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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RAB6IP1
Full Name:
DENN domain-containing protein 5A
Alias:
DENN/MADD domain containing 5A; FLJ22354; FLJ33829; FLJ43455; KIAA1091; RA6I1; RAB6 interacting 1
Type:
Unknown function
Mass (Da):
147095
Number AA:
1287
UniProt ID:
Q6IQ26
International Prot ID:
IPI00456737
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
G
G
G
G
G
G
S
A
P
S
R
F
A
D
Site 2
S13
G
G
G
G
S
A
P
S
R
F
A
D
Y
F
V
Site 3
S36
G
L
E
P
D
E
L
S
A
L
C
Q
Y
I
Q
Site 4
Y41
E
L
S
A
L
C
Q
Y
I
Q
A
S
K
A
R
Site 5
S45
L
C
Q
Y
I
Q
A
S
K
A
R
D
G
A
S
Site 6
S52
S
K
A
R
D
G
A
S
P
F
I
S
S
T
T
Site 7
S56
D
G
A
S
P
F
I
S
S
T
T
E
G
E
N
Site 8
S57
G
A
S
P
F
I
S
S
T
T
E
G
E
N
F
Site 9
T67
E
G
E
N
F
E
Q
T
P
L
R
R
T
F
K
Site 10
T72
E
Q
T
P
L
R
R
T
F
K
S
K
V
L
A
Site 11
S75
P
L
R
R
T
F
K
S
K
V
L
A
R
Y
P
Site 12
Y81
K
S
K
V
L
A
R
Y
P
E
N
V
E
W
N
Site 13
T108
P
K
G
L
A
F
K
T
Q
A
D
P
R
E
P
Site 14
S128
I
I
T
R
E
D
G
S
R
T
F
G
F
A
L
Site 15
T130
T
R
E
D
G
S
R
T
F
G
F
A
L
T
F
Site 16
Y138
F
G
F
A
L
T
F
Y
E
E
V
T
S
K
Q
Site 17
S175
P
A
D
D
R
D
Q
S
S
M
E
D
G
E
D
Site 18
S176
A
D
D
R
D
Q
S
S
M
E
D
G
E
D
T
Site 19
T183
S
M
E
D
G
E
D
T
P
V
T
K
L
Q
R
Site 20
T186
D
G
E
D
T
P
V
T
K
L
Q
R
F
N
S
Site 21
S193
T
K
L
Q
R
F
N
S
Y
D
I
S
R
D
T
Site 22
Y194
K
L
Q
R
F
N
S
Y
D
I
S
R
D
T
L
Site 23
S197
R
F
N
S
Y
D
I
S
R
D
T
L
Y
V
S
Site 24
T200
S
Y
D
I
S
R
D
T
L
Y
V
S
K
C
I
Site 25
S221
S
F
M
K
A
C
R
S
V
L
Q
Q
L
H
Q
Site 26
S232
Q
L
H
Q
A
V
T
S
P
Q
P
P
P
L
P
Site 27
Y243
P
P
L
P
L
E
S
Y
I
Y
N
V
L
Y
E
Site 28
S259
P
L
P
P
P
G
R
S
L
K
F
S
G
V
Y
Site 29
S275
P
I
I
C
Q
R
P
S
T
N
E
L
P
L
F
Site 30
T276
I
I
C
Q
R
P
S
T
N
E
L
P
L
F
D
Site 31
T323
Q
H
Y
Q
R
L
M
T
V
A
E
T
I
T
A
Site 32
S365
P
Y
L
M
G
L
H
S
N
G
L
D
D
R
S
Site 33
S372
S
N
G
L
D
D
R
S
K
L
E
L
P
Q
E
Site 34
S429
P
E
G
N
L
H
C
S
E
S
A
S
K
L
K
Site 35
S431
G
N
L
H
C
S
E
S
A
S
K
L
K
R
L
Site 36
S433
L
H
C
S
E
S
A
S
K
L
K
R
L
R
A
Site 37
S441
K
L
K
R
L
R
A
S
E
L
V
S
D
K
R
Site 38
S445
L
R
A
S
E
L
V
S
D
K
R
N
G
N
I
Site 39
S455
R
N
G
N
I
A
G
S
P
L
H
S
Y
E
L
Site 40
S459
I
A
G
S
P
L
H
S
Y
E
L
L
K
E
N
Site 41
Y460
A
G
S
P
L
H
S
Y
E
L
L
K
E
N
E
Site 42
S493
L
E
V
R
E
D
P
S
S
N
K
D
L
K
V
Site 43
S494
E
V
R
E
D
P
S
S
N
K
D
L
K
V
Q
Site 44
Y510
D
E
E
E
L
R
I
Y
Q
L
N
I
Q
I
R
Site 45
S539
E
V
F
V
I
Q
P
S
Q
D
K
E
S
W
F
Site 46
S559
M
Q
N
F
D
K
A
S
F
L
S
D
Q
P
E
Site 47
S562
F
D
K
A
S
F
L
S
D
Q
P
E
P
Y
L
Site 48
Y568
L
S
D
Q
P
E
P
Y
L
P
F
L
S
R
F
Site 49
S573
E
P
Y
L
P
F
L
S
R
F
L
E
T
Q
M
Site 50
S606
P
V
L
R
V
F
D
S
R
V
D
K
I
R
L
Site 51
T618
I
R
L
L
N
V
R
T
P
T
L
R
T
S
M
Site 52
T620
L
L
N
V
R
T
P
T
L
R
T
S
M
Y
Q
Site 53
S624
R
T
P
T
L
R
T
S
M
Y
Q
K
C
T
T
Site 54
Y626
P
T
L
R
T
S
M
Y
Q
K
C
T
T
V
D
Site 55
T631
S
M
Y
Q
K
C
T
T
V
D
E
A
E
K
A
Site 56
T649
R
L
A
K
I
D
H
T
A
I
H
P
H
L
L
Site 57
Y665
M
K
I
G
Q
G
K
Y
E
P
G
F
F
P
K
Site 58
S675
G
F
F
P
K
L
Q
S
D
V
L
S
T
G
P
Site 59
S679
K
L
Q
S
D
V
L
S
T
G
P
A
S
N
K
Site 60
S684
V
L
S
T
G
P
A
S
N
K
W
T
K
R
N
Site 61
T688
G
P
A
S
N
K
W
T
K
R
N
A
P
A
Q
Site 62
T706
K
D
R
Q
K
Q
H
T
E
H
L
R
L
D
N
Site 63
Y719
D
N
D
Q
R
E
K
Y
I
Q
E
A
R
T
M
Site 64
T725
K
Y
I
Q
E
A
R
T
M
G
S
T
I
R
Q
Site 65
S728
Q
E
A
R
T
M
G
S
T
I
R
Q
P
K
L
Site 66
T729
E
A
R
T
M
G
S
T
I
R
Q
P
K
L
S
Site 67
S736
T
I
R
Q
P
K
L
S
N
L
S
P
S
V
I
Site 68
S739
Q
P
K
L
S
N
L
S
P
S
V
I
A
Q
T
Site 69
S741
K
L
S
N
L
S
P
S
V
I
A
Q
T
N
W
Site 70
T762
L
K
E
C
R
N
K
T
K
R
M
L
V
E
K
Site 71
T785
G
H
G
E
V
N
I
T
G
V
E
E
N
T
L
Site 72
S795
E
E
N
T
L
I
A
S
L
C
D
L
L
E
R
Site 73
S805
D
L
L
E
R
I
W
S
H
G
L
Q
V
K
Q
Site 74
S815
L
Q
V
K
Q
G
K
S
A
L
W
S
H
L
L
Site 75
Y824
L
W
S
H
L
L
H
Y
Q
D
N
R
Q
R
K
Site 76
T833
D
N
R
Q
R
K
L
T
S
G
S
L
S
T
S
Site 77
S834
N
R
Q
R
K
L
T
S
G
S
L
S
T
S
G
Site 78
S836
Q
R
K
L
T
S
G
S
L
S
T
S
G
I
L
Site 79
S838
K
L
T
S
G
S
L
S
T
S
G
I
L
L
D
Site 80
S840
T
S
G
S
L
S
T
S
G
I
L
L
D
S
E
Site 81
S846
T
S
G
I
L
L
D
S
E
R
R
K
S
D
A
Site 82
S851
L
D
S
E
R
R
K
S
D
A
S
S
L
M
P
Site 83
S854
E
R
R
K
S
D
A
S
S
L
M
P
P
L
R
Site 84
S855
R
R
K
S
D
A
S
S
L
M
P
P
L
R
I
Site 85
S863
L
M
P
P
L
R
I
S
L
I
Q
D
M
R
H
Site 86
S891
A
R
A
W
V
R
L
S
M
E
K
K
L
L
S
Site 87
S898
S
M
E
K
K
L
L
S
R
H
L
K
Q
L
L
Site 88
S906
R
H
L
K
Q
L
L
S
D
H
E
L
T
K
K
Site 89
Y915
H
E
L
T
K
K
L
Y
K
R
Y
A
F
L
R
Site 90
Y932
D
E
K
E
Q
F
L
Y
H
L
L
S
F
N
A
Site 91
T986
I
S
G
E
L
G
E
T
Q
I
M
Q
I
P
R
Site 92
T999
P
R
N
V
L
E
M
T
F
E
C
Q
N
L
G
Site 93
Y1021
G
H
D
N
S
G
L
Y
A
K
W
L
V
E
Y
Site 94
S1056
G
K
G
M
D
D
G
S
L
E
R
I
L
V
G
Site 95
S1068
L
V
G
E
L
L
T
S
Q
P
E
V
D
E
R
Site 96
T1079
V
D
E
R
P
C
R
T
P
P
L
Q
Q
S
P
Site 97
S1085
R
T
P
P
L
Q
Q
S
P
S
V
I
R
R
L
Site 98
S1087
P
P
L
Q
Q
S
P
S
V
I
R
R
L
V
T
Site 99
T1094
S
V
I
R
R
L
V
T
I
S
P
N
N
K
P
Site 100
S1096
I
R
R
L
V
T
I
S
P
N
N
K
P
K
L
Site 101
S1132
K
P
E
K
E
R
G
S
L
T
L
L
L
C
G
Site 102
T1134
E
K
E
R
G
S
L
T
L
L
L
C
G
E
C
Site 103
S1157
A
F
Q
H
G
F
K
S
P
R
L
F
K
N
V
Site 104
T1175
D
F
L
E
K
A
Q
T
Y
Y
E
T
L
E
K
Site 105
T1203
R
N
F
C
R
F
V
T
A
I
N
N
T
P
R
Site 106
T1208
F
V
T
A
I
N
N
T
P
R
N
I
G
K
D
Site 107
S1262
K
D
H
T
L
V
N
S
L
I
R
V
L
Q
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation