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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PYHIN1
Full Name:
Pyrin and HIN domain-containing protein 1
Alias:
Interferon-inducible protein X
Type:
Mass (Da):
55065
Number AA:
492
UniProt ID:
Q6K0P9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y5
_
_
_
M
A
N
N
Y
K
K
I
V
L
L
K
Site 2
Y20
G
L
E
V
I
N
D
Y
H
F
R
I
V
K
S
Site 3
S27
Y
H
F
R
I
V
K
S
L
L
S
N
D
L
K
Site 4
S30
R
I
V
K
S
L
L
S
N
D
L
K
L
N
P
Site 5
Y113
K
T
K
Q
K
E
V
Y
P
A
T
P
A
C
T
Site 6
T116
Q
K
E
V
Y
P
A
T
P
A
C
T
P
S
N
Site 7
T120
Y
P
A
T
P
A
C
T
P
S
N
R
L
T
A
Site 8
S122
A
T
P
A
C
T
P
S
N
R
L
T
A
K
G
Site 9
T126
C
T
P
S
N
R
L
T
A
K
G
A
E
E
T
Site 10
T147
K
K
P
S
E
E
E
T
G
T
K
R
S
K
M
Site 11
T149
P
S
E
E
E
T
G
T
K
R
S
K
M
S
K
Site 12
T159
S
K
M
S
K
E
Q
T
R
P
S
C
S
A
G
Site 13
S162
S
K
E
Q
T
R
P
S
C
S
A
G
A
S
T
Site 14
S164
E
Q
T
R
P
S
C
S
A
G
A
S
T
S
T
Site 15
S168
P
S
C
S
A
G
A
S
T
S
T
A
M
G
R
Site 16
S170
C
S
A
G
A
S
T
S
T
A
M
G
R
S
P
Site 17
S176
T
S
T
A
M
G
R
S
P
P
P
Q
T
S
S
Site 18
T181
G
R
S
P
P
P
Q
T
S
S
S
A
P
P
N
Site 19
S182
R
S
P
P
P
Q
T
S
S
S
A
P
P
N
T
Site 20
S183
S
P
P
P
Q
T
S
S
S
A
P
P
N
T
S
Site 21
S184
P
P
P
Q
T
S
S
S
A
P
P
N
T
S
S
Site 22
T189
S
S
S
A
P
P
N
T
S
S
T
E
S
L
K
Site 23
S190
S
S
A
P
P
N
T
S
S
T
E
S
L
K
P
Site 24
S191
S
A
P
P
N
T
S
S
T
E
S
L
K
P
L
Site 25
T192
A
P
P
N
T
S
S
T
E
S
L
K
P
L
A
Site 26
S194
P
N
T
S
S
T
E
S
L
K
P
L
A
N
R
Site 27
T204
P
L
A
N
R
H
A
T
A
S
K
N
I
F
R
Site 28
S206
A
N
R
H
A
T
A
S
K
N
I
F
R
E
D
Site 29
Y228
N
A
T
K
V
F
K
Y
E
S
S
E
N
E
Q
Site 30
S230
T
K
V
F
K
Y
E
S
S
E
N
E
Q
R
R
Site 31
S231
K
V
F
K
Y
E
S
S
E
N
E
Q
R
R
M
Site 32
T242
Q
R
R
M
F
H
A
T
V
A
T
Q
T
Q
F
Site 33
S272
K
K
R
I
I
I
I
S
N
Y
S
K
R
N
S
Site 34
Y274
R
I
I
I
I
S
N
Y
S
K
R
N
S
L
L
Site 35
S279
S
N
Y
S
K
R
N
S
L
L
E
V
N
E
A
Site 36
S288
L
E
V
N
E
A
S
S
V
S
E
A
G
P
D
Site 37
T297
S
E
A
G
P
D
Q
T
F
E
V
P
K
D
I
Site 38
T341
T
K
I
V
N
R
K
T
T
I
Y
E
I
Q
D
Site 39
T342
K
I
V
N
R
K
T
T
I
Y
E
I
Q
D
K
Site 40
Y344
V
N
R
K
T
T
I
Y
E
I
Q
D
K
T
G
Site 41
S352
E
I
Q
D
K
T
G
S
M
A
V
V
G
K
G
Site 42
S386
L
R
K
R
E
N
M
S
K
L
M
S
E
M
H
Site 43
S394
K
L
M
S
E
M
H
S
F
I
Q
I
Q
K
N
Site 44
S406
Q
K
N
T
N
Q
R
S
H
D
S
R
S
M
A
Site 45
S409
T
N
Q
R
S
H
D
S
R
S
M
A
L
P
Q
Site 46
S411
Q
R
S
H
D
S
R
S
M
A
L
P
Q
E
Q
Site 47
S419
M
A
L
P
Q
E
Q
S
Q
H
P
K
P
S
E
Site 48
S425
Q
S
Q
H
P
K
P
S
E
A
S
T
T
L
P
Site 49
T429
P
K
P
S
E
A
S
T
T
L
P
E
S
H
L
Site 50
T430
K
P
S
E
A
S
T
T
L
P
E
S
H
L
K
Site 51
S434
A
S
T
T
L
P
E
S
H
L
K
T
P
Q
M
Site 52
T438
L
P
E
S
H
L
K
T
P
Q
M
P
P
T
T
Site 53
T444
K
T
P
Q
M
P
P
T
T
P
S
S
S
S
F
Site 54
T445
T
P
Q
M
P
P
T
T
P
S
S
S
S
F
T
Site 55
S447
Q
M
P
P
T
T
P
S
S
S
S
F
T
K
K
Site 56
S448
M
P
P
T
T
P
S
S
S
S
F
T
K
K
D
Site 57
S450
P
T
T
P
S
S
S
S
F
T
K
K
D
E
T
Site 58
T452
T
P
S
S
S
S
F
T
K
K
D
E
T
H
P
Site 59
T457
S
F
T
K
K
D
E
T
H
P
G
A
Q
S
S
Site 60
S464
T
H
P
G
A
Q
S
S
P
A
N
F
R
I
T
Site 61
T471
S
P
A
N
F
R
I
T
S
P
T
V
A
P
P
Site 62
T474
N
F
R
I
T
S
P
T
V
A
P
P
L
S
S
Site 63
S480
P
T
V
A
P
P
L
S
S
D
T
S
T
N
R
Site 64
S481
T
V
A
P
P
L
S
S
D
T
S
T
N
R
H
Site 65
S484
P
P
L
S
S
D
T
S
T
N
R
H
P
A
V
Site 66
T485
P
L
S
S
D
T
S
T
N
R
H
P
A
V
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation