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Updated November 2019
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Protein Info
Short Name:
TTBK2
Full Name:
Tau-tubulin kinase 2
Alias:
Type:
Mass (Da):
137412
Number AA:
1244
UniProt ID:
Q6IQ55
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
G
G
E
Q
L
D
Site 2
Y91
G
R
N
D
R
F
N
Y
V
V
M
Q
L
Q
G
Site 3
S107
N
L
A
D
L
R
R
S
Q
S
R
G
T
F
T
Site 4
S109
A
D
L
R
R
S
Q
S
R
G
T
F
T
I
S
Site 5
T112
R
R
S
Q
S
R
G
T
F
T
I
S
T
T
L
Site 6
T114
S
Q
S
R
G
T
F
T
I
S
T
T
L
R
L
Site 7
S116
S
R
G
T
F
T
I
S
T
T
L
R
L
G
R
Site 8
T117
R
G
T
F
T
I
S
T
T
L
R
L
G
R
Q
Site 9
S134
E
S
I
E
S
I
H
S
V
G
F
L
H
R
D
Site 10
T155
A
M
G
R
F
P
S
T
C
R
K
C
Y
M
L
Site 11
T171
F
G
L
A
R
Q
F
T
N
S
C
G
D
V
R
Site 12
S173
L
A
R
Q
F
T
N
S
C
G
D
V
R
P
P
Site 13
Y192
G
F
R
G
T
V
R
Y
A
S
I
N
A
H
R
Site 14
S194
R
G
T
V
R
Y
A
S
I
N
A
H
R
N
R
Site 15
S211
G
R
H
D
D
L
W
S
L
F
Y
M
L
V
E
Site 16
S237
K
D
K
E
Q
V
G
S
I
K
E
R
Y
D
H
Site 17
Y242
V
G
S
I
K
E
R
Y
D
H
R
L
M
L
K
Site 18
S256
K
H
L
P
P
E
F
S
I
F
L
D
H
I
S
Site 19
Y267
D
H
I
S
S
L
D
Y
F
T
K
P
D
Y
Q
Site 20
Y273
D
Y
F
T
K
P
D
Y
Q
L
L
T
S
V
F
Site 21
S278
P
D
Y
Q
L
L
T
S
V
F
D
N
S
I
K
Site 22
S292
K
T
F
G
V
I
E
S
D
P
F
D
W
E
K
Site 23
T300
D
P
F
D
W
E
K
T
G
N
D
G
S
L
T
Site 24
S305
E
K
T
G
N
D
G
S
L
T
T
T
T
T
S
Site 25
T307
T
G
N
D
G
S
L
T
T
T
T
T
S
T
T
Site 26
T309
N
D
G
S
L
T
T
T
T
T
S
T
T
P
Q
Site 27
T310
D
G
S
L
T
T
T
T
T
S
T
T
P
Q
L
Site 28
S312
S
L
T
T
T
T
T
S
T
T
P
Q
L
H
T
Site 29
T314
T
T
T
T
T
S
T
T
P
Q
L
H
T
R
L
Site 30
T343
G
D
L
L
R
E
N
T
D
E
V
F
P
D
E
Site 31
S353
V
F
P
D
E
Q
L
S
D
G
E
N
G
I
P
Site 32
S364
N
G
I
P
V
G
V
S
P
D
K
L
P
G
S
Site 33
S371
S
P
D
K
L
P
G
S
L
G
H
P
R
P
Q
Site 34
T402
L
G
I
C
K
A
A
T
E
E
E
N
S
H
G
Site 35
S407
A
A
T
E
E
E
N
S
H
G
Q
A
N
G
L
Site 36
S422
L
N
A
P
S
L
G
S
P
I
R
V
R
S
E
Site 37
S428
G
S
P
I
R
V
R
S
E
I
T
Q
P
D
R
Site 38
S445
P
L
V
R
K
L
R
S
I
H
S
F
E
L
E
Site 39
S448
R
K
L
R
S
I
H
S
F
E
L
E
K
R
L
Site 40
T456
F
E
L
E
K
R
L
T
L
E
P
K
P
D
T
Site 41
T463
T
L
E
P
K
P
D
T
D
K
F
L
E
T
C
Site 42
S479
E
K
M
Q
K
D
T
S
A
G
K
E
S
I
L
Site 43
S499
K
P
C
V
P
A
V
S
R
T
D
H
I
W
H
Site 44
Y507
R
T
D
H
I
W
H
Y
D
E
E
Y
L
P
D
Site 45
Y511
I
W
H
Y
D
E
E
Y
L
P
D
A
S
K
P
Site 46
S516
E
E
Y
L
P
D
A
S
K
P
A
S
A
N
T
Site 47
S520
P
D
A
S
K
P
A
S
A
N
T
P
E
Q
A
Site 48
T523
S
K
P
A
S
A
N
T
P
E
Q
A
D
G
G
Site 49
T566
Q
D
L
Q
D
F
R
T
N
E
A
V
G
H
K
Site 50
T575
E
A
V
G
H
K
T
T
G
S
P
S
D
E
E
Site 51
S577
V
G
H
K
T
T
G
S
P
S
D
E
E
P
E
Site 52
S592
V
L
Q
V
L
E
A
S
P
Q
D
E
K
L
Q
Site 53
S614
D
H
L
K
K
E
T
S
G
V
V
L
A
L
S
Site 54
T627
L
S
A
E
G
P
P
T
A
A
S
E
Q
Y
T
Site 55
T634
T
A
A
S
E
Q
Y
T
D
R
L
E
L
Q
P
Site 56
T665
A
Q
A
E
G
P
L
T
A
I
T
I
P
R
P
Site 57
S673
A
I
T
I
P
R
P
S
V
A
S
T
Q
S
T
Site 58
S676
I
P
R
P
S
V
A
S
T
Q
S
T
S
G
S
Site 59
T677
P
R
P
S
V
A
S
T
Q
S
T
S
G
S
F
Site 60
S679
P
S
V
A
S
T
Q
S
T
S
G
S
F
H
C
Site 61
T680
S
V
A
S
T
Q
S
T
S
G
S
F
H
C
G
Site 62
S683
S
T
Q
S
T
S
G
S
F
H
C
G
Q
Q
P
Site 63
T701
D
L
Q
P
M
E
P
T
V
E
L
Y
S
P
R
Site 64
Y705
M
E
P
T
V
E
L
Y
S
P
R
E
N
F
S
Site 65
S706
E
P
T
V
E
L
Y
S
P
R
E
N
F
S
G
Site 66
S723
V
T
E
G
E
P
P
S
G
G
S
R
T
D
L
Site 67
S748
M
L
P
N
I
R
E
S
N
K
S
Q
D
L
G
Site 68
S751
N
I
R
E
S
N
K
S
Q
D
L
G
P
K
E
Site 69
S781
P
G
E
T
E
E
K
S
I
L
L
E
S
D
N
Site 70
S786
E
K
S
I
L
L
E
S
D
N
E
D
E
K
L
Site 71
S817
V
I
V
E
K
D
H
S
A
T
T
E
P
L
D
Site 72
T826
T
T
E
P
L
D
V
T
K
T
Q
T
F
S
V
Site 73
T828
E
P
L
D
V
T
K
T
Q
T
F
S
V
V
P
Site 74
T830
L
D
V
T
K
T
Q
T
F
S
V
V
P
N
Q
Site 75
S832
V
T
K
T
Q
T
F
S
V
V
P
N
Q
D
K
Site 76
T851
M
K
L
L
T
V
G
T
S
E
I
S
S
R
D
Site 77
S852
K
L
L
T
V
G
T
S
E
I
S
S
R
D
I
Site 78
S855
T
V
G
T
S
E
I
S
S
R
D
I
D
P
H
Site 79
S856
V
G
T
S
E
I
S
S
R
D
I
D
P
H
V
Site 80
S886
S
K
D
D
D
I
M
S
E
D
L
P
G
H
Q
Site 81
S897
P
G
H
Q
G
D
L
S
T
F
L
H
Q
E
G
Site 82
T898
G
H
Q
G
D
L
S
T
F
L
H
Q
E
G
K
Site 83
T910
E
G
K
R
E
K
I
T
P
R
N
G
E
L
F
Site 84
S921
G
E
L
F
H
C
V
S
E
N
E
H
G
A
P
Site 85
S937
R
K
D
M
V
R
S
S
F
V
T
R
H
S
R
Site 86
T940
M
V
R
S
S
F
V
T
R
H
S
R
I
P
V
Site 87
S943
S
S
F
V
T
R
H
S
R
I
P
V
L
A
Q
Site 88
S954
V
L
A
Q
E
I
D
S
T
L
E
S
S
S
P
Site 89
T955
L
A
Q
E
I
D
S
T
L
E
S
S
S
P
V
Site 90
S958
E
I
D
S
T
L
E
S
S
S
P
V
S
A
K
Site 91
S959
I
D
S
T
L
E
S
S
S
P
V
S
A
K
E
Site 92
S960
D
S
T
L
E
S
S
S
P
V
S
A
K
E
K
Site 93
S963
L
E
S
S
S
P
V
S
A
K
E
K
L
L
Q
Site 94
S990
V
E
K
R
Q
F
K
S
F
L
G
D
L
S
S
Site 95
S996
K
S
F
L
G
D
L
S
S
A
S
D
K
L
L
Site 96
S997
S
F
L
G
D
L
S
S
A
S
D
K
L
L
E
Site 97
S999
L
G
D
L
S
S
A
S
D
K
L
L
E
E
K
Site 98
S1024
E
E
V
L
T
P
F
S
R
L
T
V
D
S
H
Site 99
T1027
L
T
P
F
S
R
L
T
V
D
S
H
L
S
R
Site 100
S1030
F
S
R
L
T
V
D
S
H
L
S
R
S
A
E
Site 101
S1033
L
T
V
D
S
H
L
S
R
S
A
E
D
S
F
Site 102
S1035
V
D
S
H
L
S
R
S
A
E
D
S
F
L
S
Site 103
S1039
L
S
R
S
A
E
D
S
F
L
S
P
I
I
S
Site 104
S1042
S
A
E
D
S
F
L
S
P
I
I
S
Q
S
R
Site 105
S1046
S
F
L
S
P
I
I
S
Q
S
R
K
S
K
I
Site 106
S1048
L
S
P
I
I
S
Q
S
R
K
S
K
I
P
R
Site 107
S1051
I
I
S
Q
S
R
K
S
K
I
P
R
P
V
S
Site 108
S1058
S
K
I
P
R
P
V
S
W
V
N
T
D
Q
V
Site 109
T1062
R
P
V
S
W
V
N
T
D
Q
V
N
S
S
T
Site 110
S1067
V
N
T
D
Q
V
N
S
S
T
S
S
Q
F
F
Site 111
S1068
N
T
D
Q
V
N
S
S
T
S
S
Q
F
F
P
Site 112
S1071
Q
V
N
S
S
T
S
S
Q
F
F
P
R
P
P
Site 113
T1084
P
P
P
G
K
P
P
T
R
P
G
V
E
A
R
Site 114
Y1095
V
E
A
R
L
R
R
Y
K
V
L
G
S
S
N
Site 115
S1100
R
R
Y
K
V
L
G
S
S
N
S
D
S
D
L
Site 116
S1101
R
Y
K
V
L
G
S
S
N
S
D
S
D
L
F
Site 117
S1103
K
V
L
G
S
S
N
S
D
S
D
L
F
S
R
Site 118
S1105
L
G
S
S
N
S
D
S
D
L
F
S
R
L
A
Site 119
S1109
N
S
D
S
D
L
F
S
R
L
A
Q
I
L
Q
Site 120
S1119
A
Q
I
L
Q
N
G
S
Q
K
P
R
S
T
T
Site 121
S1124
N
G
S
Q
K
P
R
S
T
T
Q
C
K
S
P
Site 122
T1125
G
S
Q
K
P
R
S
T
T
Q
C
K
S
P
G
Site 123
T1126
S
Q
K
P
R
S
T
T
Q
C
K
S
P
G
S
Site 124
S1130
R
S
T
T
Q
C
K
S
P
G
S
P
H
N
P
Site 125
S1133
T
Q
C
K
S
P
G
S
P
H
N
P
K
T
P
Site 126
T1139
G
S
P
H
N
P
K
T
P
P
K
S
P
V
V
Site 127
S1143
N
P
K
T
P
P
K
S
P
V
V
P
R
R
S
Site 128
S1150
S
P
V
V
P
R
R
S
P
S
A
S
P
R
S
Site 129
S1152
V
V
P
R
R
S
P
S
A
S
P
R
S
S
S
Site 130
S1154
P
R
R
S
P
S
A
S
P
R
S
S
S
L
P
Site 131
S1157
S
P
S
A
S
P
R
S
S
S
L
P
R
T
S
Site 132
S1158
P
S
A
S
P
R
S
S
S
L
P
R
T
S
S
Site 133
S1159
S
A
S
P
R
S
S
S
L
P
R
T
S
S
S
Site 134
T1163
R
S
S
S
L
P
R
T
S
S
S
S
P
S
R
Site 135
S1164
S
S
S
L
P
R
T
S
S
S
S
P
S
R
A
Site 136
S1165
S
S
L
P
R
T
S
S
S
S
P
S
R
A
G
Site 137
S1166
S
L
P
R
T
S
S
S
S
P
S
R
A
G
R
Site 138
S1167
L
P
R
T
S
S
S
S
P
S
R
A
G
R
P
Site 139
S1169
R
T
S
S
S
S
P
S
R
A
G
R
P
H
H
Site 140
S1180
R
P
H
H
D
Q
R
S
S
S
P
H
L
G
R
Site 141
S1181
P
H
H
D
Q
R
S
S
S
P
H
L
G
R
S
Site 142
S1182
H
H
D
Q
R
S
S
S
P
H
L
G
R
S
K
Site 143
S1188
S
S
P
H
L
G
R
S
K
S
P
P
S
H
S
Site 144
S1190
P
H
L
G
R
S
K
S
P
P
S
H
S
G
S
Site 145
S1193
G
R
S
K
S
P
P
S
H
S
G
S
S
S
S
Site 146
S1195
S
K
S
P
P
S
H
S
G
S
S
S
S
R
R
Site 147
S1197
S
P
P
S
H
S
G
S
S
S
S
R
R
S
C
Site 148
S1198
P
P
S
H
S
G
S
S
S
S
R
R
S
C
Q
Site 149
S1199
P
S
H
S
G
S
S
S
S
R
R
S
C
Q
Q
Site 150
S1200
S
H
S
G
S
S
S
S
R
R
S
C
Q
Q
E
Site 151
S1203
G
S
S
S
S
R
R
S
C
Q
Q
E
H
C
K
Site 152
S1219
S
K
N
G
L
K
G
S
G
S
L
H
H
H
S
Site 153
S1221
N
G
L
K
G
S
G
S
L
H
H
H
S
A
S
Site 154
S1226
S
G
S
L
H
H
H
S
A
S
T
K
T
P
Q
Site 155
T1231
H
H
S
A
S
T
K
T
P
Q
G
K
S
K
P
Site 156
S1236
T
K
T
P
Q
G
K
S
K
P
A
S
K
L
S
Site 157
S1240
Q
G
K
S
K
P
A
S
K
L
S
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation