 108
S835
N
F
R
I
L
V
E
S
V
K
N
P
E
R
K
Site 109
T843
V
K
N
P
E
R
K
T
V
P
L
F
P
H
P
Site 110
S854
F
P
H
P
P
V
P
S
L
S
T
S
E
S
K
Site 111
S856
H
P
P
V
P
S
L
S
T
S
E
S
K
P
P
Site 112
S858
P
V
P
S
L
S
T
S
E
S
K
P
P
P
Q
Site 113
S860
P
S
L
S
T
S
E
S
K
P
P
P
Q
P
S
Site 114
S867
S
K
P
P
P
Q
P
S
P
P
T
S
P
V
R
Site 115
T870
P
P
Q
P
S
P
P
T
S
P
V
R
T
P
L
Site 116
S871
P
Q
P
S
P
P
T
S
P
V
R
T
P
L
E
Site 117
T875
P
P
T
S
P
V
R
T
P
L
E
V
R
L
F
Site 118
T887
R
L
F
P
Q
L
Q
T
Y
V
P
Y
R
P
H
Site 119
Y888
L
F
P
Q
L
Q
T
Y
V
P
Y
R
P
H
P
Site 120
Y891
Q
L
Q
T
Y
V
P
Y
R
P
H
P
P
Q
L
Site 121
T902
P
P
Q
L
R
K
V
T
S
P
L
Q
S
P
T
Site 122
S903
P
Q
L
R
K
V
T
S
P
L
Q
S
P
T
K
Site 123
S907
K
V
T
S
P
L
Q
S
P
T
K
A
K
P
K
Site 124
T909
T
S
P
L
Q
S
P
T
K
A
K
P
K
V
E
Site 125
S930
P
P
L
P
E
L
Y
S
P
E
D
Q
P
P
A
Site 126
T946
P
P
L
P
R
E
A
T
I
I
R
H
T
S
V
Site 127
T951
E
A
T
I
I
R
H
T
S
V
R
G
L
K
R
Site 128
S952
A
T
I
I
R
H
T
S
V
R
G
L
K
R
Q
Site 129
S960
V
R
G
L
K
R
Q
S
D
E
R
K
R
D
R
Site 130
S977
G
Q
C
V
N
G
D
S
R
V
E
L
R
S
Y
Site 131
S983
D
S
R
V
E
L
R
S
Y
V
S
E
P
E
L
Site 132
Y984
S
R
V
E
L
R
S
Y
V
S
E
P
E
L
A
Site 133
S986
V
E
L
R
S
Y
V
S
E
P
E
L
A
T
L
Site 134
T992
V
S
E
P
E
L
A
T
L
S
G
D
M
A
Q
Site 135
S994
E
P
E
L
A
T
L
S
G
D
M
A
Q
P
S
Site 136
S1001
S
G
D
M
A
Q
P
S
L
G
L
V
G
P
E
Site 137
S1009
L
G
L
V
G
P
E
S
R
Y
Q
T
L
P
G
Site 138
Y1011
L
V
G
P
E
S
R
Y
Q
T
L
P
G
R
G
Site 139
T1013
G
P
E
S
R
Y
Q
T
L
P
G
R
G
L
S
Site 140
S1020
T
L
P
G
R
G
L
S
G
S
T
S
R
L
Q
Site 141
S1022
P
G
R
G
L
S
G
S
T
S
R
L
Q
Q
S
Site 142
T1023
G
R
G
L
S
G
S
T
S
R
L
Q
Q
S
S
Site 143
S1024
R
G
L
S
G
S
T
S
R
L
Q
Q
S
S
T
Site 144
S1030
T
S
R
L
Q
Q
S
S
T
I
A
P
Y
V
T
Site 145
T1031
S
R
L
Q
Q
S
S
T
I
A
P
Y
V
T
L
Site 146
Y1035
Q
S
S
T
I
A
P
Y
V
T
L
R
R
G
L
Site 147
T1037
S
T
I
A
P
Y
V
T
L
R
R
G
L
N
A
Site 148
S1047
R
G
L
N
A
E
S
S
K
A
T
F
P
R
P
Site 149
T1050
N
A
E
S
S
K
A
T
F
P
R
P
K
S
A
Site 150
S1056
A
T
F
P
R
P
K
S
A
L
E
R
L
Y
S
Site 151
Y1062
K
S
A
L
E
R
L
Y
S
G
D
H
Q
R
G
Site 152
S1063
S
A
L
E
R
L
Y
S
G
D
H
Q
R
G
K
Site 153
S1072
D
H
Q
R
G
K
M
S
A
E
E
Q
L
E
R
Site 154
T1094
L
V
R
E
R
K
R
T
L
G
Q
G
E
R
T
Site 155
T1101
T
L
G
Q
G
E
R
T
G
L
P
S
S
R
Y
Site 156
S1105
G
E
R
T
G
L
P
S
S
R
Y
L
S
R
P
Site 157
S1106
E
R
T
G
L
P
S
S
R
Y
L
S
R
P
L
Site 158
Y1108
T
G
L
P
S
S
R
Y
L
S
R
P
L
P
G
Site 159
S1110
L
P
S
S
R
Y
L
S
R
P
L
P
G
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation